Glycated Hemoglobin (HbA1c) as a Predictor of Outcomes during Acute Exacerbations of Chronic Obstructive Pulmonary Disease
In conclusion neither the preceding nor the present glycemic state exhibit a predictive value regarding short- or long-term outcomes of an AECOPD.PMID:33759663 | DOI:10.1080/15412555.2021.1902491 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 24, 2021 Category: Respiratory Medicine Authors: Evgenia Papathanassiou Andriana I Papaioannou Ilias Papanikolaou Emmanouil Antonakis Ioanna Makou Georgios Hillas Eleutheria Mizi Petros Bakakos Vasiliki Apollonatou Galateia Verykokou Nikolaos Roussakis Zoe Tsilogianni Spyros Papiris Stelios Loukides Source Type: research

Clinical Outcome of a Cross-Sectorial Lung Team Treating Patients with COPD at High Risk of Exacerbation: A Randomized Controlled Trial
COPD. 2021 Mar 19:1-17. doi: 10.1080/15412555.2021.1898577. Online ahead of print.ABSTRACTIn addition to the financial burden, acute exacerbation of chronic obstructive pulmonary disease (AECOPD) also has a negative impact on health status and disease progression for patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the effect of affiliation to a cross-sectorial lung team (CLT) on hospitalization and length of hospital stay for patients with COPD and ≥ one severe or two moderate AECOPD events within a year. We conducted a randomized clinical trial between 2017 and 2020....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Birgit Refsgaard Iversen Lotte Ørneborg Rodkjaer Vibeke Bregnballe Anders L økke Source Type: research

Quantitative Computed Tomography Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease Referred for Lung Volume Reduction
In conclusion, in well-characterized patients with severe COPD referred for lung volume reduction, PM CSA correlated with severity of lung disease, mortality, and need for advanced therapies. In addition to predicting clinical outcomes, targeting sarcopenia is a potential therapeutic approach in patients with severe COPD.PMID:33736550 | DOI:10.1080/15412555.2021.1897560 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Amy H Attaway Nicole Welch Ruchi Yadav Annette Bellar Umur Hatipo ğlu Yvonne Meli Marielle P K J Engelen Joe Zein Srinivasan Dasarathy Source Type: research

Clinical Outcome of a Cross-Sectorial Lung Team Treating Patients with COPD at High Risk of Exacerbation: A Randomized Controlled Trial
COPD. 2021 Mar 19:1-17. doi: 10.1080/15412555.2021.1898577. Online ahead of print.ABSTRACTIn addition to the financial burden, acute exacerbation of chronic obstructive pulmonary disease (AECOPD) also has a negative impact on health status and disease progression for patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the effect of affiliation to a cross-sectorial lung team (CLT) on hospitalization and length of hospital stay for patients with COPD and ≥ one severe or two moderate AECOPD events within a year. We conducted a randomized clinical trial between 2017 and 2020....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Birgit Refsgaard Iversen Lotte Ørneborg Rodkjaer Vibeke Bregnballe Anders L økke Source Type: research

Quantitative Computed Tomography Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease Referred for Lung Volume Reduction
In conclusion, in well-characterized patients with severe COPD referred for lung volume reduction, PM CSA correlated with severity of lung disease, mortality, and need for advanced therapies. In addition to predicting clinical outcomes, targeting sarcopenia is a potential therapeutic approach in patients with severe COPD.PMID:33736550 | DOI:10.1080/15412555.2021.1897560 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Amy H Attaway Nicole Welch Ruchi Yadav Annette Bellar Umur Hatipo ğlu Yvonne Meli Marielle P K J Engelen Joe Zein Srinivasan Dasarathy Source Type: research

Clinical Outcome of a Cross-Sectorial Lung Team Treating Patients with COPD at High Risk of Exacerbation: A Randomized Controlled Trial
COPD. 2021 Mar 19:1-17. doi: 10.1080/15412555.2021.1898577. Online ahead of print.ABSTRACTIn addition to the financial burden, acute exacerbation of chronic obstructive pulmonary disease (AECOPD) also has a negative impact on health status and disease progression for patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the effect of affiliation to a cross-sectorial lung team (CLT) on hospitalization and length of hospital stay for patients with COPD and ≥ one severe or two moderate AECOPD events within a year. We conducted a randomized clinical trial between 2017 and 2020....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Birgit Refsgaard Iversen Lotte Ørneborg Rodkjaer Vibeke Bregnballe Anders L økke Source Type: research

Quantitative Computed Tomography Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease Referred for Lung Volume Reduction
In conclusion, in well-characterized patients with severe COPD referred for lung volume reduction, PM CSA correlated with severity of lung disease, mortality, and need for advanced therapies. In addition to predicting clinical outcomes, targeting sarcopenia is a potential therapeutic approach in patients with severe COPD.PMID:33736550 | DOI:10.1080/15412555.2021.1897560 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Amy H Attaway Nicole Welch Ruchi Yadav Annette Bellar Umur Hatipo ğlu Yvonne Meli Marielle P K J Engelen Joe Zein Srinivasan Dasarathy Source Type: research

Clinical Outcome of a Cross-Sectorial Lung Team Treating Patients with COPD at High Risk of Exacerbation: A Randomized Controlled Trial
COPD. 2021 Mar 19:1-17. doi: 10.1080/15412555.2021.1898577. Online ahead of print.ABSTRACTIn addition to the financial burden, acute exacerbation of chronic obstructive pulmonary disease (AECOPD) also has a negative impact on health status and disease progression for patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the effect of affiliation to a cross-sectorial lung team (CLT) on hospitalization and length of hospital stay for patients with COPD and ≥ one severe or two moderate AECOPD events within a year. We conducted a randomized clinical trial between 2017 and 2020....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Birgit Refsgaard Iversen Lotte Ørneborg Rodkjaer Vibeke Bregnballe Anders L økke Source Type: research

Quantitative Computed Tomography Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease Referred for Lung Volume Reduction
In conclusion, in well-characterized patients with severe COPD referred for lung volume reduction, PM CSA correlated with severity of lung disease, mortality, and need for advanced therapies. In addition to predicting clinical outcomes, targeting sarcopenia is a potential therapeutic approach in patients with severe COPD.PMID:33736550 | DOI:10.1080/15412555.2021.1897560 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Amy H Attaway Nicole Welch Ruchi Yadav Annette Bellar Umur Hatipo ğlu Yvonne Meli Marielle P K J Engelen Joe Zein Srinivasan Dasarathy Source Type: research

Clinical Outcome of a Cross-Sectorial Lung Team Treating Patients with COPD at High Risk of Exacerbation: A Randomized Controlled Trial
COPD. 2021 Mar 19:1-17. doi: 10.1080/15412555.2021.1898577. Online ahead of print.ABSTRACTIn addition to the financial burden, acute exacerbation of chronic obstructive pulmonary disease (AECOPD) also has a negative impact on health status and disease progression for patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the effect of affiliation to a cross-sectorial lung team (CLT) on hospitalization and length of hospital stay for patients with COPD and ≥ one severe or two moderate AECOPD events within a year. We conducted a randomized clinical trial between 2017 and 2020....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Birgit Refsgaard Iversen Lotte Ørneborg Rodkjaer Vibeke Bregnballe Anders L økke Source Type: research

Quantitative Computed Tomography Assessment of Pectoralis and Erector Spinae Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease Referred for Lung Volume Reduction
In conclusion, in well-characterized patients with severe COPD referred for lung volume reduction, PM CSA correlated with severity of lung disease, mortality, and need for advanced therapies. In addition to predicting clinical outcomes, targeting sarcopenia is a potential therapeutic approach in patients with severe COPD.PMID:33736550 | DOI:10.1080/15412555.2021.1897560 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2021 Category: Respiratory Medicine Authors: Amy H Attaway Nicole Welch Ruchi Yadav Annette Bellar Umur Hatipo ğlu Yvonne Meli Marielle P K J Engelen Joe Zein Srinivasan Dasarathy Source Type: research

Evolution and Comparative Analysis of Hospitalizations in Spain Due to COPD and Bronchiectasis between 2004 and 2015
COPD. 2021 Mar 17:1-14. doi: 10.1080/15412555.2021.1896692. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is the leading cause of hospitalization for chronic respiratory illness in Spain. In recent years hospital admissions due to bronchiectasis have been increasing, although it is not known whether this is in proportion to COPD hospitalizations. Our main objective was to analyze the temporal evolution of discharges due to COPD, bronchiectasis, and their combination, and secondly, to assess their impact on in-hospital mortality and healthcare costs. We performed a retrospective study, based on ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 17, 2021 Category: Respiratory Medicine Authors: Annie Navarro-Rolon David de la Rosa-Carrillo Cristina Esquinas Marc Miravitlles Miguel Angel Martinez-Garc ía Pedro Almagro Source Type: research

Healthcare and Societal Costs in Patients with COPD and Breathlessness after Completion of a Comprehensive Rehabilitation Program
This study's goal was to analyze the impact of breathlessness burden on healthcare and societal costs. In this observational single-center study, patients with COPD were followed-up for 24 months after completion of a comprehensive pulmonary rehabilitation program. Every three months participants completed a cost questionnaire, covering healthcare utilization and impact on daily activities. The results were compared between participants with low (modified Medical Research Council (mMRC) grade
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 15, 2021 Category: Respiratory Medicine Authors: Cornelia A Verberkt Marieke H J van den Beuken-van Everdingen Carmen D Dirksen Jos M G A Schols Lowie E G W Vanfleteren Frits M E Franssen Miriam T J Groenen Emiel F M Wouters Daisy J A Janssen Source Type: research

Psychometric Properties of Patient-Reported Outcome Measures Assessing Self-Efficacy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review
COPD. 2021 Mar 12:1-10. doi: 10.1080/15412555.2021.1897559. Online ahead of print.ABSTRACTThis systematic review aimed to synthesize the evidence of the psychometric properties of self-efficacy patient-reported outcome measures (PROMs) in patients with chronic obstructive pulmonary disease (COPD). We conducted a systematic search of MEDLINE and other common databases from inception until September 2020. Studies that reported psychometric properties of self-efficacy outcome measures in COPD patients were included. We used the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) 2018 guideli...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 12, 2021 Category: Respiratory Medicine Authors: Sanaa A Alsubheen Adnan Wshah Roger Goldstein Dina Brooks Source Type: research

Efficacy and Safety of Inhaled Glycopyrronium Bromide in COPD: A Randomized, Parallel Group, Dose-Ranging Study (GLIMMER)
COPD. 2021 Mar 12:1-10. doi: 10.1080/15412555.2021.1894111. Online ahead of print.ABSTRACTThis Phase II, randomized, parallel group study was conducted as part of US regulatory requirements to identify the most appropriate dose of the long-acting muscarinic antagonist glycopyrronium bromide (GB) for use in a single-inhaler triple-therapy combination with the inhaled corticosteroid beclomethasone dipropionate plus the long-acting β2-agonist formoterol fumarate. Eligible subjects were adults with COPD and post-bronchodilator forced expiratory volume in 1 s (FEV1) 40-80% predicted. Subjects were randomized to receive inh...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 12, 2021 Category: Respiratory Medicine Authors: Edward Kerwin Gregory Feldman James Pearle Luis De La Cruz Melinda Edwards Carolyn Beaudot George Georges Source Type: research

Psychometric Properties of Patient-Reported Outcome Measures Assessing Self-Efficacy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review
COPD. 2021 Mar 12:1-10. doi: 10.1080/15412555.2021.1897559. Online ahead of print.ABSTRACTThis systematic review aimed to synthesize the evidence of the psychometric properties of self-efficacy patient-reported outcome measures (PROMs) in patients with chronic obstructive pulmonary disease (COPD). We conducted a systematic search of MEDLINE and other common databases from inception until September 2020. Studies that reported psychometric properties of self-efficacy outcome measures in COPD patients were included. We used the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) 2018 guideli...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 12, 2021 Category: Respiratory Medicine Authors: Sanaa A Alsubheen Adnan Wshah Roger Goldstein Dina Brooks Source Type: research

Efficacy and Safety of Inhaled Glycopyrronium Bromide in COPD: A Randomized, Parallel Group, Dose-Ranging Study (GLIMMER)
COPD. 2021 Mar 12:1-10. doi: 10.1080/15412555.2021.1894111. Online ahead of print.ABSTRACTThis Phase II, randomized, parallel group study was conducted as part of US regulatory requirements to identify the most appropriate dose of the long-acting muscarinic antagonist glycopyrronium bromide (GB) for use in a single-inhaler triple-therapy combination with the inhaled corticosteroid beclomethasone dipropionate plus the long-acting β2-agonist formoterol fumarate. Eligible subjects were adults with COPD and post-bronchodilator forced expiratory volume in 1 s (FEV1) 40-80% predicted. Subjects were randomized to receive inh...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 12, 2021 Category: Respiratory Medicine Authors: Edward Kerwin Gregory Feldman James Pearle Luis De La Cruz Melinda Edwards Carolyn Beaudot George Georges Source Type: research

Psychometric Properties of Patient-Reported Outcome Measures Assessing Self-Efficacy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review
COPD. 2021 Mar 12:1-10. doi: 10.1080/15412555.2021.1897559. Online ahead of print.ABSTRACTThis systematic review aimed to synthesize the evidence of the psychometric properties of self-efficacy patient-reported outcome measures (PROMs) in patients with chronic obstructive pulmonary disease (COPD). We conducted a systematic search of MEDLINE and other common databases from inception until September 2020. Studies that reported psychometric properties of self-efficacy outcome measures in COPD patients were included. We used the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) 2018 guideli...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 12, 2021 Category: Respiratory Medicine Authors: Sanaa A Alsubheen Adnan Wshah Roger Goldstein Dina Brooks Source Type: research

Efficacy and Safety of Inhaled Glycopyrronium Bromide in COPD: A Randomized, Parallel Group, Dose-Ranging Study (GLIMMER)
COPD. 2021 Mar 12:1-10. doi: 10.1080/15412555.2021.1894111. Online ahead of print.ABSTRACTThis Phase II, randomized, parallel group study was conducted as part of US regulatory requirements to identify the most appropriate dose of the long-acting muscarinic antagonist glycopyrronium bromide (GB) for use in a single-inhaler triple-therapy combination with the inhaled corticosteroid beclomethasone dipropionate plus the long-acting β2-agonist formoterol fumarate. Eligible subjects were adults with COPD and post-bronchodilator forced expiratory volume in 1 s (FEV1) 40-80% predicted. Subjects were randomized to receive inh...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 12, 2021 Category: Respiratory Medicine Authors: Edward Kerwin Gregory Feldman James Pearle Luis De La Cruz Melinda Edwards Carolyn Beaudot George Georges Source Type: research

COMMENTARY: Is a Change from the National Early Warning System (NEWS) Warranted in Patients with Chronic Respiratory Conditions?
COPD. 2021 Mar 8:1-6. doi: 10.1080/15412555.2021.1892051. Online ahead of print.NO ABSTRACTPMID:33682525 | DOI:10.1080/15412555.2021.1892051 (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 8, 2021 Category: Respiratory Medicine Authors: Sin éad M O'Neill Miriam Bell Avilene Casey Brendan Leen Barbara Clyne Barrie Tyner Susan M Smith Peter J Watkinson Michelle O'Neill M áirín Ryan Source Type: research

Association of Body Mass Index with Risk of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Authors: Zhang X, Chen H, Gu K, Chen J, Jiang X Abstract The association between body mass index (BMI) and chronic obstructive pulmonary disease (COPD) remains controversial. Therefore, a meta-analysis was conducted to further evaluate the relationship. A comprehensive literature search was performed in PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), and Wanfang databases to identify eligible articles until July 15, 2020. Random effect model (REM) was used to compute the pooled results with 95% confidence intervals (CIs). We conducted meta-regression and subgroup analysis to explore ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Comparative Effectiveness of Initial LAMA versus LABA in COPD: Real-World Cohort Study.
This study in the real world clinical setting of COPD treatment found that using a LAMA or a LABA (no ICS) as the initial bronchodilator is generally as effective at reducing exacerbation incidence and frequency. However, a LAMA may be more effective in patients with prior exacerbations, which supports the GOLD recommendations for newly diagnosed COPD. The role of airway obstruction on the effectiveness of bronchodilators warrants further investigation. PMID: 33569990 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 12, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Alpha-1 Antitrypsin Deficiency and Tobacco Smoking: Exploring Risk Factors and Smoking Cessation in a Registry Population.
Authors: Franciosi AN, Alkhunaizi MA, Woodsmith A, Aldaihani L, Alkandari H, Lee SE, Fee LT, McElvaney NG, Carroll TP Abstract The ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is strongly associated with COPD, even in never-smokers. Moderate AATD genotypes (MZ and SZ) have been shown to increase the severity of COPD in smokers. In this comparative study, we examine the association between AATD, genotypes, and smoking cessation. Two hundred and ninety-three Irish people with AATD [MZ (n = 91), SZ (n = 72), and ZZ/rare (n = 130)] completed a custom questionnaire asses...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 11, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Minimal Clinically Important Difference for Quadriceps Muscle Strength in People with COPD following Pulmonary Rehabilitation.
This study estimated the minimal clinically important difference (MCID) for the isotonic and isometric quadriceps muscle strength assessed with the one-repetition maximum (1RM) and hand-held dynamometry (HHD) in people with chronic obstructive pulmonary disease (COPD) following PR. A secondary analysis of a real life non-randomised controlled study was conducted in people with COPD enrolled in a 12-week community-based PR programme. Anchor and distribution-based methods were used to compute the MCIDs. The anchors explored were the St. George's respiratory questionnaire (SGRQ) and the six-minute walk test (6MWT) using Pears...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 5, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Investigating Patient and Family Satisfaction with the Respiratory Status in Patients with Chronic Obstructive Pulmonary Disease.
This study aimed to examine the level of patient and family satisfaction with the patients' current respiratory status and to identify the clinical factors closely linked to dissatisfaction. This multicenter, cross-sectional study included 454 outpatients with COPD and 296 family members. Patients and families were allocated to the satisfied and dissatisfied groups based on their satisfaction with the patients' current respiratory status. Patients' health status, dyspnoea, appetite, respiratory function, and mood disorders were assessed. Among the participants of this study, 67% of patients and 60% of their families were d...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 30, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Transcutaneous PCO2 for Exercise Gas Exchange Efficiency in Chronic Obstructive Pulmonary Disease.
Authors: Cao M, Stringer WW, Corey S, Orogian A, Cao R, Calmelat R, Lin F, Casaburi R, Rossiter HB, Porszasz J Abstract Gas exchange inefficiency and dynamic hyperinflation contributes to exercise limitation in chronic obstructive pulmonary disease (COPD). It is also characterized by an elevated fraction of physiological dead space (VD/VT). Noninvasive methods for accurate VD/VT assessment during exercise in patients are lacking. The current study sought to compare transcutaneous PCO2 (TcPCO2) with the gold standard-arterial PCO2 (PaCO2)-and other available methods (end tidal CO2 and the Jones equation) for estimat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 20, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Coenzyme Q10 in COPD: An Unexplored Opportunity?
Authors: Zozina VI, Covantev S, Kukes VG, Corlateanu A Abstract COPD represents a major cause of mortality and morbidity worldwide, is linked to systemic inflammation and tends to coexist with a variety of comorbidities. Inflammation, oxidative stress and protease-antiprotease imbalance represent the pathogenic triad of COPD. Even though oxidative stress and mitochondrial dysfunction is a well-studied phenomenon in COPD and there is a variety of studies that aim to counteract its effect, there is limited data available on the use of coenzyme Q10 in COPD. The aim of the current review is to analyze the current data ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 16, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Baseline Characteristics of Subjects with Chronic Obstructive Pulmonary Disease Associated to the Improvement in Activities of Daily Living after Exercise Training.
In conclusion, the baseline variables that best predict the improvement of individuals after exercise training are TGlittre and LCADL, showing that subjects with significant functional impairment are more likely to clinically significantly improve their ADLs. PMID: 33427517 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - January 13, 2021 Category: Respiratory Medicine Tags: COPD Source Type: research

Bacterial and Viral Infection in Patients Hospitalized for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Implication for Antimicrobial Management and Clinical Outcome.
The objectives of this study were first to evaluate the prevalence of pathogens associated to these episodes by combining conventional bacteriology and multiplex viral and bacterial PCR assays in sputum specimens, and second to determine whether C-reactive protein (CRP) value and clinical outcome could be influenced by the type of microbial agent(s) recovered from these samples. A cohort of 84 Tunisian patients hospitalized at the emergency room for AECOPD was investigated prospectively for the semi-quantitative detection of bacteria by conventional culture (the threshold of positivity was of 107 CFU/ml) and for the detect...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 30, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Adherence to GOLD Recommendations among Swiss Pulmonologists and General Practitioners.
This study confirms that discordance of real-world prescription patterns with international guidance is frequent. Further educational efforts are required to improve adherence to COPD management recommendations. PMID: 33342309 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 23, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Follow-up with Telemedicine in Early Discharge for COPD Exacerbations: Randomized Clinical Trial (TELEMEDCOPD-Trial).
In conclusion follow-up via a telemedicine program in early discharge after hospitalization is as effective as conventional home follow up, being the cost of either strategy not significantly different. PMID: 33307857 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 15, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Lung Deposition Using the Respimat ® Soft Mist™ Inhaler Mono and Fixed-Dose Combination Therapies: An In Vitro/In Silico Analysis.
Lung Deposition Using the Respimat® Soft Mist™ Inhaler Mono and Fixed-Dose Combination Therapies: An In Vitro/In Silico Analysis. COPD. 2020 Dec 11;:1-10 Authors: Ciciliani AM, Denny M, Langguth P, Voshaar T, Wachtel H Abstract Tiotropium and olodaterol are mainstay treatments for chronic obstructive pulmonary disease (COPD) and yield important clinical improvements, especially when used in fixed-dose combination. Whilst previous studies have shown consistent delivery of tiotropium to the lungs with the Respimat® inhaler, no such study has been carried out for olodaterol or the components...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Adiponectin is Associated with Neutrophils to Lymphocyte Ratio in Patients with Chronic Obstructive Pulmonary Disease.
Authors: Perrotta F, Nigro E, Pafundi PC, Polito R, Nucera F, Scialò F, Caramori G, Bianco A, Daniele A Abstract Disproportionate systemic inflammation in chronic obstructive pulmonary disease (COPD) is associated with declining lung functions and comorbidities. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have emerged as valuable markers of the systemic inflammation in COPD. Adiponectin (Acpr30) circulates in serum as complexes of different molecular weight (HMW, MMW, LMW) with multifaceted metabolic and anti-inflammatory properties implicated in airway pathophysiology. We aim...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Is the Symptom of Cough in Chronic Obstructive Pulmonary Disease Important?
Authors: Niu S, Wang S, Xu X, Yu L Abstract Chronic obstructive pulmonary disease (COPD) is a common disease and a significant burden worldwide. The clinical symptoms of this disease include progressive dyspnea, cough, expectoration, and wheezing, among others. At present, the primary focus has been on reducing the frequency of acute exacerbations and improving lung function and dyspnea symptoms, and limited attention has been paid to cough and expectoration symptoms, which may be associated with a decrease in lung function, more acute exacerbations, and hospitalizations. Therefore, this outcomes in patients with C...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 13, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Timing of Pulmonary Rehabilitation in Readmitted Patients with Severe Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.
Authors: Güell-Rous MR, Morante-Vélez F, Flotats-Farré G, Paz-Del Río LD, Closa-Rusinés C, Ouchi-Vernet D, Segura-Medina M, Bolíbar-Ribas I Abstract Early pulmonary rehabilitation (PR), started during hospitalization or within the first month after discharge, has been shown to reduce exacerbations and improve health-related-quality of life (HRQoL) and exercise capacity. However, no randomized clinical trials (RCT) have compared the efficacy of PR started during hospitalization (DHPR) to PR initiated one month post-hospitalization (PHPR). We conducted an RCT to compare DHPR to...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 10, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Gini Coefficient: A New Approach to Assess Physical Activity Inequality in COPD.
Authors: Hirata RP, Oliveira JM, Schneider LP, Bertoche MP, Rodrigues LAL, Rodrigues A, Mantoani LC, Hernandes NA, Pitta F, Furlanetto KC Abstract Increasing physical activity (PA) is a complex and challenging task in patients with chronic obstructive pulmonary disease (COPD). However, some questions are raised regarding the evaluation of PA in these patients: Have all aspects of PA evaluation in patients with COPD already been explored in the scientific literature and clinical practice? What is the clinical importance of assessing PA inequality? PA inequality is defined as the Gini coefficient (Ginicoef) of the PA...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 28, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Disproportionally Impaired Diffusion Capacity Relative to Airflow Limitation in COPD.
This study tested whether a disproportionally impaired DLCO relative to FEV1 (FEV1 z-score>-3 and DLCO z-score≤-3) is a common functional COPD phenotype associated with distinct clinical and structural features and the prognosis of two cohorts. The cross-sectional analyses of the Korea COPD Subgroup Study (KOCOSS) cohort (multicenter study in Korea) included 743 males with COPD whose DLCO was available. The cross-sectional and longitudinal analyses of the Kyoto University Cohort (single-center study in Japan) included 195 males with COPD who were prospectively followed for 10 years. A disproportionally impaire...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 24, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Oscillometry as a Predictor of Exercise Tolerance in COPD.
Authors: Yamamoto A, Shirai T, Hirai K, Tanaka Y, Watanabe H, Endo Y, Shimoda Y, Suzuki T, Noguchi R, Mochizuki E, Sakurai S, Saigusa M, Akamatsu T, Shishido Y, Akita T, Morita S, Asada K Abstract The usefulness of the oscillometry, known as forced oscillation technique, for predicting exercise tolerance in subjects with COPD is unknown. To test the hypothesis, we investigated whether oscillometry could predict a 6-minute walking distance (6MWD)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 17, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

A Systematic Review of the Use of Physiological Tests Assessing the Acute Response to Treatment During Exacerbations of COPD (with a Focus on Small Airway Function).
Authors: Alobaidi NY, Almeshari M, Stockley JA, Sapey E, Edgar RG Abstract Exacerbations are prevalent in Chronic Obstructive Pulmonary Disease (COPD) patients and associated with poor clinical outcomes. Currently, there is a lack of sensitive and specific tools that can objectively identify exacerbations and assess their progress or treatment response. FEV1 is often reported as a study outcome, but it has significant limitations. Studies have suggested that small airways measures might provide physiological biomarkers during exacerbations. Therefore, this study was done to assess which physiological tests of small...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 17, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

The Effects of Endobronchial Coil Therapy on Right Ventricular Functions.
Authors: Kilic ID, Ugurlu E, Sevgican CI, Yigit N, Cetin N, Sen G, Kaya D Abstract Lung hyperinflation is an important therapeutic target in symptomatic emphysema patients. Endobronchial therapies that reduce end-expiratory lung volume are increasingly being used in advanced cases. However, there is paucity of data regarding the effects of these therapies on the heart functions. The aim of this study is to evaluate the right ventricular functions before and after the procedure in patients who underwent endobronchial coil therapy (EBCT). Patients who were between 18 and 80 years of age and scheduled for EBCT ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 11, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

One Year Change in 6-Minute Walk Test Outcomes is Associated with COPD Prognosis.
This study aimed to examine whether change in 6MWD and desaturation in 1 year were risk factors for later mortality, lung function decline and number of exacerbations. A total of 295 COPD patients performed 6MWT at baseline and 1 year later in the Bergen COPD cohort study 2006-2011. They were clinically examined and interviewed at annual visits. Mortality information was collected from the Norwegian Cause of Death Registry in 2015. We performed cox regression for mortality outcomes, linear mixed effect models for lung function, and negative binomial regression for exacerbations. Patients who desaturated in both 6MWT...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 11, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Coding of COPD Exacerbations and the Implications on Clinical Practice, Audit and Research.
Authors: Echevarria C, Steer J, Bourke SC Abstract International Classification of Disease 10 (ICD-10) codes record hospital admissions. We aimed to measure the accuracy of COPD exacerbation (ECOPD) codes and examine coding practices for COPD exacerbation. Prospective screening and ICD-10 codes were used to identify potential ECOPD within the DECAF internal validation cohort. Two coding searches were performed. The first search identified patients with an ECOPD discharge code, and a second, broad search was developed to identify all clinically confirmed ECOPD. 717 of 1,122 (64%) patients with an ECOPD code had conf...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 11, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Diagnostic Ability of Impulse Oscillometry in Diagnosis of Chronic Obstructive Pulmonary Disease.
Authors: Chaiwong W, Namwongprom S, Liwsrisakun C, Pothirat C Abstract The diagnosis of chronic obstructive pulmonary disease (COPD) mainly relies on spirometry. Due to the complexity of spirometry, easier-to-do impulse oscillometry (IOS) has been introduced as a complementary approach to conventional pulmonary function testing. Therefore, this study aimed to assess the efficacy of the diagnostic ability of IOS for diagnosing chronic obstructive pulmonary disease (COPD). This cross-sectional study was conducted at the Lung Health Center, Chiang Mai University, Thailand, between June 2019 and January 2020. IOS and s...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 1, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research