Effects of High-Dose Vitamin D Replacement on the Serum Levels of Systemic Inflammatory Biomarkers in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Authors: Dastan F, Salamzadeh J, Pourrashid MH, Edalatifard M, Eslaminejad A Abstract Chronic Obstructive Pulmonary Disease (COPD) is associated with increased inflammatory responses to noxious particles, which can be further enhanced during Acute Exacerbation of COPD (AECOPD). Considering the important immunoregulatory function of vitamin D, high prevalence of Vitamin D Deficiency (VDD) in COPD patients and a negative link between vitamin D levels and inflammatory biomarkers, suggests the seemingly interesting mechanism of vitamin D effects on inflammation resolution during the conventional treatment of AECOPD. Th...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 27, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Changes in cycle-ergometer performance during pulmonary rehabilitation predict COPD exacerbation.
Authors: Cômes J, Prieur G, Combret Y, Gravier FE, Bonnevie T, Medrinal C PMID: 31514554 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 14, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Ergometer Performance: A New Tool for Predicting COPD Exacerbations.
Authors: Alqahtani JS, Aldhahir AM, Aldabayan YS PMID: 31505953 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 13, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Clinical and Functional Characteristics of COPD Patients Across GOLD Classifications: Results of a Multicenter Observational Study.
Authors: Radovanovic D, Contoli M, Marco FD, Sotgiu G, Pelaia G, Braido F, Corsico AG, Micheletto C, Rogliani P, Scichilone N, Saderi L, Santus P, Solidoro P Abstract Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease. The severity grading systems proposed by the Global initiative for Chronic Obstructive Lung Disease (GOLD) have changed over time. The aim of the study was to evaluate if the different GOLD classifications can capture the complexity of the disease by investigating the distribution of lung function and clinical parameters across the GOLD classification systems. This was an observa...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 12, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Correction.
Authors: PMID: 31502479 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - September 12, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Screening for Tuberculosis Among Asylum Seekers.
Authors: Joob B, Wiwanitkit V PMID: 31455113 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 30, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

What is a COPD-Like Spirometry Test Result in Resource Constrained Settings?
Authors: Gianella GE, Miranda JJ, Hurst JR Abstract The diagnosis of chronic obstructive pulmonary disease (COPD), a global health problem, is challenging in resource-constrained settings. Spirometry with an obstructive pattern after the administration of bronchodilators is required for the diagnosis of COPD. Existing COPD treatment guidelines, largely derived from studies performed in populations of cigarette-smokers, recommend pharmacologic interventions with a tendency to include new-and expensive-drugs as first line agents. As the different factors that cause nonsmokers to develop COPD lead to different phenoty...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 21, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Adaptive Support Ventilation During Non-Invasive Ventilation in Acute Exacerbation of COPD: In Statu Nascendi.
Authors: Sehgal IS, Agarwal R, Dhooria S, Prasad KT, Kalpakam H, Aggarwal AN PMID: 31424281 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 21, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Polypharmacy among Older Individuals with COPD: Trends between 2000 and 2015 in Quebec, Canada.
Authors: Sirois C, Ouali A, Simard M Abstract The treatment of chronic obstructive pulmonary disease (COPD) and concomitant diseases requires several medications. Yet there is little data on how the pharmacological burden progressed over time among older individuals with COPD. We aimed to: 1) describe the proportion of older adults with COPD in Quebec, Canada, that were exposed to polypharmacy (≥10, ≥15 or ≥20 medications/year) between 2000 and 2015; 2) calculate the proportion of individuals receiving specific prescriptions for COPD during this period. We conducted a population-based cohort study with the...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 14, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Adherence to a Mediterranean-like Diet as a Protective Factor Against COPD: A Nested Case-Control Study.
Authors: Fischer A, Johansson I, Blomberg A, Sundström B Abstract A diet rich in nutrients has been suggested to have protective effects against the development of chronic obstructive pulmonary disease (COPD). Since the traditional Mediterranean diet is high in nutrients, including antioxidants, vitamins, and minerals, it is of interest to study as a protective factor against COPD. Our aim was therefore to study its associations with development of COPD using population-based prospective data from the Västerbotten Intervention Programme (VIP) cohort. Data on diet from 370 individuals, who later visited th...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 14, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Changes in Cycle-Ergometer Performance during Pulmonary Rehabilitation Predict COPD Exacerbation.
Authors: Comes J, Prieur G, Combret Y, Gravier FE, Gouel B, Quieffin J, Lamia B, Bonnevie T, Medrinal C Abstract Early diagnosis of COPD exacerbations is vital. Exacerbations are characterised by an increase in dyspnoea that could be affect physical capacity. Changes in the physical capacity of patients with COPD during pulmonary rehabilitation could provide a predictive indication regarding the occurrence of exacerbation. This was a retrospective study of forty for patients with COPD who participated in a pulmonary rehabilitation programme between January 2015 and October 2018. Patients to have experienced at leas...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 8, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Different Relationships between FENO and COPD Characteristics in Smokers and Ex-Smokers.
Authors: Högman M, Thornadtsson A, Bröms K, Janson C, Lisspers K, Ställberg B, Hedenström H, Malinovschi A Abstract Exhaled nitric oxide (FENO) is a marker of type-2 inflammation in asthma and is used in its management. However, smokers and ex-smokers have lower FENO values, and the clinical use of FENO values in COPD patients is unclear. Therefore, we investigated if FENO had a relationship to different COPD characteristics in smoking and ex-smoking subjects. Patients with COPD (n = 533, 58% females) were investigated while in stable condition. Measurements of FENO50, blood cell c...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Right Ventricle Function in Patients with Acute Coronary Syndrome and Concomitant Undiagnosed Chronic Obstructive Pulmonary Disease.
Authors: Pavasini R, Fiorencis A, Tonet E, Gaudenzi E, Balla C, Maietti E, Biscaglia S, Papi A, Ferrari R, Contoli M, Campo G Abstract Chronic obstructive pulmonary disease (COPD) is frequently undiagnosed in patients with ischemic heart disease. Nowadays, it is still unknown whether undiagnosed concomitant COPD is related to early structural changes of the heart, as detectable by trans-thoracic echocardiography (TTE). Starting from the study population of the Screening for COPD in ACS Patients (SCAP) trial, we sought to investigate potential differences in echocardiographic parameters in patients with acute corona...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Trial of Noninvasive Ventilation with Pressure or Adaptive Support in Acute Exacerbation of COPD by Sehgal IS et  al: Further Considerations.
Trial of Noninvasive Ventilation with Pressure or Adaptive Support in Acute Exacerbation of COPD by Sehgal IS et al: Further Considerations. COPD. 2019 Jul 29;:1-2 Authors: Bhakta P, O'Brien B, Karim HMR, Esquinas A PMID: 31357894 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Age and Disease have a Distinct Influence on Postural Balance of Patients with COPD.
Authors: Boffino CC, Pereira ACAC, Coelho DB, Xavier RF, Berto CC, Da Silva M, Tanaka C, Ramos RT, Yamaguti WP, Carvalho CRF Abstract The postural imbalance is an extra-pulmonary condition, associated with chronic obstructive pulmonary disease (COPD). COPD affects older individuals and it is unclear whether balance abnormalities can be described as pathophysiological mechanism or aging. The present study aimed to evaluate the influence of age or disease on postural balance of patients with COPD. Patients with COPD over 50 years old were compared with age- and sex-matched healthy adults, and with sex-matched younger...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 24, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Depressive Symptoms Are Associated with Self-Reported Physical Limitations That Are Activity Dependent in a Cross-Sectional Analysis of Subjects with Chronic Obstructive Pulmonary Disease.
Authors: Odackal J, Lyons G, Harris D Abstract One in four patients with chronic obstructive pulmonary disease (COPD) has depression. However, the effect of depressive symptoms on self-reported physical function among patients with COPD is not fully defined. We tested the hypothesis that depressive symptoms among patients with COPD are associated with increased self-reporting of physical limitations in a nationally representative sample of adults living in the USA. We sampled 775 adults with obstructive lung disease and history of regular smoking from 2007 to 2012 National Health and Nutrition Examination Survey (N...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 14, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Dietary Patterns and Prevalence of Post-bronchodilator Airway Obstruction in Dairy Farmers Exposed to Organic Dusts.
This study investigated whether dietary patterns were associated with post-bronchodilator airway obstruction, a hallmark of COPD, in dairy farmers exposed to organic dusts. All subjects were identified by screening programs and patients with airflow obstruction were matched with subjects with normal spirometry. Six groups were compared, defined by their exposures (non-smoking dairy farmers, smokers ≥ 10 pack-years with no occupational exposure, and smoking dairy farmers) and the presence or absence of post-bronchodilator airflow obstruction, resulting in 321 study subjects. The Alternative Healthy Eating Index (AHEI) sc...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 14, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Inspiratory Constraints and Ventilatory Inefficiency Are Superior to Breathing Reserve in the Assessment of Exertional Dyspnea in COPD.
Authors: Neder JA, Berton DC, Marillier M, Bernard AC, O'Donnell DE, Canadian Respiratory Research Network Abstract Combining measurements of impaired lung mechanics (inspiratory constraints) with an index of increased respiratory stimuli to metabolic demand (poor ventilatory efficiency) might enhance the ability of cardiopulmonary exercise testing (CPET) in exposing a mechanistic role for ventilation on exertional dyspnea in COPD. In addition to the standard approach to suggest ventilatory limitation to exercise - a low breathing reserve (1-(peak ventilation (V̇E)/maximal voluntary ventilation × 100 ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 7, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The Kinematic Chain of Arm Elevation Is Impaired in Patients with Chronic Obstructive Pulmonary Disease.
Authors: Morais N, Cruz J, Marques A Abstract Patients with chronic obstructive pulmonary disease (COPD) often complain about difficulties in performing activities with their arms above shoulders height. These difficulties have been associated with increased cardiorespiratory demand and altered lung mechanics; however, musculoskeletal-related mechanisms may also contribute to constrain the mechanics of the upper body quadrant, increasing the effort to perform the activities. This exploratory research aimed to assess potential changes in the kinematic chain of arm elevation in patients with COPD. A secondary analysi...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 7, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Genuair ®/Pressair® Inhaler in COPD: The Patient Perspective.
This article reviews the latest data pertaining to the Genuair®/Pressair® device, a breath-actuated, multi-dose dry-powder inhaler with a two-step inhalation process, which is marketed for the delivery of aclidinium alone or in combination with formoterol for long-term maintenance bronchodilation treatment in chronic obstructive pulmonary disease. It contains multiple feedback mechanisms to guide effective use, and safety features to avoid double-dosing or attempted use when empty. In addition to describing the design of Genuair®, the article will provide an update on inhaler operability and performance, focusi...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - July 4, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Correction.
Authors: PMID: 31240963 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - June 28, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Efficacy of Indacaterol/Glycopyrrolate in Patients with COPD by Airway Reversibility at Baseline: A Pooled Analysis of the FLIGHT1 and FLIGHT2 12-Week Studies.
Authors: Ohar JA, Sharma S, Goodin T, Bowling A, Price B, Ozol-Godfrey A, Sanjar S Abstract Bronchodilator reversibility occurs in patients with COPD. Pooled analysis of two 12-week, placebo-controlled randomised studies (FLIGHT1 [NCT01727141]; FLIGHT2 [NCT01712516]) assessed the effect of bronchodilator reversibility on lung function, patient-reported outcomes, and safety in 2,043 patients with moderate-to-severe COPD treated with indacaterol/glycopyrrolate (IND/GLY) 27.5/15.6 µg twice daily. Reversibility was defined as post-bronchodilator increase in forced expiratory volume in one second (FEV1) of ≥12%...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - June 28, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Predictors of Nebulized Arformoterol Treatment: A Retrospective Analysis of Medicare Beneficiaries with Chronic Obstructive Pulmonary Disease.
This study examined sociodemographic and clinical characteristics, treatment patterns, and health resource utilization among Medicare beneficiaries with chronic obstructive pulmonary disease (COPD) to identify predictors of nebulized arformoterol treatment. Using Medicare administrative data from 2010 to 2014, beneficiaries with ≥2 COPD outpatient visits ≥30 d apart or ≥1 COPD-related hospitalization(s) (ICD-9-CM 491.xx, 492.xx, and 496) were identified. Inclusion criteria required ≥1 COPD medication claim(s) and continuous enrollment in Parts A, B, and D. Four cohorts were identified: (a) 11,887 arformoterol u...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - June 21, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

A Randomized Controlled Trial of Noninvasive Ventilation with Pressure Support Ventilation and Adaptive Support Ventilation in Acute Exacerbation of COPD: A Feasibility Study.
Authors: Sehgal IS, Kalpakam H, Dhooria S, Aggarwal AN, Prasad KT, Agarwal R Abstract Whether the use of adaptive support ventilation (ASV) during noninvasive ventilation (NIV) is as effective as pressure support ventilation (PSV) remains unknown. In this exploratory study, we compared the delivery of NIV with PSV vs. ASV. We randomized consecutive subjects with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) to receive NIV either with the PSV or the ASV mode. The primary outcome was NIV failure (endotracheal intubation, re-institution of NIV within 48 h of discontinuation or mortality)....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - June 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Consequences of Changing the GOLD Reports (2007-2011-2017) on the Treatment Regimen of Patients with COPD.
Authors: Brożek GM, Nowak M, Zejda JE, Jankowski M, Lawson J, Pierzchała W Abstract Detailed treatment regimens for patients with chronic obstructive pulmonary disease (COPD) were developed by the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Every few years the method of classification of COPD severity and the treatment recommendations are significantly revised. The aim of this study was to determine the clinical implications of changing GOLD reports (2007-2011-2017) and the impact that these changes would have on pharmacological treatment regimens of patients with COPD. A group of 500 randomly ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - June 5, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Airflow Obstruction and Cardio-metabolic Comorbidities.
Authors: Triest FJJ, Studnicka M, Franssen FME, Vollmer WM, Lamprecht B, Wouters EFM, Burney PGJ, Vanfleteren LEGW Abstract Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and often co-exists with cardiovascular disease (CVD), hypertension and diabetes. This international study assessed the association between airflow obstruction and these comorbidities. 23,623 participants (47.5% males, 19.0% current smokers, age: 55.1 ± 10.8 years) in 33 centers in the Burden of Obstructive Lung Disease (BOLD) initiative were included. 10.4% of subjects had airflow obstruc...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 29, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD).
Authors: Oshagbemi OA, Franssen FME, van Kraaij S, Braeken DCW, Wouters EFM, Maitland-van der Zee AH, Driessen JHM, de Vries F Abstract Although recently introduced in the pharmacological treatment algorithm of chronic obstructive pulmonary disease (COPD), there is a need for more data supporting the use of blood eosinophil counts as a biomarker to guide inhaled corticosteroids (ICS) therapy. The aim of this study was to evaluate the risk of moderate and/or severe exacerbations and all-cause mortality in a large primary care population after withdrawal of ICS compared to continued users stratified by elevated blood...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 25, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The Integrative Physiology of Exercise Training in Patients with COPD.
Authors: Neder JA, Marillier M, Bernard AC, James MD, Milne KM, O'Donnell DE Abstract Supervised exercise training (EXT) as part of pulmonary rehabilitation is arguably the most effective intervention for improving exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). In the current review, we focus on the physiological rationale for EXT and the expected physiological benefits that can be achieved in patients who can be exposed to sufficiently high training stimuli. Thus, after a brief consideration of the mechanisms of exercise limitation and their sensory consequences, we expose the po...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 18, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Development of a Nomogram to Predict the Risk of 30-Day Re-Exacerbation for Patients Hospitalized for Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Authors: Hu WP, Lhamo T, Liu D, Hang JQ, Zhang FY, Zuo YH, Zeng YY, Zhang J Abstract Acute exacerbation (AE) is the main cause of increased disability and mortality for patients with Chronic Obstructive Pulmonary Disease (COPD). Short-term re-exacerbation after discharge is common for in-hospital patients with AECOPD. Thus, we aimed to design a scoring system to effectively predict the 30-day re-exacerbation using simple and easily accessible variables. We retrospectively enrolled 686 cases hospitalized for AECOPD in two Chinese hospitals from 2005 to 2017. A variety of parameters were collected like demographics, ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 18, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Mammalian Target of Rapamycin: Is It Relevant to COPD Pathogenesis or Treatment?
Authors: Pasini E, Flati V, Comini L, Olivares A, Bertella E, Corsetti G, Vitacca M Abstract The mammalian target of rapamycin (mTOR) signalling pathway regulates fundamental metabolic processes such as inflammation, autophagy and apoptosis, all of which influence cell fate. Recent experimental data suggest that mTOR signalling is involved in many diseases, including lung diseases, but with contrasting data. Overexpression of mTOR and its signalling proteins have been linked to lung cell senescence and development of emphysema, pulmonary hypertension and inflammation. On the other hand, mTOR inhibitors, as rapamyci...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 8, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Outdoor Walking Training Compared To Cycle Ergometer Training in Severe COPD: A Randomized Controlled Feasibility Trial.
In conclusion, the study design and the OWT are feasible. Health-related quality of life improved in the OWT group compared to the CT group after three weeks' inpatient rehabilitation. A minimum of 46 participants is needed for a RCT. Trial registration: www.who.int/trialsearch DRKS00010977. PMID: 31056954 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 8, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Physical Inactivity and Sedentarism among COPD Patients: What About Dynamic Hyperinflation?
Authors: Boutou AK PMID: 31044625 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 3, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Recovery Following Acute Exacerbations of Chronic Obstructive Pulmonary Disease - A Review.
Authors: Wageck B, Cox NS, Holland AE Abstract Acute exacerbations are associated with disease progression, hospital admission and death in people with chronic obstructive pulmonary disease (COPD). The detrimental outcomes associated with acute exacerbations highlights a need to understand the time course of recovery following acute exacerbation of COPD (AECOPD) so that effective and timely interventions can be provided. The aim of this narrative review was to describe the natural recovery in physiology, symptoms and function following AECOPD. Substantial recovery of lung function and airway inflammation occurs in ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 3, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Low Body Mass Index Is Associated with Higher Odds of COPD and Lower Lung Function in Low- and Middle-Income Countries.
Authors: Grigsby MR, Siddharthan T, Pollard SL, Chowdhury M, Rubinstein A, Miranda JJ, Bernabe-Ortiz A, Alam D, Kirenga B, Jones R, van Gemert F, Checkley W Abstract The relationship of body mass index (BMI) with lung function and COPD has been previously described in several high-income settings. However, few studies have examined this relationship in resource-limited settings where being underweight is more common. We evaluated the association between BMI and lung function outcomes across 14 diverse low- and middle-income countries. We included data from 12,396 participants aged 35-95 years and used multivariable...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The COPD Comorbidome in the Light of the Degree of Dyspnea and Risk of Exacerbation.
Authors: Figueira Gonçalves JM, García Bello MÁ, Martín Martínez MD, Pérez Méndez LI, García-Talavera I, García Hernández S, Díaz Pérez D, Bethencourt Martín N Abstract The BODE group designed a bubble chart, analogous to the solar system, which depicts the prevalence of each disease and its association with mortality and called it a "comorbidome". Although this graph was used to represent mortality and, later, the risk of needing hospital admission, it was not applied to visualize the association between a set of c...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 1, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Correction.
Authors: PMID: 30961400 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 11, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Clinical Decision Support System: A Pragmatic Tool to Improve Acute Exacerbation of COPD Discharge Recommendations.
Authors: Epstein D, Barak-Corren Y, Isenberg Y, Berger G Abstract Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with significant mortality, morbidity and increased risk for further exacerbations. Therefore, appropriate measures for prevention of further exacerbations should be initiated before discharge. Unfortunately, this opportunity for treatment review and change in disease course is often missed. We designed a decision support tool to automatically generate discharge recommendations for COPD patients based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD)...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 6, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Socioeconomic circumstances and incidence of chronic obstructive pulmonary disease (COPD) in an urban population in Sweden.
Authors: Borné Y, Ashraf W, Zaigham S, Frantz S Abstract The association between socioeconomic circumstances and incidence of chronic obstructive pulmonary disease (COPD) was investigated in an urban population in Sweden. The study included all 40-89 year-old inhabitants in Malmö, Sweden (N = 117,479) without previous hospitalization due to COPD, who were followed over 14 years for COPD related hospital admissions. The Malmö Preventive Project (MPP) cohort (n = 27,358) with information on biological and lifestyle factors was also used to study the association between soc...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 30, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Bacterial Colonization in COPD Patients Admitted to a Rehabilitation Respiratory Unit and Impact on Length of Stay: A Real-Life Study.
Authors: Vitacca M, Marino S, Comini L, Fezzardi L, Paneroni M Abstract Bacterial colonization is a well-known phenomenon in acute care, but scant information is available regarding the rehabilitation setting. We retrospectively analyzed, in COPD patients admitted to a Respiratory Rehabilitative unit in 2010, the number of cultures requested, of positive cultures, and of cultures showing multiple drug resistant (MDR) organisms. We also compared hospital admissions (HA) with versus without positive cultures and with versus without MDR and investigated which baseline variables may predict length of stay (LOS)> 30 ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 23, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Right Heart Catheterization During Exercise in Patients with COPD-An Overview of Clinical Results and Methodological Aspects.
Authors: Ewert R, Heine A, Bollmann T, Müller-Heinrich A, Gläser S, Opitz CF Abstract While right heart catheterization (RHC) at rest is the gold standard to assess pulmonary hemodynamics in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH), the invasive measurement of exercise hemodynamics is less well established in this group. Since exercise hemodynamics are increasingly recognized as important clinical information in patients with PH, our goal was to review the literature in this field to provide a basis for clinical use, further studies, and future recommendat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 23, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

The Association between Chronic Obstructive Pulmonary Disease and Coronary Artery Disease in Patients Undergoing Coronary Angiography.
Authors: Hong Y, Graham MM, Southern D, McMurtry MS Abstract Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) are leading causes of morbidity and mortality. There are conflicting results regarding the association between COPD and CAD. We sought to measure the association between COPD and angiographically diagnosed CAD in a population-based cohort. We performed a retrospective analysis using data from the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH), a prospectively collected registry capturing all patients undergoing coronary angiography in Al...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 23, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Pulmonary Rehabilitation does not Improve Objective Measures of Sleep Quality in People with Chronic Obstructive Pulmonary Disease.
Authors: Cox NS, Pepin V, Burge AT, Hill CJ, Lee AL, Bondarenko J, Moore R, Nicolson C, Lahham A, Parwanta Z, McDonald CF, Holland AE Abstract Abnormal sleep duration is associated with poor health. Upwards of 50% of people with chronic obstructive pulmonary disease (COPD) report poor sleep quality. The effect of pulmonary rehabilitation on self-reported sleep quality is variable. The aim of this study was to assess the effect of pulmonary rehabilitation on objectively measured sleep quality (via actigraphy) in people with COPD. Sleep quality was assessed objectively using the SenseWear Armband (SWA, BodyMedia, Pit...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 20, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study.
Authors: Almagro P, Martínez-Camblor P, Miravitlles M, Rodríguez-Carballeira M, Navarro A, Lamprecht B, Ramirez-Garcia Luna AS, Kaiser B, Alfageme I, Casanova C, Esteban C, Soler-Cataluña JJ, de-Torres JP, Celli BR, Marin JM, Ter Riet G, Sobradillo P, Lange P, Garcia-Aymerich J, Anto JM, Turner AM, Han MK, Langhammer A, Sternberg A, Leivseth L, Bakke P, Johannessen A, Oga T, Cosío B, Ancochea J, Echazarreta A, Roche N, Burgel PR, Sin DD, Puhan MA, Soriano JB, 3CIA collaboration Abstract The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Predictors of New Airway Obstruction - An 11 Year's Population-Based Follow-Up Study.
Authors: Vasankari T, Härkänen T, Kainu A, Sääksjärvi K, Mattila T, Jousilahti P, Laitinen T Abstract In the present study we aimed to investigate the incidence and predictors of spirometry based airway obstruction in a representative population-based sample. Altogether 3,863 subjects, 1,651 males and 2,212 females aged ≥30 years had normal spirometry in year 2000. Fifty-three percent of them were never and 23% current smokers. A re-spirometry was performed 11 years later. Several characteristics, such as level of education, use of alcohol, physical activity, diet using Alterna...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Functional Electrical Stimulation Changes Muscle Oxygenation in Patients with Chronic Obstructive Pulmonary Disease During Moderate-Intensity Exercise: A Secondary Analysis.
Authors: Prieur G, Combret Y, Bonnevie T, Gravier FE, Robledo Quesada A, Quieffin J, Lamia B, Medrinal C Abstract We previously showed that functional electrical stimulation during cycle ergometry (FES-cycling) increased oxygen consumption (VO2), indicating that metabolism during exercise was increased. However, the effects on muscle oxygenation have never been studied. The aim of this secondary analysis was to analyse changes in muscle oxygenation during an FES-cycling session. Eight patients with chronic obstructive pulmonary disease who were participating in a pulmonary rehabilitation programme were enrolled. Ea...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Beta-Blockers in COPD: A Methodological Review of the Observational Studies.
Authors: Suissa S, Ernst P Abstract The use of beta-blockers in patients with chronic obstructive pulmonary disease (COPD) has received much attention. Several observational studies reported important reductions in mortality and exacerbations with these drugs, but the extent of bias in these studies is unclear. Nevertheless, the large ongoing randomized trial (βLOCK-COPD) was initiated specifically to evaluate these effects. We searched the literature to identify all observational studies investigating the effectiveness of beta-blockers in COPD patients on major outcomes, including death and COPD exacerbation....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

A Palliative Approach is Adopted for Many Patients Dying in Hospital with Chronic Obstructive Pulmonary Disease.
This study aimed to determine if symptom palliation or a palliative approach were delivered during the final hospital admission in which death occurred. Retrospective medical record audits were completed at two Australian hospitals, with all patients who died from COPD over 12 years between 1 January 2004 and 31 December 2015 included. Of 343 patients included, 217 (63%) were male with median age 79 years (IQR 71.4-85.0). Median respiratory function: FEV1 0.80L (42% predicted), FVC 2.02L (73% predicted) and DLco 9 (42% predicted). 164 (48%) used domiciliary oxygen. Sixty (18%) patients accessed specialist palliative care a...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Successful Ageing with COPD: Physical and Psychosocial Adaption to Functional Decline.
Authors: Southwell PJ, Crockett J, Burton D, Gullifer J Abstract There is considerable research regarding the adaption to functional decline associated with advanced (Stage IV) Chronic Obstructive Pulmonary Disease (COPD). This research has, however, primarily focused on physical and interventional strategies to manage disease progression and symptom burden, as opposed to the psychosocial strategies. To address this paucity, the current research explored the psychosocial strategies people with Stage IV COPD use to maintain quality of life towards the end of life. Eleven older people with Stage IV COPD living in reg...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Sedentary Behaviour and Physical Inactivity in Patients with Chronic Obstructive Pulmonary Disease: Two Sides of the Same Coin?
Authors: Schneider LP, Furlanetto KC, Rodrigues A, Lopes JR, Hernandes NA, Pitta F Abstract Despite the growing interest in sedentarism, there is no available information on the profile of patients with COPD according to sedentary behaviour (SB) and with a detailed analysis of minute-by-minute bouts. Hence, the aims of this study were to quantify the time spent in SB, light activities and moderate-to-vigorous physical activities (MVPA) and to verify the relationship of MVPA and SB in individuals with COPD, as well as to identify the profile of those physically (in)active and (non)-sedentary. A cross-sectional study...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research

Prediction of COPD and Related Events Improves by Combining Spirometry and the Single Breath Nitrogen Test.
Authors: Olofson J, Bake B, Bergman B, Ullman A, Svärdsudd K Abstract Chronic obstructive pulmonary disease (COPD) develops in small airways. Severity of small airway pathology relates to progression and mortality. The present study evaluated the prediction of COPD of a validated test for small airway disease, i.e. a slope of the alveolar plateau of the single breath nitrogen test (N2-slope). The N2-slope, spirometry, age, smoking habits, and anthropometric variables at baseline were obtained in a population-based sample (n = 592). The cohort was followed for first COPD events (first hospital adm...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 4, 2019 Category: Respiratory Medicine Tags: COPD Source Type: research