Association Between Plasminogen Activator Inhibitor-1-675 4G/5G Insertion/Deletion Polymorphism and Chronic Obstructive Pulmonary Disease.
In conclusion, PAI-1 4G/5G genetic variations are associated with COPD development in males. PMID: 27073968 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 15, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Regulation of Viral Infection-induced Airway Remodeling Cytokine Production by the TLR3-EGFR Signaling Pathway in Human Bronchial Epithelial Cells.
Authors: Jiang J, Wang Y, Tang X, Yao Y, Zhou J Abstract Toll-like receptor 3 (TLR3) is involved in the virus-induced pulmonary inflammatory response, but its role in airway remodeling after viral infection is unclear. We explored the role of TLR3 in poly(I:C)-induced inflammatory cytokines and mucin 5AC (MUC5AC) production in human bronchial epithelial cells by Western blotting, RT-PCR and ELISA. The expression of TLR3, MUC5AC, Matrixmetalloproteinase (MMP9), Transforming growth factor (TGF-β1) and Vascular endothelial growth factor (VEGF) in human bronchial epithelial cells increased in a dose-dependent mann...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 15, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Exercise Ventilatory Inefficiency Adds to Lung Function in Predicting Mortality in COPD.
Authors: Neder JA, Alharbi A, Berton DC, Alencar MC, Arbex FF, Hirai DM, Webb KA, O'Donnell DE Abstract Severity of resting functional impairment only partially predicts the increased risk of death in chronic obstructive pulmonary disease (COPD). Increased ventilation during exercise is associated with markers of disease progression and poor prognosis, including emphysema extension and pulmonary vascular impairment. Whether excess exercise ventilation would add to resting lung function in predicting mortality in COPD, however, is currently unknown. After an incremental cardiopulmonary exercise test, 288 patients (f...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 15, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Exhaled Breath Temperature as a Novel Marker of Future Development of COPD: Results of a Follow-Up Study in Smokers.
Authors: Labor M, Vrbica Ž, Gudelj I, Labor S, Jurić I, Plavec D Abstract Although only less than one-third of smokers develop COPD, early marker(s) of COPD development are lacking. The aim of this research was to assess the ability of an average equilibrium exhaled breath temperature (EBT) in identifying susceptibility to cigarette smoke so as to predict COPD development in smokers at risk. The study was a part of a multicenter prospective cohort study in current smokers (N = 140, both sexes, 40-65 years, ≥20 pack-years) with no prior diagnosis of COPD. Diagnostic workup includes history, physical, quality of...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 15, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Genetic Variants in IL6R and ADAM19 are Associated with COPD Severity in a Mexican Mestizo Population.
Authors: Pérez-Rubio G, Silva-Zolezzi I, Fernández-López JC, Camarena Á, Velázquez-Uncal M, Morales-Mandujano F, Hernández-Zenteno RJ, Flores-Trujillo F, Sánchez-Romero C, Velázquez-Montero A, Espinosa de Los Monteros C, Sansores RH, Ramírez-Venegas A, Falfán-Valencia R Abstract Chronic obstructive pulmonary disease (COPD) is a complex and multifactorial disease with a strong genetic component. Our objective is to identify the genetic variants associated with COPD risk and its severity in Mexican Mestizo population. We evaluated 1285 single-nucle...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 15, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Prulifloxacin vs Levofloxacin for Exacerbation of COPD after Failure of Other Antibiotics.
In conclusion, fluoroquinolones are very effective in the treatment of AECOPD resistant to other antibiotics. PMID: 27027547 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 31, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

End-of-Life Discussion, Patient Understanding and Determinants of Preferences in Very Severe COPD Patients: A Multicentric Study.
In conclusion, in end-stage COPD more efforts are needed to improve communication, patients' knowledge of the disease and E-o-L practice. PMID: 27027671 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 31, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Levels of IL-32 in Serum, Induced Sputum Supernatant, and Bronchial Lavage Fluid of Patients with Chronic Obstructive Pulmonary Disease.
Authors: Gasiuniene E, Lavinskiene S, Sakalauskas R, Sitkauskiene B Abstract Interleukin-32 (IL-32) is a newly described cytokine which is expected to have an important role in autoimmune disorders. It was shown that chronic obstructive pulmonary disease (COPD) has a component of autoimmunity, though the role of IL-32 in its pathogenesis is not known. The aim of this study was to estimate IL-32 concentrations in serum, induced sputum (IS) supernatant and bronchoalveolar lavage (BAL) fluid from patients with COPD, and to compare asthma patients with and healthy subjects. Outpatients with COPD (63.7 ± 8.4 ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 30, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Is There Any Additional Effect of Tele-Assistance on Long-Term Care Programmes in Hypercapnic COPD Patients? A Retrospective Study.
Authors: Vitacca M, Paneroni M, Grossetti F, Ambrosino N Abstract The evidence for tele-assistance (TA) in hypercapnic chronic obstructive pulmonary disease (COPD) patients on long-term oxygen therapy (LTOT) is scarce. The aim of this study was to evaluate the effects of addition of long-term TA to LTOT with or without non-invasive ventilation (NIV) in these patients. Retrospective analysis of a previous randomised study of patients on LTOT. According to the care programme patients were divided into Group 1: LTOT; Group 2: LTOT + NIV; Group 3: LTOT + TA and Group 4: LTOT + NIV+TA. Primary outcomes: time to first ex...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 30, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

"Walking with Only Noninvasive Ventilation in Stable Hypercapnic COPD Patients: Sufficient or not?"
"Walking with Only Noninvasive Ventilation in Stable Hypercapnic COPD Patients: Sufficient or not?" COPD. 2016 Mar 25;:1 Authors: Walker DJ, Windisch W, Dreher M Abstract We are grateful to Ulasli and Esquinas for their comments to our paper.. They argued that arterial blood gas analyses were not performed without oxygen prior to the 6-minute walk test with noninvasive ventilation (6MWT-NPPV). This point has already been discussed in our original work by indicating the limitations of our study. The reason for using oxygen prior to exercise testing was to guarantee comparable starting conditio...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 27, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Severe COPD Alters Muscle Fiber Conduction Velocity During Knee Extensors Fatiguing Contraction.
Authors: Boccia G, Coratella G, Dardanello D, Rinaldo N, Lanza M, Schena F, Rainoldi A Abstract The aim of this study was to assess the changes in muscle fiber conduction velocity (CV), as a sign of fatigue during knee extensor contraction in patients with chronic obstructive pulmonary disease (COPD) as compared with healthy controls. Eleven male patients (5 with severe and 6 with moderate COPD; age 67 ± 5 years) and 11 age-matched healthy male controls (age 65 ± 4 years) volunteered for the study. CV was obtained by multichannel surface electromyography (EMG) from the vastus lateralis (VL) and medial...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 25, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

The Relationship Between 24-Hour Symptoms and COPD Exacerbations and Healthcare Resource Use: Results from an Observational Study (ASSESS).
Authors: Miravitlles M, Worth H, Soler-Cataluña JJ, Price D, De Benedetto F, Roche N, Godtfredsen NS, van der Molen T, Löfdahl CG, Padullés L, Ribera A Abstract This observational study assessed the relationship between nighttime, early-morning and daytime chronic obstructive pulmonary disease (COPD) symptoms and exacerbations and healthcare resource use. COPD symptoms were assessed at baseline in patients with stable COPD using a standardised questionnaire during routine clinical visits. Information was recorded on exacerbations and healthcare resource use during the year before baseline and dur...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 19, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Burden and Unmet Needs of Caregivers of Chronic Obstructive Pulmonary Disease Patients: A Systematic Review of the Volume and Focus of Research Output.
Authors: Mansfield E, Bryant J, Regan T, Waller A, Boyes A, Sanson-Fisher R Abstract Caregivers of individuals with chronic obstructive pulmonary disease (COPD) experience significant burden. To develop effective interventions to support this vulnerable group, it is necessary to understand how this burden varies as a function of patient well-being and across the illness trajectory. This systematic review aimed to identify the number and type of data-based publications exploring the burden and unmet needs of caregivers of individuals with COPD. Medline, Embase, PsycINFO and Cochrane databases were searched for studi...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Incidence, Predictors, and Clinical Implications of Discontinuing Therapy with Inhaled Long-Acting Bronchodilators among Patients with Chronic Obstructive Pulmonary Disease.
In conclusion, in the real-life setting, discontinuation of inhaled long-acting bronchodilators in adults with COPD is high even after just 6 months, even though persistence to these drugs reduces the risk of severe outcomes. PMID: 26934569 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 6, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Is the Exhaled Breath Temperature Sensitive to Cigarette Smoking?
Authors: Carpagnano GE, Ruggieri C, Scioscia G, Storto MM, Zoppo L, Foschino-Barbaro MP Abstract The smoking habit is accompanied by an acute inflammatory response which follows tissue injury. It would be desirable to find a non-invasive inflammatory marker that would simplify the task of studying and monitoring smokers more simply and allow us to identify populations at risk of contracting Chronic Obstructive Pulmonary Disease (COPD). Today's expectations regarding research focus on issues ranging from inflammatory markers to those of exhaled breath temperature (EBT) are considerable. That said, although the EBT h...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 6, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Assessment of Right Ventricular Afterload in COPD.
CONCLUSIONS: Heart rate adjusted-PAAcT and RVSmVTI are simple and reproducible methods that correlate well with pulmonary artery pressure and PVR and showed high accuracy in detecting PH and increased PVR in patients with COPD. Taken into account the high feasibility of these two echo indices, they should be considered in the echocardiographic assessment of COPD patients. PMID: 26914261 [PubMed - as supplied by publisher] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 27, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review.
Authors: Lipovec NC, Beijers RJ, van den Borst B, Doehner W, Lainscak M, Schols AM Abstract Type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases (CVD) are common in patients with chronic obstructive pulmonary disease (COPD). Prevention of these co-morbidities in COPD requires knowledge on their risk factors. Metabolic syndrome (MetS) predisposes to the development of T2DM and CVD but its prevalence in COPD remains unclear. The aim of this review was to assess the prevalence of MetS and its components in COPD patients compared to controls and to investigate the contribution of clinical characteristics to MetS...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 27, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD: Journal of Chronic Obstructive Pulmonary Disease. Preface.
Authors: Miravitlles M PMID: 25938283 [PubMed - indexed for MEDLINE] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

The impact of smoke exposure on the clinical phenotype of alpha-1 antitrypsin deficiency in Ireland: exploiting a national registry to understand a rare disease.
This study illustrates the detrimental effect of smoke exposure on the clinical phenotype of AATD in Ireland and the benefit of immediate smoking cessation at any stage of lung disease. PMID: 25938284 [PubMed - indexed for MEDLINE] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Activity of the alpha-1 antitrypsin deficiency registry in Belgium.
Authors: Hutsebaut J, Janssens W, Louis R, Willersinn F, Stephenne X, Sokal E, Derom E Abstract A Belgian alpha-1-antitrypsin (AAT) deficiency registry has been established in 2003. Currently 55 patients are included. At the same time, a working group has been set up for publishing national guidelines. In 2014, several Belgian patients founded Alpha-1 Global. We hope that the integrated activities of all the stakeholders involved in AAT deficiency will permit a high quality care for all patients suffering from this disabling disease. PMID: 25938285 [PubMed - indexed for MEDLINE] (Source: COPD: Journal of Chron...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Alpha-1 antitrypsin deficiency in Canada: regional disparities in diagnosis and management.
DISCUSSION: Most patients experience a diagnostic delay of seven years after symptom onset, a period during which lung health may deteriorate further. There is marked regional variation in the rate of diagnosis and specific therapy usage for AAT in Canada. PMID: 25938286 [PubMed - indexed for MEDLINE] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

The national alpha-1 antitrypsin deficiency registry in Poland.
Authors: Chorostowska-Wynimko J, Struniawski R, Sliwinski P, Wajda B, Czajkowska-Malinowska M Abstract The alpha-1 antitrypsin deficiency (AATD) targeted screening program, together with the National Registry, were established in Poland in 2010 soon after the AATD diagnostics became available. Between 2010 and 2014 a total of 2525 samples were collected from respiratory patients countrywide; 55 patients with severe AAT deficiency or rare mutations were identified and registered, including 36 PiZZ subjects (65%). The majority of AATD patients were diagnosed with COPD (40%) or emphysema (7%), but also with bronchial ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Spanish Registry of Patients With Alpha-1 Antitrypsin Deficiency; Comparison of the Characteristics of PISZ and PIZZ Individuals.
Authors: Lara B, Miravitlles M Abstract Alpha-1 antitrypsin deficiency (AATD) is associated with an increased risk of pulmonary emphysema and liver disease. The growing interest in this deficiency in Spain led to the development of the Spanish Registry of Patients with Alpha-1 Antitrypsin Deficiency (REDAAT) in 1993. At present, the REDAAT is a network of more than 350 health care professionals and the database includes a total of 511 individuals. The adult population included consists of 469 individuals (91.8% of the total) and their phenotype distribution is: 348 Pi*ZZ (74.2%), 100 Pi*SZ (21.3%) and 21 carriers o...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Conductivity in Exhaled Breath Condensate from Subjects with Emphysema and Type ZZ alpha-1-Antitrypsin Deficiency.
Authors: Stolk J, Fumagalli M, Viglio S, Iadarola P Abstract The assessment of biomarkers in biological samples from the lung has long been employed. Upon cooling water vapor present in exhaled breath, variable amounts of droplets of condensate (EBC) containing volatile and non-volatile compounds may be easily and non-invasively obtained from patients of any age.Objective of the present study was to compare the level of EBC conductivity determined for cohorts of individuals with different inflammatory lung disorders with that of healthy never-smoking individuals.The conductivity in EBC of PiZZ-Alpha-1-antitrypsin d...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

The Clinical Profile of Subjects Included in the Swedish National Register on Individuals with Severe Alpha 1-Antitrypsin deficiency.
Authors: Piitulainen E, Tanash HA Abstract The Swedish national register of severe alpha1-antitrypsin (AAT) deficiency was established in 1991. The main aims are to prospectively study the natural history of severe AAT deficiency, and to improve the knowledge of AAT deficiency. The inclusion criteria in the register are age ≥ 18 years, and the PiZ phenotype diagnosed by isoelectric focusing. The register is kept updated by means of repeated questionnaires providing data to allow analysis of the mode of identification, lung and liver function, smoking-habits, respiratory symptoms and diagnoses as reported by phys...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

The United States Alpha-1 Foundation Research Registry: Genesis, Impact and Future.
Authors: Strange C, Monk R, Schwarz L, Walker D, Kumbhare S, Bieko T Abstract The Alpha-1 Foundation Research Registry has a long history of facilitating research studies in the United States. The current contact registry is used to invite participants to research studies. However, the next generation of individuals diagnosed with alpha-1 antitrypsin deficiency may look quite different from historical cohorts. This paper uses data from the Alpha Coded Testing (ACT) study, a home genetic testing program in which deficient individuals are invited to participate in the Registry, to demonstrate the impact that selectio...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Health-related quality of life in patients with alpha-1 antitrypsin deficiency: the French experience.
Authors: Gauvain C, Mornex JF, Pison C, Cuvelier A, Balduyck M, Pujazon MC, Fournier M, AitIlalne B, Thabut G Abstract The French registry of patients with alpha-1 antitrypsin deficiency (AATD)-associated emphysema was launched in 2006. Here, we aimed to report on the baseline characteristics of these patients, their health-related quality of life (HRQoL) and factors associated with HRQoL. Another goal was to survey the practices of French physicians regarding augmentation therapy. We included 273 patients with AATD, emphysema, obstructive-pattern [forced expiratory volume in 1 sec/forced volume capacity (FEV1/FVC)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Italian registry of patients with alpha-1 antitrypsin deficiency: general data and quality of life evaluation.
In this study, genetic and clinical findings of Italian AATD patients are presented. Moreover, we also evaluated the changes in health-related quality of life (HRQoL) in patients with COPD and AAT deficiency over a three-year period, in relation to augmentation therapy. In a period spanning 18 years (1996-2014) a total of 422 adult subjects with severe AATD were enrolled, namely 258 PI*ZZ, 74 PI*SZ, 4 PI*SS and 86 patients with at least one rare deficient allele. The 21.3% frequency for AATD patients with at least one deficient rare variant is the highest so far recorded in national registries of AATD. The registry data al...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Sex differences in alpha-1-antitrypsin deficiency lung disease-analysis from the German registry.
In conclusion, the data of the registry allow to characterize the natural course of the disease and highlight differences in the clinical presentation of patients with AATD-dependent COPD. PMID: 25938294 [PubMed - indexed for MEDLINE] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Antitrypsin Deficiency Assessment and Programme for Treatment (ADAPT): The United Kingdom Registry.
Authors: Stockley RA Abstract The study of rare diseases is compromised by its rarity. The establishment of national and international registries can overcome many of the problems and be used for many monogenetic conditions with relatively consistent outcomes and thus lead to a consistency of clinical management by centres of excellence. However, in Alpha-1 antitrypsin deficiency (AATD), the outcome is highly variable in terms of the organ(s) most affected and the diversity of disease penetration and progression. This creates the added difficulty of understanding the disease sufficiently to monitor and advise the p...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Physician-Patient Concordance in Pharmacological Management of Patients with COPD.
Authors: Small M, Higgins V, Lees A, Johns N, Mastrangelo A, Nazareth T, Turner SJ Abstract A retrospective analysis of a cross-sectional, multicenter survey was conducted in United States (US) medical practices to evaluate the concordance between patients with COPD and their physicians on disease-specific characteristics. Associations between patient and disease-related characteristics with monotherapy, dual therapy, or triple therapy prescribed as COPD maintenance regimens were also examined. Eligible physicians completed patient record forms (PRFs) for up to 6 consecutive patients with COPD. Patients for whom a ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Trends in Outpatient Visits with Benzodiazepines among US Adults With and Without Bronchitis or Chronic Obstructive Pulmonary Disease from 1999 to 2010.
Authors: Ford ES, Wheaton AG Abstract Little is known about trends in prescriptions for benzodiazepines among patients with chronic obstructive pulmonary disease (COPD). Our objective was to examine trends of office/outpatient department visits with a mention of a benzodiazepine made by patients aged ≥40 years with COPD in the United States. We used data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey from 1999-2010. From 1999 to 2010, the estimated numbers of office/outpatient department visits with a benzodiazepine mentioned increased from 20.7 million to 4...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Socioeconomic Status, Sex, Age and Access to Medications for COPD in Ontario, Canada.
Authors: Gershon A, Campitelli MA, Hwee J, Croxford R, To T, Stanbrook MB, Upshur R, Stephenson A, Stukel TA Abstract Disparities in COPD health outcomes have been found with older individuals, men and those of lower socioeconomic status doing worse. We sought to determine if this was due to differences in access to COPD medications. We conducted a retrospective cohort study using population health administrative data from Ontario, Canada, a province with universal prescription drug coverage for older adults. All individuals with COPD aged 67 years and older in 2008 who were not taking inhaled long-acting bronchodi...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Prevalence and Determinants of Chronic Obstructive Pulmonary Disease (COPD) in Bangladesh.
Authors: Alam DS, Chowdhury MA, Siddiquee AT, Ahmed S, Clemens JD Abstract RATIONALE: There is a paucity of population-based data on COPD prevalence and its determinants in Bangladesh. OBJECTIVE: To measure COPD prevalence and socioeconomic and lifestyle determinants among ≥40 years Bangladeshi adults. METHODS: In a cross-sectional study, we measured lung function of 3744 randomly selected adults ≥40 years from rural and urban areas in Bangladesh, using a handheld spirometer. COPD was defined according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria as post-bronchodilator...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Hospitalizations for COPD Exacerbations: Trends and Determinants of Death.
Authors: Molinari N, Briand C, Vachier I, Malafaye N, Aubas P, Georgescu V, Roche N, Chanez P, Bourdin A Abstract OBJECTIVES: to understand epidemiological trends in severe COPD exacerbations through analyzes of hospitalizations and deaths during three consecutive years in a French administrative region area. METHODS: Medico-administrative records of hospitalizations for COPD exacerbations were sorted from 2010 to 2012 using selected International Classification of Diseases (ICD10) codes. Four groups of hospitalization for COPD severe exacerbations were elicited leading to hospitalizations (general ward without...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Walking with Non-Invasive Ventilation Does Not Prevent Exercise-Induced Hypoxaemia in Stable Hypercapnic COPD Patients.
Authors: Walker DJ, Walterspacher S, Ekkernkamp E, Storre JH, Windisch W, Dreher M Abstract BACKGROUND: Non-invasive positive pressure ventilation (NPPV) in addition to supplemental oxygen improves arterial oxygenation, walking distance and dyspnea when applied during exercise in stable hypercapnic COPD patients. The aim of the current study was to investigate whether NPPV without supplemental oxygen is capable of preventing severe exercise-induced hypoxemia in these patients when applied during walking. METHODS AND RESULTS: 15 stable hypercapnic COPD patients (FEV1 29.9 ± 15.9%) performed two 6-minute w...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Emergency Admissions for COPD in an Urban Population: The Role of Population and Primary Care Factors.
This study examined variation between primary care teams in rates of COPD admission and assessed the role of prevalence, deprivation, practice performance, and general practitioner (GP) and nurse supply on risk of COPD admission. Retrospective observational study of National Health Service admissions for COPD of patients registered with London general practices over four years (2006-2009). We sought associations using negative binomial regression between COPD admissions and population factors, practice organization and practice performance. Trends in rates of COPD admissions across London were stable between 2006 and 2009....
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Trends in In-Hospital Outcomes Among Adults Hospitalized With Exacerbation of Chronic Obstructive Pulmonary Disease.
Authors: Lima FV, Yen TY, Patel JK Abstract BACKGROUND: Although substantial advances have been made in the treatment of chronic obstructive pulmonary disease (COPD), little is known regarding the impact of these advancements on inpatient outcomes over time. We sought to examine temporal trends in in-hospital outcomes among adults hospitalized with COPD exacerbation. METHODS: The Healthcare Cost and Utilization Project's Nationwide Inpatient Sample was utilized to identify a cohort of adults hospitalized with COPD exacerbation, identified through International Classification of Diseases-9 codes. Baseline demogr...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Social Support and Social Networks in COPD: A Scoping Review.
Authors: Barton C, Effing TW, Cafarella P Abstract A scoping review was conducted to determine the size and nature of the evidence describing associations between social support and networks on health, management and clinical outcomes amongst patients with COPD. Searches of PubMed, PsychInfo and CINAHL were undertaken for the period 1966-December 2013. A descriptive synthesis of the main findings was undertaken to demonstrate where there is current evidence for associations between social support, networks and health outcomes, and where further research is needed. The search yielded 318 papers of which 287 were exc...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Changing Pattern of Sputum Cell Counts During Successive Exacerbations of Chronic Obstructive Pulmonary Disease.
CONCLUSIONS: This non-intervention study suggests that the cellular nature of bronchitis is largely unpredictable and needs to be examined at each COPD exacerbation This has important implications in choosing the appropriate therapy. Future intervention studies would provide further evidence. PMID: 26263037 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD Multidisciplinary Team Meetings in the United Kingdom: Health Care Professionals' Perceptions of Aims and Structure.
Authors: Kruis AL, Soljak M, Chavannes NH, Elkin SL Abstract Over the last 10 years, community and hospital-based multidisciplinary teams (MDTs) have been set up for the management of patients with chronic obstructive pulmonary disease (COPD) in the UK. Meetings of the MDTs have become a regular occurrence, mostly on healthcare professionals' own initiatives. There are no standardized methods to conduct an MDT meeting, and although cancer MDT meetings are widely implemented, the value and purpose of COPD MDT meetings are less clear. Therefore, the aim of this study was to conduct a cross-sectional descriptive onlin...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Prevalence of Pulmonary Hypertension and its Influence on Survival in Patients With Advanced Chronic Obstructive Pulmonary Disease Prior to Lung Transplantation.
Authors: Hayes D, Black SM, Tobias JD, Mansour HM, Whitson BA Abstract INTRODUCTION: Prevalence of pulmonary hypertension (PH) and its influence on survival in chronic obstructive pulmonary disease (COPD) are not well studied in the lung allocation score (LAS) era. METHODS: The UNOS database was queried from 2005 to 2013 to identify first-time adult lung transplant candidates with COPD who were tracked from wait list entry date until death or censoring to determine both prevalence and influence of PH. Using right heart catheterization measurements, mild PH was defined as mean pulmonary artery pressure (mPAP) &g...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

COPD-Related Mortality and Co-morbidities in Northeastern Italy, 2008-2012: A Multiple Causes of Death Analysis.
CONCLUSIONS: MCOD analysis should be adopted to fully evaluate the burden of COPD-related mortality. Our findings support a decreasing trend in COPD-related mortality in northeastern Italy between 2008 and 2012, in line with other recent studies in Europe and beyond. PMID: 26367073 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Targeting Persons With or At High Risk for Chronic Obstructive Pulmonary Disease by State-based Surveillance.
CONCLUSIONS: Persons at high risk for COPD share many, but not all, of the characteristics of persons diagnosed with the disease. Additional questions addressing smoking duration and respiratory symptoms in the BRFSS identifies groups at high risk for having or developing COPD who may benefit from smoking cessation and case-finding interventions. PMID: 26367193 [PubMed - in process] (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Comparison of the COPD Assessment Test (CAT) and the Clinical COPD Questionnaire (CCQ) in a Clinical Population.
Authors: Sundh J, Ställberg B, Lisspers K, Kämpe M, Janson C, Montgomery S Abstract INTRODUCTION: The COPD Assessment Test (CAT) and the Clinical COPD Questionnaire (CCQ) are both clinically useful health status instruments. The main objective was to compare CAT and CCQ measurement instruments. METHODS: CAT and CCQ forms were completed by 432 randomly selected primary and secondary care patients with a COPD diagnosis. Correlation and linear regression analyses of CAT and CCQ were performed. Standardised scores were created for the CAT and CCQ scores, and separate multiple linear regression analyses fo...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

The Impact of Homogeneous Versus Heterogeneous Emphysema on Dynamic Hyperinflation in Patients With Severe COPD Assessed for Lung Volume Reduction.
Authors: Boutou AK, Zoumot Z, Nair A, Davey C, Hansell DM, Jamurtas A, Polkey MI, Hopkinson NS Abstract Dynamic hyperinflation (DH) is a pathophysiologic hallmark of Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to investigate the impact of emphysema distribution on DH during a maximal cardiopulmonary exercise test (CPET) in patients with severe COPD. This was a retrospective analysis of prospectively collected data among severe COPD patients who underwent thoracic high-resolution computed tomography, full lung function measurements and maximal CPET with inspiratory manouvers as assessment...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Maintaining Control of Chronic Obstructive Airway Disease: Adherence to Inhaled Therapy and Risks and Benefits of Switching Devices.
Authors: Melani AS, Paleari D Abstract Asthma and chronic obstructive pulmonary disease (COPD) are major obstructive airway diseases that involve underlying airway inflammation. The most widely used pharmacotherapies for asthma and COPD are inhaled agents that have been shown to be effective and safe in these patients. However, despite the availability of effective pharmacologic treatment and comprehensive treatment guidelines, the prevalence of inadequately controlled asthma and COPD is high. A main reason for this is poor adherence. Adherence is a big problem for all chronic diseases, but in asthma and COPD patie...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Addressing Assumptions for the Use of Non-invasive Cardiac Output Measurement Techniques During Exercise in COPD.
This study show that in COPD patients, CO2-rebreathing Qc values obtained using PaCO2 contents which account for any gas exchange impairment or inadequate gas mixing are similar to those obtained using thoracic bioimpedance. Alternately, the lower values for N2O rebreathing derived Qc indicates the inability of this technique to account for gas exchange impairment in the computation of Qc. These findings indicate that the choice of a gas rebreathing technique to measure Qc in patients must be dictated by the ability to include in the derived computations a correction for either gas exchange inadequacies and/or a vascular s...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Emergency Hospital Care for Exacerbation of COPD: Is Inhaled Maintenance Therapy Modified?
Authors: Pomares X, Montón C, Baré M, Pont M, Estirado C, Gea J, Quintana JM, Vidal S, Santiago A, IRYSS-COPD Appropriateness study group Abstract BACKGROUND: The impact of hospital emergency care and inward admission for acute exacerbations of COPD on inhaled maintenance treatment is not well known. OBJECTIVE: Therefore, we evaluated the impact of short-stay emergency hospital care and inward admission for acute exacerbation of COPD (eCOPD) on inhaled maintenance treatment prescribed at discharge. DESIGN: Prospective observational cohort study of patients presenting with eCOPD at emergency de...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research

Update: Non-Invasive Positive Pressure Ventilation in Chronic Respiratory Failure Due to COPD.
Authors: Altintas N Abstract Long-term non-invasive positive pressure ventilation (NPPV) has widely been accepted to treat chronic hypercapnic respiratory failure arising from different etiologies. Although the survival benefits provided by long-term NPPV in individuals with restrictive thoracic disorders or stable, slowly-progressing neuromuscular disorders are overwhelming, the benefits provided by long-term NPPV in patients with chronic obstructive pulmonary disease (COPD) remain under question, due to a lack of convincing evidence in the literature. In addition, long-term NPPV reportedly failed in the classic t...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2016 Category: Respiratory Medicine Tags: COPD Source Type: research