S100A12 is involved in the pathology of osteoarthritis by promoting M1 macrophage polarization via the NF- κB pathway
CONCLUSIONS: This study demonstrated that S100A12 promotes M1 macrophage polarization through the NF-κB pathway, and found that LINC00894 has the potential to regulate the expression of S100A12 as a therapeutic approach.PMID:38492210 | DOI:10.1080/03008207.2024.2310852 (Source: Connective Tissue Research)
Source: Connective Tissue Research - March 16, 2024 Category: Research Authors: Yi Zhang Zihua Li Cheng Chen Wang Wei Zhendong Li Hui Huang Haichao Zhou Wenbao He Jiang Xia Bing Li Yunfeng Yang Source Type: research
COL1A1 proximal promoter topology regulates its transcriptional response to transforming growth factor β
CONCLUSION: The topology of the COL1A1 proximal promoter is crucial in determining the transcriptional activity of the gene and its response to the stimulatory effects of TGF-β1.PMID:38436275 | DOI:10.1080/03008207.2024.2319051 (Source: Connective Tissue Research)
Source: Connective Tissue Research - March 4, 2024 Category: Research Authors: Elena Hitraya Svetlana Gaidarova Sonsoles Piera-Velazquez Sergio A Jimenez Source Type: research
Assessment of articular cartilage degradation in response to an impact injury using µMRI
CONCLUSIONS: This µMRI T2 study was able to detect cartilage damage in the impacted knees. In addition, greater degradation in the affected knees at 14 weeks than at 2 weeks indicated the progressive nature of cartilage deterioration over time. The µMRI results were in accord with the biochemical analysis, indicating the detection of early structural damage in the cartilage.PMID:38415672 | DOI:10.1080/03008207.2024.2319050 (Source: Connective Tissue Research)
Source: Connective Tissue Research - February 28, 2024 Category: Research Authors: Amanveer Singh Hannah Mantebea Farid Badar Syeda Batool Gabrielle Abdelmessih Talia Sebastian Michael Newton Kevin Baker Sarah Salem Yang Xia Source Type: research
