Pick's disease presenting with corticobasal syndrome: A case report and clinicopathological review
We report a case of clinically diagnosed CBS with a post-mortem diagnosis of PiD and conduct a clinicopathological review of the literature on this unusual presentation.PMID:37840526 | DOI:10.5414/NP301544 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - October 16, 2023 Category: Pathology Authors: Yuanyuan Gu Qi Zhang Stephen H Pasternak Lee Cyn Ang Source Type: research
Polypathology-associated neurodegeneration after remote head injury
We present the case of an 82-year-old man who died 4 years after developing a phenotypically mixed dementia with neuropsychiatric features and parkinsonism. He had a remote history of a severe TBI 40 years prior, following a road traffic accident which caused a large right frontal injury, requiring neurosurgical intervention. Post-mortem neuropathological examination demonstrated abnormal phosphorylated-Tau (p-Tau), beta-amyloid plaques (Aβ) and α-synuclein deposition. Spatial immunohistochemical analysis demonstrated increased perivascular accumulation of p-Tau with blood-brain barrier (BBB) disruption at the site of in...
Source: Clinical Neuropathology - October 16, 2023 Category: Pathology Authors: Declan Brennan Conor Delaney Michael Farrell Matthew Campbell Colin P Doherty Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma with review of the literature on tumor-to-tumor metastasis to gliomas
Clin Neuropathol. 2023 Oct 2. doi: 10.5414/NP301578. Online ahead of print.ABSTRACTTumor-to-tumor metastasis (TTM) is a process where one tumor metastasizes to another tumor. It is an exceedingly rare phenomenon, particularly in the central nervous system, where it most commonly occurs with meningiomas as the recipient. Herein, we present a case of tumor-to-tumor metastasis of an adenocarcinoma to a glioblastoma in a 75-year-old female. The patient had a history of high-grade ductal carcinoma in situ of the breast 8 years prior, treated with lumpectomy and radiation. She presented with a left fronto-parietal mass. Histolog...
Source: Clinical Neuropathology - October 2, 2023 Category: Pathology Authors: Georgi Galev Maximillian A Weigelt Richard A Prayson Source Type: research
Suprasellar masquerader: Chordoid glioma
CONCLUSION: The rare occurrence as well as the radiological and morphological overlaps in chordoid gliomas make them a true masquerader. Combination of GFAP and TTF-1 in the immunohistochemical panel can be useful in differential diagnosis. Mainstay of treatment is complete surgical excision, with adjuvant radiotherapy becoming increasingly important.PMID:37675487 | DOI:10.5414/NP301577 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - September 7, 2023 Category: Pathology Authors: Neha Bhardwaj Pravin Salunke Navneet Singla Chirag Ahuja Chandrashekhar Gendle Kirti Gupta Source Type: research
Suprasellar masquerader: Chordoid glioma
CONCLUSION: The rare occurrence as well as the radiological and morphological overlaps in chordoid gliomas make them a true masquerader. Combination of GFAP and TTF-1 in the immunohistochemical panel can be useful in differential diagnosis. Mainstay of treatment is complete surgical excision, with adjuvant radiotherapy becoming increasingly important.PMID:37675487 | DOI:10.5414/NP301577 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - September 7, 2023 Category: Pathology Authors: Neha Bhardwaj Pravin Salunke Navneet Singla Chirag Ahuja Chandrashekhar Gendle Kirti Gupta Source Type: research
