Gamma-delta T-cell lymphoma of the central nervous system: A case report and review of the literature
We describe a case of TCL presenting in the basal ganglia with γδ receptor expression and a remarkably aggressive clinical course. To the best of our knowledge, this is the fifth reported case of γδ TCL presenting in the CNS. We review existing literature, including the previously reported cases of γδ TCL of the CNS. In our case, a 69-year-old male presented with acute onset dysarthria and right-sided weakness, with initial imaging concerning for stroke. Repeat imaging demonstrated a 2.6-cm mass in the left basal ganglia-corona radiata. Pathologic examination of a stereotactic biopsy revealed TCL with γδ receptor p...
Source: Clinical Neuropathology - March 22, 2024 Category: Pathology Authors: Alexa T Andre Meagan Chambers Daniel E Sabath Source Type: research
Gamma-delta T-cell lymphoma of the central nervous system: A case report and review of the literature
We describe a case of TCL presenting in the basal ganglia with γδ receptor expression and a remarkably aggressive clinical course. To the best of our knowledge, this is the fifth reported case of γδ TCL presenting in the CNS. We review existing literature, including the previously reported cases of γδ TCL of the CNS. In our case, a 69-year-old male presented with acute onset dysarthria and right-sided weakness, with initial imaging concerning for stroke. Repeat imaging demonstrated a 2.6-cm mass in the left basal ganglia-corona radiata. Pathologic examination of a stereotactic biopsy revealed TCL with γδ receptor p...
Source: Clinical Neuropathology - March 22, 2024 Category: Pathology Authors: Alexa T Andre Meagan Chambers Daniel E Sabath Source Type: research
Gamma-delta T-cell lymphoma of the central nervous system: A case report and review of the literature
We describe a case of TCL presenting in the basal ganglia with γδ receptor expression and a remarkably aggressive clinical course. To the best of our knowledge, this is the fifth reported case of γδ TCL presenting in the CNS. We review existing literature, including the previously reported cases of γδ TCL of the CNS. In our case, a 69-year-old male presented with acute onset dysarthria and right-sided weakness, with initial imaging concerning for stroke. Repeat imaging demonstrated a 2.6-cm mass in the left basal ganglia-corona radiata. Pathologic examination of a stereotactic biopsy revealed TCL with γδ receptor p...
Source: Clinical Neuropathology - March 22, 2024 Category: Pathology Authors: Alexa T Andre Meagan Chambers Daniel E Sabath Source Type: research
Clinical Neuropathology 2-2024
Clin Neuropathol. 2024 Mar 21. doi: 10.5414/NPP43041. Online ahead of print.NO ABSTRACTPMID:38511673 | DOI:10.5414/NPP43041 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - March 21, 2024 Category: Pathology Authors: Christian Mawrin Source Type: research
Clinical Neuropathology 2-2024
Clin Neuropathol. 2024 Mar 21. doi: 10.5414/NPP43041. Online ahead of print.NO ABSTRACTPMID:38511673 | DOI:10.5414/NPP43041 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - March 21, 2024 Category: Pathology Authors: Christian Mawrin Source Type: research
Intratumoral histological and molecular heterogeneity in an adult diffuse glioma
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301598. Online ahead of print.ABSTRACTAdult-type diffuse gliomas are the most prevalent type of malignant adult brain tumors. Intratumoral heterogeneity can hinder accurate diagnosis and subsequent treatment. This case report documents a tumor with intratumoral heterogeneity, both histologically and by methylation analysis, located within the left cerebral hemisphere of a 29-year-old female. She presented after a witnessed generalized tonic clonic seizure at home. Two years prior she had a witnessed seizure; however, no brain imaging was done at the time. Magnetic resonance ima...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Trishhani Yogaretnam Josephine Heffernan Rosa Leung Ciara Heeney Andrea Walsh Seamus Looby John Caird Francesca M Brett Source Type: research
Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301603. Online ahead of print.ABSTRACTEndolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease. ELST can be misdiagnosed as metastatic renal cancer because of the similarity in morphology and expression of nephrogenic markers such as PAX8. The presented case of a 27-year-old man revealed that observing the characteristic location and confir...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Wenjia Sun Manxiang Wang Junqiu Yue Source Type: research
Olfactory groove schwannoma: Common pathology in an uncommon location
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301605. Online ahead of print.NO ABSTRACTPMID:38495014 | DOI:10.5414/NP301605 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Akhil Sunil Sumit Thakar Sanjay Honavalli Murali Nayana Nagappa Sriramanakoppa Saritha Aryan Source Type: research
Intratumoral histological and molecular heterogeneity in an adult diffuse glioma
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301598. Online ahead of print.ABSTRACTAdult-type diffuse gliomas are the most prevalent type of malignant adult brain tumors. Intratumoral heterogeneity can hinder accurate diagnosis and subsequent treatment. This case report documents a tumor with intratumoral heterogeneity, both histologically and by methylation analysis, located within the left cerebral hemisphere of a 29-year-old female. She presented after a witnessed generalized tonic clonic seizure at home. Two years prior she had a witnessed seizure; however, no brain imaging was done at the time. Magnetic resonance ima...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Trishhani Yogaretnam Josephine Heffernan Rosa Leung Ciara Heeney Andrea Walsh Seamus Looby John Caird Francesca M Brett Source Type: research
Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301603. Online ahead of print.ABSTRACTEndolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease. ELST can be misdiagnosed as metastatic renal cancer because of the similarity in morphology and expression of nephrogenic markers such as PAX8. The presented case of a 27-year-old man revealed that observing the characteristic location and confir...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Wenjia Sun Manxiang Wang Junqiu Yue Source Type: research
Olfactory groove schwannoma: Common pathology in an uncommon location
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301605. Online ahead of print.NO ABSTRACTPMID:38495014 | DOI:10.5414/NP301605 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Akhil Sunil Sumit Thakar Sanjay Honavalli Murali Nayana Nagappa Sriramanakoppa Saritha Aryan Source Type: research
Intratumoral histological and molecular heterogeneity in an adult diffuse glioma
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301598. Online ahead of print.ABSTRACTAdult-type diffuse gliomas are the most prevalent type of malignant adult brain tumors. Intratumoral heterogeneity can hinder accurate diagnosis and subsequent treatment. This case report documents a tumor with intratumoral heterogeneity, both histologically and by methylation analysis, located within the left cerebral hemisphere of a 29-year-old female. She presented after a witnessed generalized tonic clonic seizure at home. Two years prior she had a witnessed seizure; however, no brain imaging was done at the time. Magnetic resonance ima...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Trishhani Yogaretnam Josephine Heffernan Rosa Leung Ciara Heeney Andrea Walsh Seamus Looby John Caird Francesca M Brett Source Type: research
Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301603. Online ahead of print.ABSTRACTEndolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease. ELST can be misdiagnosed as metastatic renal cancer because of the similarity in morphology and expression of nephrogenic markers such as PAX8. The presented case of a 27-year-old man revealed that observing the characteristic location and confir...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Wenjia Sun Manxiang Wang Junqiu Yue Source Type: research
Olfactory groove schwannoma: Common pathology in an uncommon location
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301605. Online ahead of print.NO ABSTRACTPMID:38495014 | DOI:10.5414/NP301605 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Akhil Sunil Sumit Thakar Sanjay Honavalli Murali Nayana Nagappa Sriramanakoppa Saritha Aryan Source Type: research
Clinical Neuropathology 1-2024
Clin Neuropathol. 2024 Jan-Feb;43(1):1. doi: 10.5414/NPP43001.NO ABSTRACTPMID:38126179 | DOI:10.5414/NPP43001 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 21, 2023 Category: Pathology Authors: Christian Mawrin Source Type: research
