Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research

Isolated embryonal rhabdomyosarcoma of the anterior petrous bone in a young child: Focusing on the intra-operative diagnosis and differentials
CONCLUSION: Isolated petrous bone involvement of embryonal rhabdomyosarcoma is a rare presentation. Intra-operative frozen section plays a key role in decision making regarding the extent of excision. Hence, a prompt and accurate diagnosis is essential in managing these cases.PMID:38085093 | DOI:10.5414/NP301586 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ipsita Panda Murali Krishna Bethanbhatla Kirti Gupta Pravin Salunke Source Type: research

Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research

Isolated embryonal rhabdomyosarcoma of the anterior petrous bone in a young child: Focusing on the intra-operative diagnosis and differentials
CONCLUSION: Isolated petrous bone involvement of embryonal rhabdomyosarcoma is a rare presentation. Intra-operative frozen section plays a key role in decision making regarding the extent of excision. Hence, a prompt and accurate diagnosis is essential in managing these cases.PMID:38085093 | DOI:10.5414/NP301586 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ipsita Panda Murali Krishna Bethanbhatla Kirti Gupta Pravin Salunke Source Type: research

Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research

Isolated embryonal rhabdomyosarcoma of the anterior petrous bone in a young child: Focusing on the intra-operative diagnosis and differentials
CONCLUSION: Isolated petrous bone involvement of embryonal rhabdomyosarcoma is a rare presentation. Intra-operative frozen section plays a key role in decision making regarding the extent of excision. Hence, a prompt and accurate diagnosis is essential in managing these cases.PMID:38085093 | DOI:10.5414/NP301586 (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ipsita Panda Murali Krishna Bethanbhatla Kirti Gupta Pravin Salunke Source Type: research

Impact of environment on pediatric and adult brain tumors: The 2023 Brain Tumor Epidemiology Consortium meeting report
Clin Neuropathol. 2023 Dec 5. doi: 10.5414/NP301590. Online ahead of print.ABSTRACTThe Brain Tumor Epidemiology Consortium (BTEC) is an international organization with membership of individuals from the scientific community with interests related to brain tumor epidemiology including surveillance, classification, methodology, etiology, and factors associated with morbidity and mortality. The 2023 annual BTEC meeting entitled "Impact of Environment on Pediatric and Adult Brain Tumors" was held in Lexington, KY, USA on May 22 - 24, 2023. The meeting gathered scientists from the United States, Canada, Australia, and Europe an...
Source: Clinical Neuropathology - December 5, 2023 Category: Pathology Authors: Kimberly J Johnson Luc Bauchet Roberta McKean-Cowdin Carol Kruchko Ching C Lau Quinn T Ostrom Michael E Scheurer John Villano Yan Yuan Source Type: research

Impact of environment on pediatric and adult brain tumors: The 2023 Brain Tumor Epidemiology Consortium meeting report
Clin Neuropathol. 2023 Dec 5. doi: 10.5414/NP301590. Online ahead of print.ABSTRACTThe Brain Tumor Epidemiology Consortium (BTEC) is an international organization with membership of individuals from the scientific community with interests related to brain tumor epidemiology including surveillance, classification, methodology, etiology, and factors associated with morbidity and mortality. The 2023 annual BTEC meeting entitled "Impact of Environment on Pediatric and Adult Brain Tumors" was held in Lexington, KY, USA on May 22 - 24, 2023. The meeting gathered scientists from the United States, Canada, Australia, and Europe an...
Source: Clinical Neuropathology - December 5, 2023 Category: Pathology Authors: Kimberly J Johnson Luc Bauchet Roberta McKean-Cowdin Carol Kruchko Ching C Lau Quinn T Ostrom Michael E Scheurer John Villano Yan Yuan Source Type: research

Impact of environment on pediatric and adult brain tumors: The 2023 Brain Tumor Epidemiology Consortium meeting report
Clin Neuropathol. 2023 Dec 5. doi: 10.5414/NP301590. Online ahead of print.ABSTRACTThe Brain Tumor Epidemiology Consortium (BTEC) is an international organization with membership of individuals from the scientific community with interests related to brain tumor epidemiology including surveillance, classification, methodology, etiology, and factors associated with morbidity and mortality. The 2023 annual BTEC meeting entitled "Impact of Environment on Pediatric and Adult Brain Tumors" was held in Lexington, KY, USA on May 22 - 24, 2023. The meeting gathered scientists from the United States, Canada, Australia, and Europe an...
Source: Clinical Neuropathology - December 5, 2023 Category: Pathology Authors: Kimberly J Johnson Luc Bauchet Roberta McKean-Cowdin Carol Kruchko Ching C Lau Quinn T Ostrom Michael E Scheurer John Villano Yan Yuan Source Type: research

Impact of environment on pediatric and adult brain tumors: The 2023 Brain Tumor Epidemiology Consortium meeting report
Clin Neuropathol. 2023 Dec 5. doi: 10.5414/NP301590. Online ahead of print.ABSTRACTThe Brain Tumor Epidemiology Consortium (BTEC) is an international organization with membership of individuals from the scientific community with interests related to brain tumor epidemiology including surveillance, classification, methodology, etiology, and factors associated with morbidity and mortality. The 2023 annual BTEC meeting entitled "Impact of Environment on Pediatric and Adult Brain Tumors" was held in Lexington, KY, USA on May 22 - 24, 2023. The meeting gathered scientists from the United States, Canada, Australia, and Europe an...
Source: Clinical Neuropathology - December 5, 2023 Category: Pathology Authors: Kimberly J Johnson Luc Bauchet Roberta McKean-Cowdin Carol Kruchko Ching C Lau Quinn T Ostrom Michael E Scheurer John Villano Yan Yuan Source Type: research

Impact of environment on pediatric and adult brain tumors: The 2023 Brain Tumor Epidemiology Consortium meeting report
Clin Neuropathol. 2023 Dec 5. doi: 10.5414/NP301590. Online ahead of print.ABSTRACTThe Brain Tumor Epidemiology Consortium (BTEC) is an international organization with membership of individuals from the scientific community with interests related to brain tumor epidemiology including surveillance, classification, methodology, etiology, and factors associated with morbidity and mortality. The 2023 annual BTEC meeting entitled "Impact of Environment on Pediatric and Adult Brain Tumors" was held in Lexington, KY, USA on May 22 - 24, 2023. The meeting gathered scientists from the United States, Canada, Australia, and Europe an...
Source: Clinical Neuropathology - December 5, 2023 Category: Pathology Authors: Kimberly J Johnson Luc Bauchet Roberta McKean-Cowdin Carol Kruchko Ching C Lau Quinn T Ostrom Michael E Scheurer John Villano Yan Yuan Source Type: research

Impact of environment on pediatric and adult brain tumors: The 2023 Brain Tumor Epidemiology Consortium meeting report
Clin Neuropathol. 2023 Dec 5. doi: 10.5414/NP301590. Online ahead of print.ABSTRACTThe Brain Tumor Epidemiology Consortium (BTEC) is an international organization with membership of individuals from the scientific community with interests related to brain tumor epidemiology including surveillance, classification, methodology, etiology, and factors associated with morbidity and mortality. The 2023 annual BTEC meeting entitled "Impact of Environment on Pediatric and Adult Brain Tumors" was held in Lexington, KY, USA on May 22 - 24, 2023. The meeting gathered scientists from the United States, Canada, Australia, and Europe an...
Source: Clinical Neuropathology - December 5, 2023 Category: Pathology Authors: Kimberly J Johnson Luc Bauchet Roberta McKean-Cowdin Carol Kruchko Ching C Lau Quinn T Ostrom Michael E Scheurer John Villano Yan Yuan Source Type: research

SWI/SNF-deficient tumors of the central nervous system: An update
Clin Neuropathol. 2023 Nov 16. doi: 10.5414/NP301594. Online ahead of print.ABSTRACTAtypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor of the central nervous system characterized by biallelic inactivation of SWI/SNF chromatin remodeling complex members SMARCB1/INI1 or (rarely) SMARCA4/BRG1. Most high-grade central nervous system lesions showing loss of nuclear SMARCB1 or SMARCA4 protein expression can indeed be categorized as AT/RT. However, some high-grade lesions have been identified, whose clinical and/or molecular features justify separation from AT/RT. Furthermore, other recently described tumor type...
Source: Clinical Neuropathology - November 16, 2023 Category: Pathology Authors: Martin Hasselblatt Marcel Kool Michael C Fr ühwald Source Type: research

SWI/SNF-deficient tumors of the central nervous system: An update
Clin Neuropathol. 2023 Nov 16. doi: 10.5414/NP301594. Online ahead of print.ABSTRACTAtypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor of the central nervous system characterized by biallelic inactivation of SWI/SNF chromatin remodeling complex members SMARCB1/INI1 or (rarely) SMARCA4/BRG1. Most high-grade central nervous system lesions showing loss of nuclear SMARCB1 or SMARCA4 protein expression can indeed be categorized as AT/RT. However, some high-grade lesions have been identified, whose clinical and/or molecular features justify separation from AT/RT. Furthermore, other recently described tumor type...
Source: Clinical Neuropathology - November 16, 2023 Category: Pathology Authors: Martin Hasselblatt Marcel Kool Michael C Fr ühwald Source Type: research

SWI/SNF-deficient tumors of the central nervous system: An update
Clin Neuropathol. 2023 Nov 16. doi: 10.5414/NP301594. Online ahead of print.ABSTRACTAtypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor of the central nervous system characterized by biallelic inactivation of SWI/SNF chromatin remodeling complex members SMARCB1/INI1 or (rarely) SMARCA4/BRG1. Most high-grade central nervous system lesions showing loss of nuclear SMARCB1 or SMARCA4 protein expression can indeed be categorized as AT/RT. However, some high-grade lesions have been identified, whose clinical and/or molecular features justify separation from AT/RT. Furthermore, other recently described tumor type...
Source: Clinical Neuropathology - November 16, 2023 Category: Pathology Authors: Martin Hasselblatt Marcel Kool Michael C Fr ühwald Source Type: research