Interfering with the AKT/mTOR/STAT3/ID1 signaling axis with usenamine A restrains the proliferative and invasive potential of human hepatocellular carcinoma cells
Usenamine A, a novel natural compound initially isolated from the lichen Usnea longissima, has exhibited promising efficacy against hepatoma in prior investigation. Nevertheless, the underlying mechanisms respons... (Source: Chinese Medicine)
Source: Chinese Medicine - January 5, 2024 Category: Complementary Medicine Authors: Ailin Yang, Huiming Huang, Jinxin Xie, Yingying Tian, Longyan Wang, Dongxiao Liu, Xuejiao Wei, Peng Tan, Xingyun Chai, Xiaojun Zha, Pengfei Tu and Zhongdong Hu Tags: Research Source Type: research
Combination of mangiferin and T0901317 targeting autophagy promotes cholesterol efflux from macrophage foam cell in atherosclerosis
The synthetic liver X receptor ligand (LXR) T0901317 (T0) has been reported to attenuate atherosclerosis (AS) without hyperglyceridemia due to innovative drug combination or nano-sized drug delivery. Given the... (Source: Chinese Medicine)
Source: Chinese Medicine - January 5, 2024 Category: Complementary Medicine Authors: Qian Chen, Sijian Wang, Ruixia Bao, Dan Wang, Yuzheng Wu, Yi Zhang, Mengyang Liu and Tao Wang Tags: Research Source Type: research
Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke
This study aimed to investigate the potential protective effects of Atractylenolide I (Atr I), A... (Source: Chinese Medicine)
Source: Chinese Medicine - January 4, 2024 Category: Complementary Medicine Authors: Haiyan Li, Wantong Yu, Yong Yang, Sijie Li, Jun Xu, Chen Gao, Wei Zhang, Wenjie Shi, Kunlin Jin, Xunming Ji and Changhong Ren Tags: Research Source Type: research
Pharmacological properties of Polygonatum and its active ingredients for the prevention and treatment of cardiovascular diseases
Despite continued advances in prevention and treatment strategies, cardiovascular diseases (CVDs) remain the leading cause of death worldwide, and more effective therapeutic methods are urgently needed. Polygonat... (Source: Chinese Medicine)
Source: Chinese Medicine - January 2, 2024 Category: Complementary Medicine Authors: Hongyuan Lin, Wenhui Wang, Mengqi Peng, Yifan Kong, Xiaowei Zhang, Xiaohong Wei and Hongcai Shang Tags: Review Source Type: research
Machine learning integration of multi-modal analytical data for distinguishing abnormal botanical drugs and its application in Guhong injection
Determination of batch-to-batch consistency of botanical drugs (BDs) has long been the bottleneck in quality evaluation primarily due to the chemical diversity inherent in BDs. This diversity presents an obsta... (Source: Chinese Medicine)
Source: Chinese Medicine - January 2, 2024 Category: Complementary Medicine Authors: Zhu Han, Jiandong Zhao, Yu Tang and Yi Wang Tags: Research Source Type: research
Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones
The pharmacological effects of natural product therapy have received sigificant attention, among which terpenoids such as sesquiterpene lactones stand out due to their biological activity and pharmacological p... (Source: Chinese Medicine)
Source: Chinese Medicine - December 18, 2023 Category: Complementary Medicine Authors: Fei Cao, Chu Chu, Jiang-Jiang Qin and Xiaoqing Guan Tags: Review Source Type: research
The potential roles of gossypol as anticancer agent: advances and future directions
Gossypol, a polyphenolic aldehyde derived from cottonseed plants, has seen a transformation in its pharmaceutical application from a male contraceptive to a candidate for cancer therapy. This shift is supporte... (Source: Chinese Medicine)
Source: Chinese Medicine - December 15, 2023 Category: Complementary Medicine Authors: Danijela Paunovic, Jovana Rajkovic, Radmila Novakovic, Jelica Grujic-Milanovic, Reham Hassan Mekky, Dragos Popa, Daniela Calina and Javad Sharifi-Rad Tags: Review Source Type: research
Efficacy and safety of oral Chinese patent medicines in the treatment of coronary heart disease combined with hyperlipidemia: a systematic review and network meta-analysis of 78 trials
To evaluate the clinical efficacy and safety of commonly used oral Chinese patent medicines for the treatment of coronary heart disease combined with hyperlipidemia in clinical practice through a network meta-... (Source: Chinese Medicine)
Source: Chinese Medicine - December 13, 2023 Category: Complementary Medicine Authors: Zhenyu Yang, Jixin Li, Bogeng Zhou, Xuan Ji, Jianying Yuan, Junchen Yan, Xilei Nan and Dandan Guo Tags: Review Source Type: research
Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy by deubiquitinating Smad7
Salvianolic acid B (Sal B), a water-soluble phenolic compound derived from Salvia miltiorrhiza Bunge, is commonly used in Traditional Chinese Medicine to treat cardiovascular disease. In our previous study, Sal B... (Source: Chinese Medicine)
Source: Chinese Medicine - December 10, 2023 Category: Complementary Medicine Authors: Hong Luo, Lingyun Fu, Xueting Wang, Yini Xu, Ling Tao and Xiangchun Shen Tags: Research Source Type: research
Epigallocatechin gallate prevents cardiomyocytes from pyroptosis through lncRNA MEG3/TAF15/AIM2 axis in myocardial infarction
( −)-Epigallocatechin-3-gallate (EGCG), a bioactive polyphenol isolated from green tea, has recently garnered attention for its potential protective role against acute myocardial infarction (MI) via inhibiting... (Source: Chinese Medicine)
Source: Chinese Medicine - December 6, 2023 Category: Complementary Medicine Authors: Chaoshi Qin, Tingting Wang, Ni Qian, Jing Liu, Rong Xi, Qing Zou, Hui Liu and Xiaolin Niu Tags: Research Source Type: research
The role of Traditional Chinese medicine in anti-HBV: background, progress, and challenges
Chronic hepatitis B (CHB) remains a major world's most serious public health issues. Despite the remarkable effect of nucleos(t)ide analogues (NAs) in inhibiting hepatitis B virus (HBV) deoxyribonucleic acid (... (Source: Chinese Medicine)
Source: Chinese Medicine - December 2, 2023 Category: Complementary Medicine Authors: Feilin Ge, Yan Yang, Zhaofang Bai, Lanlan Si, Xuemei Wang, Jia Yu, Xiaohe Xiao, Yan Liu and Zhigang Ren Tags: Review Source Type: research
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein
Rhein can significantly delay the progression of chronic nephropathy. However, its mechanism of action has not been adequately elaborated, which hinders its extensive clinical application. In this work, the ef... (Source: Chinese Medicine)
Source: Chinese Medicine - December 1, 2023 Category: Complementary Medicine Authors: Li Wang, Xixi Yu, Hongju Li, Dahong He, Su Zeng and Zheng Xiang Tags: Research Source Type: research
Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis
Synovial neovascularization promotes rheumatoid arthritis (RA) progression. Baihu guizhi decoction (BHGZD) has a potential in restricting this pathological change of RA. (Source: Chinese Medicine)
Source: Chinese Medicine - November 30, 2023 Category: Complementary Medicine Authors: Xia Mao, Xiangying Yan, Congchong Li, Yudong Liu, Yanqiong Zhang and Na Lin Tags: Research Source Type: research
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle
Acute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which is characterized by a pathophysiological process of inflammation-related dysfunction of energy metabolism. Jieduan-Niwan... (Source: Chinese Medicine)
Source: Chinese Medicine - November 30, 2023 Category: Complementary Medicine Authors: Jiajun Liang, Xiaoyi Wei, Weixin Hou, Hanjing Wang, Ruimin Ma, Yanbin Gao, Yuqiong Du and Qiuyun Zhang Tags: Research Source Type: research
Salvianolic acid B promotes angiogenesis and inhibits cardiomyocyte apoptosis by regulating autophagy in myocardial ischemia
Myocardial ischemia (MI) can cause angina, myocardial infarction, and even death. Angiogenesis is beneficial for ensuring oxygen and blood supply to ischemic tissue, promoting tissue repair, and reducing cell ... (Source: Chinese Medicine)
Source: Chinese Medicine - November 28, 2023 Category: Complementary Medicine Authors: Qi Chen, QingYang Xu, Huilin Zhu, Junyi Wang, Ning Sun, Huimin Bian, Yu Li and Chao Lin Tags: Research Source Type: research
