Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 14:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and enhanc...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Structural changes in layers of lipid mixtures at low surface tensions
Chem Phys Lipids. 2023 Dec 11:105365. doi: 10.1016/j.chemphyslip.2023.105365. Online ahead of print.ABSTRACTLayers of pulmonary lipids on an aqueous substrate at non-equilibrium conditions can decrease the surface tension of water to quite low values. This is connected with different relaxation processes occurring at the interface and the associated changes in the surface layer structure. Results of measurements by the combination of methods like surface rheology, ellipsometry, Brewster angle microscopy, and IRRAS for spread layers of lipid mixtures open a possibility to specify the dynamics of structural changes at condit...
Source: Chemistry and Physics of Lipids - December 13, 2023 Category: Lipidology Authors: A G Bykov M A Panaeva O Y Milyaeva A V Michailov A R Rafikova E Guzman R Rubio R Miller B A Noskov Source Type: research
Structural changes in layers of lipid mixtures at low surface tensions
Chem Phys Lipids. 2023 Dec 11:105365. doi: 10.1016/j.chemphyslip.2023.105365. Online ahead of print.ABSTRACTLayers of pulmonary lipids on an aqueous substrate at non-equilibrium conditions can decrease the surface tension of water to quite low values. This is connected with different relaxation processes occurring at the interface and the associated changes in the surface layer structure. Results of measurements by the combination of methods like surface rheology, ellipsometry, Brewster angle microscopy, and IRRAS for spread layers of lipid mixtures open a possibility to specify the dynamics of structural changes at condit...
Source: Chemistry and Physics of Lipids - December 13, 2023 Category: Lipidology Authors: A G Bykov M A Panaeva O Y Milyaeva A V Michailov A R Rafikova E Guzman R Rubio R Miller B A Noskov Source Type: research
Structural changes in layers of lipid mixtures at low surface tensions
Chem Phys Lipids. 2023 Dec 11:105365. doi: 10.1016/j.chemphyslip.2023.105365. Online ahead of print.ABSTRACTLayers of pulmonary lipids on an aqueous substrate at non-equilibrium conditions can decrease the surface tension of water to quite low values. This is connected with different relaxation processes occurring at the interface and the associated changes in the surface layer structure. Results of measurements by the combination of methods like surface rheology, ellipsometry, Brewster angle microscopy, and IRRAS for spread layers of lipid mixtures open a possibility to specify the dynamics of structural changes at condit...
Source: Chemistry and Physics of Lipids - December 13, 2023 Category: Lipidology Authors: A G Bykov M A Panaeva O Y Milyaeva A V Michailov A R Rafikova E Guzman R Rubio R Miller B A Noskov Source Type: research
Structural changes in layers of lipid mixtures at low surface tensions
Chem Phys Lipids. 2023 Dec 11:105365. doi: 10.1016/j.chemphyslip.2023.105365. Online ahead of print.ABSTRACTLayers of pulmonary lipids on an aqueous substrate at non-equilibrium conditions can decrease the surface tension of water to quite low values. This is connected with different relaxation processes occurring at the interface and the associated changes in the surface layer structure. Results of measurements by the combination of methods like surface rheology, ellipsometry, Brewster angle microscopy, and IRRAS for spread layers of lipid mixtures open a possibility to specify the dynamics of structural changes at condit...
Source: Chemistry and Physics of Lipids - December 13, 2023 Category: Lipidology Authors: A G Bykov M A Panaeva O Y Milyaeva A V Michailov A R Rafikova E Guzman R Rubio R Miller B A Noskov Source Type: research
Closer Look at the Calorimetric Lower Transition in Lipid Bilayers
Chem Phys Lipids. 2023 Dec 9:105366. doi: 10.1016/j.chemphyslip.2023.105366. Online ahead of print.ABSTRACTThe thermal behavior of unilamellar vesicles has been revisited with differential scanning calorimetry to address the issue of whether it is essential to include interactions between neighboring bilayers in theories and simulations of the ripple phase. The issue focuses on the lower, aka pretransition, and the ripple phase that clearly exists between the lower and main transitions in multilamellar vesicles (MLV). We find anomalous thermal behavior in unilamellar vesicles (ULV) beginning at the same temperature as the ...
Source: Chemistry and Physics of Lipids - December 11, 2023 Category: Lipidology Authors: Sophia A Korono John F Nagle Source Type: research
Closer Look at the Calorimetric Lower Transition in Lipid Bilayers
Chem Phys Lipids. 2023 Dec 9:105366. doi: 10.1016/j.chemphyslip.2023.105366. Online ahead of print.ABSTRACTThe thermal behavior of unilamellar vesicles has been revisited with differential scanning calorimetry to address the issue of whether it is essential to include interactions between neighboring bilayers in theories and simulations of the ripple phase. The issue focuses on the lower, aka pretransition, and the ripple phase that clearly exists between the lower and main transitions in multilamellar vesicles (MLV). We find anomalous thermal behavior in unilamellar vesicles (ULV) beginning at the same temperature as the ...
Source: Chemistry and Physics of Lipids - December 11, 2023 Category: Lipidology Authors: Sophia A Korono John F Nagle Source Type: research
Unsaturation of serine lipids modulating the interaction of a cytosporone with models of the external leaflet of tumorigenic cell membranes
Chem Phys Lipids. 2023 Nov 30;258:105363. doi: 10.1016/j.chemphyslip.2023.105363. Online ahead of print.ABSTRACTCytosporone-B was isolated from fungi and incorporated in models of tumorigenic cell membranes using palmitoyloleoylglycerophosphoserine (POPS) and dipalmitoyl glycerophosphoserine (DPPS) lipids. While for DPPS, the compound condensed the monolayer and decreased the surface compressional modulus, it expanded and kept the compressional modulus for POPS. Hysteresis for compression-expansion cycles was more sensitive for POPS than for DPPS, while a high degree of destabilization was observed for POPS. As observed wi...
Source: Chemistry and Physics of Lipids - December 2, 2023 Category: Lipidology Authors: Guilherme Nu ñez Jaroque Augusto Leonardo Dos Santos Patr ícia Sartorelli Luciano Caseli Source Type: research
Unsaturation of serine lipids modulating the interaction of a cytosporone with models of the external leaflet of tumorigenic cell membranes
Chem Phys Lipids. 2023 Nov 30;258:105363. doi: 10.1016/j.chemphyslip.2023.105363. Online ahead of print.ABSTRACTCytosporone-B was isolated from fungi and incorporated in models of tumorigenic cell membranes using palmitoyloleoylglycerophosphoserine (POPS) and dipalmitoyl glycerophosphoserine (DPPS) lipids. While for DPPS, the compound condensed the monolayer and decreased the surface compressional modulus, it expanded and kept the compressional modulus for POPS. Hysteresis for compression-expansion cycles was more sensitive for POPS than for DPPS, while a high degree of destabilization was observed for POPS. As observed wi...
Source: Chemistry and Physics of Lipids - December 2, 2023 Category: Lipidology Authors: Guilherme Nu ñez Jaroque Augusto Leonardo Dos Santos Patr ícia Sartorelli Luciano Caseli Source Type: research
Unsaturation of serine lipids modulating the interaction of a cystoporone with models of the external leaflet of tumorigenic cell membranes
Chem Phys Lipids. 2023 Nov 30:105363. doi: 10.1016/j.chemphyslip.2023.105363. Online ahead of print.ABSTRACTCystoporone-B was isolated from fungi and incorporated in models of tumorigenic cell membranes using palmitoyloleoylglycerophosphoserine (POPS) and dipalmitoyl glycerophosphoserine (DPPS) lipids. While for DPPS, the compound condensed the monolayer and decreased the surface compressional modulus, it expanded and kept the compressional modulus for POPS. Hysteresis for compression-expansion cycles was more sensitive for POPS than for DPPS, while a high degree of destabilization was observed for POPS. As observed with i...
Source: Chemistry and Physics of Lipids - December 2, 2023 Category: Lipidology Authors: Guilherme Nu ñez Jaroque Augusto Leonardo Dos Santos Patr ícia Sartorelli Luciano Caseli Source Type: research
