Non-lamellar lyotropic liquid crystalline nanoparticles as nanocarriers for enhanced drug encapsulation of atorvastatin calcium and proanthocyanidins
Chem Phys Lipids. 2024 Feb 5:105377. doi: 10.1016/j.chemphyslip.2024.105377. Online ahead of print.ABSTRACTAtorvastatin calcium (ATV) and proanthocyanidins (PAC) have a strong antioxidant activity, that can benefit to reduce the atherosclerotic plaque progression. Unfortunately, the bioavailability of ATV is greatly reduced due to its limited drug solubility while the PAC drug is unstable upon exposure to the atmospheric oxygen. Herein, the lyotropic liquid crystalline nanoparticles (LLCNPs) constructed by a binary mixture of soy phosphatidylcholine (SPC) and citric acid ester of monoglyceride (citrem) at different weight ...
Source: Chemistry and Physics of Lipids - February 7, 2024 Category: Lipidology Authors: Mardhiah Maslizan Muhammad Salahuddin Haris Mokrish Ajat Siti Nurul Ain Md Jamil Shah Christirani Azhar N Idayu Zahid Intan Diana Mat Azmi Source Type: research
Bottom-up approach to explore alpha-amylase assisted membrane remodelling
Chem Phys Lipids. 2024 Jan 2;259:105374. doi: 10.1016/j.chemphyslip.2023.105374. Online ahead of print.ABSTRACTSoluble alpha-amylases play an important role in the catabolism of polysaccharides. In this work, we show that the malt α -amylase can interact with the lipid membrane and further alter its mechanical properties. Vesicle fluctuation spectroscopy is used for quantitative measurement of the membrane bending rigidity of phosphatidylcholines lipid vesicles from the shape fluctuation based on the whole contour of Giant Unilamellar Vesicles (GUVs). The bending rigidity of the 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoch...
Source: Chemistry and Physics of Lipids - January 4, 2024 Category: Lipidology Authors: Harshit Kumar Sayar Mandal Reena Yadav Suhasi Gupta Hemraj Meena Mayur Kadu Rajni Kudawla Pratibha Sharma Indu Pal Kaur Subhabrata Maiti John H Ipsen Tripta Bhatia Source Type: research
Bottom-Up Approach to Explore Alpha-Amylase Assisted Membrane Remodelling
Chem Phys Lipids. 2024 Jan 2:105374. doi: 10.1016/j.chemphyslip.2023.105374. Online ahead of print.ABSTRACTSoluble alpha-amylases play an important role in the catabolism of polysaccharides. In this work, we show that the malt α -amylase can interact with the lipid membrane and further alter its mechanical properties. Vesicle fluctuation spectroscopy is used for quantitative measurement of the membrane bending rigidity of phosphatidylcholines lipid vesicles from the shape fluctuation based on the whole contour of Giant Unilamellar Vesicles (GUVs). The bending rigidity of the 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholin...
Source: Chemistry and Physics of Lipids - January 4, 2024 Category: Lipidology Authors: Harshit Kumar Sayar Mandal Reena Yadav Suhasi Gupta Hemraj Meena Mayur Kadu Rajni Kudawla Pratibha Sharma Indu Pal Kaur Subhabrata Maiti John H Ipsen Tripta Bhatia Source Type: research
Bottom-Up Approach to Explore Alpha-Amylase Assisted Membrane Remodelling
Chem Phys Lipids. 2024 Jan 2:105374. doi: 10.1016/j.chemphyslip.2023.105374. Online ahead of print.ABSTRACTSoluble alpha-amylases play an important role in the catabolism of polysaccharides. In this work, we show that the malt α -amylase can interact with the lipid membrane and further alter its mechanical properties. Vesicle fluctuation spectroscopy is used for quantitative measurement of the membrane bending rigidity of phosphatidylcholines lipid vesicles from the shape fluctuation based on the whole contour of Giant Unilamellar Vesicles (GUVs). The bending rigidity of the 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholin...
Source: Chemistry and Physics of Lipids - January 4, 2024 Category: Lipidology Authors: Harshit Kumar Sayar Mandal Reena Yadav Suhasi Gupta Hemraj Meena Mayur Kadu Rajni Kudawla Pratibha Sharma Indu Pal Kaur Subhabrata Maiti John H Ipsen Tripta Bhatia Source Type: research
Bottom-Up Approach to Explore Alpha-Amylase Assisted Membrane Remodelling
Chem Phys Lipids. 2024 Jan 2:105374. doi: 10.1016/j.chemphyslip.2023.105374. Online ahead of print.ABSTRACTSoluble alpha-amylases play an important role in the catabolism of polysaccharides. In this work, we show that the malt α -amylase can interact with the lipid membrane and further alter its mechanical properties. Vesicle fluctuation spectroscopy is used for quantitative measurement of the membrane bending rigidity of phosphatidylcholines lipid vesicles from the shape fluctuation based on the whole contour of Giant Unilamellar Vesicles (GUVs). The bending rigidity of the 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholin...
Source: Chemistry and Physics of Lipids - January 4, 2024 Category: Lipidology Authors: Harshit Kumar Sayar Mandal Reena Yadav Suhasi Gupta Hemraj Meena Mayur Kadu Rajni Kudawla Pratibha Sharma Indu Pal Kaur Subhabrata Maiti John H Ipsen Tripta Bhatia Source Type: research
Bottom-Up Approach to Explore Alpha-Amylase Assisted Membrane Remodelling
Chem Phys Lipids. 2024 Jan 2:105374. doi: 10.1016/j.chemphyslip.2023.105374. Online ahead of print.ABSTRACTSoluble alpha-amylases play an important role in the catabolism of polysaccharides. In this work, we show that the malt α -amylase can interact with the lipid membrane and further alter its mechanical properties. Vesicle fluctuation spectroscopy is used for quantitative measurement of the membrane bending rigidity of phosphatidylcholines lipid vesicles from the shape fluctuation based on the whole contour of Giant Unilamellar Vesicles (GUVs). The bending rigidity of the 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholin...
Source: Chemistry and Physics of Lipids - January 4, 2024 Category: Lipidology Authors: Harshit Kumar Sayar Mandal Reena Yadav Suhasi Gupta Hemraj Meena Mayur Kadu Rajni Kudawla Pratibha Sharma Indu Pal Kaur Subhabrata Maiti John H Ipsen Tripta Bhatia Source Type: research
The role of glucose and fructose on lipid droplet metabolism in human normal bronchial and cancer lung cells by Raman spectroscopy
Chem Phys Lipids. 2023 Dec 29;259:105375. doi: 10.1016/j.chemphyslip.2023.105375. Online ahead of print.ABSTRACTFructose is one of the most important monosaccharides in the human diet that the human body needs for proper metabolism. This paper presents an approach to study biochemical changes caused by sugars in human normal bronchial cells (BEpiC) and human cancer lung cells (A549) by Raman spectroscopy and Raman imaging. Results after supplementation of human bronchial and lung cells with fructose are also discussed and compared with results obtained for pure human bronchial and lung cells. Based on Raman techniques we h...
Source: Chemistry and Physics of Lipids - December 30, 2023 Category: Lipidology Authors: Monika Kopec Karolina Beton-Mysur Source Type: research
The role of glucose and fructose on lipid droplet metabolism in human normal bronchial and cancer lung cells by Raman spectroscopy
Chem Phys Lipids. 2023 Dec 28:105375. doi: 10.1016/j.chemphyslip.2023.105375. Online ahead of print.ABSTRACTFructose is one of the most important monosaccharides in the human diet that the human body needs for proper metabolism. This paper presents an approach to study biochemical changes caused by sugars in human normal bronchial cells (BEpiC) and human cancer lung cells (A549) by Raman spectroscopy and Raman imaging. Results after supplementation of human bronchial and lung cells with fructose are also discussed and compared with results obtained for pure human bronchial and lung cells. Based on Raman techniques we have ...
Source: Chemistry and Physics of Lipids - December 30, 2023 Category: Lipidology Authors: Monika Kopec Karolina Beton-Mysur Source Type: research
The role of glucose and fructose on lipid droplet metabolism in human normal bronchial and cancer lung cells by Raman spectroscopy
Chem Phys Lipids. 2023 Dec 28:105375. doi: 10.1016/j.chemphyslip.2023.105375. Online ahead of print.ABSTRACTFructose is one of the most important monosaccharides in the human diet that the human body needs for proper metabolism. This paper presents an approach to study biochemical changes caused by sugars in human normal bronchial cells (BEpiC) and human cancer lung cells (A549) by Raman spectroscopy and Raman imaging. Results after supplementation of human bronchial and lung cells with fructose are also discussed and compared with results obtained for pure human bronchial and lung cells. Based on Raman techniques we have ...
Source: Chemistry and Physics of Lipids - December 30, 2023 Category: Lipidology Authors: Monika Kopec Karolina Beton-Mysur Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2024 Jan;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Epub 2023 Dec 15.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and enhance HD...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
Novel bioactive lipids enhanced HDL-mediated cholesterol efflux from macrophages through the ABCA1 receptor pathway
Chem Phys Lipids. 2023 Dec 15;258:105367. doi: 10.1016/j.chemphyslip.2023.105367. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) has traditionally been acknowledged as "good cholesterol" owing to its significant association with a decreased risk of atherosclerosis. This association is primarily attributed to HDL's direct involvement in cholesterol efflux capacity, which plays a pivotal role in reverse cholesterol transport. A novel active compound from Nannochloropsis microalgae termed lyso-DGTS, a lipid that contains EPA fatty acids, was previously isolated and found to increase paraoxonase 1 activity and en...
Source: Chemistry and Physics of Lipids - December 16, 2023 Category: Lipidology Authors: Ali Khattib Manar Shmet Rasha Ashkar Tony Hayek Soliman Khatib Source Type: research
