Astrocytic chloride regulates brain function in health and disease
Cell Calcium. 2024 Feb 7;118:102855. doi: 10.1016/j.ceca.2024.102855. Online ahead of print.ABSTRACTChloride ions (Cl-) play a pivotal role in synaptic inhibition in the central nervous system, primarily mediated through ionotropic mechanisms. A recent breakthrough emphathizes the significant influence of astrocytic intracellular chloride concentration ([Cl-]i) regulation, a field still in its early stages of exploration. Typically, the [Cl-]i in most animal cells is maintained at lower levels than the extracellular chloride [Cl-]o, a critical balance to prevent cell swelling due to osmotic pressure. Various Cl- transporte...
Source: Cell Calcium - February 16, 2024 Category: Cytology Authors: Verena Untiet Source Type: research
Astrocytic chloride regulates brain function in health and disease
Cell Calcium. 2024 Feb 7;118:102855. doi: 10.1016/j.ceca.2024.102855. Online ahead of print.ABSTRACTChloride ions (Cl-) play a pivotal role in synaptic inhibition in the central nervous system, primarily mediated through ionotropic mechanisms. A recent breakthrough emphathizes the significant influence of astrocytic intracellular chloride concentration ([Cl-]i) regulation, a field still in its early stages of exploration. Typically, the [Cl-]i in most animal cells is maintained at lower levels than the extracellular chloride [Cl-]o, a critical balance to prevent cell swelling due to osmotic pressure. Various Cl- transporte...
Source: Cell Calcium - February 16, 2024 Category: Cytology Authors: Verena Untiet Source Type: research
Astrocytic chloride regulates brain function in health and disease
Cell Calcium. 2024 Feb 7;118:102855. doi: 10.1016/j.ceca.2024.102855. Online ahead of print.ABSTRACTChloride ions (Cl-) play a pivotal role in synaptic inhibition in the central nervous system, primarily mediated through ionotropic mechanisms. A recent breakthrough emphathizes the significant influence of astrocytic intracellular chloride concentration ([Cl-]i) regulation, a field still in its early stages of exploration. Typically, the [Cl-]i in most animal cells is maintained at lower levels than the extracellular chloride [Cl-]o, a critical balance to prevent cell swelling due to osmotic pressure. Various Cl- transporte...
Source: Cell Calcium - February 16, 2024 Category: Cytology Authors: Verena Untiet Source Type: research
Astrocytic chloride regulates brain function in health and disease
Cell Calcium. 2024 Feb 7;118:102855. doi: 10.1016/j.ceca.2024.102855. Online ahead of print.ABSTRACTChloride ions (Cl-) play a pivotal role in synaptic inhibition in the central nervous system, primarily mediated through ionotropic mechanisms. A recent breakthrough emphathizes the significant influence of astrocytic intracellular chloride concentration ([Cl-]i) regulation, a field still in its early stages of exploration. Typically, the [Cl-]i in most animal cells is maintained at lower levels than the extracellular chloride [Cl-]o, a critical balance to prevent cell swelling due to osmotic pressure. Various Cl- transporte...
Source: Cell Calcium - February 16, 2024 Category: Cytology Authors: Verena Untiet Source Type: research
Astrocytic chloride regulates brain function in health and disease
Cell Calcium. 2024 Feb 7;118:102855. doi: 10.1016/j.ceca.2024.102855. Online ahead of print.ABSTRACTChloride ions (Cl-) play a pivotal role in synaptic inhibition in the central nervous system, primarily mediated through ionotropic mechanisms. A recent breakthrough emphathizes the significant influence of astrocytic intracellular chloride concentration ([Cl-]i) regulation, a field still in its early stages of exploration. Typically, the [Cl-]i in most animal cells is maintained at lower levels than the extracellular chloride [Cl-]o, a critical balance to prevent cell swelling due to osmotic pressure. Various Cl- transporte...
Source: Cell Calcium - February 16, 2024 Category: Cytology Authors: Verena Untiet Source Type: research
Astrocytic chloride regulates brain function in health and disease
Cell Calcium. 2024 Feb 7;118:102855. doi: 10.1016/j.ceca.2024.102855. Online ahead of print.ABSTRACTChloride ions (Cl-) play a pivotal role in synaptic inhibition in the central nervous system, primarily mediated through ionotropic mechanisms. A recent breakthrough emphathizes the significant influence of astrocytic intracellular chloride concentration ([Cl-]i) regulation, a field still in its early stages of exploration. Typically, the [Cl-]i in most animal cells is maintained at lower levels than the extracellular chloride [Cl-]o, a critical balance to prevent cell swelling due to osmotic pressure. Various Cl- transporte...
Source: Cell Calcium - February 16, 2024 Category: Cytology Authors: Verena Untiet Source Type: research
TRPV3 returns with a pleasant feeling of warmth
Cell Calcium. 2024 Feb 1;118:102853. doi: 10.1016/j.ceca.2024.102853. Online ahead of print.NO ABSTRACTPMID:38316097 | DOI:10.1016/j.ceca.2024.102853 (Source: Cell Calcium)
Source: Cell Calcium - February 5, 2024 Category: Cytology Authors: Michael Schaefer Source Type: research
TRPV3 returns with a pleasant feeling of warmth
Cell Calcium. 2024 Feb 1;118:102853. doi: 10.1016/j.ceca.2024.102853. Online ahead of print.NO ABSTRACTPMID:38316097 | DOI:10.1016/j.ceca.2024.102853 (Source: Cell Calcium)
Source: Cell Calcium - February 5, 2024 Category: Cytology Authors: Michael Schaefer Source Type: research
Astrocytic Na < sup > + < /sup > , K < sup > + < /sup > ATPases in physiology and pathophysiology
Cell Calcium. 2024 Jan 28;118:102851. doi: 10.1016/j.ceca.2024.102851. Online ahead of print.ABSTRACTThe Na+, K+ ATPases play a fundamental role in the homeostatic functions of astrocytes. After a brief historic prologue and discussion of the subunit composition and localization of the astrocytic Na+, K+ ATPases, the review focuses on the role of the astrocytic Na+, K+ pumps in extracellular K+ and glutamate homeostasis, intracellular Na+ and Ca2+ homeostasis and signaling, regulation of synaptic transmission and neurometabolic coupling between astrocytes and neurons. Loss-of-function mutations in the gene encoding the ast...
Source: Cell Calcium - February 3, 2024 Category: Cytology Authors: Daniela Pietrobon Fiorenzo Conti Source Type: research
TRPM2 - An adjustable thermostat
Cell Calcium. 2024 Jan 11;118:102850. doi: 10.1016/j.ceca.2024.102850. Online ahead of print.ABSTRACTThe Transient Receptor Potential Melastatin 2 (TRPM2) channel is a homotetrameric ligand-gated cation channel opened by the binding of cytosolic ADP ribose (ADPR) and Ca2+. In addition, strong temperature dependence of its activity has lately become a center of attention for both physiological and biophysical studies. TRPM2 temperature sensitivity has been affirmed to play a role in central and peripheral thermosensation, pancreatic insulin secretion, and immune cell function. On the other hand, a number of different underl...
Source: Cell Calcium - January 18, 2024 Category: Cytology Authors: Ádám Bartók L ászló Csanády Source Type: research
"Gatekeepers of heaven" breaking bad
Cell Calcium. 2023 Dec 21;118:102842. doi: 10.1016/j.ceca.2023.102842. Online ahead of print.NO ABSTRACTPMID:38211552 | DOI:10.1016/j.ceca.2023.102842 (Source: Cell Calcium)
Source: Cell Calcium - January 11, 2024 Category: Cytology Authors: Hwei Ling Ong Indu S Ambudkar Source Type: research
Trace metals and astrocytes physiology and pathophysiology
Cell Calcium. 2024 Jan 4;118:102843. doi: 10.1016/j.ceca.2024.102843. Online ahead of print.ABSTRACTSeveral trace metals, including iron, copper, manganese and zinc are essential for normal function of the nervous system. Both deficiency and excessive accumulation of these metals trigger neuropathological developments. The central nervous system (CNS) is in possession of dedicated homeostatic system that removes, accumulates, stores and releases these metals to fulfil nervous tissue demand. This system is mainly associated with astrocytes that act as dynamic reservoirs for trace metals, these being a part of a global syste...
Source: Cell Calcium - January 10, 2024 Category: Cytology Authors: Baoman Li Weiyang Yu Alexei Verkhratsky Source Type: research
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension
This study was to determine whether TRPV2 was involved in PH-induced AF and the effects of TRPV2 inhibitor tranilast on AF in rat models of PH. Monocrotaline (MCT) and SU5416/hypoxia (SuHx)-induced PH models were performed to detect atrial electrophysiological parameters. Daily tranilast (a TRPV2 inhibitor) or saline was given starting 1 day before PH establishment. PH increased the susceptibility to AF, with TRPV2 up-regulated in the right atria. Compared to PH rats, tranilast reduced AF inducibility and the prolongations of ERP and APD; mitigated cardiopulmonary remodeling and the increases in P-wave duration and P-R int...
Source: Cell Calcium - December 31, 2023 Category: Cytology Authors: Tianxin Ye Zhuonan Song Yunping Zhou Zhangchi Liu Yi Yu Fangcong Yu Yanan Chu Jiaran Shi Longbo Wang Cui Zhang Xin Liu Bo Yang Jinxiu Yang Xingxiang Wang Source Type: research
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension
This study was to determine whether TRPV2 was involved in PH-induced AF and the effects of TRPV2 inhibitor tranilast on AF in rat models of PH. Monocrotaline (MCT) and SU5416/hypoxia (SuHx)-induced PH models were performed to detect atrial electrophysiological parameters. Daily tranilast (a TRPV2 inhibitor) or saline was given starting 1 day before PH establishment. PH increased the susceptibility to AF, with TRPV2 up-regulated in the right atria. Compared to PH rats, tranilast reduced AF inducibility and the prolongations of ERP and APD; mitigated cardiopulmonary remodeling and the increases in P-wave duration and P-R int...
Source: Cell Calcium - December 31, 2023 Category: Cytology Authors: Tianxin Ye Zhuonan Song Yunping Zhou Zhangchi Liu Yi Yu Fangcong Yu Yanan Chu Jiaran Shi Longbo Wang Cui Zhang Xin Liu Bo Yang Jinxiu Yang Xingxiang Wang Source Type: research
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension
This study was to determine whether TRPV2 was involved in PH-induced AF and the effects of TRPV2 inhibitor tranilast on AF in rat models of PH. Monocrotaline (MCT) and SU5416/hypoxia (SuHx)-induced PH models were performed to detect atrial electrophysiological parameters. Daily tranilast (a TRPV2 inhibitor) or saline was given starting 1 day before PH establishment. PH increased the susceptibility to AF, with TRPV2 up-regulated in the right atria. Compared to PH rats, tranilast reduced AF inducibility and the prolongations of ERP and APD; mitigated cardiopulmonary remodeling and the increases in P-wave duration and P-R int...
Source: Cell Calcium - December 31, 2023 Category: Cytology Authors: Tianxin Ye Zhuonan Song Yunping Zhou Zhangchi Liu Yi Yu Fangcong Yu Yanan Chu Jiaran Shi Longbo Wang Cui Zhang Xin Liu Bo Yang Jinxiu Yang Xingxiang Wang Source Type: research
