Fine tuning calcium dynamics by inhibition of Store-operated Calcium Entry as a novel therapeutic approach for the treatment of chronic pancreatitis
Cell Calcium. 2023 Sep 19;116:102802. doi: 10.1016/j.ceca.2023.102802. Online ahead of print.ABSTRACTChronic pancreatitis (CP) is a complex inflammatory disorder characterized by progressive fibrosis, leading to pancreatic dysfunction, reduced quality of life and an elevated pancreatic cancer risk. Current therapeutic options for CP are restricted to symptomatic treatment. Using ex vivo and in vivo preclinical disease models, Szabó et al. now explored for the first time the involvement of Store-operated Ca2+ entry (SOCE) in the progression of CP and propose that a selective pharmacological inhibition of the SOCE signaling...
Source: Cell Calcium - September 27, 2023 Category: Cytology Authors: Ignazio Piseddu Carl Weidinger Julia Mayerle Source Type: research
Fine tuning calcium dynamics by inhibition of Store-operated Calcium Entry as a novel therapeutic approach for the treatment of chronic pancreatitis
Cell Calcium. 2023 Sep 19;116:102802. doi: 10.1016/j.ceca.2023.102802. Online ahead of print.ABSTRACTChronic pancreatitis (CP) is a complex inflammatory disorder characterized by progressive fibrosis, leading to pancreatic dysfunction, reduced quality of life and an elevated pancreatic cancer risk. Current therapeutic options for CP are restricted to symptomatic treatment. Using ex vivo and in vivo preclinical disease models, Szabó et al. now explored for the first time the involvement of Store-operated Ca2+ entry (SOCE) in the progression of CP and propose that a selective pharmacological inhibition of the SOCE signaling...
Source: Cell Calcium - September 27, 2023 Category: Cytology Authors: Ignazio Piseddu Carl Weidinger Julia Mayerle Source Type: research
Fine tuning calcium dynamics by inhibition of Store-operated Calcium Entry as a novel therapeutic approach for the treatment of chronic pancreatitis
Cell Calcium. 2023 Sep 19;116:102802. doi: 10.1016/j.ceca.2023.102802. Online ahead of print.ABSTRACTChronic pancreatitis (CP) is a complex inflammatory disorder characterized by progressive fibrosis, leading to pancreatic dysfunction, reduced quality of life and an elevated pancreatic cancer risk. Current therapeutic options for CP are restricted to symptomatic treatment. Using ex vivo and in vivo preclinical disease models, Szabó et al. now explored for the first time the involvement of Store-operated Ca2+ entry (SOCE) in the progression of CP and propose that a selective pharmacological inhibition of the SOCE signaling...
Source: Cell Calcium - September 27, 2023 Category: Cytology Authors: Ignazio Piseddu Carl Weidinger Julia Mayerle Source Type: research
Optical profiling of autonomous Ca < sup > 2+ < /sup > nanodomains generated by lysosomal TPC2 and TRPML1
Cell Calcium. 2023 Sep 18;116:102801. doi: 10.1016/j.ceca.2023.102801. Online ahead of print.ABSTRACTMultiple families of Ca2+-permeable channels co-exist on lysosomal Ca2+ stores but how each family couples to its own unique downstream physiology is unclear. We have therefore investigated the Ca2+-signalling architecture underpinning different channels on the same vesicle that drive separate pathways, using phagocytosis as a physiological stimulus. Lysosomal Ca2+-channels are a major Ca2+ source driving particle uptake in macrophages, but different channels drive different aspects of Fc-receptor-mediated phagocytosis: TPC...
Source: Cell Calcium - September 24, 2023 Category: Cytology Authors: Lianne C Davis Anthony J Morgan Antony Galione Source Type: research
Optical profiling of autonomous Ca < sup > 2+ < /sup > nanodomains generated by lysosomal TPC2 and TRPML1
Cell Calcium. 2023 Sep 18;116:102801. doi: 10.1016/j.ceca.2023.102801. Online ahead of print.ABSTRACTMultiple families of Ca2+-permeable channels co-exist on lysosomal Ca2+ stores but how each family couples to its own unique downstream physiology is unclear. We have therefore investigated the Ca2+-signalling architecture underpinning different channels on the same vesicle that drive separate pathways, using phagocytosis as a physiological stimulus. Lysosomal Ca2+-channels are a major Ca2+ source driving particle uptake in macrophages, but different channels drive different aspects of Fc-receptor-mediated phagocytosis: TPC...
Source: Cell Calcium - September 24, 2023 Category: Cytology Authors: Lianne C Davis Anthony J Morgan Antony Galione Source Type: research
Optical profiling of autonomous Ca < sup > 2+ < /sup > nanodomains generated by lysosomal TPC2 and TRPML1
Cell Calcium. 2023 Sep 18;116:102801. doi: 10.1016/j.ceca.2023.102801. Online ahead of print.ABSTRACTMultiple families of Ca2+-permeable channels co-exist on lysosomal Ca2+ stores but how each family couples to its own unique downstream physiology is unclear. We have therefore investigated the Ca2+-signalling architecture underpinning different channels on the same vesicle that drive separate pathways, using phagocytosis as a physiological stimulus. Lysosomal Ca2+-channels are a major Ca2+ source driving particle uptake in macrophages, but different channels drive different aspects of Fc-receptor-mediated phagocytosis: TPC...
Source: Cell Calcium - September 24, 2023 Category: Cytology Authors: Lianne C Davis Anthony J Morgan Antony Galione Source Type: research
Molecular architecture of TMEM63 mechanosensitive ion channels
Cell Calcium. 2023 Sep 11;115:102798. doi: 10.1016/j.ceca.2023.102798. Online ahead of print.NO ABSTRACTPMID:37729772 | DOI:10.1016/j.ceca.2023.102798 (Source: Cell Calcium)
Source: Cell Calcium - September 20, 2023 Category: Cytology Authors: Jed T Syrenne Parshuram J Sonawane Swetha E Murthy Source Type: research
Molecular architecture of TMEM63 mechanosensitive ion channels
Cell Calcium. 2023 Sep 11;115:102798. doi: 10.1016/j.ceca.2023.102798. Online ahead of print.NO ABSTRACTPMID:37729772 | DOI:10.1016/j.ceca.2023.102798 (Source: Cell Calcium)
Source: Cell Calcium - September 20, 2023 Category: Cytology Authors: Jed T Syrenne Parshuram J Sonawane Swetha E Murthy Source Type: research
Molecular architecture of TMEM63 mechanosensitive ion channels
Cell Calcium. 2023 Sep 11;115:102798. doi: 10.1016/j.ceca.2023.102798. Online ahead of print.NO ABSTRACTPMID:37729772 | DOI:10.1016/j.ceca.2023.102798 (Source: Cell Calcium)
Source: Cell Calcium - September 20, 2023 Category: Cytology Authors: Jed T Syrenne Parshuram J Sonawane Swetha E Murthy Source Type: research
Molecular architecture of TMEM63 mechanosensitive ion channels
Cell Calcium. 2023 Sep 11;115:102798. doi: 10.1016/j.ceca.2023.102798. Online ahead of print.NO ABSTRACTPMID:37729772 | DOI:10.1016/j.ceca.2023.102798 (Source: Cell Calcium)
Source: Cell Calcium - September 20, 2023 Category: Cytology Authors: Jed T Syrenne Parshuram J Sonawane Swetha E Murthy Source Type: research
Channeling hope for uranium-induced kidney damage and beyond with TRPML1
Cell Calcium. 2023 Sep 11;115:102799. doi: 10.1016/j.ceca.2023.102799. Online ahead of print.NO ABSTRACTPMID:37716038 | DOI:10.1016/j.ceca.2023.102799 (Source: Cell Calcium)
Source: Cell Calcium - September 16, 2023 Category: Cytology Authors: Kirill Kiselyov Source Type: research
Channeling hope for uranium-induced kidney damage and beyond with TRPML1
Cell Calcium. 2023 Sep 11;115:102799. doi: 10.1016/j.ceca.2023.102799. Online ahead of print.NO ABSTRACTPMID:37716038 | DOI:10.1016/j.ceca.2023.102799 (Source: Cell Calcium)
Source: Cell Calcium - September 16, 2023 Category: Cytology Authors: Kirill Kiselyov Source Type: research
Channeling hope for uranium-induced kidney damage and beyond with TRPML1
Cell Calcium. 2023 Sep 11;115:102799. doi: 10.1016/j.ceca.2023.102799. Online ahead of print.NO ABSTRACTPMID:37716038 | DOI:10.1016/j.ceca.2023.102799 (Source: Cell Calcium)
Source: Cell Calcium - September 16, 2023 Category: Cytology Authors: Kirill Kiselyov Source Type: research
Channeling hope for uranium-induced kidney damage and beyond with TRPML1
Cell Calcium. 2023 Sep 11;115:102799. doi: 10.1016/j.ceca.2023.102799. Online ahead of print.NO ABSTRACTPMID:37716038 | DOI:10.1016/j.ceca.2023.102799 (Source: Cell Calcium)
Source: Cell Calcium - September 16, 2023 Category: Cytology Authors: Kirill Kiselyov Source Type: research
Modalities of cell death, survival and adaptation: The role of the Ca < sup > 2+ < /sup > -signaling toolkit
Cell Calcium. 2023 Aug 28;115:102795. doi: 10.1016/j.ceca.2023.102795. Online ahead of print.NO ABSTRACTPMID:37666094 | DOI:10.1016/j.ceca.2023.102795 (Source: Cell Calcium)
Source: Cell Calcium - September 4, 2023 Category: Cytology Authors: Jan B Parys Geert Bultynck Source Type: research
