The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses
Cell Calcium. 2024 Apr 18;120:102889. doi: 10.1016/j.ceca.2024.102889. Online ahead of print.ABSTRACTChemical senses allow animals to detect and discriminate a vast array of molecules. The olfactory system is responsible of the detection of small volatile molecules, while water dissolved molecules are detected by taste buds in the oral cavity. Moreover, many animals respond to signaling molecules such as pheromones and other semiochemicals through the vomeronasal organ. The peripheral organs dedicated to chemical detection convert chemical signals into perceivable information through the employment of diverse receptor type...
Source: Cell Calcium - April 27, 2024 Category: Cytology Authors: Michele Dibattista Simone Pifferi Andres Hernandez-Clavijo Anna Menini Source Type: research
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses
Cell Calcium. 2024 Apr 18;120:102889. doi: 10.1016/j.ceca.2024.102889. Online ahead of print.ABSTRACTChemical senses allow animals to detect and discriminate a vast array of molecules. The olfactory system is responsible of the detection of small volatile molecules, while water dissolved molecules are detected by taste buds in the oral cavity. Moreover, many animals respond to signaling molecules such as pheromones and other semiochemicals through the vomeronasal organ. The peripheral organs dedicated to chemical detection convert chemical signals into perceivable information through the employment of diverse receptor type...
Source: Cell Calcium - April 27, 2024 Category: Cytology Authors: Michele Dibattista Simone Pifferi Andres Hernandez-Clavijo Anna Menini Source Type: research
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses
Cell Calcium. 2024 Apr 18;120:102889. doi: 10.1016/j.ceca.2024.102889. Online ahead of print.ABSTRACTChemical senses allow animals to detect and discriminate a vast array of molecules. The olfactory system is responsible of the detection of small volatile molecules, while water dissolved molecules are detected by taste buds in the oral cavity. Moreover, many animals respond to signaling molecules such as pheromones and other semiochemicals through the vomeronasal organ. The peripheral organs dedicated to chemical detection convert chemical signals into perceivable information through the employment of diverse receptor type...
Source: Cell Calcium - April 27, 2024 Category: Cytology Authors: Michele Dibattista Simone Pifferi Andres Hernandez-Clavijo Anna Menini Source Type: research
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses
Cell Calcium. 2024 Apr 18;120:102889. doi: 10.1016/j.ceca.2024.102889. Online ahead of print.ABSTRACTChemical senses allow animals to detect and discriminate a vast array of molecules. The olfactory system is responsible of the detection of small volatile molecules, while water dissolved molecules are detected by taste buds in the oral cavity. Moreover, many animals respond to signaling molecules such as pheromones and other semiochemicals through the vomeronasal organ. The peripheral organs dedicated to chemical detection convert chemical signals into perceivable information through the employment of diverse receptor type...
Source: Cell Calcium - April 27, 2024 Category: Cytology Authors: Michele Dibattista Simone Pifferi Andres Hernandez-Clavijo Anna Menini Source Type: research
VSI: The anoctamins: Structure and function: "Intracellular" anoctamins
Cell Calcium. 2024 Apr 17;120:102888. doi: 10.1016/j.ceca.2024.102888. Online ahead of print.ABSTRACTPlasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in great detail with respect to structure and function, but much less is known about the other seven intracellular members of this exciting family of proteins. This is probably due to their limited accessibility in intracellular membranous compartments, such as the endoplasmic reticulum (ER) or endosomes. However, these so-called intracellular anoctamins are also found in the plasma membrane (PM) which adds to the confusion regarding their cel...
Source: Cell Calcium - April 24, 2024 Category: Cytology Authors: Karl Kunzelmann Jiraporn Ousingsawat Rainer Schreiber Source Type: research
VSI: The anoctamins: Structure and function: "Intracellular" anoctamins
Cell Calcium. 2024 Apr 17;120:102888. doi: 10.1016/j.ceca.2024.102888. Online ahead of print.ABSTRACTPlasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in great detail with respect to structure and function, but much less is known about the other seven intracellular members of this exciting family of proteins. This is probably due to their limited accessibility in intracellular membranous compartments, such as the endoplasmic reticulum (ER) or endosomes. However, these so-called intracellular anoctamins are also found in the plasma membrane (PM) which adds to the confusion regarding their cel...
Source: Cell Calcium - April 24, 2024 Category: Cytology Authors: Karl Kunzelmann Jiraporn Ousingsawat Rainer Schreiber Source Type: research
VSI: The anoctamins: Structure and function: "Intracellular" anoctamins
Cell Calcium. 2024 Apr 17;120:102888. doi: 10.1016/j.ceca.2024.102888. Online ahead of print.ABSTRACTPlasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in great detail with respect to structure and function, but much less is known about the other seven intracellular members of this exciting family of proteins. This is probably due to their limited accessibility in intracellular membranous compartments, such as the endoplasmic reticulum (ER) or endosomes. However, these so-called intracellular anoctamins are also found in the plasma membrane (PM) which adds to the confusion regarding their cel...
Source: Cell Calcium - April 24, 2024 Category: Cytology Authors: Karl Kunzelmann Jiraporn Ousingsawat Rainer Schreiber Source Type: research
Simultaneous TIRF imaging of subplasmalemmal Ca < sup > 2+ < /sup > dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release
Cell Calcium. 2024 Apr 8;120:102883. doi: 10.1016/j.ceca.2024.102883. Online ahead of print.ABSTRACTThe basal and glucose-induced insulin secretion from pancreatic beta cells is a tightly regulated process that is triggered in a Ca2+-dependent fashion and further positively modulated by substances that raise intracellular levels of adenosine 3',5'-cyclic monophosphate (cAMP) or by certain antidiabetic drugs. In a previous study, we have temporally resolved the subplasmalemmal [Ca2+]i dynamics in beta cells that are characterized by trains of sharply delimited spikes, reaching peak values up to 5 µM. Applying total interna...
Source: Cell Calcium - April 21, 2024 Category: Cytology Authors: Charlotte Suckert Carolin Zosel Michael Schaefer Source Type: research
Simultaneous TIRF imaging of subplasmalemmal Ca < sup > 2+ < /sup > dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release
Cell Calcium. 2024 Apr 8;120:102883. doi: 10.1016/j.ceca.2024.102883. Online ahead of print.ABSTRACTThe basal and glucose-induced insulin secretion from pancreatic beta cells is a tightly regulated process that is triggered in a Ca2+-dependent fashion and further positively modulated by substances that raise intracellular levels of adenosine 3',5'-cyclic monophosphate (cAMP) or by certain antidiabetic drugs. In a previous study, we have temporally resolved the subplasmalemmal [Ca2+]i dynamics in beta cells that are characterized by trains of sharply delimited spikes, reaching peak values up to 5 µM. Applying total interna...
Source: Cell Calcium - April 21, 2024 Category: Cytology Authors: Charlotte Suckert Carolin Zosel Michael Schaefer Source Type: research
The anoctamins: Structure and function
Cell Calcium. 2024 Apr 15;120:102885. doi: 10.1016/j.ceca.2024.102885. Online ahead of print.ABSTRACTWhen activated by increase in intracellular Ca2+, anoctamins (TMEM16 proteins) operate as phospholipid scramblases and as ion channels. Anoctamin 1 (ANO1) is the Ca2+-activated epithelial anion-selective channel that is coexpressed together with the abundant scramblase ANO6 and additional intracellular anoctamins. In salivary and pancreatic glands, ANO1 is tightly packed in the apical membrane and secretes Cl-. Epithelia of airways and gut use cystic fibrosis transmembrane conductance regulator (CFTR) as an apical Cl- exit ...
Source: Cell Calcium - April 20, 2024 Category: Cytology Authors: Rainer Schreiber Jiraporn Ousingsawat Karl Kunzelmann Source Type: research
pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain
Cell Calcium. 2024 Apr 8;120:102882. doi: 10.1016/j.ceca.2024.102882. Online ahead of print.ABSTRACTStrict homeostatic control of pH in both intra- and extracellular compartments of the brain is fundamentally important, primarily due to the profound impact of free protons ([H+]) on neuronal activity and overall brain function. Astrocytes, crucial players in the homeostasis of various ions in the brain, actively regulate their intracellular [H+] (pHi) through multiple membrane transporters and carbonic anhydrases. The activation of astroglial pHi regulating mechanisms also leads to corresponding alterations in the acid-base...
Source: Cell Calcium - April 17, 2024 Category: Cytology Authors: Shefeeq M Theparambil Gulnaz Begum Christine R Rose Source Type: research
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease
Cell Calcium. 2024 Apr 6;120:102886. doi: 10.1016/j.ceca.2024.102886. Online ahead of print.ABSTRACTNeurodevelopment, a complex and highly regulated process, plays a foundational role in shaping the structure and function of the nervous system. The transient receptor potential melastatin 7 (TRPM7), a divalent cation channel with an α-kinase domain, mediates a wide range of cellular functions, including proliferation, migration, cell adhesion, and survival, all of which are essential processes in neurodevelopment. The global knockout of either TRPM7 or TRPM7-kinase is embryonically lethal, highlighting the crucial role of ...
Source: Cell Calcium - April 17, 2024 Category: Cytology Authors: Zhengwei Luo Xinyang Zhang Andrea Fleig Daniel Romo Kenneth G Hull F David Horgen Hong-Shuo Sun Zhong-Ping Feng Source Type: research
pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain
Cell Calcium. 2024 Apr 8;120:102882. doi: 10.1016/j.ceca.2024.102882. Online ahead of print.ABSTRACTStrict homeostatic control of pH in both intra- and extracellular compartments of the brain is fundamentally important, primarily due to the profound impact of free protons ([H+]) on neuronal activity and overall brain function. Astrocytes, crucial players in the homeostasis of various ions in the brain, actively regulate their intracellular [H+] (pHi) through multiple membrane transporters and carbonic anhydrases. The activation of astroglial pHi regulating mechanisms also leads to corresponding alterations in the acid-base...
Source: Cell Calcium - April 17, 2024 Category: Cytology Authors: Shefeeq M Theparambil Gulnaz Begum Christine R Rose Source Type: research
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease
Cell Calcium. 2024 Apr 6;120:102886. doi: 10.1016/j.ceca.2024.102886. Online ahead of print.ABSTRACTNeurodevelopment, a complex and highly regulated process, plays a foundational role in shaping the structure and function of the nervous system. The transient receptor potential melastatin 7 (TRPM7), a divalent cation channel with an α-kinase domain, mediates a wide range of cellular functions, including proliferation, migration, cell adhesion, and survival, all of which are essential processes in neurodevelopment. The global knockout of either TRPM7 or TRPM7-kinase is embryonically lethal, highlighting the crucial role of ...
Source: Cell Calcium - April 17, 2024 Category: Cytology Authors: Zhengwei Luo Xinyang Zhang Andrea Fleig Daniel Romo Kenneth G Hull F David Horgen Hong-Shuo Sun Zhong-Ping Feng Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
