Calcium signalling in hepatic metabolism: Health and diseases
Cell Calcium. 2023 Jul 15;114:102780. doi: 10.1016/j.ceca.2023.102780. Online ahead of print.ABSTRACTThe flexibility between the wide array of hepatic functions relies on calcium (Ca2+) signalling. Indeed, Ca2+ is implicated in the control of many intracellular functions as well as intercellular communication. Thus, hepatocytes adapt their Ca2+ signalling depending on their nutritional and hormonal environment, leading to opposite cellular functions, such as glucose storage or synthesis. Interestingly, hepatic metabolic diseases, such as obesity, type 2 diabetes and non-alcoholic fatty liver diseases, are associated with i...
Source: Cell Calcium - July 28, 2023 Category: Cytology Authors: Alexandre Humbert R émy Lefebvre Margaux Nawrot Cyrielle Caussy Jennifer Rieusset Source Type: research
Human IP < sub > 3 < /sub > receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism
Cell Calcium. 2023 Jul 17;114:102782. doi: 10.1016/j.ceca.2023.102782. Online ahead of print.ABSTRACTInositol 1,4,5-trisphosphate receptors (IP3Rs) are ER Ca2+-release channels that control a broad set of cellular processes. Animal models lacking IP3Rs in different combinations display severe developmental phenotypes. Given the importance of IP3Rs in human diseases, we investigated their role in human induced pluripotent stem cells (hiPSC) by developing single IP3R and triple IP3R knockouts (TKO). Genome edited TKO-hiPSC lacking all three IP3R isoforms, IP3R1, IP3R2, IP3R3, failed to generate Ca2+ signals in response to ag...
Source: Cell Calcium - July 23, 2023 Category: Cytology Authors: Julius R önkkö Yago Rodriguez Tiina Rasila Rub én Torregrosa-Muñumer Jana Pennonen Jouni Kvist Emilia Kuuluvainen Ludo Van Den Bosch Ville Hietakangas Geert Bultynck Henna Tyynismaa Emil Ylikallio Source Type: research
Human IP < sub > 3 < /sub > receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism
Cell Calcium. 2023 Jul 17;114:102782. doi: 10.1016/j.ceca.2023.102782. Online ahead of print.ABSTRACTInositol 1,4,5-trisphosphate receptors (IP3Rs) are ER Ca2+-release channels that control a broad set of cellular processes. Animal models lacking IP3Rs in different combinations display severe developmental phenotypes. Given the importance of IP3Rs in human diseases, we investigated their role in human induced pluripotent stem cells (hiPSC) by developing single IP3R and triple IP3R knockouts (TKO). Genome edited TKO-hiPSC lacking all three IP3R isoforms, IP3R1, IP3R2, IP3R3, failed to generate Ca2+ signals in response to ag...
Source: Cell Calcium - July 23, 2023 Category: Cytology Authors: Julius R önkkö Yago Rodriguez Tiina Rasila Rub én Torregrosa-Muñumer Jana Pennonen Jouni Kvist Emilia Kuuluvainen Ludo Van Den Bosch Ville Hietakangas Geert Bultynck Henna Tyynismaa Emil Ylikallio Source Type: research
Human IP < sub > 3 < /sub > receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism
Cell Calcium. 2023 Jul 17;114:102782. doi: 10.1016/j.ceca.2023.102782. Online ahead of print.ABSTRACTInositol 1,4,5-trisphosphate receptors (IP3Rs) are ER Ca2+-release channels that control a broad set of cellular processes. Animal models lacking IP3Rs in different combinations display severe developmental phenotypes. Given the importance of IP3Rs in human diseases, we investigated their role in human induced pluripotent stem cells (hiPSC) by developing single IP3R and triple IP3R knockouts (TKO). Genome edited TKO-hiPSC lacking all three IP3R isoforms, IP3R1, IP3R2, IP3R3, failed to generate Ca2+ signals in response to ag...
Source: Cell Calcium - July 23, 2023 Category: Cytology Authors: Julius R önkkö Yago Rodriguez Tiina Rasila Rub én Torregrosa-Muñumer Jana Pennonen Jouni Kvist Emilia Kuuluvainen Ludo Van Den Bosch Ville Hietakangas Geert Bultynck Henna Tyynismaa Emil Ylikallio Source Type: research
Human IP < sub > 3 < /sub > receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism
Cell Calcium. 2023 Jul 17;114:102782. doi: 10.1016/j.ceca.2023.102782. Online ahead of print.ABSTRACTInositol 1,4,5-trisphosphate receptors (IP3Rs) are ER Ca2+-release channels that control a broad set of cellular processes. Animal models lacking IP3Rs in different combinations display severe developmental phenotypes. Given the importance of IP3Rs in human diseases, we investigated their role in human induced pluripotent stem cells (hiPSC) by developing single IP3R and triple IP3R knockouts (TKO). Genome edited TKO-hiPSC lacking all three IP3R isoforms, IP3R1, IP3R2, IP3R3, failed to generate Ca2+ signals in response to ag...
Source: Cell Calcium - July 23, 2023 Category: Cytology Authors: Julius R önkkö Yago Rodriguez Tiina Rasila Rub én Torregrosa-Muñumer Jana Pennonen Jouni Kvist Emilia Kuuluvainen Ludo Van Den Bosch Ville Hietakangas Geert Bultynck Henna Tyynismaa Emil Ylikallio Source Type: research
Human IP < sub > 3 < /sub > receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism
Cell Calcium. 2023 Jul 17;114:102782. doi: 10.1016/j.ceca.2023.102782. Online ahead of print.ABSTRACTInositol 1,4,5-trisphosphate receptors (IP3Rs) are ER Ca2+-release channels that control a broad set of cellular processes. Animal models lacking IP3Rs in different combinations display severe developmental phenotypes. Given the importance of IP3Rs in human diseases, we investigated their role in human induced pluripotent stem cells (hiPSC) by developing single IP3R and triple IP3R knockouts (TKO). Genome edited TKO-hiPSC lacking all three IP3R isoforms, IP3R1, IP3R2, IP3R3, failed to generate Ca2+ signals in response to ag...
Source: Cell Calcium - July 23, 2023 Category: Cytology Authors: Julius R önkkö Yago Rodriguez Tiina Rasila Rub én Torregrosa-Muñumer Jana Pennonen Jouni Kvist Emilia Kuuluvainen Ludo Van Den Bosch Ville Hietakangas Geert Bultynck Henna Tyynismaa Emil Ylikallio Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Cell Calcium. 2023 Jun 28;114:102779. doi: 10.1016/j.ceca.2023.102779. Online ahead of print.ABSTRACTStore-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. In contrast, Orai...
Source: Cell Calcium - July 3, 2023 Category: Cytology Authors: Ayat S Hammad Fang Yu Jawaher Al-Hamaq F David Horgen Khaled Machaca Source Type: research
