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Protective Effect of Hydroalcoholic Extract of Punica granatum Leaves on High Fructose Induced Insulin Resistance in Experimental Animals
CONCLUSION: In conclusion, this study highlights the ability of Punica granatum extract as a candidate for addressing insulin resistance. The findings suggest that the extract may have a protective role against insulin resistance, as evidenced by improvements in serum glucose and insulin levels, lipid profile, liver enzyme levels, and histopathological characteristics. Further research and investigations are warranted to fully understand the mechanisms underlying these observed effects and to validate the potential of Punica granatum extract as a therapeutic option for managing insulin resistance and its associated complic...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Deepti Bandawane Ashwini Kotkar Pooja Ingole Source Type: research

Thymus atlanticus (Ball) Roussine Aqueous Extract Exerts Lipid-lowering and Anti-atherosclerotic Effects in Hyperlipidemic Guinea Pigs
CONCLUSION: We conclude that the supplementation with the aqueous extract of T. atlanticus could potentially protect against hyperlipidemia and consequently, the development of atherosclerosis.PMID:38038002 | DOI:10.2174/011871529X270863231123063744 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Hamza Elbouny Brahim Ouahzizi Oussama Bekkouch Amal Bennani Souliman Amrani Mhamed Ramchoun Khalid Sellam Chakib Alem Source Type: research

Association of Novel Hematological Indices with Severity of Coronary Artery Disease using SYNTAX Score in Patients with Acute Coronary Syndrome
CONCLUSION: In ACS patients MHR, MLR, and NLR showed significant correlation with Syntax score >22 which may be indicative of severity of disease. MHR is a better predictor of the severity of CAD than MLR and NLR in ACS patients.PMID:37953615 | DOI:10.2174/011871529X269740231102045028 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Vivek Mohanty Shubham Sharma Sourabh Goswami Atul Kaushik Rahul Choudhary Dharamveer Yadav Surender Deora Kuldeep Singh Source Type: research

Enhanced Efficacy of Carvedilol by Utilization of Solid Dispersion and Other Novel Strategies: A Review
Cardiovasc Hematol Disord Drug Targets. 2023 Nov 10. doi: 10.2174/011871529X247622231101075854. Online ahead of print.ABSTRACTCarvedilol is classified as a second class drug of Biopharmaceutical classification system (BCS), and it is an excellent beta blocker and vasodilating agent. It is used in a diverse range of disease states. Despite having tremendous advantages, the drug cannot be used effectively and productively due to aquaphobicity and poor bioavailability. To overcome this limitation, numerous novel approaches and tactics have been introduced over the past few years, such as Selfmicro emulsifying drug delivery sy...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Lakshita Rao Bigul Yogeshver Bhardwaj Mahek Chugh Ashish Sharma Rashmi Shah Neha Minocha Parijat Pandey Source Type: research

Association of Novel Hematological Indices with Severity of Coronary Artery Disease using SYNTAX Score in Patients with Acute Coronary Syndrome
CONCLUSION: In ACS patients MHR, MLR, and NLR showed significant correlation with Syntax score >22 which may be indicative of severity of disease. MHR is a better predictor of the severity of CAD than MLR and NLR in ACS patients.PMID:37953615 | DOI:10.2174/011871529X269740231102045028 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Vivek Mohanty Shubham Sharma Sourabh Goswami Atul Kaushik Rahul Choudhary Dharamveer Yadav Surender Deora Kuldeep Singh Source Type: research

Enhanced Efficacy of Carvedilol by Utilization of Solid Dispersion and Other Novel Strategies: A Review
Cardiovasc Hematol Disord Drug Targets. 2023 Nov 10. doi: 10.2174/011871529X247622231101075854. Online ahead of print.ABSTRACTCarvedilol is classified as a second class drug of Biopharmaceutical classification system (BCS), and it is an excellent beta blocker and vasodilating agent. It is used in a diverse range of disease states. Despite having tremendous advantages, the drug cannot be used effectively and productively due to aquaphobicity and poor bioavailability. To overcome this limitation, numerous novel approaches and tactics have been introduced over the past few years, such as Selfmicro emulsifying drug delivery sy...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Lakshita Rao Bigul Yogeshver Bhardwaj Mahek Chugh Ashish Sharma Rashmi Shah Neha Minocha Parijat Pandey Source Type: research

Association of Novel Hematological Indices with Severity of Coronary Artery Disease using SYNTAX Score in Patients with Acute Coronary Syndrome
CONCLUSION: In ACS patients MHR, MLR, and NLR showed significant correlation with Syntax score >22 which may be indicative of severity of disease. MHR is a better predictor of the severity of CAD than MLR and NLR in ACS patients.PMID:37953615 | DOI:10.2174/011871529X269740231102045028 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Vivek Mohanty Shubham Sharma Sourabh Goswami Atul Kaushik Rahul Choudhary Dharamveer Yadav Surender Deora Kuldeep Singh Source Type: research

Enhanced Efficacy of Carvedilol by Utilization of Solid Dispersion and Other Novel Strategies: A Review
Cardiovasc Hematol Disord Drug Targets. 2023 Nov 10. doi: 10.2174/011871529X247622231101075854. Online ahead of print.ABSTRACTCarvedilol is classified as a second class drug of Biopharmaceutical classification system (BCS), and it is an excellent beta blocker and vasodilating agent. It is used in a diverse range of disease states. Despite having tremendous advantages, the drug cannot be used effectively and productively due to aquaphobicity and poor bioavailability. To overcome this limitation, numerous novel approaches and tactics have been introduced over the past few years, such as Selfmicro emulsifying drug delivery sy...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Lakshita Rao Bigul Yogeshver Bhardwaj Mahek Chugh Ashish Sharma Rashmi Shah Neha Minocha Parijat Pandey Source Type: research

Association of Novel Hematological Indices with Severity of Coronary Artery Disease using SYNTAX Score in Patients with Acute Coronary Syndrome
CONCLUSION: In ACS patients MHR, MLR, and NLR showed significant correlation with Syntax score >22 which may be indicative of severity of disease. MHR is a better predictor of the severity of CAD than MLR and NLR in ACS patients.PMID:37953615 | DOI:10.2174/011871529X269740231102045028 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Vivek Mohanty Shubham Sharma Sourabh Goswami Atul Kaushik Rahul Choudhary Dharamveer Yadav Surender Deora Kuldeep Singh Source Type: research

Enhanced Efficacy of Carvedilol by Utilization of Solid Dispersion and Other Novel Strategies: A Review
Cardiovasc Hematol Disord Drug Targets. 2023 Nov 10. doi: 10.2174/011871529X247622231101075854. Online ahead of print.ABSTRACTCarvedilol is classified as a second class drug of Biopharmaceutical classification system (BCS), and it is an excellent beta blocker and vasodilating agent. It is used in a diverse range of disease states. Despite having tremendous advantages, the drug cannot be used effectively and productively due to aquaphobicity and poor bioavailability. To overcome this limitation, numerous novel approaches and tactics have been introduced over the past few years, such as Selfmicro emulsifying drug delivery sy...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Lakshita Rao Bigul Yogeshver Bhardwaj Mahek Chugh Ashish Sharma Rashmi Shah Neha Minocha Parijat Pandey Source Type: research

Association of Novel Hematological Indices with Severity of Coronary Artery Disease using SYNTAX Score in Patients with Acute Coronary Syndrome
CONCLUSION: In ACS patients MHR, MLR, and NLR showed significant correlation with Syntax score >22 which may be indicative of severity of disease. MHR is a better predictor of the severity of CAD than MLR and NLR in ACS patients.PMID:37953615 | DOI:10.2174/011871529X269740231102045028 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Vivek Mohanty Shubham Sharma Sourabh Goswami Atul Kaushik Rahul Choudhary Dharamveer Yadav Surender Deora Kuldeep Singh Source Type: research

Enhanced Efficacy of Carvedilol by Utilization of Solid Dispersion and Other Novel Strategies: A Review
Cardiovasc Hematol Disord Drug Targets. 2023 Nov 10. doi: 10.2174/011871529X247622231101075854. Online ahead of print.ABSTRACTCarvedilol is classified as a second class drug of Biopharmaceutical classification system (BCS), and it is an excellent beta blocker and vasodilating agent. It is used in a diverse range of disease states. Despite having tremendous advantages, the drug cannot be used effectively and productively due to aquaphobicity and poor bioavailability. To overcome this limitation, numerous novel approaches and tactics have been introduced over the past few years, such as Selfmicro emulsifying drug delivery sy...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Lakshita Rao Bigul Yogeshver Bhardwaj Mahek Chugh Ashish Sharma Rashmi Shah Neha Minocha Parijat Pandey Source Type: research

Association of Novel Hematological Indices with Severity of Coronary Artery Disease using SYNTAX Score in Patients with Acute Coronary Syndrome
CONCLUSION: In ACS patients MHR, MLR, and NLR showed significant correlation with Syntax score >22 which may be indicative of severity of disease. MHR is a better predictor of the severity of CAD than MLR and NLR in ACS patients.PMID:37953615 | DOI:10.2174/011871529X269740231102045028 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Vivek Mohanty Shubham Sharma Sourabh Goswami Atul Kaushik Rahul Choudhary Dharamveer Yadav Surender Deora Kuldeep Singh Source Type: research

Enhanced Efficacy of Carvedilol by Utilization of Solid Dispersion and Other Novel Strategies: A Review
Cardiovasc Hematol Disord Drug Targets. 2023 Nov 10. doi: 10.2174/011871529X247622231101075854. Online ahead of print.ABSTRACTCarvedilol is classified as a second class drug of Biopharmaceutical classification system (BCS), and it is an excellent beta blocker and vasodilating agent. It is used in a diverse range of disease states. Despite having tremendous advantages, the drug cannot be used effectively and productively due to aquaphobicity and poor bioavailability. To overcome this limitation, numerous novel approaches and tactics have been introduced over the past few years, such as Selfmicro emulsifying drug delivery sy...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Lakshita Rao Bigul Yogeshver Bhardwaj Mahek Chugh Ashish Sharma Rashmi Shah Neha Minocha Parijat Pandey Source Type: research

Association of Novel Hematological Indices with Severity of Coronary Artery Disease using SYNTAX Score in Patients with Acute Coronary Syndrome
CONCLUSION: In ACS patients MHR, MLR, and NLR showed significant correlation with Syntax score >22 which may be indicative of severity of disease. MHR is a better predictor of the severity of CAD than MLR and NLR in ACS patients.PMID:37953615 | DOI:10.2174/011871529X269740231102045028 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Vivek Mohanty Shubham Sharma Sourabh Goswami Atul Kaushik Rahul Choudhary Dharamveer Yadav Surender Deora Kuldeep Singh Source Type: research