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Protective Effect of Hydroalcoholic Extract of Punica granatum Leaves on High Fructose Induced Insulin Resistance in Experimental Animals
CONCLUSION: In conclusion, this study highlights the ability of Punica granatum extract as a candidate for addressing insulin resistance. The findings suggest that the extract may have a protective role against insulin resistance, as evidenced by improvements in serum glucose and insulin levels, lipid profile, liver enzyme levels, and histopathological characteristics. Further research and investigations are warranted to fully understand the mechanisms underlying these observed effects and to validate the potential of Punica granatum extract as a therapeutic option for managing insulin resistance and its associated complic...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Deepti Bandawane Ashwini Kotkar Pooja Ingole Source Type: research

Thymus atlanticus (Ball) Roussine Aqueous Extract Exerts Lipid-lowering and Anti-atherosclerotic Effects in Hyperlipidemic Guinea Pigs
CONCLUSION: We conclude that the supplementation with the aqueous extract of T. atlanticus could potentially protect against hyperlipidemia and consequently, the development of atherosclerosis.PMID:38038002 | DOI:10.2174/011871529X270863231123063744 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Hamza Elbouny Brahim Ouahzizi Oussama Bekkouch Amal Bennani Souliman Amrani Mhamed Ramchoun Khalid Sellam Chakib Alem Source Type: research

Recent Developments in Drug Targets and Combination Therapy for the Clinical Management of Hypertension
Cardiovasc Hematol Disord Drug Targets. 2023 Nov 30. doi: 10.2174/011871529X278907231120053559. Online ahead of print.ABSTRACTRaised blood pressure is the most common complication worldwide that may lead to atherosclerosis and ischemic heart disease. Unhealthy lifestyles, smoking, alcohol consumption, junk food, and genetic disorders are some of the causes of hypertension. To treat this condition, numerous antihypertensive medications are available, either alone or in combination, that work via various mechanisms of action. Combinational therapy provides a certain advantage over monotherapy in the sense that it acts in mul...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Pradeep Kumar Niranjan Shiv Bahadur Source Type: research