Cancer associated fibroblasts modulate the cytotoxicity of anti-cancer drugs in breast cancer: An in vitro study
CONCLUSIONS: The treatment of breast cancer cell lines with anti-cancer drugs in combination with secretome isolated from molecular subtype specific CAFs, reduced the cytotoxic effect of the drugs. In addition, LCMS data also highlighted different composition of secreted proteins from different breast cancer associated fibroblasts. Thus, TME has heterogenous population of CAFs across the breast cancer subtypes and in vitro experiments highlight their contribution to chemotherapy resistance which needs further validation.PMID:38517765 | DOI:10.3233/BD-230011 (Source: Breast Disease)
Source: Breast Disease - March 22, 2024 Category: Cancer & Oncology Authors: Dharambir Kashyap Shalmoli Bhattacharya Santosh Irinike Siddhant Khare Ashim Das Gurpreet Singh Amanjit Bal Source Type: research
Use of axillary ultrasound to guide breast cancer management in the genomic assay era
CONCLUSION: A cut-off of ≤5 ultrasound-detected abnormal nodes can distinguish between patients with limited versus high nodal burden, with high specificity. Hence, incorporating the number of abnormal ultrasound-detected nodes into clinical practice may prove useful in guiding between upfront surgery and gene assay testing or neoadjuvant chemotherapy in this group of patients.PMID:38489166 | DOI:10.3233/BD-230032 (Source: Breast Disease)
Source: Breast Disease - March 15, 2024 Category: Cancer & Oncology Authors: Geok Hoon Lim John Carson Allen Yien Sien Lee Sze Yiun Teo Li Ching Lau Thida Win Lester Chee Hao Leong Source Type: research
Clinicopathological analysis of 38 male patients diagnosed with breast cancer
CONCLUSIONS: According to our cohort, MBC is seen in older males, presents in later stages, and shows hormone receptor positivity and a tendency to bone involvement. MBC is a heterogenous but distinct biological entity requiring a specific clinical and pathological approach.PMID:38363600 | PMC:PMC10894578 | DOI:10.3233/BD-230050 (Source: Breast Disease)
Source: Breast Disease - February 16, 2024 Category: Cancer & Oncology Authors: Seniha Irem Sahin Serdar Balci Gulnur Guler Kadri Altundag Source Type: research
Impact of the COVID-19 pandemic on breast cancer pathological stage at diagnosis in Tunisian patients
CONCLUSION: Our findings proved an increase in alarming rates of advanced stage BC associated with the COVID-19 crisis. These findings support recommendations for a quick restoration of BC screening at full capacity, with adequate prioritization strategies to mitigate harm.PMID:38363601 | PMC:PMC10894576 | DOI:10.3233/BD-230051 (Source: Breast Disease)
Source: Breast Disease - February 16, 2024 Category: Cancer & Oncology Authors: Meriam Triki Mouna Zghal Houda Ben Ayed Saadia Makni Maroua Bouhamed Semi Fendri Slim Charfi Tahya Boudawara Manel Mellouli Source Type: research
Clinicopathological analysis of 38 male patients diagnosed with breast cancer
CONCLUSIONS: According to our cohort, MBC is seen in older males, presents in later stages, and shows hormone receptor positivity and a tendency to bone involvement. MBC is a heterogenous but distinct biological entity requiring a specific clinical and pathological approach.PMID:38363600 | PMC:PMC10894578 | DOI:10.3233/BD-230050 (Source: Breast Disease)
Source: Breast Disease - February 16, 2024 Category: Cancer & Oncology Authors: Seniha Irem Sahin Serdar Balci Gulnur Guler Kadri Altundag Source Type: research
Impact of the COVID-19 pandemic on breast cancer pathological stage at diagnosis in Tunisian patients
CONCLUSION: Our findings proved an increase in alarming rates of advanced stage BC associated with the COVID-19 crisis. These findings support recommendations for a quick restoration of BC screening at full capacity, with adequate prioritization strategies to mitigate harm.PMID:38363601 | PMC:PMC10894576 | DOI:10.3233/BD-230051 (Source: Breast Disease)
Source: Breast Disease - February 16, 2024 Category: Cancer & Oncology Authors: Meriam Triki Mouna Zghal Houda Ben Ayed Saadia Makni Maroua Bouhamed Semi Fendri Slim Charfi Tahya Boudawara Manel Mellouli Source Type: research
