Cancer associated fibroblasts modulate the cytotoxicity of anti-cancer drugs in breast cancer: An in vitro study
CONCLUSIONS: The treatment of breast cancer cell lines with anti-cancer drugs in combination with secretome isolated from molecular subtype specific CAFs, reduced the cytotoxic effect of the drugs. In addition, LCMS data also highlighted different composition of secreted proteins from different breast cancer associated fibroblasts. Thus, TME has heterogenous population of CAFs across the breast cancer subtypes and in vitro experiments highlight their contribution to chemotherapy resistance which needs further validation.PMID:38517765 | DOI:10.3233/BD-230011
Source: Breast Disease - Category: Cancer & Oncology Authors: Dharambir Kashyap Shalmoli Bhattacharya Santosh Irinike Siddhant Khare Ashim Das Gurpreet Singh Amanjit Bal Source Type: research
More News: Breast Cancer | Breast Lumpectomy | Cancer | Cancer & Oncology | Chemotherapy | Herceptin | Lumpectomy | Mastectomy | Study | Tamoxifen