Blood Cells, Molecules and Diseases 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research
Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research
Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research
Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research
Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research
Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research
Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research
Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research
Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research
Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research
Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research
Acquired elliptocytosis in chronic myeloid neoplasms: An enigmatic relationship to acquired red cell membrane protein and genetic abnormalities
Blood Cells Mol Dis. 2023 Jun 22;103:102778. doi: 10.1016/j.bcmd.2023.102778. Online ahead of print.ABSTRACTNineteen reports of 41 cases of acquired red cell elliptocytosis associated with a chronic myeloid neoplasm are described. Although the majority of cases have an abnormality of the long arm of chromosome 20, del(q20), several cases do not. Moreover, in one case a specific qualitative abnormality of red cell protein band 4.1(4.1R) was reported; however, several subsequent cases could find no abnormality of a red cell membrane protein or found a different abnormality, usually quantitative. Thus, this striking red cell ...
Source: Blood Cells, Molecules and Diseases - June 28, 2023 Category: Hematology Authors: Marshall A Lichtman Ronald Sham Source Type: research
Acquired elliptocytosis in chronic myeloid neoplasms: An enigmatic relationship to acquired red cell membrane protein and genetic abnormalities
Blood Cells Mol Dis. 2023 Jun 22;103:102778. doi: 10.1016/j.bcmd.2023.102778. Online ahead of print.ABSTRACTNineteen reports of 41 cases of acquired red cell elliptocytosis associated with a chronic myeloid neoplasm are described. Although the majority of cases have an abnormality of the long arm of chromosome 20, del(q20), several cases do not. Moreover, in one case a specific qualitative abnormality of red cell protein band 4.1(4.1R) was reported; however, several subsequent cases could find no abnormality of a red cell membrane protein or found a different abnormality, usually quantitative. Thus, this striking red cell ...
Source: Blood Cells, Molecules and Diseases - June 28, 2023 Category: Hematology Authors: Marshall A Lichtman Ronald Sham Source Type: research
Acquired elliptocytosis in chronic myeloid neoplasms: An enigmatic relationship to acquired red cell membrane protein and genetic abnormalities
Blood Cells Mol Dis. 2023 Jun 22;103:102778. doi: 10.1016/j.bcmd.2023.102778. Online ahead of print.ABSTRACTNineteen reports of 41 cases of acquired red cell elliptocytosis associated with a chronic myeloid neoplasm are described. Although the majority of cases have an abnormality of the long arm of chromosome 20, del(q20), several cases do not. Moreover, in one case a specific qualitative abnormality of red cell protein band 4.1(4.1R) was reported; however, several subsequent cases could find no abnormality of a red cell membrane protein or found a different abnormality, usually quantitative. Thus, this striking red cell ...
Source: Blood Cells, Molecules and Diseases - June 28, 2023 Category: Hematology Authors: Marshall A Lichtman Ronald Sham Source Type: research
Essential genetic modifiers and their measurable impact in a community-recruited population analysis for non-severe hemoglobin E/ β-thalassemia prenatal genetic counseling
Blood Cells Mol Dis. 2023 Jun 15:102765. doi: 10.1016/j.bcmd.2023.102765. Online ahead of print.ABSTRACTThe study aimed to identify essential phenotype-modulating factors among the pre-existence of several important ones and clarify their measurable impact on the clinical severity of hemoglobin (Hb) E/β-thalassemia in a community-recruited population analysis. This prospective study was designed to compare modifiers between community- (less or no symptoms) and hospital-recruited individuals with Hb E/β-thalassemia. The formerly included couples previously assessed for prenatal thalassemia at-risk status at 42 community a...
Source: Blood Cells, Molecules and Diseases - June 23, 2023 Category: Hematology Authors: Peerapon Wong Thirabhat Chitsobhak Suporn Jittasathian Chonnigarn Sirichantharawat Naritsara Cherdchoo Weerapong Prangcharoen Patcharanapa Jongautchariyakul Katechan Jampachaisri Akamon Tapprom Rawisut Deoisares Piyatida Chumnumsiriwath Source Type: research
