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Commentary on "unmasking the morphological alteration of erythrocytes among women suffering from PCOS"
Blood Cells Mol Dis. 2024 Feb 28:102840. doi: 10.1016/j.bcmd.2024.102840. Online ahead of print.NO ABSTRACTPMID:38429180 | DOI:10.1016/j.bcmd.2024.102840 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - March 1, 2024 Category: Hematology Authors: Shuwei Fan Guomei Shi Kelan Li Source Type: research

Diamond-Blackfan anemia, the archetype of ribosomopathy: How distinct is it from the other constitutional ribosomopathies?
Blood Cells Mol Dis. 2024 Feb 17:102838. doi: 10.1016/j.bcmd.2024.102838. Online ahead of print.ABSTRACTDiamond-Blackfan anemia (DBA) was the first ribosomopathy described in humans. DBA is a congenital hypoplastic anemia, characterized by macrocytic aregenerative anemia, manifesting by differentiation blockage between the BFU-e/CFU-e developmental erythroid progenitor stages. In 50 % of the DBA cases, various malformations are noted. Strikingly, for a hematological disease with a relative erythroid tropism, DBA is due to ribosomal haploinsufficiency in 24 different ribosomal protein (RP) genes. A few other genes have been...
Source: Blood Cells, Molecules and Diseases - February 27, 2024 Category: Hematology Authors: L Da Costa Narla Mohandas Ludivine David-NGuyen Jessica Platon Isabelle Marie Marie Fran çoise O'Donohue Thierry Leblanc Pierre-Emmanuel Gleizes Source Type: research

Rare bleeding disorders: Real-world data from a Spanish tertiary hospital
CONCLUSION: Our study on an unusual large single center cohort of RBD patients portrays location-dependent distinct genetic drives and clinical practice particularities.PMID:38387429 | DOI:10.1016/j.bcmd.2024.102837 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - February 22, 2024 Category: Hematology Authors: Daniel Mart ínez-Carballeira Alberto Caro Ángel Bernardo Jos é Ramón Corte Jos é Carlos Iglesias Isabel Asunci ón Hernández de Castro Laura Guti érrez Inmaculada Soto Source Type: research

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research