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Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Mol Dis. 2024 Jan;104:102800. doi: 10.1016/j.bcmd.2023.102800. Epub 2023 Nov 2.ABSTRACTRed blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and calcium flux in RBCs from a mouse model of SCD mice. We found that akin to humans with SCD, sickle (HbSS) Townes mice, have higher baseline levels and increased calcium flux in RBCs compared to control (HbAA) animals. As HbSS mice, unlike humans with SCD, have high mean corpuscular volume compared with HbAA, we highlight the imp...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Luis E F Almeida Meghann L Smith Sayuri Kamimura Sebastian Vogel Zenaide M N Quezado Source Type: research

Clonal hematopoiesis and acquired genetic abnormalities of the red cell: An historical review
Blood Cells Mol Dis. 2024 Jan;104:102801. doi: 10.1016/j.bcmd.2023.102801. Epub 2023 Nov 5.ABSTRACTSeveral syndromes affecting the red cell that mimic those induced by germline mutations may result from a somatic mutation that accompanies a myeloid malignancy. These syndromes are most notable in cases of myelodysplastic syndrome, but they are not limited to any one category of myeloid neoplasm. Their occurrence in males exceed the male predominance that is evident in myeloid neoplasms. The syndromes include disorders of globin chain synthesis (α- and β-thalassemia), heme synthesis (erythropoietic porphyria and erythropoi...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Marshall A Lichtman Source Type: research

Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Mol Dis. 2024 Jan;104:102800. doi: 10.1016/j.bcmd.2023.102800. Epub 2023 Nov 2.ABSTRACTRed blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and calcium flux in RBCs from a mouse model of SCD mice. We found that akin to humans with SCD, sickle (HbSS) Townes mice, have higher baseline levels and increased calcium flux in RBCs compared to control (HbAA) animals. As HbSS mice, unlike humans with SCD, have high mean corpuscular volume compared with HbAA, we highlight the imp...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Luis E F Almeida Meghann L Smith Sayuri Kamimura Sebastian Vogel Zenaide M N Quezado Source Type: research

Clonal hematopoiesis and acquired genetic abnormalities of the red cell: An historical review
Blood Cells Mol Dis. 2024 Jan;104:102801. doi: 10.1016/j.bcmd.2023.102801. Epub 2023 Nov 5.ABSTRACTSeveral syndromes affecting the red cell that mimic those induced by germline mutations may result from a somatic mutation that accompanies a myeloid malignancy. These syndromes are most notable in cases of myelodysplastic syndrome, but they are not limited to any one category of myeloid neoplasm. Their occurrence in males exceed the male predominance that is evident in myeloid neoplasms. The syndromes include disorders of globin chain synthesis (α- and β-thalassemia), heme synthesis (erythropoietic porphyria and erythropoi...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Marshall A Lichtman Source Type: research

Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Mol Dis. 2024 Jan;104:102800. doi: 10.1016/j.bcmd.2023.102800. Epub 2023 Nov 2.ABSTRACTRed blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and calcium flux in RBCs from a mouse model of SCD mice. We found that akin to humans with SCD, sickle (HbSS) Townes mice, have higher baseline levels and increased calcium flux in RBCs compared to control (HbAA) animals. As HbSS mice, unlike humans with SCD, have high mean corpuscular volume compared with HbAA, we highlight the imp...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Luis E F Almeida Meghann L Smith Sayuri Kamimura Sebastian Vogel Zenaide M N Quezado Source Type: research

Clonal hematopoiesis and acquired genetic abnormalities of the red cell: An historical review
Blood Cells Mol Dis. 2023 Nov 5;104:102801. doi: 10.1016/j.bcmd.2023.102801. Online ahead of print.ABSTRACTSeveral syndromes affecting the red cell that mimic those induced by germline mutations may result from a somatic mutation that accompanies a myeloid malignancy. These syndromes are most notable in cases of myelodysplastic syndrome, but they are not limited to any one category of myeloid neoplasm. Their occurrence in males exceed the male predominance that is evident in myeloid neoplasms. The syndromes include disorders of globin chain synthesis (α- and β-thalassemia), heme synthesis (erythropoietic porphyria and er...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Marshall A Lichtman Source Type: research

Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Mol Dis. 2023 Nov 2;104:102800. doi: 10.1016/j.bcmd.2023.102800. Online ahead of print.ABSTRACTRed blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and calcium flux in RBCs from a mouse model of SCD mice. We found that akin to humans with SCD, sickle (HbSS) Townes mice, have higher baseline levels and increased calcium flux in RBCs compared to control (HbAA) animals. As HbSS mice, unlike humans with SCD, have high mean corpuscular volume compared with HbAA, we highlight...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Luis E F Almeida Meghann L Smith Sayuri Kamimura Sebastian Vogel Zenaide M N Quezado Source Type: research

Clonal hematopoiesis and acquired genetic abnormalities of the red cell: An historical review
Blood Cells Mol Dis. 2023 Nov 5;104:102801. doi: 10.1016/j.bcmd.2023.102801. Online ahead of print.ABSTRACTSeveral syndromes affecting the red cell that mimic those induced by germline mutations may result from a somatic mutation that accompanies a myeloid malignancy. These syndromes are most notable in cases of myelodysplastic syndrome, but they are not limited to any one category of myeloid neoplasm. Their occurrence in males exceed the male predominance that is evident in myeloid neoplasms. The syndromes include disorders of globin chain synthesis (α- and β-thalassemia), heme synthesis (erythropoietic porphyria and er...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Marshall A Lichtman Source Type: research

Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Mol Dis. 2023 Nov 2;104:102800. doi: 10.1016/j.bcmd.2023.102800. Online ahead of print.ABSTRACTRed blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and calcium flux in RBCs from a mouse model of SCD mice. We found that akin to humans with SCD, sickle (HbSS) Townes mice, have higher baseline levels and increased calcium flux in RBCs compared to control (HbAA) animals. As HbSS mice, unlike humans with SCD, have high mean corpuscular volume compared with HbAA, we highlight...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Luis E F Almeida Meghann L Smith Sayuri Kamimura Sebastian Vogel Zenaide M N Quezado Source Type: research

Clonal hematopoiesis and acquired genetic abnormalities of the red cell: An historical review
Blood Cells Mol Dis. 2023 Nov 5;104:102801. doi: 10.1016/j.bcmd.2023.102801. Online ahead of print.ABSTRACTSeveral syndromes affecting the red cell that mimic those induced by germline mutations may result from a somatic mutation that accompanies a myeloid malignancy. These syndromes are most notable in cases of myelodysplastic syndrome, but they are not limited to any one category of myeloid neoplasm. Their occurrence in males exceed the male predominance that is evident in myeloid neoplasms. The syndromes include disorders of globin chain synthesis (α- and β-thalassemia), heme synthesis (erythropoietic porphyria and er...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Marshall A Lichtman Source Type: research

Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Mol Dis. 2023 Nov 2;104:102800. doi: 10.1016/j.bcmd.2023.102800. Online ahead of print.ABSTRACTRed blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and calcium flux in RBCs from a mouse model of SCD mice. We found that akin to humans with SCD, sickle (HbSS) Townes mice, have higher baseline levels and increased calcium flux in RBCs compared to control (HbAA) animals. As HbSS mice, unlike humans with SCD, have high mean corpuscular volume compared with HbAA, we highlight...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Luis E F Almeida Meghann L Smith Sayuri Kamimura Sebastian Vogel Zenaide M N Quezado Source Type: research

Clonal hematopoiesis and acquired genetic abnormalities of the red cell: An historical review
Blood Cells Mol Dis. 2023 Nov 5;104:102801. doi: 10.1016/j.bcmd.2023.102801. Online ahead of print.ABSTRACTSeveral syndromes affecting the red cell that mimic those induced by germline mutations may result from a somatic mutation that accompanies a myeloid malignancy. These syndromes are most notable in cases of myelodysplastic syndrome, but they are not limited to any one category of myeloid neoplasm. Their occurrence in males exceed the male predominance that is evident in myeloid neoplasms. The syndromes include disorders of globin chain synthesis (α- and β-thalassemia), heme synthesis (erythropoietic porphyria and er...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Marshall A Lichtman Source Type: research

Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Mol Dis. 2023 Nov 2;104:102800. doi: 10.1016/j.bcmd.2023.102800. Online ahead of print.ABSTRACTRed blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and calcium flux in RBCs from a mouse model of SCD mice. We found that akin to humans with SCD, sickle (HbSS) Townes mice, have higher baseline levels and increased calcium flux in RBCs compared to control (HbAA) animals. As HbSS mice, unlike humans with SCD, have high mean corpuscular volume compared with HbAA, we highlight...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Luis E F Almeida Meghann L Smith Sayuri Kamimura Sebastian Vogel Zenaide M N Quezado Source Type: research

Clonal hematopoiesis and acquired genetic abnormalities of the red cell: An historical review
Blood Cells Mol Dis. 2023 Nov 5;104:102801. doi: 10.1016/j.bcmd.2023.102801. Online ahead of print.ABSTRACTSeveral syndromes affecting the red cell that mimic those induced by germline mutations may result from a somatic mutation that accompanies a myeloid malignancy. These syndromes are most notable in cases of myelodysplastic syndrome, but they are not limited to any one category of myeloid neoplasm. Their occurrence in males exceed the male predominance that is evident in myeloid neoplasms. The syndromes include disorders of globin chain synthesis (α- and β-thalassemia), heme synthesis (erythropoietic porphyria and er...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Marshall A Lichtman Source Type: research

Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Mol Dis. 2023 Nov 2;104:102800. doi: 10.1016/j.bcmd.2023.102800. Online ahead of print.ABSTRACTRed blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and calcium flux in RBCs from a mouse model of SCD mice. We found that akin to humans with SCD, sickle (HbSS) Townes mice, have higher baseline levels and increased calcium flux in RBCs compared to control (HbAA) animals. As HbSS mice, unlike humans with SCD, have high mean corpuscular volume compared with HbAA, we highlight...
Source: Blood Cells, Molecules and Diseases - November 11, 2023 Category: Hematology Authors: Luis E F Almeida Meghann L Smith Sayuri Kamimura Sebastian Vogel Zenaide M N Quezado Source Type: research