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Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research

Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research

Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research

Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research

Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research

Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research

Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research

Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research

Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research

Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research

Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research

Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research

Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research

Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Mol Dis. 2023 Jun 17:102776. doi: 10.1016/j.bcmd.2023.102776. Online ahead of print.ABSTRACTThe root cause of sickle cell disease (SCD) has been known for nearly a century, however, few therapies to treat the disease are available. Over several decades of work, with advances in gene editing technology and after several iterations of mice with differing genotype/phenotype relationships, researchers have developed humanized SCD mouse models. However, while a large body of preclinical studies has led to huge gains in basic science knowledge about SCD in mice, this knowledge has not led to the development of effect...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Sayuri Kamimura Meghann Smith Sebastian Vogel Luis E F Almeida Swee Lay Thein Zenaide M N Quezado Source Type: research

Hypoferremia of inflammation: Innate host defense against infections
Blood Cells Mol Dis. 2023 Jun 21:102777. doi: 10.1016/j.bcmd.2023.102777. Online ahead of print.ABSTRACTIron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.PMID:37391347 | ...
Source: Blood Cells, Molecules and Diseases - June 30, 2023 Category: Hematology Authors: Tomas Ganz Elizabeta Nemeth Source Type: research