Blood Cells, Molecules and Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Blood Cells Mol Dis. 2024 Jan 19;106:102827. doi: 10.1016/j.bcmd.2024.102827. Online ahead of print.ABSTRACTJM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plas...
Source: Blood Cells, Molecules and Diseases - February 1, 2024 Category: Hematology Authors: Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cl áudia Sirlene Oliveira Bruna Candia Piccoli Alessandro de Souza Prestes Bruna Cogo Borin Andre Passaglia Schuch Estael Ochoa-Rodr íguez Yanier Nu ñez-Figueredo Jo ão Source Type: research

Regarding γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity
Blood Cells Mol Dis. 2024 Mar;105:102825. doi: 10.1016/j.bcmd.2024.102825. Epub 2024 Jan 12.NO ABSTRACTPMID:38278055 | DOI:10.1016/j.bcmd.2024.102825 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - January 26, 2024 Category: Hematology Authors: Lucy Z Kornblith Bindhya Sadhanandhan Sreepriya Arun Rebecca Long Alicia J Johnson Jamie Noll C N Ramchand John K Olynyk David H Farrell Source Type: research

A comparative study of two routinely used protocols for ex vivo erythroid differentiation
CONCLUSIONS: We provide data supporting the use of one protocol or the other to study the biological processes occurring in the early or late stages of erythroid differentiation, depending on the physiological process or pathological defect under investigation in a given study.PMID:38278056 | DOI:10.1016/j.bcmd.2024.102829 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - January 26, 2024 Category: Hematology Authors: Auria Godard Robert Seute Alexandra Grimaldi Thomas Granier Jacques Chiaroni Wassim El Nemer Maria De Grandis Source Type: research

Unveiling mortality risk factors in paediatric sickle cell disease patients during acute crises in the Democratic Republic of the Congo
This study aims to identify predictive factors of mortality in SCD children admitted to emergency care in Lubumbashi, DRC. We performed a non-interventional cohort follow-up on SCD patients aged 0 to 16 admitted for a "true emergency". Demographic, clinical, and biological data were collected. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors associated with mortality. Among the 121 patients included, 24 died during the follow-up period. Univariate regression revealed age, Mikobi score, referral origin, stroke, and severe infection as significant risk factors. Mult...
Source: Blood Cells, Molecules and Diseases - January 24, 2024 Category: Hematology Authors: Paul Muteb Boma St éphanie Luntadila Ngimbi Junior Makiese Kindundu Jean Isra ël Wela Nathalie Lukanke Ngoie Valentin Mukeba Ngwamah Sandra Mbuyi Tshiswaka Jos éphine Kalenga Monga Jules Mulefu Panda Bruno Bonnech ère Source Type: research

Regarding γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity
Blood Cells Mol Dis. 2024 Mar;105:102826. doi: 10.1016/j.bcmd.2024.102826. Epub 2024 Jan 17.NO ABSTRACTPMID:38262103 | DOI:10.1016/j.bcmd.2024.102826 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - January 23, 2024 Category: Hematology Authors: Sangsang Wang Diao Yu Junwu Zhang Source Type: research

Effect of voxelotor on murine bone marrow and peripheral blood with hematopoietic progenitor cell mobilization for gene therapy of sickle cell disease
We examined whether treatment with GBT1118, the murine analog of voxelotor, could be a safe and feasible alternative to red cell transfusion. We found that 3 weeks of treatment with GBT1118 increased the percentage of bone marrow hematopoietic stem cells and upon plerixafor mobilization, the percentage of peripheral blood hematopoietic stem cells. Our data suggest that voxelotor should be further explored for its potential safety and utility as preparation for hematopoietic stem cell mobilization and collection.PMID:38262104 | DOI:10.1016/j.bcmd.2024.102824 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - January 23, 2024 Category: Hematology Authors: Avital Mendelson Yunfeng Liu Weili Bao Patricia A Shi Source Type: research

Bio-net dataset: AI-based diagnostic solutions using peripheral blood smear images
This study presents a large customized annotated blood cell dataset (named the Bio-Net dataset from healthy individuals) and blood cell detection and counting in the peripheral blood smear images. A mini-version of the dataset for specialized WBC-based image processing tasks is also equipped to classify the healthy and mature WBCs in their respective classes. An object detection algorithm called You Only Look Once (YOLO) with a refashion disposition has been trained on the novel dataset to automatically detect and classify blood cells into RBCs, WBCs, and platelets and compare the results with other publicly available data...
Source: Blood Cells, Molecules and Diseases - January 19, 2024 Category: Hematology Authors: Usman Ali Shams Isma Javed Muhammad Fizan Aqib Raza Shah Ghulam Mustafa Muhammad Zubair Yehia Massoud Muhammad Qasim Mehmood Muhammad Asif Naveed Source Type: research

Unmasking the morphological alteration of erythrocytes among women suffering from PCOS
Blood Cells Mol Dis. 2024 Mar;105:102821. doi: 10.1016/j.bcmd.2023.102821. Epub 2024 Jan 3.ABSTRACTDyslipidemia is frequently observed in polycystic ovarian syndrome (PCOS). Changes in plasma lipid levels potentially alter erythrocyte membrane lipid composition due to lack of inbuilt lipid synthesis machinery. Therefore, development of morphologically altered erythrocytes in PCOS patients with dyslipidemia is expected. However, this has not been established so far. So, we took this opportunity to explore the morphological alterations among dyslipidemic PCO women. We recruited thirty-five dyslipidemic PCOS women (satisfying...
Source: Blood Cells, Molecules and Diseases - January 13, 2024 Category: Hematology Authors: Sutithi Dey Ipsita Chakraborty Payel Biswas Ayantika Paul Pratip Chakraborty Rajen Haldar Source Type: research

Characterization of a cohort of Angolan children with sickle cell anemia treated with hydroxyurea
CONCLUSIONS: the present study provided a valuable contribution to the understanding of the clinical and laboratory profiles of Angolan children with SCA. These findings support the evidence that the implementation of prophylactic measures and treatment with HU is associated with increased survival in children with SCA.PMID:38215581 | DOI:10.1016/j.bcmd.2023.102822 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - January 12, 2024 Category: Hematology Authors: Br ígida Santos Catarina Ginete Elis ângela Gonçalves Mariana Delgadinho Armandina Miranda Paula Faustino Ana Paula Arez Miguel Brito Source Type: research

Impact of CD34 positive cell dose in donor graft on the outcomes after haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide - A retrospective single-center study with a Japanese cohort
CONCLUSION: Our data suggest that a higher dose of CD34+ cells in haplo-PBSCT with PTCy positively impacts the outcomes without an increase of GVHD.PMID:38199143 | DOI:10.1016/j.bcmd.2023.102820 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - January 10, 2024 Category: Hematology Authors: Yumiko Maruyama Hidekazu Nishikii Naoki Kurita Tatsuhiro Sakamoto Keiichiro Hattori Yasuhito Suehara Yasuhisa Yokoyama Takayasu Kato Naoshi Obara Mamiko Sakata-Yanagimoto Shigeru Chiba Source Type: research