Alzheimer's disease with frailty: Prevalence, screening, assessment, intervention strategies and challenges
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01211. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide and is expected to surge in prevalence due to aging populations. Frailty, characterized by muscle function decline, becomes more prevalent with age, imposing substantial burdens on patients and caregivers. This paper aimed to comprehensively review the current literature on AD coupled with frailty, encompassing prevalence, screening, assessment, and treatment while delving into the field's challenges and future trajectories. Frailty and AD coexist in...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Yi Deng Haiyin Wang Kaicheng Gu Peipei Song Source Type: research
Healthy aging, early screening, and interventions for frailty in the elderly
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01204. Online ahead of print.ABSTRACTWith the intensification of population aging worldwide, the health problems of the elderly have become a particular concern. Functional disability is a prominent problem in the aging of this population, resulting in the decreased quality of life of senile people. Risk factors for functional disability in the elderly include geriatric syndromes and the associated diseases such as frailty. The influence of frailty on the health of the elderly has been a hot topic in recent years. As a dynamic and reversible geriatric syndrome, it has becom...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Yi Deng Keming Zhang Jiali Zhu Xiaofeng Hu Rui Liao Source Type: research
Facing frailty: Are you ready?
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01191. Online ahead of print.ABSTRACTBy far, there is no general consensus concerning the definition of frailty even though it may be a global public health concern with aging of the population. It is regarded as a pathophysiological state before development of a severe illness that is associated with many adverse outcomes. Although previous studies attempted to verify its clinical value to prevent the development of serious illness, robust evidence is lacking. Based on previous studies of frailty, the current study analyzed the problems with existing investigations of frai...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Tetsuya Asakawa Takashi Karako Source Type: research
Geriatric syndromes, chronic inflammation, and advances in the management of frailty: A review with new insights
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01184. Online ahead of print.ABSTRACTAs people age, geriatric syndromes characterized by frailty significantly impact both clinical practice and public health. Aging weakens people's immune functions, leading to chronic low-grade inflammation that ultimately contributes to the development of frailty. Effectively managing geriatric syndromes and frailty can help alleviate the economic burden of an aging population. This review delves into the intricate relationship among aging, infection-induced inflammation, chronic inflammation, and frailty. In addition, it analyzes variou...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Niuniu Li Gaolin Liu Hong Gao Qiang Wu Juan Meng Fei Wang Siwei Jiang Meixia Chen Wenhui Xu Yifan Zhang Yanjun Wang Yingqian Feng Juncai Liu Cheng Xu Hongzhou Lu Source Type: research
The framework for modern community medicine in Japan
Biosci Trends. 2023 Aug 24. doi: 10.5582/bst.2023.01199. Online ahead of print.ABSTRACTAlong with the transition to depopulation and an aging society in Japan, the modification of community medicine and its related systems is required. With this in mind, the Japanese government has recently advocated two major plans: 'Community Healthcare Vision' and 'Community-based Integrated Care System'. This paper proposes a theoretical framework to understand modern community medicine based on the ongoing government plans. The key viewpoints consisting of the framework are 'community and/or region', 'care systematization,' and 'cowor...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Kazuhiko Kotani Source Type: research
Alzheimer's disease with frailty: Prevalence, screening, assessment, intervention strategies and challenges
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01211. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide and is expected to surge in prevalence due to aging populations. Frailty, characterized by muscle function decline, becomes more prevalent with age, imposing substantial burdens on patients and caregivers. This paper aimed to comprehensively review the current literature on AD coupled with frailty, encompassing prevalence, screening, assessment, and treatment while delving into the field's challenges and future trajectories. Frailty and AD coexist in...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Yi Deng Haiyin Wang Kaicheng Gu Peipei Song Source Type: research
Healthy aging, early screening, and interventions for frailty in the elderly
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01204. Online ahead of print.ABSTRACTWith the intensification of population aging worldwide, the health problems of the elderly have become a particular concern. Functional disability is a prominent problem in the aging of this population, resulting in the decreased quality of life of senile people. Risk factors for functional disability in the elderly include geriatric syndromes and the associated diseases such as frailty. The influence of frailty on the health of the elderly has been a hot topic in recent years. As a dynamic and reversible geriatric syndrome, it has becom...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Yi Deng Keming Zhang Jiali Zhu Xiaofeng Hu Rui Liao Source Type: research
Facing frailty: Are you ready?
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01191. Online ahead of print.ABSTRACTBy far, there is no general consensus concerning the definition of frailty even though it may be a global public health concern with aging of the population. It is regarded as a pathophysiological state before development of a severe illness that is associated with many adverse outcomes. Although previous studies attempted to verify its clinical value to prevent the development of serious illness, robust evidence is lacking. Based on previous studies of frailty, the current study analyzed the problems with existing investigations of frai...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Tetsuya Asakawa Takashi Karako Source Type: research
Geriatric syndromes, chronic inflammation, and advances in the management of frailty: A review with new insights
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01184. Online ahead of print.ABSTRACTAs people age, geriatric syndromes characterized by frailty significantly impact both clinical practice and public health. Aging weakens people's immune functions, leading to chronic low-grade inflammation that ultimately contributes to the development of frailty. Effectively managing geriatric syndromes and frailty can help alleviate the economic burden of an aging population. This review delves into the intricate relationship among aging, infection-induced inflammation, chronic inflammation, and frailty. In addition, it analyzes variou...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Niuniu Li Gaolin Liu Hong Gao Qiang Wu Juan Meng Fei Wang Siwei Jiang Meixia Chen Wenhui Xu Yifan Zhang Yanjun Wang Yingqian Feng Juncai Liu Cheng Xu Hongzhou Lu Source Type: research
The framework for modern community medicine in Japan
Biosci Trends. 2023 Aug 24. doi: 10.5582/bst.2023.01199. Online ahead of print.ABSTRACTAlong with the transition to depopulation and an aging society in Japan, the modification of community medicine and its related systems is required. With this in mind, the Japanese government has recently advocated two major plans: 'Community Healthcare Vision' and 'Community-based Integrated Care System'. This paper proposes a theoretical framework to understand modern community medicine based on the ongoing government plans. The key viewpoints consisting of the framework are 'community and/or region', 'care systematization,' and 'cowor...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Kazuhiko Kotani Source Type: research
Alzheimer's disease with frailty: Prevalence, screening, assessment, intervention strategies and challenges
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01211. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide and is expected to surge in prevalence due to aging populations. Frailty, characterized by muscle function decline, becomes more prevalent with age, imposing substantial burdens on patients and caregivers. This paper aimed to comprehensively review the current literature on AD coupled with frailty, encompassing prevalence, screening, assessment, and treatment while delving into the field's challenges and future trajectories. Frailty and AD coexist in...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Yi Deng Haiyin Wang Kaicheng Gu Peipei Song Source Type: research
Healthy aging, early screening, and interventions for frailty in the elderly
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01204. Online ahead of print.ABSTRACTWith the intensification of population aging worldwide, the health problems of the elderly have become a particular concern. Functional disability is a prominent problem in the aging of this population, resulting in the decreased quality of life of senile people. Risk factors for functional disability in the elderly include geriatric syndromes and the associated diseases such as frailty. The influence of frailty on the health of the elderly has been a hot topic in recent years. As a dynamic and reversible geriatric syndrome, it has becom...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Yi Deng Keming Zhang Jiali Zhu Xiaofeng Hu Rui Liao Source Type: research
Facing frailty: Are you ready?
Biosci Trends. 2023 Aug 23. doi: 10.5582/bst.2023.01191. Online ahead of print.ABSTRACTBy far, there is no general consensus concerning the definition of frailty even though it may be a global public health concern with aging of the population. It is regarded as a pathophysiological state before development of a severe illness that is associated with many adverse outcomes. Although previous studies attempted to verify its clinical value to prevent the development of serious illness, robust evidence is lacking. Based on previous studies of frailty, the current study analyzed the problems with existing investigations of frai...
Source: BioScience Trends - August 23, 2023 Category: Biomedical Science Authors: Tetsuya Asakawa Takashi Karako Source Type: research
