Neoadjuvant therapies in resectable hepatocellular carcinoma: Exploring strategies to improve prognosis
Biosci Trends. 2024 Feb 20. doi: 10.5582/bst.2023.01436. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC), a challenging malignancy, often necessitates surgical intervention, notably liver resection. However, the high recurrence rate, reaching 70% within 5 years post-resection, significantly impacts patient outcomes. Neoadjuvant therapies aim to preoperatively address this challenge, reducing lesion size, improving surgical resection rates, deactivating potential micro-metastases, and ultimately lowering postoperative recurrence rates. This review concentrates on advances in research on and clinical use of neoa...
Source: BioScience Trends - February 21, 2024 Category: Biomedical Science Authors: Ya-Nan Ma Xuemei Jiang Peipei Song Wei Tang Source Type: research
Monoclonal antibody therapy for Alzheimer's disease focusing on intracerebral targets
Biosci Trends. 2024 Feb 21. doi: 10.5582/bst.2023.01288. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is one of the most common neurodegenerative diseases. Due to the complexity of the disorder and the presence of the blood-brain barrier (BBB), its drug discovery and development are facing enormous challenges, especially after several failures of monoclonal antibody (mAb) trials. Nevertheless, the Food and Drug Administration's approval of the mAb aducanumab has ushered in a new day. As we better understand the disease's pathogenesis and identify novel intracerebral therapeutic targets, antibody-based therapies h...
Source: BioScience Trends - February 21, 2024 Category: Biomedical Science Authors: Xiaolei Gu Long Qi Qing Qi Jing Zhou Song Chen Ling Wang Source Type: research
Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiang-Shan Tan Yanmin Yang Jingyang Wang Yimeng Wang Tingting Lv Yuyuan Shu Wei Xu Lingtao Chong Source Type: research
New mechanisms: From lactate to lactylation to rescue heart failure
Biosci Trends. 2024 Feb 8. doi: 10.5582/bst.2024.01000. Online ahead of print.ABSTRACTLactylation of α-myosin heavy chain (α-MHC) has recently been reported to preserve sarcomeric structure and function and attenuate the development of heart failure. Specifically, lactylation enhanced the interaction of α-MHC with the sarcomeric protein Titin, thereby maintaining normal sarcomeric structure and myocardial contractile function. Furthermore, the administration of lactate or inhibition of lactate efflux potentially treats heart failure by restoring lactylation of α-MHC and the interaction of α-MHC with Titin. This findin...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Linfeng Yi Dan Tang Xing Xiang Chungang Xiao Huifang Tang Hong Huang Source Type: research
Effect of transcatheter arterial chemoembolization combined with lenvatinib plus anti-PD-1 antibodies in patients with unresectable hepatocellular carcinoma: A treatment with Chinese characteristics
This article will contribute to a comprehensive understanding of the role of triple therapy with Chinese characteristics in patients with uHCC.PMID:38325823 | DOI:10.5582/bst.2023.01326 (Source: BioScience Trends)
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiayi Wu Junyi Wu Shuqun Li Mengchao Luo Zhenxin Zeng Yinan Li Yangkai Fu Han Li Deyi Liu Xiangye Ou Zhongtai Lin Shaoming Wei Maolin Yan Source Type: research
Roadmap for ending TB in China by 2035: The challenges and strategies
Biosci Trends. 2024 Feb 8. doi: 10.5582/bst.2023.01325. Online ahead of print.ABSTRACTTuberculosis (TB) is one of the top ten causes of death worldwide, taking the lives of over a million people annually. In addition to being a serious health issue, TB is also closely linked to eradicating poverty according to the Sustainable Development Goals (SDGs) of the United Nations (UN). All UN members have committed to ending the TB epidemic by 2030. China has one of the highest TB loads worldwide, ranking third in the world on many TB burden indices. The national strategy for TB control is aimed at creating a collaborative network...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Qishun Feng Guoliang Zhang Liang Chen Huizhong Wu Yingzhou Yang Qian Gao Tetsuya Asakawa Yanlin Zhao Shuihua Lu Lin Zhou Hongzhou Lu Source Type: research
Socioeconomic disparities in education placement for children of primary school age with autism spectrum disorder in China
This study describes four placements (regular schools, special schools, institutions, homes) and their influencing factors retrospectively in a large sample (n = 2,190) of Chinese primary school-aged children (6-12 years old). We divided ASD into severe and mild to moderate categories for analysis. Children with ASD were more likely to study in a regular school (48.60%), while 13.88% were in a special school. Children with severe ASD were placed in less regular settings than children with mild to moderate ASD. However, families with higher socioeconomic status (SES) were more likely to place their children in regular schoo...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Yanan Zhao Rong Zhang Xiaoying Zheng Source Type: research
Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiang-Shan Tan Yanmin Yang Jingyang Wang Yimeng Wang Tingting Lv Yuyuan Shu Wei Xu Lingtao Chong Source Type: research
New mechanisms: From lactate to lactylation to rescue heart failure
Biosci Trends. 2024 Feb 8. doi: 10.5582/bst.2024.01000. Online ahead of print.ABSTRACTLactylation of α-myosin heavy chain (α-MHC) has recently been reported to preserve sarcomeric structure and function and attenuate the development of heart failure. Specifically, lactylation enhanced the interaction of α-MHC with the sarcomeric protein Titin, thereby maintaining normal sarcomeric structure and myocardial contractile function. Furthermore, the administration of lactate or inhibition of lactate efflux potentially treats heart failure by restoring lactylation of α-MHC and the interaction of α-MHC with Titin. This findin...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Linfeng Yi Dan Tang Xing Xiang Chungang Xiao Huifang Tang Hong Huang Source Type: research
Effect of transcatheter arterial chemoembolization combined with lenvatinib plus anti-PD-1 antibodies in patients with unresectable hepatocellular carcinoma: A treatment with Chinese characteristics
This article will contribute to a comprehensive understanding of the role of triple therapy with Chinese characteristics in patients with uHCC.PMID:38325823 | DOI:10.5582/bst.2023.01326 (Source: BioScience Trends)
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiayi Wu Junyi Wu Shuqun Li Mengchao Luo Zhenxin Zeng Yinan Li Yangkai Fu Han Li Deyi Liu Xiangye Ou Zhongtai Lin Shaoming Wei Maolin Yan Source Type: research
Roadmap for ending TB in China by 2035: The challenges and strategies
Biosci Trends. 2024 Feb 8. doi: 10.5582/bst.2023.01325. Online ahead of print.ABSTRACTTuberculosis (TB) is one of the top ten causes of death worldwide, taking the lives of over a million people annually. In addition to being a serious health issue, TB is also closely linked to eradicating poverty according to the Sustainable Development Goals (SDGs) of the United Nations (UN). All UN members have committed to ending the TB epidemic by 2030. China has one of the highest TB loads worldwide, ranking third in the world on many TB burden indices. The national strategy for TB control is aimed at creating a collaborative network...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Qishun Feng Guoliang Zhang Liang Chen Huizhong Wu Yingzhou Yang Qian Gao Tetsuya Asakawa Yanlin Zhao Shuihua Lu Lin Zhou Hongzhou Lu Source Type: research
Socioeconomic disparities in education placement for children of primary school age with autism spectrum disorder in China
This study describes four placements (regular schools, special schools, institutions, homes) and their influencing factors retrospectively in a large sample (n = 2,190) of Chinese primary school-aged children (6-12 years old). We divided ASD into severe and mild to moderate categories for analysis. Children with ASD were more likely to study in a regular school (48.60%), while 13.88% were in a special school. Children with severe ASD were placed in less regular settings than children with mild to moderate ASD. However, families with higher socioeconomic status (SES) were more likely to place their children in regular schoo...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Yanan Zhao Rong Zhang Xiaoying Zheng Source Type: research
Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiang-Shan Tan Yanmin Yang Jingyang Wang Yimeng Wang Tingting Lv Yuyuan Shu Wei Xu Lingtao Chong Source Type: research
New mechanisms: From lactate to lactylation to rescue heart failure
Biosci Trends. 2024 Feb 8. doi: 10.5582/bst.2024.01000. Online ahead of print.ABSTRACTLactylation of α-myosin heavy chain (α-MHC) has recently been reported to preserve sarcomeric structure and function and attenuate the development of heart failure. Specifically, lactylation enhanced the interaction of α-MHC with the sarcomeric protein Titin, thereby maintaining normal sarcomeric structure and myocardial contractile function. Furthermore, the administration of lactate or inhibition of lactate efflux potentially treats heart failure by restoring lactylation of α-MHC and the interaction of α-MHC with Titin. This findin...
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Linfeng Yi Dan Tang Xing Xiang Chungang Xiao Huifang Tang Hong Huang Source Type: research
Effect of transcatheter arterial chemoembolization combined with lenvatinib plus anti-PD-1 antibodies in patients with unresectable hepatocellular carcinoma: A treatment with Chinese characteristics
This article will contribute to a comprehensive understanding of the role of triple therapy with Chinese characteristics in patients with uHCC.PMID:38325823 | DOI:10.5582/bst.2023.01326 (Source: BioScience Trends)
Source: BioScience Trends - February 7, 2024 Category: Biomedical Science Authors: Jiayi Wu Junyi Wu Shuqun Li Mengchao Luo Zhenxin Zeng Yinan Li Yangkai Fu Han Li Deyi Liu Xiangye Ou Zhongtai Lin Shaoming Wei Maolin Yan Source Type: research
