Differential effects of temporal regularity on auditory-evoked response amplitude: a decrease in silence and increase in noise
Conclusions:
Our results indicate that the human auditory system is able to involuntarily utilize temporal regularity in sound signals to modulate the neural activity in the auditory cortex in accordance with the surrounding acoustic environment. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - December 3, 2013 Category: Neurology Authors: Hidehiko OkamotoHenning TeismannSumru KeceliChristo PantevRyusuke Kakigi Source Type: research
Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats
This study investigates the effects of the mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on ethanol withdrawal induced anxiety using two behavioural paradigms. Male Wistar rats were fed a Modified Liquid Diet (MLD) containing low fat cow milk, sucrose, and maltodextrin with a gradual introduction of 2.4%, 4.8% and 7.2% ethanol for 20 days. Six hours into ethanol withdrawal, the rats were intraperitoneally injected with normal saline and MPEP (2.5, 5.0, 10, 20, 30 mg/kg) and were assessed for ethanol withdrawal induced anxiety-like syndrome using an automated elevated plus maze and an open field. MPEP at 10 m...
Source: Behavioral and Brain Functions - November 26, 2013 Category: Neurology Authors: Jaya KumarHermizi HapidinYvonne-Tee BeeZalina Ismail Source Type: research
Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure
Conclusions:
Decreased cerebral perfusion and greater WMH may contribute to sleep difficulties in HF. Future studies are needed to confirm these findings and clarify the effects of cerebral blood flow and WMH on sleep in healthy and patient samples. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 30, 2013 Category: Neurology Authors: Michael AloscoAdam BrickmanMary SpitznagelErica GriffithAtul NarkhedeRonald CohenLawrence SweetJoel HughesJim RosneckJohn Gunstad Source Type: research
A relationship between bruxism and orofacial-dystonia? A trigeminal electrophysiological approach in a case report of pineal cavernoma
Conclusions:
We found evidence of activation and peripheral sensitization of the nociceptive fibers, the primary and secondary nociceptive neurons in the central nervous system, and the endogenous pain control systems (including both the inhibitory and facilitatory processes), in the tested subject. These data suggest that bruxism and central orofacial pain can coexist, but are two independent symptoms, which may explain why numerous experimental and clinical studies fail to reach unequivocal conclusions. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 28, 2013 Category: Neurology Authors: Gianni FrisardiCesare IaniGianfranco SauFlavio FrisardiCarlo LeornadisAurea LumbauPaolo EnricoDonatella SircaEnrico StaderiniGiacomo Chessa Source Type: research
The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia
Conclusions:
Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the GM volumetric vulnerability of the orbital regions in the inferior frontal gyri. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 25, 2013 Category: Neurology Authors: Kazutaka OhiRyota HashimotoHidenaga YamamoriYuka YasudaMichiko FujimotoSatomi Umeda-YanoMasaki FukunagaYoshiyuki WatanabeMasao IwaseHiroaki KazuiMasatoshi Takeda Source Type: research
Differential sensitivity to the acute and sensitizing behavioral effects of methylphenidate as a function of strain in adolescent and young adult rats
Conclusions:
Our findings suggest that SHR rats are more vulnerable than other strains to methylphenidate-induced cross-sensitization to cocaine, at least when methylphenidate is administered in a non-home environment. Given that SHR rats are typically used to model features of attention deficit hyperactivity disorder, these findings may have important implications for the treatment of this disorder with methylphenidate. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 17, 2013 Category: Neurology Authors: Leora YetnikoffAndreas Arvanitogiannis Source Type: research
Adolescent social defeat decreases spatial working memory performance in adulthood
Conclusions:
The results demonstrate that severe social stressors during adolescence can produce long term deficits in aspects of cognitive function. Given the dependence of spatial working memory on prefrontal dopamine, pharmacologically reversing dopaminergic deficiencies caused by adolescent social stress has the potential to treat such cognitive deficits. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 17, 2013 Category: Neurology Authors: Andrew NovickLeah MiillerGina ForsterMichael Watt Source Type: research
Exposure to cues associated with palatable food reward results in a dopamine D2 receptor-dependent suppression of evoked synaptic responses in the entorhinal cortex
Conclusions:
Exposure to cues associated with palatable food results in a suppression of synaptic responses in olfactory inputs to the entorhinal cortex that is mediated in part by activation of dopamine D2 receptors. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 4, 2013 Category: Neurology Authors: Juliana HutterC Chapman Source Type: research
Astragalus injection protects cerebral ischemic injury by inhibiting neuronal apoptosis and the expression of JNK3 after cerebral ischemia reperfusion in rats
Conclusions:
It is suggested that astragalus injection could inhibit neuronal apoptosis, reduce infarct volume and improve neurobehavioral function by down-regulating the expression of JNK3 gene after cerebral ischemia reperfusion injury in rats. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 1, 2013 Category: Neurology Authors: Guangyi LiuJinming SongYunliang GuoTingting WangZhen Zhou Source Type: research
Slow angled-descent forepaw grasping (SLAG): an innate behavioral task for identification of individual experimental mice possessing functional vision
Conclusions:
We propose that the SLAG assay is immediately useful to quickly and clearly identify experimental mice possessing functional vision. SLAG is based on a behavioral readout with a significant innate component with no requirement for training. This will facilitate the selection of mice of known sighted status in vision-dependent experiments that focus on other types of behavior, neuroscience, and/or cognitive memory. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - August 23, 2013 Category: Neurology Authors: Macarena Gil-PagésRobert StilesChristopher ParksSteven NeierMaja RadulovicAlfredo OliverosAlejandro FerrerBrendan ReedKatelynn WiltonAdam Schrum Source Type: research
Functional Val66Met polymorphism of Brain-derived neurotrophic factor in type 2 diabetes with depression in Han Chinese subjects
Conclusions:
The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - August 22, 2013 Category: Neurology Authors: Jian-Xin ZhouHe-Chao LiXue-Jun BaiBao-Cheng ChangChun-Jun LiPei SunLi-Ming Chen Source Type: research
Objective assessment of drowsiness and reaction time during intermittent Ramadan fasting in young men: a case-crossover study
Background:
Ramadan fasting and its attendant lifestyle changes induce changes in the circadian rhythm and in associated physiological and metabolic functions. Previous studies that have assessed psychomotor performance during Ramadan fasting have reported conflicting results. Therefore, we designed this study to objectively assess the effects of intermittent fasting during and outside Ramadan (to control for lifestyle changes) on drowsiness, blink total duration and mean reaction time (MRT) test while controlling for potential confounders.
Methods:
Eight healthy volunteers with a mean age of 25.3 +/- 2.9 years and a mean ...
Source: Behavioral and Brain Functions - August 12, 2013 Category: Neurology Authors: Ahmed BaHammamSamar NashwanOmeima HammadMunir SharifSeithikurippu Pandi-Perumal Source Type: research
Voxel-level comparison of arterial spin-labeled perfusion magnetic resonance imaging in adolescents with internet gaming addiction
Conclusions:
In this study, we used ASL perfusion fMRI and noninvasively quantified resting CBF to demonstrate that IGA alters the CBF distribution in the adolescent brain. The results support the hypothesis that IGA is a behavioral addiction that may share similar neurobiological abnormalities with other addictive disorders. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - August 12, 2013 Category: Neurology Authors: Qi FengXue ChenJinhua SunYan ZhouYawen SunWeina DingYong ZhangZhiguo ZhuangJianrong XuYasong Du Source Type: research
Possible association between common variants of the phenylalanine hydroxylase (PAH) gene and memory performance in healthy adults
Conclusions:
Our findings suggest that common genetic variations in PAH are associated with verbal memory in healthy adults. Unknown functional polymorphisms in PAH or those in other genes nearby might affect memory performance. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - July 30, 2013 Category: Neurology Authors: Toshiya TeraishiDaimei SasayamaHiroaki HoriNoriko YamamotoTakashi FujiiJunko MatsuoAnna NagashimaYukiko KinoshitaKotaro HattoriMiho OtaSayaka FujiiHiroshi Kunugi Source Type: research
Pharmacotherapy response and regional cerebral blood flow characteristics in patients with obsessive-compulsive disorder
Conclusions:
The characteristics of increased rCBF in forebrain regions and decreased rCBF in posterior brain regions before treatment of OCD patients was a potentially predictor of treatment response to guide treatment options. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - July 30, 2013 Category: Neurology Authors: Sheng-lin WenMu-hua ChengMin-feng ChengJi-hui YueHong Wang Source Type: research
