Alteration in amyloid β42, phosphorylated tau protein, interleukin 6, and acetylcholine during diabetes-accelerated memory dysfunction in diabetic rats: correlation of amyloid β42 with changes in glucose metabolism
Conclusion:
Our longitudinal research model suggest that changes in the measured biomarkers appear before learning and memory impairments do. Aβ42 and ACh in the diabetes model group clearly changed from day 0 to day 45, and then P-tau and IL-6 varied significantly from day 45 to day 75. The reduced ACh levels observed possibly correlated with the factors common to changes in Aβ42, P-tau, and IL-6. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - August 14, 2015 Category: Neurology Authors: You ZhouYing ZhaoHailong XieYan WangLin LiuXinjia Yan Source Type: research
Zebrafish sexual behavior: role of sex steroid hormones and prostaglandins
Conclusions:
Exposure to sex hormones, but not prostaglandins altered mating behavior in zebrafish. The expression patterns of the studied genes indicate that there are large regional and gender-based differences in gene expression and that E2 treatment alter the gene expression pattern in all regions of the brain. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - August 13, 2015 Category: Neurology Authors: Ajay PradhanPer-Erik Olsson Source Type: research
Development of behavioral parameters and ERPs in a novel-target visual detection paradigm in children, adolescents and young adults
Conclusions:
The results reveal differences in the ERP indexes for the cognitive evaluation of the stimuli presented, depending on the age of the subjects. The ability of the target condition to induce the modulation of the studied components would depend on the posterior-anterior gradient of cortex maturation and on the gradient of maturation of the low to higher order association areas. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - July 4, 2015 Category: Neurology Authors: María Rojas-BenjumeaAna Sauqué-PoggioCatarina Barriga-PaulinoElena Rodríguez-MartínezCarlos Gómez Source Type: research
A 40-bp VNTR polymorphism in the 3′-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism
Background:
ADHD and alcoholism are psychiatric diseases with pathophysiology related to dopamine system. DAT1 belongs to the SLC6 family of transporters and is involved in the regulation of extracellular dopamine levels. A 40 bp variable number tandem repeat (VNTR) polymorphism in the 3′-untranslated region of DAT1/SLC6A3 gene was previously reported to be associated with various phenotypes involving disturbed regulation of dopaminergic neurotransmission.
Methods:
A total of 1312 subjects were included and genotyped for 40 bp VNTR polymorphism of DAT1/SLC6A3 gene in this study (441 alcoholics, 400 non-alcoholic controls...
Source: Behavioral and Brain Functions - June 11, 2015 Category: Neurology Authors: Omar ¿erýIvo PacltIvana DrtílkováPavel TheinerMarta Kope¿kováPetr ZvolskýVladimir Balcar Source Type: research
Evaluating cognitive and motivational accounts of greater reinforcement effects among children with attention-deficit/hyperactivity disorder
Conclusions:
Both baseline cognition and trait SR predict reinforcement effects on cognition, but only SR shares significant variance with diagnostic group. These results suggest that ADHD children’s greater response to reinforcement on cognition is strongly related to their heightened trait sensitivity to rewarding stimuli, consistent with motivational models of ADHD. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - April 29, 2015 Category: Neurology Authors: Whitney FoscoLarry HawkKeri RoschMichelle Bubnik Source Type: research
Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model
Conclusions:
These results provides support for anxiolytic activity of Urtica urens, in line with its medicinal traditional use, and may also suggest a better side-effect profile of Urtica urens relative to diazepam. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - April 24, 2015 Category: Neurology Authors: Zouhra DoukkaliKhalid TaghzoutiEL BouididaMohamed NadjmouddineYahya CherrahKatim Alaoui Source Type: research
The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats
Ischemic stroke is a major cause of death and disability all over the world. Ischemic stroke results from a temporary or permanent reduction of cerebral blood flow that leads to functional and structural damage in different brain regions. Despite decades of intense research, the beneficial treatment of stroke remains limited. In light of this, the search for effective means ameliorating cerebral ischemia-reperfusion injury (CIRI) is one of the major problems of experimental medicine and biology. Recently, the 5-Lipoxygenase (5-LO, a key enzyme metabolizing arachidonic acid to produce leukotrienes) inhibitors have been show...
Source: Behavioral and Brain Functions - April 18, 2015 Category: Neurology Authors: Guojuan LiangBin ShiWeinan LuoJunqing Yang Source Type: research
Neural correlates of positive and negative performance feedback in younger and older adults
Conclusions:
These results suggest that performance feedback serves as a reward in both younger and older adults. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - April 16, 2015 Category: Neurology Authors: Barbara DruekeLydia WeichertThomas ForkmannVerena MainzSiegfried GauggelMaren Boecker Source Type: research
Parent ratings of executive function in young preschool children with symptoms of attention-deficit/-hyperactivity disorder
Conclusions:
Early symptoms of ADHD were linked to parent-reported difficulties primarily within inhibition and working memory, suggesting that deficiencies within these two EF domains characterize early forms of ADHD. Our findings support the clinical utility of the BRIEF-P as a measure of EF in young preschool children with symptoms of ADHD. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - April 15, 2015 Category: Neurology Authors: Annette SkoganPål ZeinerJens EgelandAnne-Grethe UrnesTed Reichborn-KjennerudHeidi Aase Source Type: research
Neuronal representation of stand and squat in the primary motor cortex of monkeys
Conclusions/significanceThe present study examines the neuronal activity related to lower limb voluntary movements in M1 and find topographical information of various neurons tuned to different stages of the stand and squat task. This work may contribute to understanding the fundamental principles of neural control of lower limb movements. Especially, the topographical information suggests us where to implant the chronic microelectrode arrays to harvest the most quantity and highest quality neurons related to lower limb movements, which may accelerate to develop cortically controlled lower limb neuroprosthetics for spinal ...
Source: Behavioral and Brain Functions - April 9, 2015 Category: Neurology Authors: Chaolin MaXuan MaHang ZhangJiang XuJiping He Source Type: research
The roles of interoceptive sensitivity and metacognitive interoception in panic
Conclusion:
Our findings support the idea that hypervigilance to body symptoms is not necessarily a bottom-up dispositional tendency (where patients are hypersensitive about bodily signals), but rather a metacognitive process related to threatening beliefs about body/somatic sensations. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - April 8, 2015 Category: Neurology Authors: Adrián YorisSol EstevesBlas CoutoMargherita MelloniRafael KichicMarcelo CetkovichRoberto FavaloroJason MoserFacundo ManesAgustin IbanezLucas Sedeño Source Type: research
Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1–42) rat model of Alzheimer’s disease
This study was undertaken in order to evaluate the possible anxiolytic, antidepressant and antioxidant properties of the methanolic extract of Piper nigrum fruits in beta-amyloid (1–42) rat model of Alzheimer’s disease.
Methods:
The anxiolytic- and antidepressant-like effects of the methanolic extract were studied by means of in vivo (elevated plus-maze and forced swimming tests) approaches. Also, the antioxidant activity in the amygdala was assessed using superoxide dismutase, glutathione peroxidase and catalase specific activities, the total content of the reduced glutathione, protein carbonyl and malondialdehyde lev...
Source: Behavioral and Brain Functions - March 29, 2015 Category: Neurology Authors: Lucian HritcuJaurès NoumedemOana CioancaMonica HancianuPaula PostuMarius Mihasan Source Type: research
Erratum: Age-dependent decline in learning and memory performances of WAG/Rij rat model of absence epilepsy
No description available (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - March 28, 2015 Category: Neurology Authors: Ay¿e KarsonTijen UtkanFuat Balc¿Feyza Ar¿c¿o¿luNurbay Ate¿ Source Type: research
The possible link between elevated serum levels of epithelial cell-derived neutrophil- activating peptide-78 (ENA-78/CXCL5) and autoimmunity in autistic children
Background:
In autoimmune disorders, the underlying pathogenic mechanism is the formation of antigen-antibody complexes which trigger an inflammatory response by inducing the infiltration of neutrophils. Epithelial cell-derived neutrophil-activating peptide-78 (ENA-78) is a chemokine that recruits and activates neutrophils, thus it could play a pathogenic role in inflammation and autoimmune disorders. Some autistic children have elevated levels of brain specific auto-antibodies. We are the first to evaluate serum expression of ENA-78 and its relation to antineuronal auto-antibodies in autistic children.
Methods:
Serum ENA-...
Source: Behavioral and Brain Functions - March 19, 2015 Category: Neurology Authors: Gehan MostafaLaila AL-Ayadhi Source Type: research
Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats
Conclusions:
The present results suggest the retrieval of pain memory could be alleviated by the pre-treatment of EA, which is at least partially attributed to the down-regulated expression and combining capacity of p-CREB and the decreased expression of p-CREB in astrocytes and microglia cells. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - March 4, 2015 Category: Neurology Authors: Jing SunXiao-mei ShaoFang FangZui ShenYuan-yuan WuJian-qiao Fang Source Type: research
