Hippocampal neuronal cyclooxygenase-2 downstream signaling imbalance in a rat model of chronic aluminium gluconate administration
Conclusions:
The PGS/PGs/PG receptors signaling pathway in chronic aluminium gluconate-overloaded rat hippocampus is disturbed, which may be involved in the mechanism of aluminium neurotoxicity. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - February 18, 2015 Category: Neurology Authors: Hong WangMengliang YeLijuan YuJianfeng WangYuanxin GuoWenjuan LeiJunqing Yang Source Type: research
Neurochemical, structural and neurobehavioral evidence of neuronal protection by whey proteins in diabetic albino mice
Conclusion:
The results of this study show that dietary supplementation with WP reduced oxidative stress, protected CNS neurons and improved the neurobehavior of diabetic mice. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - February 13, 2015 Category: Neurology Authors: Jamaan AjaremAhmed AllamHossam EbaidSaleh MaodaaSanad AL-SobeaiAhmed RadyAli MetwalliNaif AltoomKhaled IbrahimMohammad Sabri Source Type: research
Tat-induced histopathological alterations mediate hippocampus-associated behavioural impairments in rats
Conclusion:
This study highlights the relationship between hippocampal-associated behavioural changes and histologic alterations following stereotaxic intra-hippocampal administration of Tat protein in rats. The implications of this study may positively impact the fields of immunology and neuroscience by encouraging future researchers to consider novel strategies to understand the complexities of the pathogenesis of HIV-associated neurocognitive disorder. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - February 7, 2015 Category: Neurology Authors: Rivona HarricharanVeneesha ThaverVivienne RussellWilliam Daniels Source Type: research
Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: relation to gastrointestinal manifestations
This study was the first to investigate plasma levels of PUFAs and serum carnitine in relation to GI manifestations in autistic children.
Methods:
Plasma levels of PUFAs (including linoleic, alphalinolenic, arachidonic ?AA? and docosahexaenoic ?DHA? acids) and serum carnitine were measured in 100 autistic children and 100 healthy-matched children.
Results:
Reduced levels of serum carnitine and plasma DHA, AA, linolenic and linoleic acids were found in 66%, 62%, 60%, 43% and 38%, respectively of autistic children. On the other hand, 54% of autistic patients had elevated ?6/?3 ratio. Autistic patients with GI manifestations ...
Source: Behavioral and Brain Functions - February 7, 2015 Category: Neurology Authors: Gehan MostafaLaila AL-Ayadhi Source Type: research
Neuregulin1ß improves cognitive dysfunction and up-regulates expression of p-ERK1/2 in rats with chronic omethoate poisoning
ObjectiveTo observe the effects of neuregulin1? (NRG1?) on the level of phosphorylated ERK1/2 (p-ERK1/2), and explore the therapeutic mechanism of NRG1? on the cognitive dysfunction in rats with chronic omethoate poisoning.
Methods:
Rats with strong learning and memory ability, 50 in total, were selected by Y-electric maze test. Among which, 15 rats were randomly selected into control group, and the rest 35 rats were used to establish experimental cognitive impairment models by being injected with omethoate subcutaneously. The 30 cases of successful cognitive impairment models were randomly divided into model group and tre...
Source: Behavioral and Brain Functions - February 7, 2015 Category: Neurology Authors: Lixia RongKun DingMeizeng ZhangYunliang Guo Source Type: research
Beraprost sodium protects against chronic brain injury in aluminum-overload rats
Conclusions:
BPS has a significant neuroprotective effect on chronic brain injury induced by aluminum overload in rats. Remodeling the balance of PGIS/IP signaling pathway and inhibition of oxidative stress involve in the neuroprotective mechanism of BPS in aluminum-overload rats. The PGIS/IP signaling pathway is a potential therapeutic strategy for chronic brain injury patients. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - February 7, 2015 Category: Neurology Authors: Yongquan PanLijuan YuWenjuan LeiYuanxin GuoJianfeng WangHuarong YuYong TangJunqing Yang Source Type: research
Patterns of linguistic and numerical performance in aphasia
Background:
Empirical research on the relationship between linguistic and numerical processing revealed inconsistent results for different levels of cognitive processing (e.g., lexical, semantic) as well as different stimulus materials (e.g., Arabic digits, number words, letters, non-number words). Information of dissociation patterns in aphasic patients was used in order to investigate the dissociability of linguistic and numerical processes. The aim of the present prospective study was a comprehensive, specific, and systematic investigation of relationships between linguistic and numerical processing, considering the imp...
Source: Behavioral and Brain Functions - February 4, 2015 Category: Neurology Authors: Dajana RathFrank DomahsKatharina DresselDolores Claros-SalinasElise KleinKlaus WillmesHelga Krinzinger Source Type: research
Decoding the processing of lying using functional connectivity MRI
Conclusions:
The current study may shed new light on the neural pattern of deception from a functional integration viewpoint. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - January 17, 2015 Category: Neurology Authors: Weixiong JiangHuasheng LiuLingli ZengJian LiaoHui ShenAijing LuoDewen HuWei Wang Source Type: research
Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice
Conclusion:
These results suggest that causal attribution of the discrepancy in behavioral variance phenotypes to the Disc1 L100P mutant mouse line existing among different research groups needs to be cautiously investigated in further study by taking into account the effect(s) of other ENU-induced mutations and/or SNPs from DBA/2 J. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - December 8, 2014 Category: Neurology Authors: Yosefu ArimeRyutaro FukumuraIkuo MiuraKazuyuki MekadaAtsushi YoshikiShigeharu WakanaYoichi GondoKazufumi Akiyama Source Type: research
Post-adolescent developmental changes in cortical complexity
Conclusions:
During post-adolescence there are common changes in cortical complexity in the same regions for both genders, but there are also gender specific changes in some cortical areas. The sex differences from different cortical measurements (FD, GM volume and surface-area of cortical ribbon) could suggest a maturation delay in specific brain regions for each gender in relation to the other and might be explained through the functional role of the corresponding regions reflected in gender difference of developed abilities. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - November 27, 2014 Category: Neurology Authors: Anca-Larisa SanduEdouard IzardKarsten SpechtHarald BeneventiArvid LundervoldMartin Ystad Source Type: research
The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
Conclusions:
Our results provide evidence of an interaction between the BDNF met allele and early parenting on the development of depression/anxiety symptoms. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - November 25, 2014 Category: Neurology Authors: Subin ParkBung-Nyun KimJae-Won KimYeon-Kyung JungJin LeeMin-Sup ShinHee YooSoo-Churl Cho Source Type: research
Time course change of COX2-PGI2/TXA2 following global cerebral ischemia reperfusion injury in rat hippocampus
Conclusions: I/R injury significantly increased the COX2 expression, PGI2 and TXA2 levels, and the PGI2/TXA2 ratio in rat hippocampus in a time-dependent manner. As a consequence, the increased PGI2 level and PGI2/TXA2 ratio may represent a physiological mechanism to protect the brain against the neuronal damage produced by I/R injury. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - November 11, 2014 Category: Neurology Authors: Lijuan YuBin YangJia WangLei ZhaoWeinan LuoQingsong JiangJunqing Yang Source Type: research
A matter of timing: harm reduction in learned helplessness
Conclusions:
The refined analysis allows abbreviation of the test for learned helplessness from 15 trials to 10 trials thereby reducing pain and stress of the experimental animals without losing statistical power. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - November 3, 2014 Category: Neurology Authors: Sophie RichterAlexander SartoriusPeter GassBarbara Vollmayr Source Type: research
Assessment of in vivo microstructure alterations in gray matter using DKI in internet gaming addiction
Background:
The aim of the current study was to investigate the utility of diffusional kurtosis imaging (DKI) in the detection of gray matter (GM) alterations in people suffering from Internet Gaming Addiction (IGA).
Methods:
DKI was applied to 18 subjects with IGA and to 21 healthy controls (HC). Whole-brain voxel-based analyses were performed with the following derived parameters: mean kurtosis metrics (MK), radial kurtosis (K[up tack]), and axial kurtosis (K//). A significance threshold was set at P (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 24, 2014 Category: Neurology Authors: Yawen SunJinhua SunYan ZhouWeina DingXue ChenZhiguo ZhuangJianrong XuYasong Du Source Type: research
Colour vision in ADHD: Part 1 - Testing the retinal dopaminergic hypothesis
Conclusion:
Poorer discrimination of red as well as blue color saturation in the female ADHD group may be partly attributable to a hypo-dopaminergic state in the retina, given that color perception (blue-yellow and red-green) is based on input from S-cones (short wavelength cone system) early in the visual pathway. The origin of female superiority in red perception may be rooted in sex-specific functional specialization in hunter-gather societies. The absence of this sexual dimorphism for red colour perception in ADHD females warrants further investigation. (Source: Behavioral and Brain Functions)
Source: Behavioral and Brain Functions - October 24, 2014 Category: Neurology Authors: Soyeon KimMohamed Al-HajSamantha ChenStuart FullerUmesh JainMarisa CarrascoRosemary Tannock Source Type: research
