Arteriosclerosis, Thrombosis and Vascular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

PAR4 Antagonism in Patients With Coronary Artery Disease Receiving Antiplatelet Therapies
CONCLUSIONS: PAR4 antagonism has additive antithrombotic effects when used in addition to ticagrelor, aspirin, or their combination, in patients with stable coronary heart disease.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05093790.PMID:38357820 | DOI:10.1161/ATVBAHA.123.320448 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Jennifer Nash Mohammed N Meah Beth Whittington Samuel Debono Jennifer Raftis Mark R Miller Andrew Sorbie Nicholas L Mills Josselin Nespoux Lorraine Bruce Rodger Duffin Neeraj Dhaun Mairi Brittan Longfei Chao Samira Merali Minji Kim Zhaoqing Wang Yue Zhang Source Type: research

Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease
CONCLUSIONS: Collectively, this study provides a comprehensive understanding of the roles of various immune cells and inflammatory cytokine storms in the development of CALs in KD and offers a valuable resource for identifying novel therapeutic targets for patients with KD with CALs.PMID:38357816 | DOI:10.1161/ATVBAHA.123.320188 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Yeshi Chen Minna Yang Mingming Zhang Hongmao Wang Yang Zheng Rui Sun Xiaohui Li Source Type: research

Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis
CONCLUSIONS: Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.PMID:38357817 | DOI:10.1161/ATVBAHA.123.320001 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Lucien G J Cayer Arun Surendran Tobias Karakach Harold M Aukema Amir Ravandi Source Type: research

Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Arterioscler Thromb Vasc Biol. 2024 Feb 15. doi: 10.1161/ATVBAHA.124.320708. Online ahead of print.NO ABSTRACTPMID:38357818 | DOI:10.1161/ATVBAHA.124.320708 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Adrien Lupieri Livia S A Passos Robert A Levine Victor Nizet Elena Aikawa Source Type: research

Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research

Angiogenesis in Chronic Thromboembolic Pulmonary Hypertension: A Janus-Faced Player?
Arterioscler Thromb Vasc Biol. 2024 Feb 8. doi: 10.1161/ATVBAHA.123.319852. Online ahead of print.ABSTRACTChronic thromboembolic pulmonary hypertension (CTEPH) is a rare form of pulmonary hypertension characterized by the presence of organized thrombi that obstruct pulmonary arteries, ultimately leading to right heart failure and death. Among others, impaired angiogenesis and inflammatory thrombosis have been shown to contribute to the progression of CTEPH. In this review, we summarize the 2-faced nature of angiogenesis in both thrombus formation and resolution in the context of CTEPH and highlight the dual role of angioge...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 8, 2024 Category: Cardiology Authors: Lynn Willems Kondababu Kurakula Janne Verhaegen Frederikus A Klok Marion Delcroix Marie-Jos é Goumans Rozenn Quarck Source Type: research

Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations
CONCLUSIONS: Our results unravel the SMC proteome signature associated with vascular disorders, which may help identify potential therapeutic targets to accelerate the pathway to translation.PMID:38328934 | DOI:10.1161/ATVBAHA.123.320274 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 8, 2024 Category: Cardiology Authors: R édouane Aherrahrou Ferheen Baig Konstantinos Theofilatos Dillon Lue Alicia Beele Tiit Örd Minna U Kaikkonen Zouhair Aherrahrou Qi Cheng Saikat Ghosh Santosh Karnewar Vaishnavi Karnewar Aloke Finn Gary K Owens Michael Joner Manuel Mayr Mete Civelek Source Type: research

Predicting Lipid-Rich Plaque Progression in Coronary Arteries Using Multimodal Imaging and Wall Shear Stress Signatures
CONCLUSIONS: Luminal exposure to high TSVI, solely or combined with a lipid-rich plaque phenotype, is associated with enhanced plaque progression at 1-year follow-up. Where plaque progression occurred, low TAWSS was also observed. These findings suggest TSVI, in addition to low TAWSS, as a potential biomechanical predictor for plaque progression, showing promise for clinical translation to improve patient prognosis.PMID:38328935 | DOI:10.1161/ATVBAHA.123.320337 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 8, 2024 Category: Cardiology Authors: Giuseppe De Nisco Eline M J Hartman Elena Torta Joost Daemen Claudio Chiastra Diego Gallo Umberto Morbiducci Jolanda J Wentzel Source Type: research

Plasma S1P Orchestrates the Reverse Transendothelial Migration of Aortic Intimal Myeloid Cells in Mice
CONCLUSIONS: Functional and expression studies support a novel role for S1P signaling in the regulation of lipopolysaccharide-induced RTM and the homeostatic maintenance of aortic intimal MCs. Our data provide insight into how circulating plasma mediators help orchestrate intimal MC dynamics.PMID:38328936 | DOI:10.1161/ATVBAHA.123.320227 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 8, 2024 Category: Cardiology Authors: Chanele K Polenz Corey A Scipione Sharon J Hyduk Marwan G Althagafi Hisham M Ibrahim Myron I Cybulsky Source Type: research

p53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice
CONCLUSIONS: Our data reveal the importance of p53 acetylation in coronary microvascular function, cardiac function, and remodeling and may provide a promising approach to improve hypertension-induced CMD and to prevent the transition of cardiac hypertrophy to HF.PMID:38328937 | DOI:10.1161/ATVBAHA.123.319601 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 8, 2024 Category: Cardiology Authors: Xiaochen He Aubrey C Cantrell Quinesha A Williams Wei Gu Yingjie Chen Jian-Xiong Chen Heng Zeng Source Type: research

In Utero and Early-Childhood Exposure to the Great Chinese Famine and Adult Arterial Stiffness: A Cross-Sectional Study
Arterioscler Thromb Vasc Biol. 2024 Feb 1. doi: 10.1161/ATVBAHA.124.320666. Online ahead of print.NO ABSTRACTPMID:38299354 | DOI:10.1161/ATVBAHA.124.320666 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2024 Category: Cardiology Authors: Shouling Wu Xiujuan Zhao Lu Li Xu Han Qian Liu Shuohua Chen Hemei Geng Hannah VanEvery Xinyuan Zhang Source Type: research

Neutrophils and Neutrophil Extracellular Traps Cause Vascular Occlusion and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice
CONCLUSIONS: After SAH, skull-derived neutrophils are primed for NETosis, and there are persistent brain iNETs, which correlated with delayed deficits. The findings from this study suggest that, after SAH, neutrophils and NETosis are therapeutic targets, which can prevent vascular occlusion by NETs in the brain, thereby lessening the risk of DCI. Finally, NET markers may be biomarkers, which can predict which patients with aneurysmal SAH are at risk for developing DCI.PMID:38299355 | DOI:10.1161/ATVBAHA.123.320224 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2024 Category: Cardiology Authors: Hussein A Zeineddine Sung-Ha Hong Pedram Peesh Ari Dienel Kiara Torres Peeyush Thankamani Pandit Kanako Matsumura Shuning Huang Wen Li Anjali Chauhan John Hagan Sean P Marrelli Louise D McCullough Spiros L Blackburn Jaroslaw Aronowski Devin W McBride Source Type: research

Regulation of YAP Promotor Accessibility in Endothelial Mechanotransduction
CONCLUSIONS: Our findings reveal a role for AmotL2 and nuclear-cytoskeletal force transmission in modulating the epigenetic and transcriptional regulation of YAP to maintain a mechano-enforced positive feedback loop of vascular homeostasis. These findings may offer an explanation as to the proinflammatory phenotype that leads to aneurysm formation observed in AmotL2 endothelial deletion models.PMID:38299356 | DOI:10.1161/ATVBAHA.123.320300 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2024 Category: Cardiology Authors: Aarren J Mannion Honglei Zhao Yuanyuan Zhang Ylva von Wright Otto Bergman Joy Roy Pipsa Saharinen Lars Holmgren Source Type: research

Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation
CONCLUSIONS: An altered phospholipid metabolism occurs in atherosclerosis, affecting both the aorta and the adjacent heart tissue. Plaque-progression lipids lysophosphatidylcholine(18:0) and lysophosphatidic acid(18:1), as identified by MS imaging on tissue, reflect cardiovascular risk in human plasma.PMID:38299357 | DOI:10.1161/ATVBAHA.123.320278 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2024 Category: Cardiology Authors: Jianhua Cao Marta Martin-Lorenzo Kim van Kuijk Elias Wieland Marion J Gijbels Britt S R Claes Angeles Heredero Gonzalo Aldamiz-Echevarria Ron M A Heeren Pieter Goossens Judith Sluimer Benjamin Balluff Gloria Alvarez-Llamas Source Type: research