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< em > ANGPTL3 < /em > Downregulation Increases Intracellular Lipids by Reducing Energy Utilization
CONCLUSIONS: In conclusion, intracellular ANGPTL3 downregulation by silencing RNA led to an increase in triglycerides content due to a reduction in energy substrate utilization resembling a primary intracellular hepatocyte hypothyroidism.PMID:38385290 | DOI:10.1161/ATVBAHA.123.319789 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Grazia Pennisi Samantha Maurotti Ester Ciociola Oveis Jamialahmadi Giorgio Bertolazzi Angela Mirarchi Per-Olof Bergh Francesca Scionti Rosellina M Mancina Rocco Spagnuolo Claudio Tripodo Jan Boren Salvatore Petta Stefano Romeo Source Type: research

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
CONCLUSIONS: Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. These findings facilitate both the mapping of cardiovascular disease susceptibility loci to specific cell types and the identification of novel molecular and cellular therapeutic targets for the treatment of the disease.PMID:38385291 | DOI:10.1161/ATVBAHA.123.320524 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Alexander C Bashore Hanying Yan Chenyi Xue Lucie Y Zhu Eunyoung Kim Thomas Mawson Johana Coronel Allen Chung Nadja Sachs Sebastian Ho Leila S Ross Michael Kissner Emmanuelle Passegu é Robert C Bauer Lars Maegdefessel Mingyao Li Muredach P Reilly Source Type: research

Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution
CONCLUSIONS: Inhibition of P-selectin-dependent activation of monocytes and neutrophils accelerates venous thrombosis resolution due to reduced infiltration and activation of innate immune cells at the site of thrombus formation, which prevents early thrombus stabilization and facilitates fibrinolysis.PMID:38385292 | DOI:10.1161/ATVBAHA.123.320016 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Julia B Kral-Pointner Patrick Haider Petra L Szabo Manuel Salzmann Mira Brekalo Karl H Schneider Waltraud C Schrottmaier Christoph Kaun Sonja Bleichert Attila Kiss Romana Sickha Christian Hengstenberg Kurt Huber Christine Brostjan Helga Bergmeister Alice Source Type: research

Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease
Arterioscler Thromb Vasc Biol. 2024 Feb 22. doi: 10.1161/ATVBAHA.123.318339. Online ahead of print.ABSTRACTAirway epithelial cells play an indispensable role in protecting the lung from inhaled pathogens and allergens by releasing an array of mediators that orchestrate inflammatory and immune responses when confronted with harmful environmental triggers. While this process is undoubtedly important for containing the effects of various harmful insults, dysregulation of the inflammatory response can cause lung diseases including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. A key cellular mechanism t...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Amit Jairaman Murali Prakriya Source Type: research

TF-FVIIa PAR2- β-Arrestin in Mouse Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection
CONCLUSIONS: These data provide insights into a TF-FVIIa signaling axis through PAR2-β-arrestin coupling that is a regulator of inflammation-triggered tissue repair and hemodynamic compromise in coxsackievirus B3 infection and can potentially be targeted with selective coagulation inhibitors.PMID:38385286 | DOI:10.1161/ATVBAHA.123.320157 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Meike Kespohl Carl Christoph Goetzke Nadine Althof Clara Bredow Nicolas Kelm Sandra Pinkert Thomas Bukur Valesca Bukur Kristin Grunz Dilraj Kaur Arnd Heuser Michael M ülleder Martina Sauter Karin Klingel Hartmut Weiler Nikolaus Berndt Matthias M Gaida Wo Source Type: research

Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy
Arterioscler Thromb Vasc Biol. 2024 Feb 22. doi: 10.1161/ATVBAHA.123.319220. Online ahead of print.ABSTRACTHypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications before achieving blood pressure control. Genomic advances offer mechanistic understanding of blood pressure variability, therapeutic targets, therapeutic response, and promise a stratified approach to treatment of primary hypertension. Cyclic guanosine monophosphate augmentation, aldosterone synthase ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Emma F Magavern Vikas Kapil Manish Saxena Ajay Gupta Mark J Caulfield Source Type: research

Differences in Cardiometabolic Proteins in Pregnancy Prioritize Relevant Targets of Preeclampsia
CONCLUSIONS: These results demonstrate the value of performing targeted proteomics using a panel of cardiovascular biomarkers to identify biomarkers relevant to preeclampsia pathophysiology and highlight the need for larger multiomic studies to define modifiable pathways of surveillance and intervention upstream to preeclampsia diagnosis.PMID:38385288 | DOI:10.1161/ATVBAHA.124.320737 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Kathryn J Lindley Andrew Perry Marni Jacobs Lauren Petty Kaushik Amancherla Shilin Zhao Claire Barker Victor G Davila-Roman Sadiya S Khan Sarah S Osmundson Kahraman Tanriverdi Jane E Freedman Jennifer Below Ravi V Shah Louise C Laurent Source Type: research

Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease
CONCLUSIONS: Our results characterize the electrophysiological abnormalities associated with L casei cell wall extract-induced KD and show that IL-1Ra is more effective in preventing KD-induced myocardial dysfunction and arrhythmias than anti-TNFα therapy. These findings support the advancement of clinical trials using IL-1Ra in patients with KD.PMID:38385289 | DOI:10.1161/ATVBAHA.123.320382 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Thassio Mesquita Yen-Nien Lin Shuang Chen Youngho Lee Rodrigo Miguel-Dos-Santos Asli E Atici Michael C Fishbein Magali Noval Rivas Moshe Arditi Eugenio Cingolani Source Type: research