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Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):763-767. doi: 10.1161/ATVBAHA.123.319563. Epub 2024 Mar 27.ABSTRACT PMID:38536897 | PMC:PMC10977651 | DOI:10.1161/ATVBAHA.123.319563 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 27, 2024 Category: Cardiology Authors: Elena Aikawa Mark C Blaser Sasha A Singh Robert A Levine Magdi H Yacoub Source Type: research

Clonal Hematopoiesis: The Emergent CVD Risk Factor
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):768-771. doi: 10.1161/ATVBAHA.123.319562. Epub 2024 Mar 27.NO ABSTRACTPMID:38536898 | PMC:PMC10977652 | DOI:10.1161/ATVBAHA.123.319562 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 27, 2024 Category: Cardiology Authors: Jesse D Cochran Kenneth Walsh Source Type: research

Multi-Omics and Single-Cell Omics: New Tools in Drug Target Discovery
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):759-762. doi: 10.1161/ATVBAHA.124.320686. Epub 2024 Mar 27.NO ABSTRACTPMID:38536899 | PMC:PMC10977648 | DOI:10.1161/ATVBAHA.124.320686 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 27, 2024 Category: Cardiology Authors: Joseph Loscalzo Source Type: research

Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):763-767. doi: 10.1161/ATVBAHA.123.319563. Epub 2024 Mar 27.NO ABSTRACTPMID:38536897 | DOI:10.1161/ATVBAHA.123.319563 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 27, 2024 Category: Cardiology Authors: Elena Aikawa Mark C Blaser Sasha A Singh Robert A Levine Magdi H Yacoub Source Type: research

Clonal Hematopoiesis: The Emergent CVD Risk Factor
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):768-771. doi: 10.1161/ATVBAHA.123.319562. Epub 2024 Mar 27.NO ABSTRACTPMID:38536898 | DOI:10.1161/ATVBAHA.123.319562 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 27, 2024 Category: Cardiology Authors: Jesse D Cochran Kenneth Walsh Source Type: research

Multi-Omics and Single-Cell Omics: New Tools in Drug Target Discovery
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):759-762. doi: 10.1161/ATVBAHA.124.320686. Epub 2024 Mar 27.NO ABSTRACTPMID:38536899 | DOI:10.1161/ATVBAHA.124.320686 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 27, 2024 Category: Cardiology Authors: Joseph Loscalzo Source Type: research

Role of Colchicine in Cardiovascular Disease Management
Arterioscler Thromb Vasc Biol. 2024 Mar 21. doi: 10.1161/ATVBAHA.124.319851. Online ahead of print.ABSTRACTColchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in extremely high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can even add to secondary prevention of major adverse cardiovascular events. As...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Leo F Buckley Peter Libby Source Type: research

Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis in Mice
CONCLUSIONS: Our study provides a novel mechanism with which GLP-1(32-36) acts in modulating metabolic reprogramming toward glycolytic flux in partnership with GLP-1R for improved angiogenesis in high glucose-exposed EPCs and T1DM murine models. We propose that GLP-1(32-36) could be used as a monotherapy or add-on therapy with existing treatments for peripheral artery disease.REGISTRATION: URL: www.ebi.ac.uk/metabolights/; Unique identifier: MTBLS9543.PMID:38511325 | DOI:10.1161/ATVBAHA.124.320714 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Yikai Zhang Shengyao Wang Qiao Zhou Yi Xie Yepeng Hu Weihuan Fang Changxin Yang Zhe Wang Shu Ye Xinyi Wang Chao Zheng Source Type: research

Remnant Cholesterol, Not LDL Cholesterol, Explains Peripheral Artery Disease Risk Conferred by apoB: A Cohort Study
CONCLUSIONS: PAD risk conferred by elevated apoB-containing lipoproteins was explained mainly by elevated remnants, while myocardial infarction risk was explained by both elevated remnants and LDL.PMID:38511326 | DOI:10.1161/ATVBAHA.123.320175 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Benjamin N Wadstr öm Kasper M Pedersen Anders B Wulff B ørge G Nordestgaard Source Type: research

Virus-Associated CD8 < sup > + < /sup > T-Cells Are Not Activated Through Antigen-Mediated Interaction Inside Atherosclerotic Lesions
CONCLUSIONS: This study suggests that virus-specific CD8+ T-cells are tissue enriched in atherosclerotic lesions; however, their potential contribution to inflammation may involve antigen-independent mechanisms.PMID:38511327 | DOI:10.1161/ATVBAHA.123.320539 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Maaike J M de Jong Frank H Schaftenaar Marie A C Depuydt Fernando Lozano Vigario George M C Janssen Judith A H M Peeters Lauren Goncalves Anouk Wezel Harm J Smeets Johan Kuiper Ilze Bot Peter van Veelen Bram Sl ütter Source Type: research

Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19
CONCLUSIONS: Taken together, these observations further elucidate the pathological mechanisms that underlie immune dysfunction and coagulation abnormalities in COVID-19, contributing to our growing understanding of SARS-CoV-2 infections that could also be leveraged to develop novel diagnostic and therapeutic strategies.PMID:38511328 | DOI:10.1161/ATVBAHA.122.318721 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Sascha N Goonewardena Qinzhong Chen Ashley M Tate Olga G Grushko Dilna Damodaran Pennelope Blakely Salim S Hayek David J Pinsky Robert S Rosenson Source Type: research

Role of Colchicine in Cardiovascular Disease Management
Arterioscler Thromb Vasc Biol. 2024 Mar 21. doi: 10.1161/ATVBAHA.124.319851. Online ahead of print.ABSTRACTColchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in extremely high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can even add to secondary prevention of major adverse cardiovascular events. As...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Leo F Buckley Peter Libby Source Type: research

Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis in Mice
CONCLUSIONS: Our study provides a novel mechanism with which GLP-1(32-36) acts in modulating metabolic reprogramming toward glycolytic flux in partnership with GLP-1R for improved angiogenesis in high glucose-exposed EPCs and T1DM murine models. We propose that GLP-1(32-36) could be used as a monotherapy or add-on therapy with existing treatments for peripheral artery disease.REGISTRATION: URL: www.ebi.ac.uk/metabolights/; Unique identifier: MTBLS9543.PMID:38511325 | DOI:10.1161/ATVBAHA.124.320714 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Yikai Zhang Shengyao Wang Qiao Zhou Yi Xie Yepeng Hu Weihuan Fang Changxin Yang Zhe Wang Shu Ye Xinyi Wang Chao Zheng Source Type: research

Remnant Cholesterol, Not LDL Cholesterol, Explains Peripheral Artery Disease Risk Conferred by apoB: A Cohort Study
CONCLUSIONS: PAD risk conferred by elevated apoB-containing lipoproteins was explained mainly by elevated remnants, while myocardial infarction risk was explained by both elevated remnants and LDL.PMID:38511326 | DOI:10.1161/ATVBAHA.123.320175 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Benjamin N Wadstr öm Kasper M Pedersen Anders B Wulff B ørge G Nordestgaard Source Type: research

Virus-Associated CD8 < sup > + < /sup > T-Cells Are Not Activated Through Antigen-Mediated Interaction Inside Atherosclerotic Lesions
CONCLUSIONS: This study suggests that virus-specific CD8+ T-cells are tissue enriched in atherosclerotic lesions; however, their potential contribution to inflammation may involve antigen-independent mechanisms.PMID:38511327 | DOI:10.1161/ATVBAHA.123.320539 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Maaike J M de Jong Frank H Schaftenaar Marie A C Depuydt Fernando Lozano Vigario George M C Janssen Judith A H M Peeters Lauren Goncalves Anouk Wezel Harm J Smeets Johan Kuiper Ilze Bot Peter van Veelen Bram Sl ütter Source Type: research