New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Arch Pharm Res. 2024 Feb;47(2):127-145. doi: 10.1007/s12272-024-01485-2. Epub 2024 Jan 24.ABSTRACTInsulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated. The therapeut...
Source: Archives of Pharmacal Research - January 24, 2024 Category: Drugs & Pharmacology Authors: Defeng Li Jinling Fan Lin Du Guoyan Ren Source Type: research
