Potential biological functions and future perspectives of sialylated milk oligosaccharides
Arch Pharm Res. 2024 Apr 1. doi: 10.1007/s12272-024-01492-3. Online ahead of print.ABSTRACTSialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety assessment of 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) revealed low toxicity in various animal models and human participants. SLs constitute a unique milk component, highlighting the essential nutrients and bioactive components crucial for infant development, along with numerous associated health benefits for various diseases. This review explores the safety, biosynthesis, and po...
Source: Archives of Pharmacal Research - April 1, 2024 Category: Drugs & Pharmacology Authors: Thuy Le Lam Nguyen Dung Van Nguyen Kyung-Sun Heo Source Type: research
Potential biological functions and future perspectives of sialylated milk oligosaccharides
Arch Pharm Res. 2024 Apr 1. doi: 10.1007/s12272-024-01492-3. Online ahead of print.ABSTRACTSialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety assessment of 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) revealed low toxicity in various animal models and human participants. SLs constitute a unique milk component, highlighting the essential nutrients and bioactive components crucial for infant development, along with numerous associated health benefits for various diseases. This review explores the safety, biosynthesis, and po...
Source: Archives of Pharmacal Research - April 1, 2024 Category: Drugs & Pharmacology Authors: Thuy Le Lam Nguyen Dung Van Nguyen Kyung-Sun Heo Source Type: research
Potential biological functions and future perspectives of sialylated milk oligosaccharides
Arch Pharm Res. 2024 Apr 1. doi: 10.1007/s12272-024-01492-3. Online ahead of print.ABSTRACTSialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety assessment of 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) revealed low toxicity in various animal models and human participants. SLs constitute a unique milk component, highlighting the essential nutrients and bioactive components crucial for infant development, along with numerous associated health benefits for various diseases. This review explores the safety, biosynthesis, and po...
Source: Archives of Pharmacal Research - April 1, 2024 Category: Drugs & Pharmacology Authors: Thuy Le Lam Nguyen Dung Van Nguyen Kyung-Sun Heo Source Type: research
Potential biological functions and future perspectives of sialylated milk oligosaccharides
Arch Pharm Res. 2024 Apr 1. doi: 10.1007/s12272-024-01492-3. Online ahead of print.ABSTRACTSialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety assessment of 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) revealed low toxicity in various animal models and human participants. SLs constitute a unique milk component, highlighting the essential nutrients and bioactive components crucial for infant development, along with numerous associated health benefits for various diseases. This review explores the safety, biosynthesis, and po...
Source: Archives of Pharmacal Research - April 1, 2024 Category: Drugs & Pharmacology Authors: Thuy Le Lam Nguyen Dung Van Nguyen Kyung-Sun Heo Source Type: research
Potential biological functions and future perspectives of sialylated milk oligosaccharides
Arch Pharm Res. 2024 Apr 1. doi: 10.1007/s12272-024-01492-3. Online ahead of print.ABSTRACTSialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety assessment of 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) revealed low toxicity in various animal models and human participants. SLs constitute a unique milk component, highlighting the essential nutrients and bioactive components crucial for infant development, along with numerous associated health benefits for various diseases. This review explores the safety, biosynthesis, and po...
Source: Archives of Pharmacal Research - April 1, 2024 Category: Drugs & Pharmacology Authors: Thuy Le Lam Nguyen Dung Van Nguyen Kyung-Sun Heo Source Type: research
The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents
We examined the abuse potential of 25E-NBOMe using the conditioned place preference in male mice and self-administration paradigms in male rats. Additionally, immunoblot assay, enzyme-linked immunosorbent assay, and microdialysis were used to determine the molecular effects of 25E-NBOMe in the nucleus accumbens (NAc). Our data demonstrated that 25E-NBOMe induces conditioned place preference, and the dopaminergic signaling in the NAc mediates these. Following 25E-NBOMe administration, expression of dopamine transporter and dopamine D1 receptor (D1DR) were enhanced in the NAc of male mice, and NAc dopamine levels were reduce...
Source: Archives of Pharmacal Research - March 29, 2024 Category: Drugs & Pharmacology Authors: Young-Jung Kim Wun-A Kook Shi-Xun Ma Bo-Ram Lee Yong-Hyun Ko Seon-Kyung Kim Youyoung Lee Jae-Gyeong Lee Sooyeun Lee Kyeong-Man Kim Seok-Yong Lee Choon-Gon Jang Source Type: research
The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents
We examined the abuse potential of 25E-NBOMe using the conditioned place preference in male mice and self-administration paradigms in male rats. Additionally, immunoblot assay, enzyme-linked immunosorbent assay, and microdialysis were used to determine the molecular effects of 25E-NBOMe in the nucleus accumbens (NAc). Our data demonstrated that 25E-NBOMe induces conditioned place preference, and the dopaminergic signaling in the NAc mediates these. Following 25E-NBOMe administration, expression of dopamine transporter and dopamine D1 receptor (D1DR) were enhanced in the NAc of male mice, and NAc dopamine levels were reduce...
Source: Archives of Pharmacal Research - March 29, 2024 Category: Drugs & Pharmacology Authors: Young-Jung Kim Wun-A Kook Shi-Xun Ma Bo-Ram Lee Yong-Hyun Ko Seon-Kyung Kim Youyoung Lee Jae-Gyeong Lee Sooyeun Lee Kyeong-Man Kim Seok-Yong Lee Choon-Gon Jang Source Type: research
The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents
We examined the abuse potential of 25E-NBOMe using the conditioned place preference in male mice and self-administration paradigms in male rats. Additionally, immunoblot assay, enzyme-linked immunosorbent assay, and microdialysis were used to determine the molecular effects of 25E-NBOMe in the nucleus accumbens (NAc). Our data demonstrated that 25E-NBOMe induces conditioned place preference, and the dopaminergic signaling in the NAc mediates these. Following 25E-NBOMe administration, expression of dopamine transporter and dopamine D1 receptor (D1DR) were enhanced in the NAc of male mice, and NAc dopamine levels were reduce...
Source: Archives of Pharmacal Research - March 29, 2024 Category: Drugs & Pharmacology Authors: Young-Jung Kim Wun-A Kook Shi-Xun Ma Bo-Ram Lee Yong-Hyun Ko Seon-Kyung Kim Youyoung Lee Jae-Gyeong Lee Sooyeun Lee Kyeong-Man Kim Seok-Yong Lee Choon-Gon Jang Source Type: research
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
