Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities
Arch Pharm Res. 2023 Sep 28. doi: 10.1007/s12272-023-01466-x. Online ahead of print.ABSTRACTArtemongolins A-K (1-11), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through comprehensive spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculations. The absolute configurations of compounds 1, 4, and 7 were undoubtedly determined by a single-crystal X-ray crystallography. Artemongolins A-K (1-11) featured a rare 5/7/5/5/5/10 hexacyclic system composed of a germacrene and a guaianolide by a fused 2-oxaspiro[4,4]nonane-1-one ring system. Antihepatoma evaluati...
Source: Archives of Pharmacal Research - September 28, 2023 Category: Drugs & Pharmacology Authors: Chong Shang Yun-Bao Ma Yuan Wang Xiao-Feng He Tian-Ze Li Ji-Jun Chen Source Type: research
Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities
Arch Pharm Res. 2023 Sep 28. doi: 10.1007/s12272-023-01466-x. Online ahead of print.ABSTRACTArtemongolins A-K (1-11), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through comprehensive spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculations. The absolute configurations of compounds 1, 4, and 7 were undoubtedly determined by a single-crystal X-ray crystallography. Artemongolins A-K (1-11) featured a rare 5/7/5/5/5/10 hexacyclic system composed of a germacrene and a guaianolide by a fused 2-oxaspiro[4,4]nonane-1-one ring system. Antihepatoma evaluati...
Source: Archives of Pharmacal Research - September 28, 2023 Category: Drugs & Pharmacology Authors: Chong Shang Yun-Bao Ma Yuan Wang Xiao-Feng He Tian-Ze Li Ji-Jun Chen Source Type: research
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2
Arch Pharm Res. 2023 Sep 26. doi: 10.1007/s12272-023-01468-9. Online ahead of print.ABSTRACTIn a previous study, we discovered that the ethanolic extract of sea buckthorn (Hippophae rhamnoides) fruits exhibited anti-osteoporosis effects both in vitro and in vivo. Through bioassay-guided fractionation, we identified the hexane fraction (HRH) as the active fraction, which was further fractionated using preparative HPLC. Among the resulting six fractions, HRHF4 showed significant activity. In the present study, we focused on the bioassay-guided isolation of bioactive compounds from the HRHF4 fraction. We successfully identifi...
Source: Archives of Pharmacal Research - September 26, 2023 Category: Drugs & Pharmacology Authors: Da Eun Lee Kun Hee Park Joo-Hyun Hong Seon Hee Kim Ki-Moon Park Ki Hyun Kim Source Type: research
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs
Arch Pharm Res. 2023 Sep 26. doi: 10.1007/s12272-023-01465-y. Online ahead of print.ABSTRACTThe fact that mitochondria play a crucial part in energy generation has led to the nickname "powerhouses" of the cell being applied to them. They also play a significant role in many other cellular functions, including calcium signalling, apoptosis, and the creation of vital biomolecules. As a result, cellular function and health as a whole can be significantly impacted by mitochondrial malfunction. Indeed, malignancies frequently have increased levels of mitochondrial biogenesis and quality control. Adverse selection exists for har...
Source: Archives of Pharmacal Research - September 26, 2023 Category: Drugs & Pharmacology Authors: Surapriya Surendranath Prabhu Aathira Sujathan Nair Saiprabha Vijayakumar Nirmala Source Type: research
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2
Arch Pharm Res. 2023 Sep 26. doi: 10.1007/s12272-023-01468-9. Online ahead of print.ABSTRACTIn a previous study, we discovered that the ethanolic extract of sea buckthorn (Hippophae rhamnoides) fruits exhibited anti-osteoporosis effects both in vitro and in vivo. Through bioassay-guided fractionation, we identified the hexane fraction (HRH) as the active fraction, which was further fractionated using preparative HPLC. Among the resulting six fractions, HRHF4 showed significant activity. In the present study, we focused on the bioassay-guided isolation of bioactive compounds from the HRHF4 fraction. We successfully identifi...
Source: Archives of Pharmacal Research - September 26, 2023 Category: Drugs & Pharmacology Authors: Da Eun Lee Kun Hee Park Joo-Hyun Hong Seon Hee Kim Ki-Moon Park Ki Hyun Kim Source Type: research
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs
Arch Pharm Res. 2023 Sep 26. doi: 10.1007/s12272-023-01465-y. Online ahead of print.ABSTRACTThe fact that mitochondria play a crucial part in energy generation has led to the nickname "powerhouses" of the cell being applied to them. They also play a significant role in many other cellular functions, including calcium signalling, apoptosis, and the creation of vital biomolecules. As a result, cellular function and health as a whole can be significantly impacted by mitochondrial malfunction. Indeed, malignancies frequently have increased levels of mitochondrial biogenesis and quality control. Adverse selection exists for har...
Source: Archives of Pharmacal Research - September 26, 2023 Category: Drugs & Pharmacology Authors: Surapriya Surendranath Prabhu Aathira Sujathan Nair Saiprabha Vijayakumar Nirmala Source Type: research
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2
Arch Pharm Res. 2023 Sep 26. doi: 10.1007/s12272-023-01468-9. Online ahead of print.ABSTRACTIn a previous study, we discovered that the ethanolic extract of sea buckthorn (Hippophae rhamnoides) fruits exhibited anti-osteoporosis effects both in vitro and in vivo. Through bioassay-guided fractionation, we identified the hexane fraction (HRH) as the active fraction, which was further fractionated using preparative HPLC. Among the resulting six fractions, HRHF4 showed significant activity. In the present study, we focused on the bioassay-guided isolation of bioactive compounds from the HRHF4 fraction. We successfully identifi...
Source: Archives of Pharmacal Research - September 26, 2023 Category: Drugs & Pharmacology Authors: Da Eun Lee Kun Hee Park Joo-Hyun Hong Seon Hee Kim Ki-Moon Park Ki Hyun Kim Source Type: research
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs
Arch Pharm Res. 2023 Sep 26. doi: 10.1007/s12272-023-01465-y. Online ahead of print.ABSTRACTThe fact that mitochondria play a crucial part in energy generation has led to the nickname "powerhouses" of the cell being applied to them. They also play a significant role in many other cellular functions, including calcium signalling, apoptosis, and the creation of vital biomolecules. As a result, cellular function and health as a whole can be significantly impacted by mitochondrial malfunction. Indeed, malignancies frequently have increased levels of mitochondrial biogenesis and quality control. Adverse selection exists for har...
Source: Archives of Pharmacal Research - September 26, 2023 Category: Drugs & Pharmacology Authors: Surapriya Surendranath Prabhu Aathira Sujathan Nair Saiprabha Vijayakumar Nirmala Source Type: research
Review on pharmacological effects of gastrodin
Arch Pharm Res. 2023 Sep 25. doi: 10.1007/s12272-023-01463-0. Online ahead of print.ABSTRACTGastrodia elata Blume is a well-known traditional Chinese medicine that is mainly used to treat diseases related to the nervous system, such as stroke, epilepsy, and headache. Gastrodin is the main bioactive component of Gastrodia elata Blume, and studies have shown that it has extensive pharmacological activity. This narrative review aims to systematically review relevant studies on the pharmacological effects of gastrodin to provide researchers with the latest and most useful information. Studies have shown that gastrodin has prom...
Source: Archives of Pharmacal Research - September 25, 2023 Category: Drugs & Pharmacology Authors: Guirong Xiao Rong Tang Nan Yang Yanhua Chen Source Type: research
Review on pharmacological effects of gastrodin
Arch Pharm Res. 2023 Sep 25. doi: 10.1007/s12272-023-01463-0. Online ahead of print.ABSTRACTGastrodia elata Blume is a well-known traditional Chinese medicine that is mainly used to treat diseases related to the nervous system, such as stroke, epilepsy, and headache. Gastrodin is the main bioactive component of Gastrodia elata Blume, and studies have shown that it has extensive pharmacological activity. This narrative review aims to systematically review relevant studies on the pharmacological effects of gastrodin to provide researchers with the latest and most useful information. Studies have shown that gastrodin has prom...
Source: Archives of Pharmacal Research - September 25, 2023 Category: Drugs & Pharmacology Authors: Guirong Xiao Rong Tang Nan Yang Yanhua Chen Source Type: research
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.PMID:37733287 | DOI:10.1007/s12272-023-01460-3 (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - September 21, 2023 Category: Drugs & Pharmacology Authors: Jie Xu Aizhen Xiong Xunjiang Wang Xing Yan Yilin Chen Xuanling Ye Zhengtao Wang Lili Ding Li Yang Source Type: research
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.PMID:37733287 | DOI:10.1007/s12272-023-01460-3 (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - September 21, 2023 Category: Drugs & Pharmacology Authors: Jie Xu Aizhen Xiong Xunjiang Wang Xing Yan Yilin Chen Xuanling Ye Zhengtao Wang Lili Ding Li Yang Source Type: research
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.PMID:37733287 | DOI:10.1007/s12272-023-01460-3 (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - September 21, 2023 Category: Drugs & Pharmacology Authors: Jie Xu Aizhen Xiong Xunjiang Wang Xing Yan Yilin Chen Xuanling Ye Zhengtao Wang Lili Ding Li Yang Source Type: research
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.PMID:37733287 | DOI:10.1007/s12272-023-01460-3 (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - September 21, 2023 Category: Drugs & Pharmacology Authors: Jie Xu Aizhen Xiong Xunjiang Wang Xing Yan Yilin Chen Xuanling Ye Zhengtao Wang Lili Ding Li Yang Source Type: research
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone
Arch Pharm Res. 2023 Sep 20. doi: 10.1007/s12272-023-01462-1. Online ahead of print.ABSTRACTTolperisone, a muscle relaxant used for post-stroke spasticity, is metabolized to its main metabolite by CYP2D6 and to a lesser extent by CYP2C19 and CYP1A2. We investigated the effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on tolperisone pharmacokinetics. A 150 mg oral dose of tolperisone was given to 184 healthy Korean subjects and plasma concentrations of tolperisone were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). A 3.14-fold significant increase in AUC0-∞ was observed in ...
Source: Archives of Pharmacal Research - September 20, 2023 Category: Drugs & Pharmacology Authors: Ji-Young Byeon Chang-Keun Cho Pureum Kang Se-Hyung Kim Choon-Gon Jang Seok-Yong Lee Yun Jeong Lee Source Type: research
