Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Arch Pharm Res. 2024 Mar 16. doi: 10.1007/s12272-024-01489-y. Online ahead of print.ABSTRACTAstragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and oth...
Source: Archives of Pharmacal Research - March 17, 2024 Category: Drugs & Pharmacology Authors: Ya-Xiao Liu Xiao-Mei Song Lin-Wei Dan Jia-Mei Tang Yi Jiang Chong Deng Dong-Dong Zhang Yu-Ze Li Wei Wang Source Type: research
The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus
Arch Pharm Res. 2024 Mar 14. doi: 10.1007/s12272-024-01490-5. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) is a persistent metabolic disorder marked by deficiencies in insulin secretion and/or function, affecting various tissues and organs and leading to numerous complications. Mitochondrial biogenesis, the process by which cells generate new mitochondria utilizing existing ones plays a crucial role in energy homeostasis, glucose metabolism, and lipid handling. Recent evidence suggests that promoting mitochondrial biogenesis can alleviate insulin resistance in the liver, adipose tissue, and skeletal muscle...
Source: Archives of Pharmacal Research - March 15, 2024 Category: Drugs & Pharmacology Authors: Wenwen Ding Xiaoxue Yang Kaiyi Lai Yu Jiang Ying Liu Source Type: research
Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway
Arch Pharm Res. 2024 Mar 15. doi: 10.1007/s12272-024-01488-z. Online ahead of print.ABSTRACTMicrobiota-derived catabolism of nutrients is closely related to ulcerative colitis (UC). The level of indole-3-acetic acid (IAA), a microbiota-dependent metabolite of tryptophan, was decreased significantly in the feces of UC patients. Thus supplementation with IAA could be a potential therapeutic method for ameliorating colitis. In this work, the protective effect of supplementation with IAA on dextran sulfate sodium (DSS)-induced colitis was evaluated, and the underlying mechanism was elucidated. The results indicated that the ad...
Source: Archives of Pharmacal Research - March 15, 2024 Category: Drugs & Pharmacology Authors: Xinyan Qu Yingying Song Qingjun Li Qi Xu Yanru Li Huimin Zhang Xuemei Cheng Charles R Mackay Quanbo Wang Wei Liu Source Type: research
The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus
Arch Pharm Res. 2024 Mar 14. doi: 10.1007/s12272-024-01490-5. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) is a persistent metabolic disorder marked by deficiencies in insulin secretion and/or function, affecting various tissues and organs and leading to numerous complications. Mitochondrial biogenesis, the process by which cells generate new mitochondria utilizing existing ones plays a crucial role in energy homeostasis, glucose metabolism, and lipid handling. Recent evidence suggests that promoting mitochondrial biogenesis can alleviate insulin resistance in the liver, adipose tissue, and skeletal muscle...
Source: Archives of Pharmacal Research - March 15, 2024 Category: Drugs & Pharmacology Authors: Wenwen Ding Xiaoxue Yang Kaiyi Lai Yu Jiang Ying Liu Source Type: research
Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway
Arch Pharm Res. 2024 Mar 15. doi: 10.1007/s12272-024-01488-z. Online ahead of print.ABSTRACTMicrobiota-derived catabolism of nutrients is closely related to ulcerative colitis (UC). The level of indole-3-acetic acid (IAA), a microbiota-dependent metabolite of tryptophan, was decreased significantly in the feces of UC patients. Thus supplementation with IAA could be a potential therapeutic method for ameliorating colitis. In this work, the protective effect of supplementation with IAA on dextran sulfate sodium (DSS)-induced colitis was evaluated, and the underlying mechanism was elucidated. The results indicated that the ad...
Source: Archives of Pharmacal Research - March 15, 2024 Category: Drugs & Pharmacology Authors: Xinyan Qu Yingying Song Qingjun Li Qi Xu Yanru Li Huimin Zhang Xuemei Cheng Charles R Mackay Quanbo Wang Wei Liu Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
Arch Pharm Res. 2024 Feb 28. doi: 10.1007/s12272-024-01486-1. Online ahead of print.ABSTRACTGymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated. The chemical structures of these new compounds (2-8) were determined by analyzing their 1D and 2D NMR spectra and HR-EISMS, and their absolute configurations were unambiguously assigned by quantum chemical ECD calculat...
Source: Archives of Pharmacal Research - February 28, 2024 Category: Drugs & Pharmacology Authors: Seulah Lee Mina Jang Rhim Ryoo Jongtae Roh Sung-Kyun Ko Ki Hyun Kim Source Type: research
