Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways
Conclusions
Senescent cells with inflammatory phenotype are present in GCA arteries and are associated with the tissue inflammatory bulk, suggesting a potential implication in disease pathogenesis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Veroutis, D., Argyropoulou, O. D., Goules, A. V., Kambas, K., Palamidas, D. A., Evangelou, K., Havaki, S., Polyzou, A., Valakos, D., Xingi, E., Karatza, E., Boki, K. A., Cavazza, A., Kittas, C., Thanos, D., Ricordi, C., Marvisi, C., Muratore, F., Galli, E Tags: ARD, Vasculitis Source Type: research
Subclinical giant cell arteritis increases the risk of relapse in polymyalgia rheumatica
Conclusions
Patients with PMR and subclinical GCA had a significantly higher number of relapses during a 2-year follow-up than patients with isolated PMR. Lower starting doses and rapid glucocorticoid tapering in the first 3 months emerged as risk factors for relapse. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: De Miguel, E., Karalilova, R., Macchioni, P., Ponte, C., Conticini, E., Cowley, S., Tomelleri, A., Monti, S., Monjo, I., Batalov, Z., Klinowski, G., Falsetti, P., Kane, D. J., Campochiaro, C., Hocevar, A. Tags: Editor's choice, ARD Lay summaries, ARD, Vasculitis Source Type: research
CD_99 G1 neutrophils modulate osteogenic differentiation of mesenchymal stem cells in the pathological process of ankylosing spondylitis
Conclusions
Our results revealed the dynamics of cell subpopulations, gene expression and intercellular interactions during AS pathogenesis. These findings provide new insights into the cellular and molecular mechanisms of osteogenesis and will benefit the development of novel therapeutic strategies. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Feng, X., Wang, C., Ji, B., Qiao, J., Xu, Y., Zhu, S., Ji, Z., Zhou, B., Tong, W., Xu, W. Tags: Open access, ARD, Spondyloarthritis Source Type: research
Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis
Conclusions
Altogether, our preclinical and clinical data indicate that alterations in the Trp metabolism play an active role in the pathogenesis of RA and could be considered as a new therapeutic avenue. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Moulin, D., Millard, M., Taïeb, M., Michaudel, C., Aucouturier, A., Lefevre, A., Bermudez-Humaran, L. G., Langella, P., Sereme, Y., Wanherdrick, K., Gautam, P., Mariette, X., Dieude, P., Gottenberg, J.-E., Jouzeau, J.-Y., Skurnik, D., Emond, P., M Tags: Open access, ARD, Rheumatoid arthritis Source Type: research
Single-cell resolution of longitudinal blood transcriptome profiles in rheumatoid arthritis, systemic lupus erythematosus and healthy control pregnancies
Conclusion
We found distinct RA, SLE and pregnancy signatures, and no expression patterns could be attributed to medication or disease activity. Our results support the need for close postpartum follow-up of patients with SLE. Gene expression patterns in RA were closer to healthy controls than to SLE, and primarily became evident after cell-type adjustment. Adjusting for cell abundance unravelled gene expression signatures less associated with variation in cell-composition and highlighted genes with expression profiles associated with changes in specialised cell populations. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Lien, H. J. T., Pedersen, T. T., Jakobsen, B., Flatberg, A., Chawla, K., Saetrom, P., Fenstad, M. H. Tags: Open access, ARD, Rheumatoid arthritis Source Type: research
Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome
Conclusions
This analysis highlights the need to explore functional consequences of genetic associations in disease tissue. HLA-DPB2 SNP rs3128921 could potentially be used to stratify patients to more aggressive treatment immediately at diagnosis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Goldmann, K., Spiliopoulou, A., Iakovliev, A., Plant, D., Nair, N., Cubuk, C., The MATURA Consortium, McKeigue, P., Barnes, M. R., Barton, A., Pitzalis, C., Lewis, M. J. Tags: Open access, ARD, Rheumatoid arthritis Source Type: research
In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation
Conclusion
Whereas ACPA associate with low counts of affected joints in early RA, RF associates with elevated measures of systemic inflammation in an ACPA-dependent manner. This latter finding corroborates in vitro models of ACPA and RF in immune complex-induced inflammation. These phenotypic associations are independent of classification criteria. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Pertsinidou, E., Saevarsdottir, S., Manivel, V. A., Klareskog, L., Alfredsson, L., Mathsson-Alm, L., Hansson, M., Cornillet, M., Serre, G., Holmdahl, R., Skriner, K., Jakobsson, P.-J., Westerlind, H., Askling, J., Rönnelid, J. Tags: Open access, ARD, Rheumatoid arthritis Source Type: research
New approach to testing treatments for osteoarthritis: FastOA
Animal models of post traumatic osteoarthritis have shown many promising treatments for disease, but human trials have mostly failed to identify effective treatments. This viewpoint suggests that the frequent failure of drug and treatment development in osteoarthritis is due, in part, to the advanced stage of disease of patients in trials and suggests that mirroring the animal model approach might be more successful. It suggests a path forward by enriching trial enrollees with those likely to develop post traumatic OA quickly. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Felson, D., Lotz, M. K., Jin, Y., Jones, M., Kim, J. S., Spindler, K. Tags: ARD Viewpoint Source Type: research
Polymyalgia rheumatica: crafting the future of a simple (but not easy!) clinical syndrome
Since its first description in 1888,1 the concept of polymyalgia rheumatica (PMR) has significantly evolved. Initially perceived as a mild form of rheumatoid arthritis,2 its recognition as a distinct clinical entity came only in 1957 when Barber introduced the term.3 Is PMR a separate entity? Although characteristic for PMR, polymyalgic symptoms, including pain and stiffness in the shoulder and pelvic girdle, are non-specific clinical manifestation. They may serve as the initial presentation for a range of elderly-onset rheumatic (eg, rheumatoid arthritis, spondylarthritis, crystal-induced arthritis, vasculitis and connect...
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Bond, M., Dejaco, C. Tags: ARD Editorials Source Type: research
Correction: Identification of two tofacitinib subpopulations with different relative risk versus TNF inhibitors: an analysis of the open label, randomised controlled study ORAL Surveillance
Kristensen LE, Danese S, Yndestad A, et al. Identification of two tofacitinib subpopulations with different relative risk versus TNF inhibitors: an analysis of the open label, randomised controlled study ORAL Surveillance. Ann Rheum Dis 2023;82:901-910. doi:10.1136/ard-2022-223715
In figure 1C of the originally published version of the manuscript, the plotted value for All cause death for the Age ≥65 years and Ever smoked group showed the incidence rate (95% Confidence Interval [CI]) (1.81 (1.15, 2.71)) instead of the hazard ratio (HR) vs tumour necrosis factor inhibitors (TNFi (95% CI)) (2.09 (0.85, 5.13)).
This data p...
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Tags: Open access, ARD Lay summaries, ARD Correction Source Type: research
Correction: Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis
Tavasolian F, Lively S, Pastrello C, et al. Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis. Ann Rheum Dis 2023;82:1429-43.
The Patient and public involvement statement should read:
An ongoing longitudinal AS cohort was used for the study with the approval of the UHN research ethics board (REB# 21–5565). All patients and healthy controls (HC) provided written consent to participate. AS patients fulfilled the modified New York AS criteria.30 31 AS patients (n=40) had an average age of 47±10 years, while HC (n=28) had an average age of 37±11 years. Table 1 prov...
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Tags: ARD Correction Source Type: research
Correction: A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis
de Rooy DPC, Zhernakova A, Tsonaka R, et al. A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis. Annals of the Rheumatic Diseases 2014;73:1163-1169.
In the result section it is written ‘As depicted, carrying the minor C-allele was associated with less severe joint damage progression.’ The word minor is incorrect and should be removed, as the C-allele was not the minor allele.
All presented data are correct.
doi:10.1136/annrhemdis-2013–2 03 375 (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Tags: ARD Correction Source Type: research
Correction: Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study
Knevel R, Krabben A, Brouwer E, et al. Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study. Ann Rheum Dis 2012;71:1651–7. doi: 10.1136/annrheumdis-2011-200724.
Table 2 includes a wrong minor allele frequency. The MAF of rs7665842 was incorrectly reported as 0.40. It should be 0.25.
All other presented data are correct. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Tags: ARD Correction Source Type: research
Response to: Correspondence on 'ACR/EULAR antiphospholipid syndrome classification criteria by Damoiseaux and van Beers
We appreciate the comments by Damoiseaux and van Beers1 in response to the publication of the 2023 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) Antiphospholipid Syndrome (APS) classification criteria.2 3 Here, we address a few of the authors points, including: (1) choosing ELISA for antiphospholipid antibodies (aPL) as compared with automated methods, is ‘disputable’; (2) anticardiolipin antibody (aCL) and anti-β2-glycoprotein-I antibody (aβ2GPI) IgM alone, or single one-time lupus-anticoagulant (LA) positivity alone is ‘not of any value for cla...
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Barbhaiya, M., Zuily, S., Bertolaccini, M. L., Willis, R., Devreese, K., Erkan, D. Tags: ARD Correspondence response Source Type: research
Correspondence on "ACR/EULAR antiphospholipid syndrome classification criteria"
The new American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) antiphospholipid syndrome (APS) classification criteria were generated by a well-structured stepwise approach.1 Contrary to the revised Sapporo criteria,2 the new criteria are characterised by high specificity. Obviously, this is at the cost of sensitivity, but for clinical intervention studies and understanding pathogenic mechanisms more homogeneous patient populations, as achieved by more stringent disease criteria, are a prerequisite. With respect to the definition and implementation of the laboratory parameters, an essential pilar...
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Damoiseaux, J., van Beers, J. Tags: ARD Correspondence Source Type: research
