Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor induced myositis
Conclusions
We identified three distinct types of ICI-myositis based on transcriptomic analyses. The IL6 pathway was overexpressed in all groups, the type I interferon pathway activation was specific for ICI-DM, the type 2 IFN pathway was overexpressed in both ICI-DM and ICI-MYO1 and only ICI-MYO1 patients developed myocarditis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 11, 2023 Category: Rheumatology Authors: Pinal-Fernandez, I., Quintana, A., Milisenda, J. C., Casal-Dominguez, M., Munoz-Braceras, S., Derfoul, A., Torres-Ruiz, J., Pak, K., Dell'Orso, S., Naz, F., Gutierrez-Cruz, G., Milone, M., Shelly, S., Duque-Jaimez, Y., Tobias-Baraja, E., Matas-Garcia, A., Tags: ARD, Myositis Source Type: research
Uptake and effectiveness of newer biologic and targeted synthetic disease-modifying antirheumatic drugs in psoriatic arthritis: results from five Nordic biologics registries
Conclusion
Uptake of newer b/tsDMARDs occurred mainly in biologic-experienced patients. Regardless of mode of action, only a minority of patients starting a second or later b/tsDMARD course remained on drug and achieved LDA. Superior outcomes for adalimumab indicate that the positioning of newer b/tsDMARDs in the PsA treatment algorithm remains to be established. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 11, 2023 Category: Rheumatology Authors: Glintborg, B., Di Giuseppe, D., Wallman, J. K., Nordström, D. C., Gudbjornsson, B., Hetland, M. L., Askling, J., Grondal, G., Sokka, T., Provan, S. A., Michelsen, B., Kristianslund, E. K., Dreyer, L., Love, T. J., Lindström, U. Tags: Editor's choice, ARD Lay summaries, ARD, Psoriatic arthritis Source Type: research
Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance
Conclusions
An increase in pre-DC in peripheral blood predicted RA treatment resistance. Pre-DC could have pathophysiological relevance to RA treatment response. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 11, 2023 Category: Rheumatology Authors: Yamada, S., Nagafuchi, Y., Wang, M., Ota, M., Hatano, H., Takeshima, Y., Okubo, M., Kobayashi, S., Sugimori, Y., Masahiro, N., Yoshida, R., Hanata, N., Suwa, Y., Tsuchida, Y., Iwasaki, Y., Sumitomo, S., Kubo, K., Shimane, K., Setoguchi, K., Azuma, T., Kan Tags: Open access, ARD, Rheumatoid arthritis Source Type: research
Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage
Conclusions
We have identified the major pathogenic B cell epitope of the RA-associated autoantigen GPI, at position 293–307, exposed only on structurally modified GPI on the cartilage surface. B cells to this neo-epitope escape tolerance and could potentially play a role in the pathogenesis of RA. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 11, 2023 Category: Rheumatology Authors: Li, T., Ge, C., Krämer, A., Sareila, O., Leu Agelii, M., Johansson, L., Forslind, K., Lönnblom, E., Yang, M., Xu, B., Li, Q., Cheng, L., Bergström, G., Fernandez, G., Kastbom, A., Rantapää-Dahlqvist, S., Gjertsson, Tags: ARD, Rheumatoid arthritis Source Type: research
Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force
Conclusions
These international, consensus agreed overarching principles and points-to-consider for T2T in cSLE lay the foundation for future T2T approaches in cSLE, endorsed by the Paediatric Rheumatology European Society. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 11, 2023 Category: Rheumatology Authors: Smith, E. M. D., Aggarwal, A., Ainsworth, J., Al-Abadi, E., Avcin, T., Bortey, L., Burnham, J., Ciurtin, C., Hedrich, C. M., Kamphuis, S., Levy, D. M., Lewandowski, L. B., Maxwell, N., Morand, E. F., Ozen, S., Pain, C. E., Ravelli, A., Saad Magalhaes, C., Tags: Open access, ARD Lay summaries, ARD Recommendation Source Type: research
