Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor induced myositis

Conclusions
We identified three distinct types of ICI-myositis based on transcriptomic analyses. The IL6 pathway was overexpressed in all groups, the type I interferon pathway activation was specific for ICI-DM, the type 2 IFN pathway was overexpressed in both ICI-DM and ICI-MYO1 and only ICI-MYO1 patients developed myocarditis.

Source: Annals of the Rheumatic Diseases - May 11, 2023 Category: Rheumatology Authors: Pinal-Fernandez, I., Quintana, A., Milisenda, J. C., Casal-Dominguez, M., Munoz-Braceras, S., Derfoul, A., Torres-Ruiz, J., Pak, K., Dell'Orso, S., Naz, F., Gutierrez-Cruz, G., Milone, M., Shelly, S., Duque-Jaimez, Y., Tobias-Baraja, E., Matas-Garcia, A., Tags: ARD, Myositis Source Type: research