Clinical image: synovitis of the metacarpophalangeal joints
A woman in her 40s with long-standing IgM-rheumatoid factor and anti-cyclic citrullinated peptide positive, erosive rheumatoid arthritis (RA) presented with pain and swelling of the second and third metacarpophalangeal (MCP) joints of the right hand. Seven years earlier, she had received MCP II and III silicone implants and an arthrodesis of MCP I of her right hand because of severe joint destruction despite intensive treatment (figure 1A). At presentation radiographic examination showed loosening of both prostheses with extensive lucencies at the prosthesis–bone interface (figure 1B); other joints showed no progress...
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: van der Weele, L., Niessink, T., Maas, M., Don Griot, P., Janssen, M., Otto, C., Jansen, T. L., Tas, S. W., de Vries, N. Tags: ARD, Images in rheumatology Source Type: research
Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy
Conclusions
Genetic factors influence the response to TPTD at the lumbar spine and hip with a magnitude of effect that is clinically relevant. Further studies are required to identify the causal genetic variants and underlying mechanisms as well as to explore how genetic testing for these variants might be implemented in clinical practice. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Alonso, N., Albagha, O. M. E., Azfer, A., Larraz-Prieto, B., Berg, K., Riches, P. L., Ostanek, B., Kocjan, T., Marc, J., Langdahl, B. L., Ralston, S. H. Tags: Editor's choice, ARD, Osteoporosis Source Type: research
A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis
Conclusions
The presence of the mtDNA variant m.16519C increases the risk of rapid progression of knee OA. Among the most modulated biological processes associated with this variant, inflammation and negative regulation of cellular process stand out. The design of therapies based on the maintenance of mitochondrial function is recommended. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Duran-Sotuela, A., Fernandez-Moreno, M., Suarez-Ulloa, V., Vazquez-Garcia, J., Relano, S., Hermida-Gomez, T., Balboa-Barreiro, V., Lourido-Salas, L., Calamia, V., Fernandez-Puente, P., Ruiz-Romero, C., Fernandez-Tajes, J., Vaamonde-Garcia, C., de Andres, Tags: Open access, ARD, Osteoarthritis Source Type: research
Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis
Conclusion
Targeting KDM7A/B histone demethylases could be an attractive strategy to protect joints against osteoarthritis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Assi, R., Cherifi, C., Cornelis, F. M. F., Zhou, Q., Storms, L., Pazmino, S., Coutinho de Almeida, R., Meulenbelt, I., Lories, R. J., Monteagudo, S. Tags: ARD, Osteoarthritis Source Type: research
Incidence, prevalence and mortality of IgG4-related disease in the USA: a claims-based analysis of commercially insured adults
Conclusions
The incidence of IgG4-RD is similar to that of systemic rheumatic diseases such as ANCA-associated vasculitis and systemic sclerosis but may be increasing as familiarity with this diagnosis grows. Clinicians should be aware of this condition, especially given the excess risk of death. Identification of effective therapies is an important research agenda. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Wallace, Z. S., Miles, G., Smolkina, E., Petruski-Ivleva, N., Madziva, D., Cook, C., Fu, X., Zhang, Y., Stone, J. H., Choi, H. K. Tags: ARD, Epidemiology Source Type: research
Rheumatoid factor autoantibody repertoire profiling reveals distinct binding epitopes in health and autoimmunity
Conclusions
Our results demonstrate both the need and feasibility to redefine ‘RF’ into pathological and physiological autoantibody subtypes. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Oskam, N., Ooijevaar-De Heer, P., Kos, D., Jeremiasse, J., van Boheemen, L., Verstappen, G. M., Kroese, F. G. M., van Schaardenburg, D., Wolbink, G., Rispens, T. Tags: ARD, Autoimmunity Source Type: research
Rituximab versus azathioprine for maintenance of remission for patients with ANCA-associated vasculitis and relapsing disease: an international randomised controlled trial
Conclusions
Following induction of remission with rituximab, fixed-interval, repeat-dose rituximab was superior to azathioprine for preventing disease relapse in patients with AAV with a prior history of relapse.
Trial registration number
NCT01697267; ClinicalTrials.gov identifier (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Smith, R. M., Jones, R. B., Specks, U., Bond, S., Nodale, M., Al-jayyousi, R., Andrews, J., Bruchfeld, A., Camilleri, B., Carette, S., Cheung, C. K., Derebail, V., Doulton, T., Ferraro, A., Forbess, L., Fujimoto, S., Furuta, S., Gewurz-Singer, O., Harper, Tags: Open access, ARD Lay summaries, ARD, Vasculitis Source Type: research
Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes
Conclusion
Four discrete SLE patient longitudinal autoantibody clusters were predictive of long-term disease activity, organ involvement, treatment requirements and mortality risk. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Choi, M. Y., Chen, I., Clarke, A. E., Fritzler, M. J., Buhler, K. A., Urowitz, M., Hanly, J., St-Pierre, Y., Gordon, C., Bae, S.-C., Romero-Diaz, J., Sanchez-Guerrero, J., Bernatsky, S., Wallace, D. J., Isenberg, D. A., Rahman, A., Merrill, J. T., Fortin, Tags: ARD, Systemic Lupus erythematosus Source Type: research
Comparative safety and effectiveness of TNF inhibitors, IL6 inhibitors and methotrexate for the treatment of immune checkpoint inhibitor-associated arthritis
Conclusion
The treatment of ICI-IA with a biologic DMARD is associated with more rapid arthritis control than with MTX, but may be associated with a shorter time to cancer progression. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Bass, A. R., Abdel-Wahab, N., Reid, P. D., Sparks, J. A., Calabrese, C., Jannat-Khah, D. P., Ghosh, N., Rajesh, D., Aude, C. A., Gedmintas, L., MacFarlane, L., Arabelovic, S., Falohun, A., Mushtaq, K., Haj, F. A., Diab, A., Shah, A. A., Bingham, C. O., Ch Tags: ARD, Inflammatory arthritis Source Type: research
Cancer risks with JAKi and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis or psoriatic arthritis: a national real-world cohort study
Conclusion
In clinical practice, the short-term risk of cancer other than NMSC in individuals initiating treatment with JAKi is not higher than for TNFi, but we found evidence of increased risk for NMSC. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Huss, V., Bower, H., Hellgren, K., Frisell, T., Askling, J., Behalf of the ARTIS group, behalf of the ARTIS group, Ahlenius, Baecklund, Chatzidionysiou, Feltelius, Forsblad-dElia, Kastbom, Klareskog, Lindqvist, Lindström, Turesson, Sjöwall Tags: Open access, ARD, Inflammatory arthritis Source Type: research
Identification of two tofacitinib subpopulations with different relative risk versus TNF inhibitors: an analysis of the open label, randomised controlled study ORAL Surveillance
Conclusions
This posthoc analysis of ORAL Surveillance identified two tofacitinib subpopulations with different relative risk versus TNFi. High risk was confined to patients defined by distinct risk factors age ≥65 years or smoking, and these differentiating risk factors accounted for the excess risk observed with tofacitinib versus TNFi. These findings can guide individualised benefit/risk assessment and clinical decision-making on treatment with tofacitinib.
Trial registration numbers
NCT02092467, NCT01262118, NCT01484561, NCT00147498, NCT00413660, NCT00550446, NCT00603512, NCT00687193, NCT01164579, NCT00976599, NCT...
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Kristensen, L. E., Danese, S., Yndestad, A., Wang, C., Nagy, E., Modesto, I., Rivas, J., Benda, B. Tags: Open access, ARD Lay summaries, ARD, Rheumatoid arthritis Source Type: research
What is a response in randomised controlled trials in giant cell arteritis?
Glucocorticoids (GCs) are the gold standard for treatment of giant cell arteritis (GCA); however, there is a need for studies on GC-sparing agents, given that up to 85% of patients receiving GC only develop adverse events. Previous randomised controlled trials (RCTs) have applied different primary endpoints, limiting the comparison of treatment effects in meta-analyses and creating an undesired heterogeneity of outcomes. The harmonisation of response assessment is therefore an important unmet need in GCA research. In this viewpoint article, we discuss the challenges and opportunities with the development of new, internatio...
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Dejaco, C., Ramiro, S., Touma, Z., Bond, M., Soowamber, M., Sanchez-Alvarez, C., Langford, C. A. Tags: ARD Viewpoint Source Type: research
EULAR study group on 'MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
The ‘MHC-I (major histocompatibility complex class I)-opathy’ concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behcet’s disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis. Progress in understanding the cause and trea...
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Kuiper, J. J., Prinz, J. C., Stratikos, E., Kusnierczyk, P., Arakawa, A., Springer, S., Mintoff, D., Padjen, I., Shumnalieva, R., Vural, S., Kötter, I., van de Sande, M. G., Boyvat, A., de Boer, J. H., Bertsias, G., de Vries, N., Krieckaert, C. L. Tags: Open access, ARD Reviews Source Type: research
Correspondence on 'classification criteria: time for a rethink 'by D Porter et al
We take the following three main messages from Porter and colleagues’ thoughtful viewpoint article.1 Although disease classification criteria are developed for research purposes, they are commonly used for diagnosis in the clinic. This common practice is wrong since the prior probabilities for the targeted disease are always higher in the research and lower in clinical practice settings. Therefore, the use of the same criteria for diagnosis in general practice would cause an unacceptably high number of false positives in that setting. The use of classification criteria for research purposes, the usual setting being e...
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Yazici, H., Yazici, Y. Tags: ARD Correspondence Source Type: research
Response to: 'Correspondence on 'Variants in urate transporters, ADH1B, GCKR and MEPE genes associated with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank by Takei et al
Takei et al conducted a genome-wide association study (GWAS) in European individuals with gout versus asymptomatic hyperuricaemia controls. They reported nine independent genetic variants in or near ABCG2, SLC2A9, GCKR, ADH1B, SLC22A11, PDX1, MLXIPL and CNBD1 associated with gout using ‘a more stringent’ threshold of r2<0.01 for linkage disequilibrium (LD) clumping. Compared with our study, they found three additional loci in PDX1 (rs182200427), MLXPIL (rs7805504) and CNBD1 (rs181604403) that were not included in the non-imputed UK Biobank dataset used in our study. And more importantly, they reported a sing...
Source: Annals of the Rheumatic Diseases - June 12, 2023 Category: Rheumatology Authors: Sandoval-Plata, G., Morgan, K., Abhishek, A. Tags: ARD Correspondence response Source Type: research
