In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation

Conclusion
Whereas ACPA associate with low counts of affected joints in early RA, RF associates with elevated measures of systemic inflammation in an ACPA-dependent manner. This latter finding corroborates in vitro models of ACPA and RF in immune complex-induced inflammation. These phenotypic associations are independent of classification criteria.

Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Pertsinidou, E., Saevarsdottir, S., Manivel, V. A., Klareskog, L., Alfredsson, L., Mathsson-Alm, L., Hansson, M., Cornillet, M., Serre, G., Holmdahl, R., Skriner, K., Jakobsson, P.-J., Westerlind, H., Askling, J., Rönnelid, J. Tags: Open access, ARD, Rheumatoid arthritis Source Type: research