Single-cell resolution of longitudinal blood transcriptome profiles in rheumatoid arthritis, systemic lupus erythematosus and healthy control pregnancies

Conclusion We found distinct RA, SLE and pregnancy signatures, and no expression patterns could be attributed to medication or disease activity. Our results support the need for close postpartum follow-up of patients with SLE. Gene expression patterns in RA were closer to healthy controls than to SLE, and primarily became evident after cell-type adjustment. Adjusting for cell abundance unravelled gene expression signatures less associated with variation in cell-composition and highlighted genes with expression profiles associated with changes in specialised cell populations.

http://ard.bmj.com/cgi/content/short/83/3/300?rss=1

Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Lien, H. J. T., Pedersen, T. T., Jakobsen, B., Flatberg, A., Chawla, K., Saetrom, P., Fenstad, M. H. Tags: Open access, ARD, Rheumatoid arthritis Source Type: research