Metabolic and metabolomics insights into dilated cardiomyopathy (DCM)
Background: Dilated cardiomyopathy (DCM) is the most common form of heart muscle disease characterized by progressive dilatation and ventricular dysfunction. Metabolomics is an emerging and powerful discipline that provides a global information on the phenotype of mammalian systems via the study of endogenous and exogenous metabolites in cells, tissues and biofluids. These studies aid in the identification of biomarkers to prevent diseases in later life or help to early detect onset of diseases as well as aiding in the elucidation of disease mechanisms. ...
Source: Annals of Nutrition and Metabolism - April 26, 2022 Category: Nutrition Source Type: research
Follistatin-like 1 and family with sequence similarity to 19 member A5 levels are decreased in obese children and associated with glucose metabolism
Conclusion: The serum levels of FAM19A5 and FSTL1 were decreased in obese children; therefore, FAM19A5 and FSTL1 likely play important roles in glucose metabolism in obese children. (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - April 20, 2022 Category: Nutrition Source Type: research
Postoperative vitamin profile after receiving a novel peripheral parenteral nutrition solution: Multicenter randomized controlled phase III trial
Conclusion: Blood vitamin levels were decreased when patients were administered PPN without vitamin supplementation during the first week after surgery. The novel PPN formula containing multivitamins recommended by FDA2000 can be safely administered to postoperative patients to maintain blood vitamin levels. (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - April 19, 2022 Category: Nutrition Source Type: research
Society News
Ann Nutr Metab 2022;78:124 –124 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - April 1, 2022 Category: Nutrition Source Type: research
Society News
Ann Nutr Metab 2022;78:121 –123 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - April 1, 2022 Category: Nutrition Source Type: research
Higher inflammation is associated with cardiometabolic phenotype and biochemical health in women with obesity
Conclusion
The prevalence of MUO was lower using CMDS than EOSS. C3 and CRP may be useful clinical biomarkers of risk or treatment targets in women with obesity. (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - March 18, 2022 Category: Nutrition Source Type: research
Tackling Protein-Calorie Malnutrition during World Crises
Undernutrition is still highly prevalent in developing countries and leads to a multitude of problems as it weakens the immune system, which leads to increased risk of infections and diet-related diseases. COVID-19 has worsened the existing situation and has resulted in unprecedented health, social, and economic disruptions across the world. Before COVID-19, about 54% children under 5 years were moderately or seriously malnourished, and after the COVID-19 pandemic, early estimates suggest that an additional 2.6 million children were stunted; 9.3 million were wasted, with an addition of 2.1 million maternal anemia ...
Source: Annals of Nutrition and Metabolism - March 17, 2022 Category: Nutrition Source Type: research
Long-Chain Polyunsaturated Fatty Acids Supplementation and Respiratory Infections
Background: Long-chain polyunsaturated fatty acids (LCPUFAs) can actively affect the maintenance and optimal functioning of immune cells. The metabolites of both omega-3 and omega-6 play an important role in the synthesis of different mediators, such as prostaglandins, leukotrienes, thromboxanes, protectins, and resolvins, that can interfere with the virus and modulate inflammation.Summary: In this narrative review, we aim to identify whether LCPUFA supplementation may be effective in protecting the population against respiratory tract infections. We included only randomized controlled trials performed in both pediatric an...
Source: Annals of Nutrition and Metabolism - March 10, 2022 Category: Nutrition Source Type: research
Hydration Biomarkers Are Related to the Differential Abundance of Fecal Microbiota and Plasma Lipopolysaccharide-Binding Protein in Adults
Conclusions: Taxa common between markers are associated with the intestinal mucus layer, which suggests a potential link between hydration status and intestinal mucus homeostasis. The relationship between LBP and copeptin indicates that copeptin may be sensitive to metabolic endotoxemia and potentially gut barrier function.Ann Nutr Metab 2021;77(suppl 4):37 –45 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - February 28, 2022 Category: Nutrition Source Type: research
The Acute Effect of Adequate Water Intake on Glucose Regulation in Low Drinkers
Conclusion: Acute increases in water intake may mildly reduce daily plasma glucose concentrations in low drinkers. This may be due to acutely increased urinary glucose output when low drinkers are given adequate amounts of water. Increased water intake also led to decreased cortisol concentration.Ann Nutr Metab 2021;77(suppl 4):33 –36 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - February 28, 2022 Category: Nutrition Source Type: research
Estimating Differences in Risk of Chronic Kidney Disease Based on Water Intake in a National Sample
Conclusions: Not meeting recommended daily TWI was associated increased presentation of high-risk kidney function. Even though the NHANES data are not focused on areas where chronic kidney disease is prevalent, results from this are an indication that hydration does play a role in kidney function.Ann Nutr Metab 2021;77(suppl 4):30 –32 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - February 28, 2022 Category: Nutrition Source Type: research
Self-Reported Changes in Thirst and Alertness during Variable Prescribed Fluid Intake
Conclusion: A reduction in water intake resulted in an increase in thirst and decrease in alertness. Following 3 days of fluid restriction, 750 –1,000 mL of water intake was needed to decrease thirst and increase alertness. Overall, an inverse relationship was observed between self-reported thirst and alertness.Ann Nutr Metab 2021;77(suppl 4):28 –29 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - February 28, 2022 Category: Nutrition Source Type: research
Urinary UDP-Glucose as a Novel Actionable Biomarker of Dehydration-Induced Acute Kidney Injury
Conclusion: This study supports the hypothesis that UDP-Glc, released by damaged cells during severe dehydration, induces the renal recruitment of inflammatory macrophages leading to PT injury and kidney dysfunction (Fig. 1). Blocking the UDP-Glc/P2Y14 pathway represents, therefore, a new therapeutic avenue for the attenuation of dehydration-induced renal inflammation and injury. In this context, urinary UDP-Glc is a promising actionable biomarker for dehydration-induced AKI.Ann Nutr Metab 2021;77(suppl 4):25 –27 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - February 28, 2022 Category: Nutrition Source Type: research
Modeling Hydration Status Given Daily Measures of Body Mass, Urine Color, and Thirst
Conclusions: The WUT model accurately predicts copeptin concentrations on out of training data observations, suggesting that first morning measures of W, U, and T are effective for tracking hydration status by indirectly monitoring arginine vasopressin. More research is needed to determine potential cut-scores of predicted copeptin levels to aid practitioner decisions.Ann Nutr Metab 2021;77(suppl 4):23 –24 (Source: Annals of Nutrition and Metabolism)
Source: Annals of Nutrition and Metabolism - February 28, 2022 Category: Nutrition Source Type: research
Hippocrates Was Right: Now What? Water As a Part of Healthy Aging
Background: Aging is defined as the progressive organism change leading to debility, disease, and death [1]. We know that as we age, our risk increases for diseases such as diabetes, cancer, and chronic kidney disease, and many of our homeostatic processes change as well, such as cell signaling, metabolism, and proteostasis [2]. The data clearly show that water intake decreases with aging, especially after age 60 years [3]. However, the question becomes “Do we drink less because we age, or do we age because we drink less?” (Fig. 1).Summary: There are data to support both directions of this hypothesis. One example suppo...
Source: Annals of Nutrition and Metabolism - February 28, 2022 Category: Nutrition Source Type: research
