Allogeneic hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia
This study was aimed to explore the prognosis of allogenic hematopoietic stem cell transplantation (allo-HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL). This retrospective case series study included children with ALL who underwent allo-HSCT at Beijing Children ’s Hospital of Capital Medical University, Beijing, China, between January 2009 and December 2019. The outcomes included 5-year overall survival (OS) and event-free survival (EFS). A total of 75 children (52 males) were included. The median age at presentation was 5.30 years, and the median time from diagnosis to transplantation was 1.64 year...
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Genetic and clinical characteristics of primary hemophagocytic lymphohistiocytosis in children
AbstractTo analyze the genetic variation and prognosis of primary hemophagocytic lymphohistiocytosis (pHLH) in children and the clinical features of isolated central nervous system HLH (CNS-HLH). We retrospectively analyzed the clinical and genetic data of 480 HLH children admitted to our hospital from September 2017 to September 2022. There were 66 patients (13.75%) with pHLH, and the median age was 3.21 years (0.17–12.92 years). Variants inUNC13D (22/66, 33.33%),PRF1 (20/66, 30.30%) andXIAP (11/66, 16.67%) were the most common. More CNS involvement was observed in pHLH patients than in secondary hemophagocytic lymph...
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Low fixed dose pembrolizumab with gemcitabine, vinorelbine, liposomal doxorubicin (Pembro100 -GVD) as an effective salvage regimen in relapsed refractory classical hodgkin ’s lymphoma and primary mediastinal B cell lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Imatinib and CAR T cell therapy enable sustained response in a young patient with refractory RCSD1-ABL1-positive acute lymphoblastic leukemia
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Successful use of venetoclax combined with azacitidine in isolated extramedullary relapse of acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: a case report
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Unicentric Castleman ’s disease presenting as amyloid A cardiac amyloidosis: a case report
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome: a case report and literature review
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Overcoming right heart failure through successful treatment of cardiac dominant diffuse large B-cell lymphoma: a case report
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Detection of a rare JAK2exon13InDel-mutation in chronic eosinophilic leukemia with bilateral cerebral infarctions and L öffler endocarditis
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Osteolytic lesion as initial presentation in FIP1L1-PDGFRA-rearranged myeloid/lymphoid neoplasm with eosinophilia: a case report
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Correction to: Prognostic relevance of sarcopenia, geriatric, and nutritional assessments in older patients with diffuse large B ‑cell lymphoma: results of a multicentric prospective cohort study
(Source: Annals of Hematology)
Source: Annals of Hematology - January 1, 2024 Category: Hematology Source Type: research
Clinical characteristics and outcomes of Epstein-Barr virus viral load after allogeneic hematopoietic stem cell transplantation
AbstractEpstein-Barr virus (EBV) reactivation can occur following allogenic hematopoietic stem cell transplantation (allo-HSCT). However, the clinical characteristics and outcomes of EBV-viral load are not well known. Thus, we retrospectively analyzed the clinical features and prognostic impact of the EBV viral load in 121 allo-HSCT recipients from our hospital. EBV DNA quantification was performed in whole blood after transplantation. Patients were grouped based on whether EBV DNA quantification reached > 1000 copies/mL during follow-up (N = 50) or not (N = 71). Patients with EBV > 1000 EBV copies...
Source: Annals of Hematology - December 29, 2023 Category: Hematology Source Type: research
Refractory hemophagocytic lymphohistiocytosis secondary to polatuzumab vedotin plus rituximab and bendamustine
(Source: Annals of Hematology)
Source: Annals of Hematology - December 29, 2023 Category: Hematology Source Type: research
Correction to: Correlation between IPSET ‑t risk at diagnosis and subsequent hemorrhage in patients with essential thrombocythemia; a single institution experience
(Source: Annals of Hematology)
Source: Annals of Hematology - December 29, 2023 Category: Hematology Source Type: research
Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
AbstractSickle cell anemia (SCA) causes a long-standing vascular inflammation state, leading to endothelial dysfunction and chronic overexpression of several adhesion molecules, which contributes to acute and constant vaso-occlusive (VOC) episodes. It has been demonstrated that hydroxyurea (HU) can reduce VOC events, organ damage, blood transfusions, and even the adhesion properties to endothelial cells of SCA subjects. Due to VOC episodes, these patients are also more susceptible to recurrent bacterial translocation and dysbiosis. Given this, our study aimed to uncover the interplay between adhesion molecules, gut microbi...
Source: Annals of Hematology - December 28, 2023 Category: Hematology Source Type: research
