The mTORC1 pathway participate in hyper-function of B cells in immune thrombocytopenia
In this study, increased antibody production, enhanced terminal differentiation and highly expressed costimulatory molecules CD80 and CD86 were found in B cells of patients with ITP. In addition, RNA sequencing revealed highly activated mTOR pathway in these pathogenic B cells, indicating that the mTOR pathway may be involved in B cell hyper-function. Furthermore, mTOR inhibitors rapamycin or Torin1 effectively blocked the activation of mTORC1 in B cells, resulting in reduce antibody secretion, impaired differentiation of B cells into plasmablasts and downregulation of costimulatory molecules. Interestingly, as an unspecif...
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
COVID-19 infection outcomes in patients receiving CD20 targeting T-cell engaging bispecific antibodies for B-cell non-Hodgkin lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Erythema nodosum as a manifestation of cytokine release syndrome after CAR T-cell therapy
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Correction to: RE ‑MIND2: comparative effectiveness of tafasitamab plus lenalidomide versus polatuzumab vedotin/bendamustine/rituximab (pola‑BR), CAR‑T therapies, and lenalidomide/rituximab (R2) based on real‑world data in patients with relapsed/refractory diffuse large B‑cell lymphoma
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Administration of tocilizumab in septic patients with pancytopenia and hyper-inflammatory syndrome
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Cyclin D2-positive mantle cell lymphoma with t(2;12)(p12;p13) arising in immune deficiency/dysregulation
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Characteristics and outcomes associated with venous thrombotic complications among patients with paroxysmal nocturnal hemoglobinuria
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Comment on: JAK2 V617F-mutated polycythemia vera developing in a patient with a 20-year-long chronic myeloid leukemia at the time of first molecular response
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
The efficacy of first salvage therapy determines the outcomes of adult patients with type 1 primary refractory acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Heyde syndrome
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Mast cell leukemia associated with essential thrombocythemia: a type of MCL-AHN (MCL-AMN)
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Paroxysmal nocturnal hemoglobinuria with ulcerative colitis
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Correction to: Efficacy and safety of ixazomib plus lenalidomide and dexamethasone following injectable pi ‑based therapy in relapsed/refractory multiple myeloma
(Source: Annals of Hematology)
Source: Annals of Hematology - August 23, 2023 Category: Hematology Source Type: research
Are accessory spleen screening and resection in refractory immune cytopenia an effective strategy or a waste of resources?
AbstractSplenectomy remains an effective treatment for refractory immune cytopenia (RIC), which encompasses immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Accessory spleens (AS) have been described without identifying specific risk factors. We retrospectively analyzed patients with RIC after splenectomy who underwent splenic scintigraphy (SS) at our institution. Seventy-one patients were included. Sixty-two patients had ITP, five had AIHA, and four had Evans syndrome. Seventy-five percent (n = 53) were women. Eleven patients (15.5%) had an AS detected by SS. A complete response (CR) to first-line ste...
Source: Annals of Hematology - August 22, 2023 Category: Hematology Source Type: research
Time-dependent analysis of the impact on early cytomegalovirus reactivation of HLA mismatch and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation from related donors in acquired aplastic anemia
In conclusion, our data suggest that the higher HLA disparity and aGvHD increases susceptibility to early CMV reactivation. In particular, the dynamic landmarking analysis demonstrated the time-varying effect of aGvHD on CMV reactivation, and HLA mismatch showed a profound impact over time following HCT. (Source: Annals of Hematology)
Source: Annals of Hematology - August 22, 2023 Category: Hematology Source Type: research
