Feasibility of allogeneic hematopoietic stem cell transplantation in advanced age
In conclusion, older adults can safely and effectively undergo allo-HSCT with proper patient selection and individualized transplantation procedures. (Source: Annals of Hematology)
Source: Annals of Hematology - November 4, 2023 Category: Hematology Source Type: research
Pulmonary Erdheim-Chester disease successfully treated with vemurafenib
(Source: Annals of Hematology)
Source: Annals of Hematology - November 4, 2023 Category: Hematology Source Type: research
Epigenetically dysregulated NOTCH-Delta-HES signaling cascade can serve as a subtype classifier for acute lymphoblastic leukemia
AbstractThe NOTCH-Delta-HES signaling cascade is regarded as a double-edged sword owing to its dual tumor-suppressor and oncogenic roles, in different cellular environments. In the T-cells, it supports leukemogenesis by promoting differentiation while in B-cells, it controls leukemogenesis by inhibiting early differentiation/inducing growth arrest in the lead to apoptosis. The present study was undertaken to assess if this bi-faceted behavior of NOTCH family can be exploited as a diagnostic biomarker or subtype classifier of acute lymphoblastic leukemia (ALL). In this pursuit, expression of seven NOTCH cascade genes was an...
Source: Annals of Hematology - November 3, 2023 Category: Hematology Source Type: research
The clinical spectrum and prognostic factors of Erdheim-Chester disease and mixed Langerhans cell histiocytosis and Erdheim-Chester disease
AbstractErdheim-Chester disease (ECD) is a rare and probably fatal multisystemic non-Langerhans cell histiocytosis (LCH). To comprehensively investigate the clinical features, genomic analysis, treatments, and prognostic factors of ECD, we retrospectively analyzed the clinical data of 75 ECD patients and 10 mixed LCH and ECD patients in our center. The median age at diagnosis was 46 years (range, 5–70). ECD patients were older at diagnosis (p = 0.006) and had more cardiac involvement (p = 0.011) as well as vascular (p = 0.031) involvement compared to mixed LCH and ECD patients. 64.8% of ECD patients and 87....
Source: Annals of Hematology - November 3, 2023 Category: Hematology Source Type: research
Correction to: A case of sudden hearing loss in a patient with chronic myelomonocytic leukemia
(Source: Annals of Hematology)
Source: Annals of Hematology - November 3, 2023 Category: Hematology Source Type: research
CD45 inhibition in myeloid leukaemia cells sensitizes cellular responsiveness to chemotherapy
AbstractMyeloid malignancies are a group of blood disorders characterized by the proliferation of one or more haematopoietic myeloid cell lineages, predominantly in the bone marrow, and are often caused by aberrant protein tyrosine kinase activity. The protein tyrosine phosphatase CD45 is a trans-membrane molecule expressed on all haemopoietic blood cells except that of platelets and red cells. CD45 regulates various cellular physiological processes including proliferation, apoptosis, and lymphocyte activation. However, its role in chemotherapy response is still unknown; therefore, the aim of this study was to investigate ...
Source: Annals of Hematology - November 2, 2023 Category: Hematology Source Type: research
Association of inflammation and abnormal lipid metabolism with risk of thrombosis and thrombosis progression in patients with polycythemia vera: a retrospective study
AbstractTo date, no therapeutic strategy has been shown to be effective in reducing the risk of polycythemia vera (PV) transforming into myelofibrosis or leukemia, and the main goal of current treatment is to prevent thrombotic events. Recent studies have shown that higher levels of inflammation are associated with an increased risk of thrombosis in PV patients, while the correlation between inflammation and abnormal lipid metabolism with the risk of thrombosis in PV has not been reported. In this retrospective study, 148 patients with newly diagnosed PV who visited the Affiliated Hospitals of Nanchang University from Janu...
Source: Annals of Hematology - November 1, 2023 Category: Hematology Source Type: research
A pilot study of cord blood-derived natural killer cells as maintenance therapy after autologous hematopoietic stem cell transplantation
AbstractNatural killer (NK) cell based immunotherapy is an emerging strategy in hematologic malignancies because allogeneic NK cells can provide potent antitumor immunity without inducing graft-versus-host disease. Thus, we expanded cord blood-derived NK (CB-NK) cells ex vivo from random (MHC mismatched and KIR mismatched) donors, and investigate the feasibility and efficacy of repeated infusions CB-NK cells as maintenance therapy after autologous hematopoietic stem cell transplantation (ASCT). Thirty-one patients with acute myeloid leukemia and high-risk lymphoma received ASCT and the adoptive CB-NK cell multiple infusion...
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
Alternative treatment modality for severe aplastic anemia in a resource-limited setting: a single-institution prospective cohort study from Upper Egypt
In conclusion, E-PAG+ CsA was found to be a safe and effective alternative treatment for children with SAA particularly in countries with limited resources. (Source: Annals of Hematology)
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
AbstractPLK1 is overexpressed in acute myeloid leukemia (AML). A phase 1b trial of the PLK1 inhibitor onvansertib (ONV) combined with decitabine (DAC) demonstrated initial safety and efficacy in patients with relapsed/refractory (R/R) AML. The current study aimed to identify molecular predictors of response to ONV + DAC in R/R AML patients. A total of 44 R/R AML patients were treated with ONV + DAC and considered evaluable for efficacy. Bone marrow (BM) samples were collected at baseline for genomic and transcriptomic analysis (n = 32). A 10-gene expression signature, predictive of response to ONV + DAC, was derived from t...
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
Bleeding risk assessment in immune thrombocytopenia
AbstractThe bleeding risk in immune thrombocytopenia (ITP) is related not only to low platelet count but also to the presence of platelet dysfunction. However, diagnosing a concomitant platelet dysfunction is challenging as most of the available platelet function assays (PFAs) require a platelet count of greater than 100,000/ μL. Sonoclot coagulation and platelet function analyzer works on the principle of viscoelastometry, and results remain unaffected by the platelet counts. To assess the platelet function in adult acute ITP patients with the help of sonoclot coagulation and platelet function analyzer and correlate it w...
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
Excellent outcome of stem cell transplantation for sickle cell disease
AbstractMany sickle cell disease (SCD) patients lack matched family donors (MFD) or matched unrelated donors (MUD), implying haploidentical donors (MMFD) as a logical donor choice. We used a reduced toxicity protocol for all donor types. We included 31 patients (2 –22 years) with MFD (n = 15), MMFD (10), or MUD (6) HSCT and conditioning with alemtuzumab/ATG, thiotepa, fludarabine and treosulfan, and post-transplant cyclophosphamide for MMFD. After the initial six patients, treosulfan was replaced by targeted busulfan (AUC 65–75 ng*h/ml). After a median follow-up of 26 mont hs (6–123), all patients are alive an...
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
Chronic neutrophilic leukemia with JAK2 mutation: is it true chronic neutrophilic leukemia?
(Source: Annals of Hematology)
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
Alemtuzumab induced acquired hemophilia A in multiple sclerosis: a case report
(Source: Annals of Hematology)
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
Recurrent arterial thrombosis as the primary symptom in a patient with polycythemia vera
(Source: Annals of Hematology)
Source: Annals of Hematology - October 11, 2023 Category: Hematology Source Type: research
