Hypomethylating agents plus modified priming regimens compared with venetoclax-based regimens based on molecular characteristics for newly diagnosed patients with acute myeloid leukemia: a multi-center cohort study
In conclusion, HMAs plus modified priming regimens might be a potential alternative therapeutic approach for patients with ND AML, but VEN-based regimens presented predominance in specific molecular subgroups. Molecular characteristics contribute to guiding choice of trea tment. (Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Effectiveness of single-dose 6 mg pegfilgrastim in mobilizing peripheral blood stem cells in allogeneic hematopoietic cell transplantation donors
AbstractA single injection of 12 mg pegfilgrastim was used to mobilize peripheral blood progenitor cells (PBPCs) from healthy donors in some studies. The purpose of this study was to determine if 6 mg of pegfilgrastim was effective and safe for mobilizing CD34+ cells in donors for allogeneic hematopoietic stem cell transplantation. We conducted a retrospective case-matched design. A single dosage of 6 mg pegfilgrastim was used to mobilize PBPCs from 60 healthy donors. Granulocyte colony-stimulating factor (G-CSF, 10 μg/kg) was administered daily to the matched donors. Leukapheresis was scheduled to commence on day 4 of th...
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Epstein –Barr virus reactivation correlates with worse outcomes for patients exposed to hepatitis B virus after haploidentical hematopoietic stem cell transplantation
This study aimed to assess the clinical outcomes of these patients. We conducted a retrospective research including 61 patients exposed to H BV after undergoing haplo-HSCT. The patients were classified into two groups: the CMV reactivation group and no CMV reactivation group. The results were compared between the two groups using the K-W test for continuous variables, Pearson's chi-square test for categorical variables, Kaplan–Meier cu rves to estimate overall survival (OS) and leukemia-free survival (LFS), and a Cox proportional hazards model to analyze multivariable influences. The 3-year cumulative HBV reactivation ra...
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
High prevalence of past hepatitis B virus infection in diffuse large B cell lymphoma: a retrospective study from Italy
AbstractStudies from high endemic areas, mostly China, indicate that surface antigen positive (HBsAgpos) chronic hepatitis B virus (HBV) infection is associated with an increased risk of developing diffuse large B-cell lymphoma (DLBCL), whereas studies in low endemic areas have provided conflicting results. Past infection, serologically defined by negative HBsAg and positive anti-core antibody (HBsAgnegHBcAbpos), has also been suggested to increase the risk of B-cell non-Hodgkin ’s lymphoma (NHL) in high endemic areas. We retrospectively reviewed unselected clinical records of 253 patients with DLBCL (54% male, aged 60.3...
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
The experience of diagnosis and treatment for TAFRO syndrome
AbstractEarly identification, diagnosis and treatment of TAFRO syndrome are very importants. We retrospectively analysed 6 patients with TAFRO syndrome. Their clinical manifestations, treatment methods, survival and other aspects were summarized. All patients were pathologically diagnosed with Castleman ’s disease, with fever, an inflammatory storm state and varying degrees of anasarca. All patients received steroid therapy; four of them also received chemotherapy, and 1 received rituximab. Of the 3 patients with severe disease, only 1 patient who received the recommended dose of glucocorticoids survived. Early administr...
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Safe and successful teclistamab treatment in very elderly multiple myeloma (MM) patients: a case report and experience from a total of three octogenarians
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
The role of ruxolitinib treatment in JAK-mutated Ph-like acute lymphoblastic leukemia
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
A case report of dyskeratosis congenita caused by a novel TERC mutation
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Multiple myeloma relapse as extramedullary plasmacytoma of the penis
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Diagnosis of sinusoidal obstruction syndrome: can biopsy be the key?
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
A case of sudden hearing loss in a patient with chronic myelomonocytic leukemia
AbstractChronic myelomonocytic leukemia is a myeloid stem cell disease characterized by an abnormal production and accumulation of monocytic cells in association with other signs of myeloproliferation. Extramedullary manifestations of CMML are common and can affect the spleen, liver skin, and lymph nodes. However, otologic manifestations are extremely rare and could have occurred from either direct leukemic infiltration, hemorrhage of the cochlea, labyrinth, leukostasis, or infection. There is no standard treatment protocol for sensorineural hearing loss in CMML patients. More research is needed to improve the understandin...
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Clonal myeloid disorders following CAR T-cell therapy
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Ibrutinib plus rituximab and lenalidomide for primary intestinal diffuse large B-cell lymphoma relapsed after anti-CD19 CAR-T cell therapy: a case report
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Clonal hematopoiesis with TET2 mutations spawning synchronous primary central nervous system lymphoma and myelodysplastic syndrome
(Source: Annals of Hematology)
Source: Annals of Hematology - November 11, 2023 Category: Hematology Source Type: research
Outcomes of allogeneic hematopoietic cell transplantation under letermovir prophylaxis for cytomegalovirus infection
AbstractCytomegalovirus (CMV) infection is a major infectious complication following allogeneic hematopoietic cell transplantation (allo-HCT). Although letermovir (LMV) prophylaxis dramatically reduces the incidence of early clinically significant CMV (csCMV) infection, it remains unclear whether it has a beneficial effect on nonrelapse mortality (NRM) and overall survival (OS). Herein, we evaluated the impact of LMV prophylaxis on posttransplant outcomes using the registry database of the Japanese Society for Transplantation and Cellular Therapy. Adult patients who underwent allo-HCT between 2017 and 2019 were analyzed (n...
Source: Annals of Hematology - November 10, 2023 Category: Hematology Source Type: research
