HIV viral load suppression among people with mental disorders at two urban HIV clinics in Uganda: a parallel convergent mixed methods study using the social ecological model
Uganda adopted and implemented the Universal Test and Treat (UTT) guidelines in 2017, which require HIV-infected persons to be initiated on antiretroviral therapy (ART) at any CD4 + cell count, and to be routi... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 19, 2023 Category: Infectious Diseases Authors: Regina Ndagire, Rachel Nante Wangi, Kevin Ouma Ojiambo, Joanita Nangendo, Juliet Nakku, Herbert Muyinda and Fred C. Semitala Tags: Research Source Type: research
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
Suboptimal antiretroviral (ART) adherence can lead to virologic failure with consequent HIV-1 resistance. Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a powerful biomarker of cumulative adheren... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 14, 2023 Category: Infectious Diseases Authors: Y. Singh, J. Castillo-Mancilla, R. Madimabe, L. Jennings, C. M. Ferraris, R. N. Robbins, P. L. Anderson, R. H. Remien and C. Orrell Tags: Research Source Type: research
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
CONCLUSION: TFV-DP in DBS showed a step-wise inverse relationship with VB and drug resistance, with evidence of low cumulative ART adherence in PWH who developed antiretroviral resistance. Monitoring TFV-DP concentrations could be a valuable tool for predicting future VB and future resistance.PMID:37705102 | PMC:PMC10500931 | DOI:10.1186/s12981-023-00552-w (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 13, 2023 Category: Infectious Diseases Authors: Y Singh J Castillo-Mancilla R Madimabe L Jennings C M Ferraris R N Robbins P L Anderson R H Remien C Orrell Source Type: research
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
CONCLUSION: TFV-DP in DBS showed a step-wise inverse relationship with VB and drug resistance, with evidence of low cumulative ART adherence in PWH who developed antiretroviral resistance. Monitoring TFV-DP concentrations could be a valuable tool for predicting future VB and future resistance.PMID:37705102 | PMC:PMC10500931 | DOI:10.1186/s12981-023-00552-w (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 13, 2023 Category: Infectious Diseases Authors: Y Singh J Castillo-Mancilla R Madimabe L Jennings C M Ferraris R N Robbins P L Anderson R H Remien C Orrell Source Type: research
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
CONCLUSION: TFV-DP in DBS showed a step-wise inverse relationship with VB and drug resistance, with evidence of low cumulative ART adherence in PWH who developed antiretroviral resistance. Monitoring TFV-DP concentrations could be a valuable tool for predicting future VB and future resistance.PMID:37705102 | PMC:PMC10500931 | DOI:10.1186/s12981-023-00552-w (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 13, 2023 Category: Infectious Diseases Authors: Y Singh J Castillo-Mancilla R Madimabe L Jennings C M Ferraris R N Robbins P L Anderson R H Remien C Orrell Source Type: research
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
CONCLUSION: TFV-DP in DBS showed a step-wise inverse relationship with VB and drug resistance, with evidence of low cumulative ART adherence in PWH who developed antiretroviral resistance. Monitoring TFV-DP concentrations could be a valuable tool for predicting future VB and future resistance.PMID:37705102 | PMC:PMC10500931 | DOI:10.1186/s12981-023-00552-w (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 13, 2023 Category: Infectious Diseases Authors: Y Singh J Castillo-Mancilla R Madimabe L Jennings C M Ferraris R N Robbins P L Anderson R H Remien C Orrell Source Type: research
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
CONCLUSION: TFV-DP in DBS showed a step-wise inverse relationship with VB and drug resistance, with evidence of low cumulative ART adherence in PWH who developed antiretroviral resistance. Monitoring TFV-DP concentrations could be a valuable tool for predicting future VB and future resistance.PMID:37705102 | DOI:10.1186/s12981-023-00552-w (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 13, 2023 Category: Infectious Diseases Authors: Y Singh J Castillo-Mancilla R Madimabe L Jennings C M Ferraris R N Robbins P L Anderson R H Remien C Orrell Source Type: research
HIV-1-related factors interact with p53 to influence cellular processes
AIDS Res Ther. 2023 Sep 10;20(1):66. doi: 10.1186/s12981-023-00563-7.ABSTRACTHuman immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also c...
Source: AIDS Research and Therapy - September 10, 2023 Category: Infectious Diseases Authors: Shanling Liu Ting Guo Jinwei Hu Weiliang Huang Pengfei She Yong Wu Source Type: research
HIV-1-related factors interact with p53 to influence cellular processes
AIDS Res Ther. 2023 Sep 10;20(1):66. doi: 10.1186/s12981-023-00563-7.ABSTRACTHuman immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also c...
Source: AIDS Research and Therapy - September 10, 2023 Category: Infectious Diseases Authors: Shanling Liu Ting Guo Jinwei Hu Weiliang Huang Pengfei She Yong Wu Source Type: research
HIV-1-related factors interact with p53 to influence cellular processes
AIDS Res Ther. 2023 Sep 10;20(1):66. doi: 10.1186/s12981-023-00563-7.ABSTRACTHuman immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also c...
Source: AIDS Research and Therapy - September 10, 2023 Category: Infectious Diseases Authors: Shanling Liu Ting Guo Jinwei Hu Weiliang Huang Pengfei She Yong Wu Source Type: research
HIV-1-related factors interact with p53 to influence cellular processes
Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (n... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 10, 2023 Category: Infectious Diseases Authors: Shanling Liu, Ting Guo, Jinwei Hu, Weiliang Huang, Pengfei She and Yong Wu Tags: Review Source Type: research
Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
CONCLUSION: We demonstrated insignificant changes in both insulin resistance and pancreatic beta cell function in clinically stable young adult Ugandan PWH on dolutegravir for 48 weeks. We add to the body of evidence demonstrating glucose metabolic safety of dolutegravir in ART naïve patients. Ugandan guidelines should reconsider restricting DTG initiation in ART naive adults at high risk for diabetes.PMID:37689695 | PMC:PMC10492310 | DOI:10.1186/s12981-023-00564-6 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 9, 2023 Category: Infectious Diseases Authors: Frank Mulindwa Barbara Castelnuovo Nele Brusselaers Martin Nabwana Robert Bollinger Allan Buzibye Eva Laker Agnes Odongpiny Ronald Kiguba Jean-Marc Schwarz Source Type: research
Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
CONCLUSION: We demonstrated insignificant changes in both insulin resistance and pancreatic beta cell function in clinically stable young adult Ugandan PWH on dolutegravir for 48 weeks. We add to the body of evidence demonstrating glucose metabolic safety of dolutegravir in ART naïve patients. Ugandan guidelines should reconsider restricting DTG initiation in ART naive adults at high risk for diabetes.PMID:37689695 | DOI:10.1186/s12981-023-00564-6 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 9, 2023 Category: Infectious Diseases Authors: Frank Mulindwa Barbara Castelnuovo Nele Brusselaers Martin Nabwana Robert Bollinger Allan Buzibye Eva Laker Agnes Odongpiny Ronald Kiguba Jean-Marc Schwarz Source Type: research
Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
The Uganda Ministry of Health issued restrictive guidelines on the use of dolutegravir (DTG) in persons stratified to have a heightened risk of diabetes mellitus. This followed multiple reports of persons with... (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 9, 2023 Category: Infectious Diseases Authors: Frank Mulindwa, Barbara Castelnuovo, Nele Brusselaers, Martin Nabwana, Robert Bollinger, Allan Buzibye, Eva Laker Agnes Odongpiny, Ronald Kiguba and Jean-Marc Schwarz Tags: Research Source Type: research
A structural equation modeling approach to investigate HIV testing willingness for men who have sex with men in China
CONCLUSION: HIV testing needs to be increased among MSM as they exhibit a moderate willingness to test. Improving education on HIV knowledge and risk behavior might enhance the willingness of MSM to test for HIV in China.PMID:37661282 | PMC:PMC10476389 | DOI:10.1186/s12981-023-00561-9 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 3, 2023 Category: Infectious Diseases Authors: Han Jiang Wei He Haiying Pan Xiaoni Zhong Source Type: research
