Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00222 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - April 3, 2017 Category: Chemistry Authors: Kellie A. Woll, Wesley Peng, Qiansheng Liang, Lianteng Zhi, Jack A. Jacobs, Lina Maciunas, Natarajan Bhanu, Benjamin A. Garcia, Manuel Covarrubias, Patrick J. Loll, William P. Dailey and Roderic G. Eckenhoff Source Type: research

Systematic Investigation of Ginkgo Biloba Leaves for Treating Cardio-cerebrovascular Diseases in an Animal Model
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00762 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - April 3, 2017 Category: Chemistry Authors: Yinfeng Yang, Yan Li, Jinghui Wang, Ke Sun, Weiyang Tao, Zhenzhong Wang, Wei Xiao, Yanqiu Pan, Shuwei Zhang and Yonghua Wang Source Type: research

Affinity Selection –Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01133 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 31, 2017 Category: Chemistry Authors: Scott S. Walker, David Degen, Elliott Nickbarg, Donna Carr, Aileen Soriano, Mihir Mandal, Ronald E. Painter, Payal Sheth, Li Xiao, Xinwei Sher, Nicholas Murgolo, Jing Su, David B. Olsen, Richard H. Ebright and Katherine Young Source Type: research

Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00140 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 31, 2017 Category: Chemistry Authors: Chia-Lin Chen, Jen-Chi Hsu, Chin-Wei Lin, Chia-Hung Wang, Ming-Hung Tsai, Chung-Yi Wu, Chi-Huey Wong and Che Ma Source Type: research

Single Particle Observation of SV40 VP1 Polyanion-Induced Assembly Shows That Substrate Size and Structure Modulate Capsid Geometry
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01066 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 30, 2017 Category: Chemistry Authors: Chenglei Li, Andrew R. Kneller, Stephen C. Jacobson and Adam Zlotnick Source Type: research

Rational Redesign of a Functional Protein Kinase-Substrate Interaction
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00089 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 29, 2017 Category: Chemistry Authors: Catherine Chen, Wutigri Nimlamool, Chad J. Miller, Hua Jane Lou and Benjamin E. Turk Source Type: research

Recruitment and Regulation of the Non-ribosomal Peptide Synthetase Modifying Cytochrome P450 Involved in Nikkomycin Biosynthesis
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00081 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 28, 2017 Category: Chemistry Authors: Courtney E. Wise and Thomas M. Makris Source Type: research

The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00053 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 27, 2017 Category: Chemistry Authors: Raphael Bieri, Nicole Scherr, Marie-The ́rèse Ruf, Jean-Pierre Dangy, Philipp Gersbach, Matthias Gehringer, Karl-Heinz Altmann and Gerd Pluschke Source Type: research

Histo-Blood Group Antigen Presentation Is Critical for Binding of Norovirus VLP to Glycosphingolipids in Model Membranes
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00152 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 27, 2017 Category: Chemistry Authors: Waqas Nasir, Martin Frank, Angelika Kunze, Marta Bally, Francisco Parra, Per-Georg Nyholm, Fredrik Ho ̈ök and Göran Larson Source Type: research

Tracing Effects of Fluorine Substitutions on G-Quadruplex Conformational Changes
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01096 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 27, 2017 Category: Chemistry Authors: Jonathan Dickerhoff, Linn Haase, Walter Langel and Klaus Weisz Source Type: research

Stepwise Loop Insertion Strategy for Active Site Remodeling to Generate Novel Enzyme Functions
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00018 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 27, 2017 Category: Chemistry Authors: Md Anarul Hoque, Yong Zhang, Liuqing Chen, Guangyu Yang, Mst Afroza Khatun, Haifeng Chen, Liu Hao and Yan Feng Source Type: research

An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01115 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 24, 2017 Category: Chemistry Authors: Duncan R. M. Smith, Agustinus R. Uria, Eric J. N. Helfrich, Daniela Milbredt, Karl-Heinz van Pe ́e, Jörn Piel and Rebecca J. M. Goss Source Type: research

New Ulvan-Degrading Polysaccharide Lyase Family: Structure and Catalytic Mechanism Suggests Convergent Evolution of Active Site Architecture
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00126 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 23, 2017 Category: Chemistry Authors: ThirumalaiSelvi Ulaganathan, Michal T. Boniecki, Elizabeth Foran, Vitaliy Buravenkov, Naama Mizrachi, Ehud Banin, William Helbert and Miroslaw Cygler Source Type: research

Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00116 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 22, 2017 Category: Chemistry Authors: S. Denise Field, Jacob Arkin, Jing Li and Lyn H. Jones Source Type: research

Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood –Brain Barrier through a Receptor-Free Mechanism
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00087 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 21, 2017 Category: Chemistry Authors: Vera Neves, Frederico Aires-da-Silva, Mauri ́cio Morais, Lurdes Gano, Elisabete Ribeiro, Antónia Pinto, Sandra Aguiar, Diana Gaspar, Célia Fernandes, João D. G. Correia and Miguel A. R. B. Castanho Source Type: research

A Chemical Probe Strategy for Interrogating Inhibitor Selectivity Across the MEK Kinase Family
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01060 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 20, 2017 Category: Chemistry Authors: Kristine K. Deibler, Rama K. Mishra, Matthew R. Clutter, Aleksandar Antanasijevic, Raymond Bergan, Michael Caffrey and Karl A. Scheidt Source Type: research

Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01068 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 20, 2017 Category: Chemistry Authors: Philipp Ottis and Craig M. Crews Source Type: research

Meeting Proceedings ICBS2016 Translating the Power of Chemical Biology to Clinical Advances
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00205 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 17, 2017 Category: Chemistry Authors: Yugo Kuriki, Toru Komatsu, Peter D. Ycas, Sara K. Coulup, Erick J. Carlson and William C. K. Pomerantz Source Type: research

Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00142 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 16, 2017 Category: Chemistry Authors: Tathyana Mar Amorim Franco, Lorenza Favrot, Olivia Vergnolle and John S. Blanchard Source Type: research

Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00003 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 15, 2017 Category: Chemistry Authors: Vito Valiante, Derek J. Mattern, Anja Schu ̈ffler, Fabian Horn, Grit Walther, Kirstin Scherlach, Lutz Petzke, Joachim Dickhaut, Reinhard Guthke, Christian Hertweck, Markus Nett, Eckhard Thines and Axel A. Brakhage Source Type: research

Glycation of Lysozyme by Glycolaldehyde Provides New Mechanistic Insights in Diabetes-Related Protein Aggregation
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01103 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 14, 2017 Category: Chemistry Authors: Laura Marin ̃o, Carlos Andrés Maya-Aguirre, Kris Pauwels, Bartolomé Vilanova, Joaquin Ortega-Castro, Juan Frau, Josefa Donoso and Miquel Adrover Source Type: research

Biased Signaling by Agonists of Protease Activated Receptor 2
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01088 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 14, 2017 Category: Chemistry Authors: Yuhong Jiang, Mei-Kwan Yau, W. Mei Kok, Junxian Lim, Kai-Chen Wu, Ligong Liu, Timothy A. Hill, Jacky Y. Suen and David P. Fairlie Source Type: research

Structure –Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-group and Cross-group ComD Receptor Activation
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00007 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 10, 2017 Category: Chemistry Authors: Yifang Yang, Bimal Koirala, Lucia A. Sanchez, Naiya R. Phillips, Sally R. Hamry and Yftah Tal-Gan Source Type: research

A Fluorescent Probe Distinguishes between Inhibition of Early and Late Steps of Lipopolysaccharide Biogenesis in Whole Cells
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00159 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 9, 2017 Category: Chemistry Authors: Eileen Moison, Ran Xie, Ge Zhang, Matthew D. Lebar, Timothy C. Meredith and Daniel Kahne Source Type: research

Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01159 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 8, 2017 Category: Chemistry Authors: Lindsay S. Roberts, Peter Yan, Leslie A. Bateman and Daniel K. Nomura Source Type: research

A Near-Infrared, Wavelength-Shiftable, Turn-on Fluorescent Probe for the Detection and Imaging of Cancer Tumor Cells
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01094 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 7, 2017 Category: Chemistry Authors: Zhenhua Shen, Bijeta Prasai, Yuko Nakamura, Hisataka Kobayashi, Milcah S. Jackson and Robin L. McCarley Source Type: research

Ion Mobility-Mass Spectrometry Reveals a Dipeptide That Acts as a Molecular Chaperone for Amyloid β
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00045 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 6, 2017 Category: Chemistry Authors: Molly T. Soper-Hopper, Joseph D. Eschweiler and Brandon T. Ruotolo Source Type: research

The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00016 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 3, 2017 Category: Chemistry Authors: Elise A. Span, Daniel L. M. Suess, Marc C. Deller, R. David Britt and Michael A. Marletta Source Type: research

Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01069 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 3, 2017 Category: Chemistry Authors: Kelsey R. Schramma and Mohammad R. Seyedsayamdost Source Type: research

NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01116 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 3, 2017 Category: Chemistry Authors: Ana Gimeno, Niels-Christian Reichardt, F. Javier Can ̃ada, Lukas Perkams, Carlo Unverzagt, Jesús Jiménez-Barbero and Ana Ardá Source Type: research

Mitochondrial Cysteine Desulfurase and ISD11 Coexpressed in Escherichia coli Yield Complex Containing Acyl Carrier Protein
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01005 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 2, 2017 Category: Chemistry Authors: Kai Cai, Ronnie O. Frederick, Marco Tonelli and John L. Markley Source Type: research

Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01101 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 2, 2017 Category: Chemistry Authors: Olivier-Mohamad Soueidan, Thomas W. Scully, Jatinder Kaur, Rashmi Panigrahi, Alexandr Belovodskiy, Victor Do, Carson D. Matier, M. Joanne Lemieux, Frank Wuest, Chris Cheeseman and F. G. West Source Type: research

Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00118 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 2, 2017 Category: Chemistry Authors: Dake Hao, Wenwu Xiao, Ruiwu Liu, Priyadarsini Kumar, Yuanpei Li, Ping Zhou, Fuzheng Guo, Diana L. Farmer, Kit S. Lam, Fengshan Wang and Aijun Wang Source Type: research

The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00883 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 1, 2017 Category: Chemistry Authors: Jung-Hwa Cho, Carter J. Swanson, Jeannie Chen, Ang Li, Lisa G. Lippert, Shannon E. Boye, Kasey Rose, Sivaraj Sivaramakrishnan, Cheng-Ming Chuong and Robert H. Chow Source Type: research

Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01158 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - March 1, 2017 Category: Chemistry Authors: Leslie A. Bateman, Wan-Min Ku, Martin J. Heslin, Carlo M. Contreras, Christine F. Skibola and Daniel K. Nomura Source Type: research

The Ecstasy and Agony of Assay Interference Compounds
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00119 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 28, 2017 Category: Chemistry Authors: Courtney Aldrich, Carolyn Bertozzi, Gunda I. Georg, Laura Kiessling, Craig Lindsley, Dennis Liotta, Kenneth M. Merz, Alanna Schepartz and Shaomeng Wang Source Type: research

Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01077 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 23, 2017 Category: Chemistry Authors: Ge ́raldine Ganne, Karl Brillet, Beata Basta, Béatrice Roche, Françoise Hoegy, Véronique Gasser and Isabelle J. Schalk Source Type: research

A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00006 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 23, 2017 Category: Chemistry Authors: Lauren B. Crowe, Philip F. Hughes, David A. Alcorta, Takuya Osada, Aaron P. Smith, Juliane Totzke, David R. Loiselle, Isaac D. Lutz, Madhusudhana Gargesha, Debasish Roy, Jose Roques, David Darr, H. Kim Lyerly, Neil L. Spector and Timothy A.J. Haystead Source Type: research

Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01129 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 22, 2017 Category: Chemistry Authors: Joel R. Walker, Mary P. Hall, Chad A. Zimprich, Matthew B. Robers, Sarah J. Duellman, Thomas Machleidt, Jacquelynn Rodriguez and Wenhui Zhou Source Type: research

O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00113 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 22, 2017 Category: Chemistry Authors: Yuka E. Lewis, Ana Galesic, Paul M. Levine, Cesar A. De Leon, Natalie Lamiri, Caroline K. Brennan and Matthew R. Pratt Source Type: research

Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01040 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 22, 2017 Category: Chemistry Authors: Geng-Yuan Chen, You Jung Kang, A. Sophia Gayek, Wiphu Youyen, Erkan Tu ̈zel, Ryoma Ohi and William O. Hancock Source Type: research

Mechanistic Debris Generated by Twister Ribozymes
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00010 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 21, 2017 Category: Chemistry Authors: Ronald R. Breaker Source Type: research

Change in Heat Capacity for Enzyme Catalysis Determines Temperature Dependence of Enzyme Catalyzed Rates
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00065 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 21, 2017 Category: Chemistry Authors: Joanne K. Hobbs, Wanting Jiao, Ashley D. Easter, Emily J. Parker, Louis A. Schipper and Vickery L. Arcus Source Type: research

The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00958 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 20, 2017 Category: Chemistry Authors: Rebecca L Hancock, Norma Masson, Kate Dunne, Emily Flashman and Akane Kawamura Source Type: research

Evolution and Distribution of C7 –Cyclitol Synthases in Prokaryotes and Eukaryotes
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00066 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 17, 2017 Category: Chemistry Authors: Andrew R. Osborn, Kelsey M. Kean, Khaled M. Alseud, Khaled H. Almabruk, Shumpei Asamizu, Janet A. Lee, P. Andrew Karplus and Taifo Mahmud Source Type: research

Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00999 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 17, 2017 Category: Chemistry Authors: Pamela T. Wong, Edward W. Roberts, Shengzhuang Tang, Jhindan Mukherjee, Jayme Cannon, Alyssa J. Nip, Kaitlin Corbin, Matthew F. Krummel and Seok Ki Choi Source Type: research

Determinants of BH3 Sequence Specificity for the Disruption of Bcl-xL/cBid Complexes in Membranes
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01084 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 17, 2017 Category: Chemistry Authors: Kushal Kumar Das, Raed Shalaby and Ana J. Garci ́a-Sáez Source Type: research

Modification of the Orthosteric PPAR γ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01015 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 16, 2017 Category: Chemistry Authors: Richard Brust, Hua Lin, Jakob Fuhrmann, Alice Asteian, Theodore M. Kamenecka and Douglas J. Kojetin Source Type: research

Characterization of CYP115 As a Gibberellin 3-Oxidase Indicates That Certain Rhizobia Can Produce Bioactive Gibberellin A4
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01038 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 16, 2017 Category: Chemistry Authors: Ryan S. Nett, Tiffany Contreras and Reuben J. Peters Source Type: research

The SUV39H1 Protein Lysine Methyltransferase Methylates Chromatin Proteins Involved in Heterochromatin Formation and VDJ Recombination
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01076 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 16, 2017 Category: Chemistry Authors: Srikanth Kudithipudi, Maren Kirstin Schuhmacher, Adam Fiseha Kebede and Albert Jeltsch Source Type: research