The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00958 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 20, 2017 Category: Chemistry Authors: Rebecca L Hancock, Norma Masson, Kate Dunne, Emily Flashman and Akane Kawamura Source Type: research

Evolution and Distribution of C7 –Cyclitol Synthases in Prokaryotes and Eukaryotes
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00066 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 17, 2017 Category: Chemistry Authors: Andrew R. Osborn, Kelsey M. Kean, Khaled M. Alseud, Khaled H. Almabruk, Shumpei Asamizu, Janet A. Lee, P. Andrew Karplus and Taifo Mahmud Source Type: research

Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00999 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 17, 2017 Category: Chemistry Authors: Pamela T. Wong, Edward W. Roberts, Shengzhuang Tang, Jhindan Mukherjee, Jayme Cannon, Alyssa J. Nip, Kaitlin Corbin, Matthew F. Krummel and Seok Ki Choi Source Type: research

Determinants of BH3 Sequence Specificity for the Disruption of Bcl-xL/cBid Complexes in Membranes
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01084 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 17, 2017 Category: Chemistry Authors: Kushal Kumar Das, Raed Shalaby and Ana J. Garci ́a-Sáez Source Type: research

Modification of the Orthosteric PPAR γ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01015 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 16, 2017 Category: Chemistry Authors: Richard Brust, Hua Lin, Jakob Fuhrmann, Alice Asteian, Theodore M. Kamenecka and Douglas J. Kojetin Source Type: research

Characterization of CYP115 As a Gibberellin 3-Oxidase Indicates That Certain Rhizobia Can Produce Bioactive Gibberellin A4
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01038 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 16, 2017 Category: Chemistry Authors: Ryan S. Nett, Tiffany Contreras and Reuben J. Peters Source Type: research

The SUV39H1 Protein Lysine Methyltransferase Methylates Chromatin Proteins Involved in Heterochromatin Formation and VDJ Recombination
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01076 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 16, 2017 Category: Chemistry Authors: Srikanth Kudithipudi, Maren Kirstin Schuhmacher, Adam Fiseha Kebede and Albert Jeltsch Source Type: research

Identifying Functional Cysteine Residues in the Mitochondria
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01074 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 15, 2017 Category: Chemistry Authors: Daniel W. Bak, Mattia D. Pizzagalli and Eranthie Weerapana Source Type: research

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00031 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 15, 2017 Category: Chemistry Authors: Kenneth D. Clevenger, Romila Mascarenhas, Daniel Catlin, Rui Wu, Neil L. Kelleher, Eric J. Drake, Andrew M. Gulick, Dali Liu and Walter Fast Source Type: research

Inositol Pyrophosphate Specificity of the SPX-Dependent Polyphosphate Polymerase VTC
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00026 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 15, 2017 Category: Chemistry Authors: Ruta Gerasimaite, Igor Pavlovic, Samanta Capolicchio, Alexandre Hofer, Andrea Schmidt, Henning J. Jessen and Andreas Mayer Source Type: research

Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00020 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 15, 2017 Category: Chemistry Authors: Allison M. Roberts, David K. Miyamoto, Tucker R. Huffman, Leslie A. Bateman, Ashley N. Ives, David Akopian, Martin J. Heslin, Carlo M. Contreras, Michael Rape, Christine F. Skibola and Daniel K. Nomura Source Type: research

Structural and Epimeric Isomers of HPPH [3-Devinyl 3-{1-(1-hexyloxy) ethyl}pyropheophorbide-a]: Effects on Uptake and Photodynamic Therapy of Cancer
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00023 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 15, 2017 Category: Chemistry Authors: Courtney Saenz, Ravindra R. Cheruku, Tymish Y. Ohulchanskyy, Penny Joshi, Walter A. Tabaczynski, Joseph R. Missert, Yihui Chen, Paula Pera, Erin Tracy, Aimee Marko, Daniel Rohrbach, Ulas Sunar, Heinz Baumann and Ravindra K. Pandey Source Type: research

A Pair of Residues That Interactively Affect Diterpene Synthase Product Outcome
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01075 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 14, 2017 Category: Chemistry Authors: Meirong Jia, Ke Zhou, Samuel Tufts, Samuel Schulte and Reuben J. Peters Source Type: research

Tools for Studying Glycans: Recent Advances in Chemoenzymatic Glycan Labeling
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01089 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 13, 2017 Category: Chemistry Authors: Aime Lopez Aguilar, Jennie Grace Briard, Linette Yang, Ben Ovryn, Matthew Scott Macauley and Peng Wu Source Type: research

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01052 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 13, 2017 Category: Chemistry Authors: Marc P. Baggelaar, Annelot C. M. van Esbroeck, Eva J. van Rooden, Bogdan I. Florea, Herman S. Overkleeft, Giovanni Marsicano, Francis Chaouloff and Mario van der Stelt Source Type: research

Structural Insights into the Regulation of Hippo Signaling
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01058 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 9, 2017 Category: Chemistry Authors: Leah Cairns, Thao Tran and Jennifer M. Kavran Source Type: research

Identification of a Novel Epoxyqueuosine Reductase Family by Comparative Genomics
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01100 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 8, 2017 Category: Chemistry Authors: Re ́mi Zallot, Robert Ross, Wei-Hung Chen, Steven D. Bruner, Patrick A. Limbach and Valérie de Crécy-Lagard Source Type: research

FRET Studies of Quinolone-Based Bitopic Ligands and Their Structural Analogues at the Muscarinic M1 Receptor
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00828 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 6, 2017 Category: Chemistry Authors: Regina Messerer, Michael Kauk, Daniela Volpato, Maria Consuelo Alonso Canizal, Jessika Klo ̈ckner, Ulrike Zabel, Susanne Nuber, Carsten Hoffmann and Ulrike Holzgrabe Source Type: research

Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01154 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 3, 2017 Category: Chemistry Authors: Mikhail Metelev, Anatolii Arseniev, Leah B. Bushin, Konstantin Kuznedelov, Tatiana O. Artamonova, Ruslan Kondratenko, Mikhail Khodorkovskii, Mohammad R. Seyedsayamdost and Konstantin Severinov Source Type: research

Probing the Structural Mechanism of Partial Agonism in Glycine Receptors Using the Fluorescent Artificial Amino Acid, ANAP
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00926 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 2, 2017 Category: Chemistry Authors: Ming S. Soh, Argel Estrada-Mondragon, Nela Durisic, Angelo Keramidas and Joseph W. Lynch Source Type: research

Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01006 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 1, 2017 Category: Chemistry Authors: David E. Hacker, Jan Hoinka, Emil S. Iqbal, Teresa M. Przytycka and Matthew C. T. Hartman Source Type: research

The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00877 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 30, 2017 Category: Chemistry Authors: Balyn W. Zaro, Anna R. Batt, Kelly N. Chuh, Marisol X. Navarro and Matthew R. Pratt Source Type: research

Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01148 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 30, 2017 Category: Chemistry Authors: Marcus J. C. Long, Jesse R. Poganik, Souradyuti Ghosh and Yimon Aye Source Type: research

Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00953 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 27, 2017 Category: Chemistry Authors: Christian Burgard, Nestor Zaburannyi, Suvd Nadmid, Josef Maier, Holger Jenke-Kodama, Eva Luxenburger, Hubert S. Bernauer and Silke C. Wenzel Source Type: research

Genetic Organization of Anabaenopeptin and Spumigin Biosynthetic Gene Clusters in the Cyanobacterium Sphaerospermopsis torques-reginae ITEP-024
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00948 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 26, 2017 Category: Chemistry Authors: Stella T. Lima, Danillo O. Alvarenga, Augusto Etchegaray, David P. Fewer, Jouni Jokela, Alessandro M. Varani, Miriam Sanz, Felipe A. Do ̈rr, Ernani Pinto, Kaarina Sivonen and Marli F. Fiore Source Type: research

Novel Triazole-Piperazine Hybrid Molecules Induce Apoptosis via Activation of the Mitochondrial Pathway and Exhibit Antitumor Efficacy in Osteosarcoma Xenograft Nude Mice Model
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01007 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 26, 2017 Category: Chemistry Authors: Chandra Bhushan Mishra, Raj Kumar Mongre, Shikha Kumari, Dong Kee Jeong and Manisha Tiwari Source Type: research

Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4 β-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00842 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 25, 2017 Category: Chemistry Authors: Wei Zhao, Chen Zhou, Ze-Yuan Guan, Ping Yin, Fusheng Chen and Ya-Jie Tang Source Type: research

Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00782 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 24, 2017 Category: Chemistry Authors: Edward Grimley, Chenzhong Liao, Egon J. Ranghini, Zaneta Nikolovska-Coleska and Gregory R. Dressler Source Type: research

Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00646 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 24, 2017 Category: Chemistry Authors: Anirudh Ranganathan, Philipp Heine, Axel Rudling, Andreas Plu ̈ckthun, Lutz Kummer and Jens Carlsson Source Type: research

Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01117 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 24, 2017 Category: Chemistry Authors: Caroline Ray, Erik J. Soderblom, Yushi Bai, F. Ivy Carroll, Marc G. Caron and Larry S. Barak Source Type: research

Sequence-Defined Backbone Modifications Regulate Antibacterial Activity of OligoTEAs
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00837 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 24, 2017 Category: Chemistry Authors: Mintu Porel, Dana N. Thornlow, Christine M. Artim and Christopher A. Alabi Source Type: research

Differential Ability of Five DNA Glycosylases to Recognize and Repair Damage on Nucleosomal DNA
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00921 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 23, 2017 Category: Chemistry Authors: Eric D. Olmon and Sarah Delaney Source Type: research

Chemoproteomic Profiling of Acetanilide Herbicides Reveals Their Role in Inhibiting Fatty Acid Oxidation
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01001 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 20, 2017 Category: Chemistry Authors: Jessica L. Counihan, Megan Duckering, Esha Dalvie, Wan-min Ku, Leslie A. Bateman, Karl J. Fisher and Daniel K. Nomura Source Type: research

Biosynthesis of the Methylthioxylose Capping Motif of Lipoarabinomannan in Mycobacterium tuberculosis
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01071 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 20, 2017 Category: Chemistry Authors: Shiva kumar Angala, Michael R. McNeil, Libin Shi, Maju Joe, Ha Pham, Sophie Zuberogoitia, Je ́rôme Nigou, Claudia M. Boot, Todd L. Lowary, Martine Gilleron and Mary Jackson Source Type: research

Deciphering the Functions of Protein O-GlcNAcylation with Chemistry
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01065 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 19, 2017 Category: Chemistry Authors: Matthew Worth, Hao Li and Jiaoyang Jiang Source Type: research

An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01002 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 19, 2017 Category: Chemistry Authors: Martin Daniel-Ivad, Nabeela Hameed, Stephanie Tan, Rachna Dhanjal, Daniel Socko, Patricia Pak, Tomas Gverzdys, Marie A. Elliot and Justin R. Nodwell Source Type: research

Extensive Turnover of Compatible Solutes in Cyanobacteria Revealed by Deuterium Oxide (D2O) Stable Isotope Probing
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00890 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 18, 2017 Category: Chemistry Authors: Richard Baran, Rebecca Lau, Benjamin P. Bowen, Spencer Diamond, Nick Jose, Ferran Garcia-Pichel and Trent R. Northen Source Type: research

Fluorescent Branched RNAs for High-Throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00971 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 18, 2017 Category: Chemistry Authors: Adam Katolik, Nathaniel E. Clark, Nobuhiro Tago, Eric J. Montemayor, P. John Hart and Masad J. Damha Source Type: research

Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00998 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 18, 2017 Category: Chemistry Authors: Qin Wu, Hidde L. Ploegh and Matthias C. Truttmann Source Type: research

Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01033 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 17, 2017 Category: Chemistry Authors: Omkar P. Dhamale, Roger Lawrence, Elena M. Wiegmann, Bhahwal A. Shah, Kanar Al-Mafraji, William C. Lamanna, Torben Lu ̈bke, Thomas Dierks, Geert-Jan Boons and Jeffrey D. Esko Source Type: research

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01031 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 13, 2017 Category: Chemistry Authors: Manuel A. Ortega, Dillon P. Cogan, Subha Mukherjee, Neha Garg, Bo Li, Gabrielle N. Thibodeaux, Sonia I. Maffioli, Stefano Donadio, Margherita Sosio, Jerome Escano, Leif Smith, Satish K. Nair and Wilfred A. van der Donk Source Type: research

Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00852 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 13, 2017 Category: Chemistry Authors: Narae Shin, Kenjiro Hanaoka, Wen Piao, Takuya Miyakawa, Tomotsumi Fujisawa, Satoshi Takeuchi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Masaru Tanokura, Tetsuo Nagano and Yasuteru Urano Source Type: research

Structural and Functional Basis of C-Methylation of Coumarin Scaffolds by NovO
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01053 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 13, 2017 Category: Chemistry Authors: Joanna C. Sadler, Chun-wa H. Chung, Julie E. Mosley, Glenn A. Burley and Luke D. Humphreys Source Type: research

A Highly Promiscuous ß-Ketoacyl-ACP Synthase (KAS) III-like Protein Is Involved in Pactamycin Biosynthesis
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01043 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 12, 2017 Category: Chemistry Authors: Mostafa E. Abugrain, Corey J. Brumsted, Andrew R. Osborn, Benjamin Philmus and Taifo Mahmud Source Type: research

Chemical Modifications to RNA: A New Layer of Gene Expression Regulation
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00960 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 12, 2017 Category: Chemistry Authors: Jinghui Song and Chengqi Yi Source Type: research

Development of Autologous C5 Vaccine Nanoparticles to Reduce Intravascular Hemolysis in Vivo
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00994 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 12, 2017 Category: Chemistry Authors: Lingjun Zhang, Wen Qiu, Stephen Crooke, Yan Li, Areeba Abid, Bin Xu, M.G. Finn and Feng Lin Source Type: research

Global N-Glycan Site Occupancy of HIV-1 gp120 by Metabolic Engineering and High-Resolution Intact Mass Spectrometry
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00854 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 9, 2017 Category: Chemistry Authors: Weston B. Struwe, Alexandra Stuckmann, Anna-Janina Behrens, Kevin Pagel and Max Crispin Source Type: research

N@a and N@d: Oligomer and Partner Specification by Asparagine in Coiled-Coil Interfaces
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00935 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 9, 2017 Category: Chemistry Authors: Jordan M. Fletcher, Gail J. Bartlett, Aimee L. Boyle, Jonathan J. Danon, Laura E. Rush, Andrei N. Lupas and Derek N. Woolfson Source Type: research

Duration Control of Protein Expression in Vivo by Light-Mediated Reversible Activation of Translation
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00684 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 4, 2017 Category: Chemistry Authors: Shinzi Ogasawara Source Type: research

Profiling Protease Specificity: Combining Yeast ER Sequestration Screening (YESS) with Next Generation Sequencing
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00547 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 3, 2017 Category: Chemistry Authors: Qing Li, Li Yi, Kam Hon Hoi, Peter Marek, George Georgiou and Brent L. Iverson Source Type: research