Translocation of an Intracellular Protein via Peptide-Directed Ligation
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01013 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 3, 2017 Category: Chemistry Authors: Christiane Stiller, Dennis M. Kru ̈ger, Nicolas Brauckhoff, Marcel Schmidt, Petra Janning, Hazem Salamon and Tom N. Grossmann Source Type: research

A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01012 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 29, 2016 Category: Chemistry Authors: Brittany A. Moser and Aaron P. Esser-Kahn Source Type: research

Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00918 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 29, 2016 Category: Chemistry Authors: Naina Sharma, Kathryn E. Carlson, Jerome C. Nwachukwu, Sathish Srinivasan, Abhishek Sharma, Kendall W. Nettles and John A. Katzenellenbogen Source Type: research

Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00922 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 28, 2016 Category: Chemistry Authors: Christopher F. Stratton, Myles B. Poulin, Quan Du and Vern L. Schramm Source Type: research

Trapping Reactions of the Sulfenyl and Sulfinyl Tautomers of Sulfenic Acids
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00980 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 28, 2016 Category: Chemistry Authors: Murugaeson R. Kumar and Patrick J. Farmer Source Type: research

Identification of the Ferric-Acinetobactin Outer Membrane Receptor in Aeromonas salmonicida subsp. salmonicida and Structure –Activity Relationships of Synthetic Acinetobactin Analogues
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00805 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 28, 2016 Category: Chemistry Authors: Miguel Balado, Yuri Segade, Diego Rey, Carlos R. Osorio, Jaime Rodri ́guez, Manuel L. Lemos and Carlos Jiménez Source Type: research

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00939 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 27, 2016 Category: Chemistry Authors: Philip Olivares, Emily C. Ulrich, Jonathan R. Chekan, Wilfred A. van der Donk and Satish K. Nair Source Type: research

hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00962 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 27, 2016 Category: Chemistry Authors: Elisa Barile, Guya D. Marconi, Surya K. De, Carlo Baggio, Luca Gambini, Ahmed F. Salem, Manoj K. Kashyap, Januario E. Castro, Thomas J. Kipps and Maurizio Pellecchia Source Type: research

Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5 ′-Methylthioadenosine Phosphorylase
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00885 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 27, 2016 Category: Chemistry Authors: Ross S. Firestone, Scott A. Cameron, Jerome M. Karp, Vickery L. Arcus and Vern L. Schramm Source Type: research

Discovery of Inhibitors of MicroRNA-21 Processing Using Small Molecule Microarrays
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00945 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 23, 2016 Category: Chemistry Authors: Colleen M. Connelly, Robert E. Boer, Michelle H. Moon, Peter Gareiss and John S. Schneekloth Source Type: research

The GLO1 Gene Is Required for Full Activity of O-Acetyl Homoserine Sulfhydrylase Encoded by MET17
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00815 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 22, 2016 Category: Chemistry Authors: Matias I. Kinzurik, Kien Ly, Karine M. David, Richard C. Gardner and Bruno Fedrizzi Source Type: research

A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00981 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 22, 2016 Category: Chemistry Authors: Rishikesh U. Kulkarni, Hang Yin, Narges Pourmandi, Feroz James, Maroof M. Adil, David V. Schaffer, Yi Wang and Evan W. Miller Source Type: research

Proteoform-Specific Protein Binding of Small Molecules in Complex Matrices
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01018 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 21, 2016 Category: Chemistry Authors: Geuncheol Gil, Pan Mao, Bharathi Avula, Zulfiqar Ali, Amar G. Chittiboyina, Ikhlas A. Khan, Larry A. Walker and Daojing Wang Source Type: research

Mechanism of the Spontaneous and Directional Membrane Insertion of a 2-Transmembrane Ion Channel
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01085 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 21, 2016 Category: Chemistry Authors: Steffen Altrichter, Maximilian Haase, Belinda Loh, Andreas Kuhn and Sebastian Leptihn Source Type: research

Heparin-Promoted Cellular Uptake of the Cell-Penetrating Glycosaminoglycan Binding Peptide, GBPECP, Depends on a Single Tryptophan
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00864 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 21, 2016 Category: Chemistry Authors: Li-Chun Hung, Ingjye Jiang, Chien-Jung Chen, Jia-Yin Lu, Yi-Fen Hsieh, Ping-Hsieh Kuo, Yi-Lin Hung, Lily Hui-Ching Wang, Margaret Dah-Tsyr Chang and Shih-Che Sue Source Type: research

SIRT7 Is an RNA-Activated Protein Lysine Deacylase
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00954 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 20, 2016 Category: Chemistry Authors: Zhen Tong, Miao Wang, Yi Wang, David D. Kim, Jennifer K. Grenier, Ji Cao, Sushabhan Sadhukhan, Quan Hao and Hening Lin Source Type: research

Engineering High Affinity Protein –Protein Interactions Using a High-Throughput Microcapillary Array Platform
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00794 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 20, 2016 Category: Chemistry Authors: Sungwon Lim, Bob Chen, Mihalis S. Kariolis, Ivan K. Dimov, Thomas M. Baer and Jennifer R. Cochran Source Type: research

Engineering Cyclohexanone Monooxygenase for the Production of Methyl Propanoate
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00965 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 20, 2016 Category: Chemistry Authors: Hugo L. van Beek, Elvira Romero and Marco W. Fraaije Source Type: research

Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00995 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 16, 2016 Category: Chemistry Authors: Yulia Y. Tyurina, Wenjia Lou, Feng Qu, Vladimir A Tyurin, Dariush Mohammadyani, Jenney Liu, Maik Hu ̈ttemann, Michael A. Frasso, Peter Wipf, H. Bayir, Miriam. L. Greenberg and Valerian E. Kagan Source Type: research

Internal Structure and Preferential Protein Binding of Colloidal Aggregates
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00791 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 16, 2016 Category: Chemistry Authors: Da Duan, Hayarpi Torosyan, Daniel Elnatan, Christopher K. McLaughlin, Jennifer Logie, Molly S. Shoichet, David A. Agard and Brian K. Shoichet Source Type: research

A Look into the Biochemistry of Magnetosome Biosynthesis in Magnetotactic Bacteria
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01000 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 16, 2016 Category: Chemistry Authors: Shiran Barber-Zucker and Raz Zarivach Source Type: research

LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00776 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 15, 2016 Category: Chemistry Authors: Dhanusha A. Nalawansha and Mary Kay H. Pflum Source Type: research

Elucidating the Origin of Long Residence Time Binding for Inhibitors of the Metalloprotease Thermolysin
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00979 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 13, 2016 Category: Chemistry Authors: Jonathan Cramer, Stefan G. Krimmer, Veronica Fridh, Tobias Wulsdorf, Robert Karlsson, Andreas Heine and Gerhard Klebe Source Type: research

Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00747 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 13, 2016 Category: Chemistry Authors: Sanket J. Mishra, Suman Ghosh, Andrew R. Stothert, Chad A. Dickey and Brian S. J. Blagg Source Type: research

A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00928 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 12, 2016 Category: Chemistry Authors: Zahra Khedri, An Xiao, Hai Yu, Corinna Susanne Landig, Wanqing Li, Sandra Diaz, Brian R. Wasik, Colin R. Parrish, Lee-Ping Wang, Ajit Varki and Xi Chen Source Type: research

Probing the Binding Interfaces of Histone-Aptamer by Photo Cross-Linking Mass Spectrometry
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00797 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 12, 2016 Category: Chemistry Authors: Congcong Lu, Shanshan Tian, Guijin Zhai, Zuofei Yuan, Yijun Li, Xiwen He, Yukui Zhang and Kai Zhang Source Type: research

Cell-Density Dependence of Host-Defense Peptide Activity and Selectivity in the Presence of Host Cells
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00910 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 9, 2016 Category: Chemistry Authors: Filippo Savini, Vincenzo Luca, Alessio Bocedi, Renato Massoud, Yoonkyung Park, Maria Luisa Mangoni and Lorenzo Stella Source Type: research

Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00876 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 9, 2016 Category: Chemistry Authors: David L. Shen, Ta-Wei Liu, Wesley Zandberg, Tom Clark, Razieh Eskandari, Matthew G. Alteen, Hong Yee Tan, Yanping Zhu, Samy Cecioni and David Vocadlo Source Type: research

Histone Ketoamide Adduction by 4-Oxo-2-nonenal Is a Reversible Posttranslational Modification Regulated by Sirt2
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00713 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 7, 2016 Category: Chemistry Authors: Yiwen Cui, Xin Li, Jianwei Lin, Quan Hao and Xiang David Li Source Type: research

Live Cell Imaging of Endogenous mRNA Using RNA-Based Fluorescence “Turn-On” Probe
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00586 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 7, 2016 Category: Chemistry Authors: Wei Qiang Ong, Y. Rose Citron, Sayaka Sekine and Bo Huang Source Type: research

Assigning the Algal Source of Dimethylsulfide Using a Selective Lyase Inhibitor
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00844 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 6, 2016 Category: Chemistry Authors: Uria Alcolombri, Lei Lei, Diana Meltzer, Assaf Vardi and Dan S. Tawfik Source Type: research

What Can We Learn from Bioactivity Data? Chemoinformatics Tools and Applications in Chemical Biology Research
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00706 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 5, 2016 Category: Chemistry Authors: Lina Humbeck and Oliver Koch Source Type: research

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00898 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 5, 2016 Category: Chemistry Authors: Monika Jankute, Luke J. Alderwick, Stephan Noack, Natacha Veerapen, Je ́rôme Nigou and Gurdyal S. Besra Source Type: research

Observing Biosynthetic Activity Utilizing Next Generation Sequencing and the DNA Linked Enzyme Coupled Assay
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00652 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 5, 2016 Category: Chemistry Authors: Markus de Raad, Cyrus Modavi, David J. Sukovich and J. Christopher Anderson Source Type: research

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00849 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 2, 2016 Category: Chemistry Authors: Sarah A. Head, Wei Q. Shi, Eun Ju Yang, Benjamin A. Nacev, Sam Y. Hong, Kalyan K. Pasunooti, Ruo-Jing Li, Joong Sup Shim and Jun O. Liu Source Type: research

Mapping the Phosphorylation Pattern of Drosophila melanogaster RNA Polymerase II Carboxyl-Terminal Domain Using Ultraviolet Photodissociation Mass Spectrometry
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00729 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 1, 2016 Category: Chemistry Authors: Joshua E. Mayfield, Michelle R. Robinson, Victoria C. Cotham, Seema Irani, Wendy L. Matthews, Anjana Ram, David S. Gilmour, Joe R. Cannon, Yan Jessie Zhang and Jennifer S. Brodbelt Source Type: research

Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00562 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 1, 2016 Category: Chemistry Authors: Kamil Makowski, Luisa Vigevani, Fernando Albericio, Juan Valca ́rcel and Mercedes Álvarez Source Type: research

Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00683 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 30, 2016 Category: Chemistry Authors: Amalia I. Paunovic, Lauren Drowley, Anneli Nordqvist, Elke Ericson, Elizabeth Mouchet, Anna Jonebring, Gunnar Gro ̈nberg, Alexander J. Kvist, Ola Engkvist, Martin R. Brown, Karin Gedda, Marie-José Goumans, Qing-Dong Wang and Alleyn T. Plowright Source Type: research

Genome Mining of Amino Group Carrier Protein-Mediated Machinery: Discovery and Biosynthetic Characterization of a Natural Product with Unique Hydrazone Unit
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00818 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 30, 2016 Category: Chemistry Authors: Kenichi Matsuda, Fumihito Hasebe, Yuh Shiwa, Yu Kanesaki, Takeo Tomita, Hirofumi Yoshikawa, Kazuo Shin-ya, Tomohisa Kuzuyama and Makoto Nishiyama Source Type: research

Structure and Function of a C –C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00621 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 30, 2016 Category: Chemistry Authors: Guohui Pan, Xiaoqin Gao, Keqiang Fan, Junlin Liu, Bing Meng, Jinmin Gao, Bin Wang, Chaobo Zhang, Hui Han, Guomin Ai, Yihua Chen, Dong Wu, Zhi-Jie Liu and Keqian Yang Source Type: research

An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00977 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 29, 2016 Category: Chemistry Authors: Atsushi Kimishima, Cody J. Wenthur, Bin Zhou and Kim D. Janda Source Type: research

Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00732 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 29, 2016 Category: Chemistry Authors: Irina Koryakina, Christian Kasey, John B. McArthur, Andrew N. Lowell, Joseph A. Chemler, Shasha Li, Douglas A. Hansen, David H. Sherman and Gavin J. Williams Source Type: research

Complete Tetrasaccharide Repeat Unit Biosynthesis of the Immunomodulatory Bacteroides fragilis Capsular Polysaccharide A
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00931 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 28, 2016 Category: Chemistry Authors: Sunita Sharma, Katelyn M. Erickson and Jerry M. Troutman Source Type: research

Targeting NF- κB p65 with a Helenalin Inspired Bis-electrophile
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00751 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 28, 2016 Category: Chemistry Authors: John C. Widen, Aaron M. Kempema, Peter W. Villalta and Daniel A. Harki Source Type: research

Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00841 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 22, 2016 Category: Chemistry Authors: Yongmei Xu, Andrea F. Moon, Shuqin Xu, Juno M. Krahn, Jian Liu and Lars C. Pedersen Source Type: research

Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00788 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 22, 2016 Category: Chemistry Authors: Paul C. Jordan, Sarah K. Stevens, Yuen Tam, Ryan P. Pemberton, Shuvam Chaudhuri, Antitsa D. Stoycheva, Natalia Dyatkina, Guangyi Wang, Julian A. Symons, Jerome Deval and Leo Beigelman Source Type: research

An Effective Bacterial Fucosidase for Glycoprotein Remodeling
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00821 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 18, 2016 Category: Chemistry Authors: Tsung-I Tsai, Shiou-Ting Li, Chiu-Ping Liu, Karen Y. Chen, Sachin S. Shivatare, Chin-Wei Lin, Shih-Fen Liao, Chih-Wei Lin, Tsui-Ling Hsu, Ying-Ta Wu, Ming-Hung Tsai, Meng-Yu Lai, Nan-Horng Lin, Chung-Yi Wu and Chi-Huey Wong Source Type: research

A Malaria Transmission-Blocking (+)-Usnic Acid Derivative Prevents Plasmodium Zygote-to-Ookinete Maturation in the Mosquito Midgut
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00902 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 17, 2016 Category: Chemistry Authors: Rebecca Pastrana-Mena, Derrick K. Mathias, Michael Delves, Krithika Rajaram, Jonas G. King, Rebecca Yee, Beatrice Trucchi, Luisella Verotta and Rhoel R. Dinglasan Source Type: research

Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00779 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 15, 2016 Category: Chemistry Authors: Ryan A. McClure, Anthony W. Goering, Kou-San Ju, Joshua A. Baccile, Frank C. Schroeder, William W. Metcalf, Regan J. Thomson and Neil. L Kelleher Source Type: research

Probing the Catalytic Charge-Relay System in Alanine Racemase with Genetically Encoded Histidine Mimetics
ACS Chemical BiologyDOI: 10.1021/acschembio.6b00940 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - November 15, 2016 Category: Chemistry Authors: Vangmayee Sharma, Yane-Shih Wang and Wenshe R. Liu Source Type: research