CRISPR Approaches to Small Molecule Target Identification
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00965 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 25, 2018 Category: Chemistry Authors: Marco Jost and Jonathan S. Weissman Source Type: research

Heterologous Production and Purification of a Functional Chloroform Reductive Dehalogenase
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00846 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 25, 2018 Category: Chemistry Authors: Bat-Erdene Jugder, Karl A. P. Payne, Karl Fisher, Susanne Bohl, Helene Lebhar, Mike Manefield, Matthew Lee, David Leys and Christopher P. Marquis Source Type: research

A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01016 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 24, 2018 Category: Chemistry Authors: Thomas E. Speltz, Jeanne M. Danes, Joshua D. Stender, Jonna Frasor and Terry W. Moore Source Type: research

A Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00822 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 23, 2018 Category: Chemistry Authors: Gloria Andolina, La ́szló-Csaba Bencze, Katja Zerbe, Maik Müller, Jessica Steinmann, Harsha Kocherla, Milon Mondal, Jens Sobek, Kerstin Moehle, Goran Malojčić, Bernd Wollscheid and John A. Robinson Source Type: research

Genetically Encoded Glutamate Indicators with Altered Color and Topology
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01085 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 22, 2018 Category: Chemistry Authors: Jiahui Wu, Ahmed S. Abdelfattah, Hang Zhou, Araya Ruangkittisakul, Yong Qian, Klaus Ballanyi and Robert E. Campbell Source Type: research

[ASAP] Genetically Encoded Glutamate Indicators with Altered Color and Topology
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01085 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 22, 2018 Category: Chemistry Authors: Jiahui Wu, Ahmed S. Abdelfattah, Hang Zhou, Araya Ruangkittisakul, Yong Qian, Klaus Ballanyi, Robert E. Campbell Source Type: research

Dual Allosteric Inhibition of SHP2 Phosphatase
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00980 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 18, 2018 Category: Chemistry Authors: Michelle Fodor, Edmund Price, Ping Wang, Hengyu Lu, Andreea Argintaru, Zhouliang Chen, Meir Glick, Huai-Xiang Hao, Mitsunori Kato, Robert Koenig, Jonathan R. LaRochelle, Gang Liu, Eric McNeill, Dyuti Majumdar, Gisele A. Nishiguchi, Lawrence B. Perez, Greg Source Type: research

Establishment of LCMS Based Platform for Discovery of Quorum Sensing Inhibitors: Signal Detection in Pseudomonas aeruginosa PAO1
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00875 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 18, 2018 Category: Chemistry Authors: Manoj Kushwaha, Shreyans K. Jain, Nisha Sharma, Vidushi Abrol, Sundeep Jaglan and Ram A. Vishwakarma Source Type: research

Protein Inhibitors of CRISPR-Cas9
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00831 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 17, 2018 Category: Chemistry Authors: Joseph Bondy-Denomy Source Type: research

Chemical Control of a CRISPR-Cas9 Acetyltransferase
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00883 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 17, 2018 Category: Chemistry Authors: Jonathan H. Shrimp, Carissa Grose, Stephanie R. T. Widmeyer, Abigail L. Thorpe, Ajit Jadhav and Jordan L. Meier Source Type: research

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01039 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 17, 2018 Category: Chemistry Authors: Franziska Kundel, Suman De, Patrick Flagmeier, Mathew H. Horrocks, Magnus Kjaergaard, Sarah L. Shammas, Sophie E. Jackson, Christopher M. Dobson and David Klenerman Source Type: research

Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01097 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 17, 2018 Category: Chemistry Authors: Isabel Aparici-Espert, Guillermo Garcia-Lainez, Inmaculada Andreu, Miguel Angel Miranda and Virginie Lhiaubet-Vallet Source Type: research

Investigation of Amide Bond Formation during Dehydrophos Biosynthesis
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00949 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 12, 2018 Category: Chemistry Authors: Emily C. Ulrich, Despina J. Bougioukou and Wilfred A. van der Donk Source Type: research

Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01058 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 12, 2018 Category: Chemistry Authors: Kazuo Takayama and Hiroyuki Mizuguchi Source Type: research

Live Cell Visualization of Multiple Protein –Protein Interactions with BiFC Rainbow
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00931 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 11, 2018 Category: Chemistry Authors: Sheng Wang, Miao Ding, Boxin Xue, Yingping Hou and Yujie Sun Source Type: research

Time-Resolved Tracking of Separately Internalized Neuropeptide Y2 Receptors by Two-Color Pulse-Chase
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00999 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 11, 2018 Category: Chemistry Authors: Jonathan Lotze, Philipp Wolf, Ulrike Reinhardt, Oliver Seitz, Karin Mo ̈rl and Annette G. Beck-Sickinger Source Type: research

Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor α
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00985 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 11, 2018 Category: Chemistry Authors: Yanhong Jiang, Qiwen Deng, Hui Zhao, Mingsheng Xie, Longjian Chen, Feng Yin, Xuan Qin, Weihao Zheng, Yongjuan Zhao and Zigang Li Source Type: research

[ASAP] Live Cell Visualization of Multiple Protein –Protein Interactions with BiFC Rainbow
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00931 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 11, 2018 Category: Chemistry Authors: Sheng Wang, Miao Ding, Boxin Xue, Yingping Hou, Yujie Sun Source Type: research

Identifying Novel Enhancer Elements with CRISPR-Based Screens
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00778 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 10, 2018 Category: Chemistry Authors: Jason C. Klein, Wei Chen, Molly Gasperini and Jay Shendure Source Type: research

A Single Amide Linkage in the Passenger Strand Suppresses Its Activity and Enhances Guide Strand Targeting of siRNAs
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01012 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 10, 2018 Category: Chemistry Authors: Travis Hardcastle, Irina Novosjolova, Venubabu Kotikam, Samwel K. Cheruiyot, Daniel Mutisya, Scott D. Kennedy, Martin Egli, Melissa L. Kelley, Anja van Brabant Smith and Eriks Rozners Source Type: research

Discovery of a 29-Amino-Acid Reactive Abiotic Peptide for Selective Cysteine Arylation
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00520 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 9, 2018 Category: Chemistry Authors: Ethan D. Evans and Bradley L. Pentelute Source Type: research

Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00958 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 8, 2018 Category: Chemistry Authors: Vanessa Porkolab, Eric Chabrol, Norbert Varga, Stefania Ordanini, Ieva Sutkevic ̌iu̅tė, Michel Thépaut, Maria José García-Jiménez, Eric Girard, Pedro M. Nieto, Anna Bernardi and Franck Fieschi Source Type: research

Multiple Chemical Inducible Tal Effectors for Genome Editing and Transcription Activation
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00606 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 8, 2018 Category: Chemistry Authors: Chen Zhao, Yue Zhang, Yingze Zhao, Yue Ying, Runna Ai, Jingfang Zhang and Yu Wang Source Type: research

Next-Generation DNA-Functionalized Quantum Dots as Biological Sensors
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00887 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 4, 2018 Category: Chemistry Authors: Ganglin Wang, Zhi Li and Nan Ma Source Type: research

[ASAP] Next-Generation DNA-Functionalized Quantum Dots as Biological Sensors
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00887 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 4, 2018 Category: Chemistry Authors: Ganglin Wang, Zhi Li, Nan Ma Source Type: research

Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00685 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 3, 2018 Category: Chemistry Authors: Yan Chen, Jin-Yi Zhu, Kwon Ho Hong, David C. Mikles, Gunda I. Georg, Alex S. Goldstein, John K. Amory and Ernst Scho ̈nbrunn Source Type: research

Comparison of the Response of Bacterial IscU and SufU to Zn2+ and Select Transition-Metal Ions
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00442 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - January 3, 2018 Category: Chemistry Authors: Poorna Roy, Mariia A. Bauman, Hayfa Habes Almutairi, Walimuni Geethamala Jayawardhana, Nathan M. Johnson and Andrew T. Torelli Source Type: research

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00907 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 28, 2017 Category: Chemistry Authors: Mattia Mori, Lesia Kovalenko, Savina Malancona, Francesco Saladini, Davide De Forni, Manuel Pires, Nicolas Humbert, Eleonore Real, Thomas Botzanowski, Sarah Cianfe ́rani, Alessia Giannini, Maria Chiara Dasso Lang, Giulia Cugia, Barbara Poddesu, Franco Lo Source Type: research

The Future of Multiplexed Eukaryotic Genome Engineering
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00842 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 28, 2017 Category: Chemistry Authors: David B. Thompson, Soufiane Aboulhouda, Eriona Hysolli, Cory J. Smith, Stan Wang, Oscar Castanon and George M. Church Source Type: research

Correction to Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01056 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 28, 2017 Category: Chemistry Authors: Ashish Gupta, Renesh Bedre, Sudarshan Singh Thapa, Afsana Sabrin, Guannan Wang, Maheshi Dassanayake and Anne Grove Source Type: research

Homospermidine Lipids: A Compound Class Specifically Formed during Fruiting Body Formation of Myxococcus xanthus DK1622
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00816 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 28, 2017 Category: Chemistry Authors: Michael Hoffmann, David Auerbach, Fabian Panter, Thomas Hoffmann, Pieter C. Dorrestein and Rolf Mu ̈ller Source Type: research

Crocadepsins Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00900 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 28, 2017 Category: Chemistry Authors: Frank Surup, Konrad Viehrig, Shwan Rachid, Alberto Plaza, Christine K. Maurer, Rolf W. Hartmann and Rolf Mu ̈ller Source Type: research

Discovering the Genome-Wide Activity of CRISPR-Cas Nucleases
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00847 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 27, 2017 Category: Chemistry Authors: Shengdar Q. Tsai Source Type: research

Mining Plants for Bacterial Quorum Sensing Modulators
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00859 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 27, 2017 Category: Chemistry Authors: Shimrit David, Aviad Mandabi, Shaked Uzi, Asaph Aharoni and Michael M. Meijler Source Type: research

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017 Utility and Limitations
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00903 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 26, 2017 Category: Chemistry Authors: Jonathan B. Baell and J. Willem M. Nissink Source Type: research

Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00560 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 20, 2017 Category: Chemistry Authors: Thiago M. A. Santos, Matthew G. Lammers, Maoquan Zhou, Ian L. Sparks, Madhusudan Rajendran, Dong Fang, Crystal L. Y. De Jesus, Gabriel F. R. Carneiro, Qiang Cui and Douglas B. Weibel Source Type: research

Type II-C CRISPR-Cas9 Biology, Mechanism, and Application
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00855 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 20, 2017 Category: Chemistry Authors: Aamir Mir, Alireza Edraki, Jooyoung Lee and Erik J. Sontheimer Source Type: research

Modulating DNA Repair Pathways to Improve Precision Genome Engineering
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00777 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 20, 2017 Category: Chemistry Authors: Katherine S. Pawelczak, Navnath S. Gavande, Pamela S. VanderVere-Carozza and John J. Turchi Source Type: research

Determinants and Prediction of Esterase Substrate Promiscuity Patterns
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00996 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 20, 2017 Category: Chemistry Authors: Mo ́nica Martínez-Martínez, Cristina Coscolín, Gerard Santiago, Jennifer Chow, Peter J. Stogios, Rafael Bargiela, Christoph Gertler, José Navarro-Fernández, Alexander Bollinger, Stephan Thies, Celia Méndez-García, Ana Popovic, Greg Brown, T Source Type: research

Expanding the Bioactive Chemical Space of Anthrabenzoxocinones through Engineering the Highly Promiscuous Biosynthetic Modification Steps
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00743 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 19, 2017 Category: Chemistry Authors: Xianyi Mei, Xiaoli Yan, Hui Zhang, Mingjia Yu, Guangqing Shen, Linjun Zhou, Zixin Deng, Chun Lei and Xudong Qu Source Type: research

Retraction of “The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer”
ACS Chemical BiologyDOI: 10.1021/acschembio.7b01061 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 19, 2017 Category: Chemistry Authors: Brandi M. Baughman, Samantha G. Pattenden, Jacqueline L. Norris, Lindsey I. James and Stephen V. Frye Source Type: research

Site-Selective RNA Splicing Nanozyme: DNAzyme and RtcB Conjugates on a Gold Nanoparticle
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00437 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 19, 2017 Category: Chemistry Authors: Jessica R. Petree, Kevin Yehl, Kornelia Galior, Roxanne Glazier, Brendan Deal and Khalid Salaita Source Type: research

Mode of Action and Heterologous Expression of the Natural Product Antibiotic Vancoresmycin
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00733 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 19, 2017 Category: Chemistry Authors: Bernhard Kepplinger, Stephanie Morton-Laing, Kenneth Holst Seistrup, Emma Claire Louise Marrs, Adam Paul Hopkins, John David Perry, Henrik Strahl, Michael John Hall, Jeff Errington and Nicholas Edward Ellis Allenby Source Type: research

Direct Substrate Identification with an Analog Sensitive (AS) Viral Cyclin-Dependent Kinase (v-Cdk)
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00972 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 19, 2017 Category: Chemistry Authors: Angie C. Uman ̃a, Satoko Iwahori and Robert F. Kalejta Source Type: research

Identification and Experimental Characterization of an Extremophilic Brine Pool Alcohol Dehydrogenase from Single Amplified Genomes
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00792 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 18, 2017 Category: Chemistry Authors: Stefan W. Gro ̈tzinger, Ram Karan, Eva Strillinger, Stefan Bader, Annika Frank, Israa S. Al Rowaihi, Anastassja Akal, Wiebke Wackerow, John A. Archer, Magnus Rueping, Dirk Weuster-Botz, Michael Groll, Jörg Eppinger and Stefan T. Arold Source Type: research

Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington ’s Disease (HD) and Spino Cerebellar Ataxia (SCAs)
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00699 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 18, 2017 Category: Chemistry Authors: Eshan Khan, Arpita Tawani, Subodh Kumar Mishra, Arun Kumar Verma, Arun Upadhyay, Mohit Kumar, Rajat Sandhir, Amit Mishra and Amit Kumar Source Type: research

NRPS-Derived Isoquinolines and Lipopetides Mediate Antagonism between Plant Pathogenic Fungi and Bacteria
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00731 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 18, 2017 Category: Chemistry Authors: Saima Khalid, Joshua A. Baccile, Joseph E. Spraker, Joanna Tannous, Muhammad Imran, Frank C. Schroeder and Nancy P. Keller Source Type: research

Reaction-Based Fluorescent Probes for the Imaging of Nitroxyl (HNO) in Biological Systems
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00901 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 15, 2017 Category: Chemistry Authors: Baoli Dong, Xiuqi Kong and Weiying Lin Source Type: research

[ASAP] Reaction-Based Fluorescent Probes for the Imaging of Nitroxyl (HNO) in Biological Systems
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00901 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 15, 2017 Category: Chemistry Authors: Baoli Dong, Xiuqi Kong, Weiying Lin Source Type: research

Innovations in Undergraduate Chemical Biology Education
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00986 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - December 14, 2017 Category: Chemistry Authors: Aaron R. Van Dyke, Daniel H. Gatazka and Mariah M. Hanania Source Type: research